检索结果-南通市图书馆

Synthesis of a copolymer carrier for anticancer drug luteolin for targeting human breast cancer cells

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2019年第4期39卷 474-481页

作者： Mahin Maleki Ali Aidy Elahe Karimi Shaahin Shahbazi Nader Safarian naser Abbasi Biotechnology and Medicinal Plants Research Center Ilam University of Medical SciencesIlamIran Department of Chemistry Ilam BranchIslamic Azad UniversityIlamIran Department of Internal Medicine Faculty of MedicineIlam University of Medical SciencesIlamIran Department of Medical Oncology and Hematology Faculty of MedicineTehran University of Medical ScienceTehranIran Department of Pharmacology Medical SchoolIlam University of Medical SciencesIlamIran

OBJECTIVE: To focus a new chemoprevention approach that uses nanotechnology to deliver luteolin to human breast cancer cells(MCF-7), and its underlying ***: Water-soluble copolymer-encapsulated nanoparticle-luteolin(CENL) was formulated using the hydrophobic drug luteolin. The ability to load and release he anticancer drug into/from the synthesized hyperbranched polyester was evaluated by high-performance liquid *** successful synthesis of CENL was supported by analytical techniques including fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography,and dynamic light scattering. Cell viability was measured using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide color method. Reactive oxygen species(ROS) were measured using a dichlorofluorescein probe and intracellular calcium(Cai2+) was evaluated with a flu3-AM ***: The results showed that the drug delivery system is stable and that the loading capacity is high. Treatment with nanoparticles containing luteolin and free luteolin resulted in cell death in breast cancer cells at high concentrations (IC50(33 ± 4) and(48 ± 6) μM, respectively)At high concentrations,CENL reduced cell viability and increased ROS and Cai2+ ***: Our results demonstrate that CENL has potential for human breast cancer treatment.

关键词： Polymers Materials testing Drug delivery systems Luteolin

Application of AVO and Seismic Attributes Techniques for Characterizing Pliocene Sand Reservoirs in Darfeel Field, Eastern Mediterranean, Egypt

在线全文

学校读者我要写书评

暂无评论

International Journal of Geosciences 2022年第10期13卷 973-984页

作者： Islam Hashem Abd El-naser Helal Amir M. S. Lala Belayim Petroleum Company Cairo Egypt Faculty of Science Ain Shams University Cairo Egypt

Mediterranean Sea considered as a main hydrocarbon province in Egypt as a huge reservoirs have been discovered till now. Port Fouad marine is a gas and condensate field located in Eastern Mediterranean Sea about 30 KM off Egyptian coast, in a water depth of about 30 m. The Concession is operated by PETROBEL on behalf of Petrosaid (Port Said Petroleum Company). The field was put on production on April 1996, from the Miocene turbidities sands of Wakar Formation plus Pilocene Kafr EL Sheikh Formation. Darfeel field is located within Port Fouad Concession, seven wells have been drilled till now and producing from Pliocene section (Kafr El Sheikh Formation). Pliocene is the main reservoir in Darfeel field which characterized by turbidities sand stone. The aim of this work is to identify the distribution of turbidities sand and characterize sand reservoirs using AVO (amplitude verses offset) and seismic attributes techniques. The workflow is starting from conventional seismic interpretation, maps (time, depth, and amplitude), depositional environments, and finally structure setting. In addition to use some of unconventional seismic interpretation such as seismic attributes. AVO analysis and attributes had been applied in a temp of differentiate between gas sand reservoirs and non-gas reservoirs. The final result aid to identify the reservoir distribution and characterization of sand reservoirs through the field. So, the use of different seismic techniques is powerful techniques in identifying reservoir distribution.

关键词： AVO Darfeel Field Seismic Attributes Wakar Formation Kafr El Sheikh Formation Turbidities

Transmembrane serine protease 2 and angiotensin-converting enzyme 2 anti-inflammatory receptors for COVID-19/inflammatory bowel diseases treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第46期27卷 7943-7955页

作者： naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz Amir Hossein Abdolghaffari Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKaraj 141554364Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group(GPIG) Universal Scientific Education and Research Network(USERN)Tehran ***Iran

long-term,and relapsing inflammatory *** may spontaneously grow in the colon,and in severe cases may result in tumor lesions such as invasive carcinoma in inflamed regions of the *** epidemiological reports indicate that old age and underlying diseases such as IBD contribute to severity and mortality in patients with coronavirus disease 2019(COVID-19).Currently,the ongoing COVID-19 pandemic caused serious morbidity and mortality *** has also been shown that the transmembrane serine protease 2 is an essential factor for viral activation and viral ***,viral entry causes a'cytokine storm'that induces excessive generation of proinflammatory cytokines/chemokines including interleukin(IL)-6,IL-2,IL-7,tumor necrosis factor-α,and interferon-γ.Future research could concentrate on developing inflammatory immunological responses that are efficient to encounter *** analysis elucidates the role of inflammation and immune responses during IBD infection with COVID-19 and provides a list of possible targets for IBD-regulated therapies in *** from clinical,in vitro,and in vivo studies were collected in English from PubMed,Google Scholar,Scopus,and the Cochrane library until May 2021.

