Transmembrane serine protease 2 and angiotensin-converting enzyme 2 anti-inflammatory receptors for COVID-19/inflammatory bowel diseases treatment

作     者：Naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz Amir Hossein Abdolghaffari 

作者机构：Department of Toxicology and PharmacologyFaculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehran ***Iran Medicinal Plants Research CenterInstitute of Medicinal PlantsACECRKaraj 141554364Iran Toxicology and Diseases Group(TDG)Pharmaceutical Sciences Research Center(PSRC)The Institute of Pharmaceutical Sciences(TIPS)Tehran University of Medical SciencesTehran ***Iran Department of Toxicology and PharmacologyFaculty of PharmacyTehran University of Medical SciencesTehran ***Iran Gastrointestinal Pharmacology Interest Group(GPIG)Universal Scientific Education and Research Network(USERN)Tehran ***Iran 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第46期

页      面：7943-7955页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Inflammatory bowel diseases COVID-19 Transmembrane serine protease 2 Inflammation Pro-inflammatory Immunological responses 

摘      要：long-term,and relapsing inflammatory *** may spontaneously grow in the colon,and in severe cases may result in tumor lesions such as invasive carcinoma in inflamed regions of the *** epidemiological reports indicate that old age and underlying diseases such as IBD contribute to severity and mortality in patients with coronavirus disease 2019(COVID-19).Currently,the ongoing COVID-19 pandemic caused serious morbidity and mortality *** has also been shown that the transmembrane serine protease 2 is an essential factor for viral activation and viral ***,viral entry causes a cytokine storm that induces excessive generation of proinflammatory cytokines/chemokines including interleukin(IL)-6,IL-2,IL-7,tumor necrosis factor-α,and interferon-γ.Future research could concentrate on developing inflammatory immunological responses that are efficient to encounter *** analysis elucidates the role of inflammation and immune responses during IBD infection with COVID-19 and provides a list of possible targets for IBD-regulated therapies in *** from clinical,in vitro,and in vivo studies were collected in English from PubMed,Google Scholar,Scopus,and the Cochrane library until May 2021.