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Vasoprotective effects of rice bran water extract on rats fed with high-fat diet

Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 778-784页

作者： narongsuk munkong Pintusorn Hansakul Bhornprom Yoysungnoen Ariyaphong Wongnoppavich Seewaboon Sireeratawong Noppamat Kaendee Nusiri Lerdvuthisopon Department of Medicine School of MedicineUniversity of Phayao Department of Preclinical Science Faculty of MedicineThammasat University Department of Biochemistry Faculty of MedicineChiang Mai University Department of Pharmacology Faculty of MedicineChiang Mai University Department of Health Promotion Faculty of Health ScienceSrinakharinwirot University

Objective:To elucidate the protective effects of rice bran water extract on the expression of endothelial nitric oxide synthase(e NOS),nuclear factor-kappa B(NF-k B),and a cluster of differentiation 36(CD36) in the vasculature of high-fat diet-fed rats.Methods:Male Sprague-Dawley rats were divided into three groups.Group I served as control,Group II was treated with high-fat diet,and Group III was treated with high-fat diet and rice bran water extract at 2 205 mg/kg/day.After four weeks,the metabolic parameters,malondialdehyde as a marker of oxidative stress,and histological features of the aorta were evaluated.The levels of transcripts and proteins in aorta were determined by real-time PCR and Western blot analysis,respectively.Results:In comparison with the Group II,rice bran water extract administration resulted in a significant reduction in body weight,visceral fat tissue weights,blood glucose levels,and serum total-cholesterol and free fatty acid levels in Group III.Serum triglyceride levels tended to decrease in the Group III.Also,rice bran water extract administration obviously decreased malondialdehyde levels in both serum and aorta.Interestingly,rice bran water extract treatment demonstrated a significant up-regulation of e NOS expression and down-regulation of NF-k B p65 and CD36 expressions.Nonetheless,all groups showed normal histology of aorta.Conclusions:Rice bran water extract exhibited vasoprotective effects in the high-fat diet-induced obesity condition by modulating the expression of e NOS,NF-kB,and CD36 and metabolic parameters.

关键词： Rice bran Metabolic syndrome Cardiovascular disease Endothelial nitric oxide synthase Nuclear factor-kappa B Cluster of differentiation 36

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Anti-insulin resistant effect of ferulic acid on high fat diet-induced obese mice

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Asian Pacific Journal of Tropical Biomedicine 2018年第12期8卷 604-608页

作者： Jarinyaporn Naowaboot Pritsana Piyabhan Pholawat Tingpej narongsuk munkong Wason Parklak Patchareewan Pannangpetch Division of Pharmacology Department of Preclinical ScienceFaculty of MedicineThammasat University (Rangsit Campus) Division of Physiology Department of Preclinical ScienceFaculty of MedicineThammasat University (Rangsit Campus) Division of Microbiology Department of Preclinical ScienceFaculty of MedicineThammasat University (Rangsit Campus) Division of Pathology School of MedicineUniversity of Phayao Graduate Academy Faculty of MedicineThammasat University (Rangsit Campus) Department of Pharmacology Faculty of MedicineKhon Kaen University

Objective: To evaluate the insulin sensitivity action of ferulic acid(FA) in skeletal muscle and hypothalamus of high-fat diet(HFD)-induced obese mice. Methods: Obese mouse model was induced by HFD(45 kcal% lard fat) for 16 weeks. After 8 weeks of HFD feeding, these obese mice were orally treated with FA at doses of 25 and 50 mg/kg/day for 8 weeks. At the end of all treatments, the epididymal fat, pancreas, skeletal muscle and hypothalamus were removed for biochemical parameter and protein expression examinations. Results: FA treatment significantly decreased leptin level in fat tissue and insulin level in pancreas(P < 0.05). Interestingly, obese mice treated with FA increased the protein expressions of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and phosphorylated-protein kinase B in both muscle and brain(P < 0.05). The phosphorylations of adenosine monophosphate-activated protein kinase and acetyl-CoA carboxylase in muscle, and leptin receptor protein in hypothalamus were also increased(P < 0.05). The pancreatic islets histology showed smaller size in obese mice treated with FA compared to untreated obese mice. Conclusions: These findings indicate the beneficial effect of FA in improving insulin resistance in HFD-induced obese mice. These effects are probably mediated via modulating the insulin receptor substrate/phosphatidylinositol 3-kinase/protein kinase B or adenosine monophosphate-activated protein kinase pathways.

关键词： protein obese mice insulin FA

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