关键词： Inflammatory bowel diseases COVID-19 Transmembrane serine protease 2 Inflammation Pro-inflammatory Immunological responses

A review on the best practices in concrete pavement design and materials in wet-freeze climates similar to Michigan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2019年第3期6卷 245-255页

作者： naser P. Sharifi Siyu Chen Zhanping You Thomas Van Dam Christopher Gilbertson Department of Civil and Environmental Engineering Michigan Technological University Houghton MI 49931 USA Nichols Consulting Engineers Chtd. Reno NV 89509 USA

The research presented in this paper aims to identify best practices of design and materials for concrete pavements in wet-freeze climates similar to the Michigan State. For the purposes of this paper, a best practice is a procedure that has been shown by field-validated research or experience to produce improved results and that is established or proposed as a standard suitable for widespread implementation. The local wet-freeze climate makes the requirements for Michigan's pavement system different from many other regions. Wetfreeze climates can result in various concrete pavement distress mechanisms such as thermally-induced cracking, freeze-thaw deterioration, accelerated cracking due to loss of support, frost heave, and material degradation. Therefore, appropriate procedures for design and material selection need to be selected to withstand high precipitation and freezing winter temperatures. Failure to take into account the climatic conditions may lead to inadequate or reduced pavement performance. However, utilizing appropriate techniques and materials could potentially improve the quality and increase the service life of the concrete pavement. Three design methods and five materials have been identified, and examples of their successful performance in wet-freeze climates are provided. In addition, the reasons that give them the superior performance in wet-freeze climates are discussed in detail.

关键词： Concrete pavements Pavement design Pavement materials Best practice Wet-freeze climate

Mammalian target of rapamycin;novel insight for management of inflammatory bowel diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Pharmacology 2022年第1期11卷 1-5页

作者： naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz Amir Hossein Abdolghaffari Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Department of Pharmacology Medicinal Plants Research CenterInstitute of Medicinal PlantsACECRKaraj ***Iran Toxicology and Diseases Group(TDG) Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehran ***Iran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group(GPIG) Universal Scientific Education and Research Network(USERN)Tehran ***Iran

Inflammatory bowel diseases(IBDs),with blurred etiology,show a rising trend and are of global *** various factors involved in IBD pathogenesis and development,inflammation has been shown to play a major *** of the molecular and cellular pathways that induce IBD is an emerging subject to develop targeted *** target of rapamycin(mTOR)is one the most common receptors of many inflammatory pathways,including that of *** this end,we intend to overview the mTOR inhibitors for their possible efficacy in present and future approaches to treatment of IBD.

关键词： Inflammatory bowel diseases Inflammation Mammalian target of rapamycin Mammalian target of rapamycin inhibitors

Herd-prevalence of Coxiella burnetii(Q fever) antibodies in dairy cattle farms based on bulk tank milk analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第1期4卷 58-60页

作者： Mohammad Khalili Ehsanollah Sakhaee Mohammad Reza Aflatoonian naser Shahabi-Nejad Research Center of Tropical and Infectious Diseases Kerman University of Medical SciencesKermanIran Department of Pathobiology School of Veterinary MedicineShahid Bahonar University of KermanIran Department of Clinical Sciences School of Veterinary MedicineShahid Bahonar University of KermanIran

Objective:To determine the prevalence of Coxiella burnetii(***) antibody positive randomly selected dairy herds in southeast Iran(Kerman).Methods:Bulk tank milk samples were collected randomly from 44 sufficiently large commercial dairy herds,included near 12 000 dairy cattle,in Kerman(The largest province of Iran),southeast *** samples were tested for antibodies against *** using the commercial CHEKIT(?) Q fever antibody ELISA Test Kit(Idexx,Liebefeld-Bern,Switzerland).Results:The prevalence of positive,negative and intermediate herds were 45.4%,43.2%and 11.4%,***:The result supports the hypothesis of high prevalence and endemic pattern of Q fever in *** investigation highlights the importance of further studies on Q fever in Iran.

关键词： Q fever Coxiella burnetii Bulk tank milk Dairy cattle ELISA Iran

用于电催化氧化甲醛的新型Ni(OH)_2-X/CPE负载电极的制备（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 2016年第1期37卷 159-168页

作者： Safura Kavian Seyed naser Azizi Shahram Ghasemi 马赞德兰大学化学学院分析部马赞德兰大学化学学院

采用一种简易的方法制备了新型Ni(OH)_2-X/CPE电极,并将其用于电催化氧化甲醛反应.采用扫描电镜和能量散射谱对所制Ni(OH)_2-X/CPE电极进行了表征,并运用循环伏安法、电化学阻抗谱和计时电流法考察了该电极的电化学性能.结果表明,该Ni(O... 详细信息

采用一种简易的方法制备了新型Ni(OH)_2-X/CPE电极,并将其用于电催化氧化甲醛反应.采用扫描电镜和能量散射谱对所制Ni(OH)_2-X/CPE电极进行了表征,并运用循环伏安法、电化学阻抗谱和计时电流法考察了该电极的电化学性能.结果表明,该Ni(OH)_2-X/CPE电极对甲醛氧化表现出高电催化活性,这归功于X具有纳米孔结构和大的比表面积.电子传递系数和催化反应速率常数分别为0.7和6.1×10~4cm^3/(mol·s).该电极对甲醛氧化具有高而稳定的电催化活性,且制备重复性高,有望应用于燃料电池中.

关键词：燃料电池电催化剂多孔NaX纳米分子筛甲醛计时电流法

Corrosion Protection of 5083 AA in SalineWater by Polyacrylonitrile Nanofibers

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2021年第11期9卷 1927-1939页

作者： Enas H.Ali Juman A.naser Zainab W.Ahmed Taki A.Himdan Department of Chemistry College of Education for Pure Science-Ibn Al-HaithamUniversity of BaghdadBaghdadIraq

Polymeric nanofibers are a promising technology to protect the metal surfaces from *** the literature search,the use of polyacrylonitrile nanofibres(PANNFs)as a corrosion inhibitor coating for aluminum alloys has not been *** work includes the development of a new,lightweight,high surface area and efficient coating of PANNFs that produced using electrospinning process to resist the corrosion of aluminum alloys(AA5083)which immersed in 0.6 M NaCl at alkaline medium(pH=12)and acidic medium(pH=1)at a range of temperatures(293–323)*** PANNFs coating was successfully deposited on AA 5083 specimens,where these samples were considered as a collector electrode in the electrospinning *** corrosion experiments of the aluminum alloys coated with PANNFs before and after immersion in both corrosive mediums were investigated using cyclic potential polarization(CPP).The results confirmed that the PANNFs coating was able to protect the surface of the aluminum specimens from corrosion,by reducing the corrosion current and increasing the surface polarization resistance,thus reducing the corrosion *** protection efficiency was found in the alkaline medium 98.8%while in the acidic medium 83.3%.So,it was in both mediums decreased with the increase in *** shape,distribution and size of the polymeric nanofibers that formed the coating were also examined using field emission scanning electron microscopy(FE-SEM)and the percentages of the structural components of these fibers were detected using the X-ray dispersion spectroscopy(EDS).The surface of aluminum specimens was completely covered by *** electrospun nanofibers have worn out and lined up spacing after immersion in the corrosive *** diameters average of PANNFs was found to be about 200 and 150 nm before and after immersion,respectively.

关键词： Corrosion protection nanofibers polyacrylonitrile aluminum alloy saline medium protection efficiency

利用水/氧化锌纳米流体改善平板太阳能集热器的性能

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2021年第11期28卷 3391-3403页

作者： SHOKRGOZAR ABBASI Ali KHAN Aghaiy naser Department of Mechanical Engineering Payame Noor UniversityIran

本文通过实验研究了水/氧化锌纳米流体作为工作流体对太阳能集热器性能的影响,其中纳米粒子的体积浓度为0.4%,粒径为40 nm,流体的质量流量为1~3 kg/min。平板集热器吸收的太阳能被水/氧化锌纳米流体吸收,纳米流体被泵送到热交换器对水... 详细信息

本文通过实验研究了水/氧化锌纳米流体作为工作流体对太阳能集热器性能的影响,其中纳米粒子的体积浓度为0.4%,粒径为40 nm,流体的质量流量为1~3 kg/min。平板集热器吸收的太阳能被水/氧化锌纳米流体吸收,纳米流体被泵送到热交换器对水进行加热。测量设备不同部位的温度、辐射水平、流量和压力,使用ASHRAE标准来计算效率,结果表明:与水相比,使用水/氧化锌纳米流体可提高集热器的性能;当质量流量为1 kg/min时,与水相比,纳米流体可使集热器效率提高16%。

关键词：太阳能集热器悬浮液太阳能加热系统集热器效率水/氧化锌纳米流体