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Multifactorial nature of hepatocellular carcinoma drug resistance: Could plant polyphenols be helpful?

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World Journal of Gastroenterology 2007年第14期13卷 2037-2043页

作者： natale D'Alessandro Paola poma Giuseppe Montalto Department of Pharmacological Sciences University of Palermo Italy Department of Clinical Medicine University of Palermo PalermoItaly

Primary hepatocellular carcinoma （HCC） is a quite frequent tumor which results in high mortality and most often exhibits a poor response to present drug therapies. Clearly, a thorough understanding of the biological bases of this malignancy might suggest new strategies for its treatment. Here we examine the evidences that both ＂pharmacological＂ mechanisms （e.g. drug transporter or detoxification enzyme over-expression） and alterations in other critical factors, including the IAPs （Inhibitory of Apoptosis Proteins）, involved in enhancement of cell survival and proliferation may determine the therapeutic resistance of HCC; we also underline the possible role in the process of the activation of transcription factors, like nF-κb, capable of contemporaneously up-regulating the mechanisms discussed. On this basis, we finally comment on the possible use of natural multi-targeted antitumoral agents like plant polyphenols to achieve sensitization to treatments in HCC.

关键词： Hepatocellular carcinoma Drug resistance Drug transporters Inhibition of cell death LAPs nF-κb Plant polyphenols

Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review

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World Journal of Diabetes 2024年第5期15卷 1001-1010页

作者： Douglas nitzke Juliana Czermainski Carolina Rosa Chaline Coghetto Sabrina Alves Fernandes Randhall b Carteri Department of nutrition Centro Universitário CESUCACachoeirinha 94935-630Brazil Department of Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90430-080Brazil Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil

bACKGROUnD Type 2 diabetes is a chronic,non-communicable disease with a substantial global impact,affecting a significant number of *** etiology is closely tied to imbalanced dietary practices and sedentary ***,increasing die-tary fiber(DF)intake has consistently demonstrated health benefits in numerous studies,including improvements in glycemic control and weight *** To investigate the efficacy of DF interventions in the management of type 2 diabetes mellitus(T2DM).METHODS A systematic literature review was conducted to explore the association between DF intake and the management of *** the inclusion and exclusion criteria,a total of 26 studies were included in this *** The main strategies implied to increased DF intake were:High DF diet plus acarbose(2 studies);DF supplements(14 studies);and high DF diets(10 studies).Overall,most studies indicated that increased DF intake resulted in im-provements in glycemic control and weight management in T2DM *** DF represents a valuable strategy in the treatment of type 2 diabetes,improving health *** intake offers the potential to improve quality of life and reduce complications and mortality associated with ***,through supplements or enriched foods,DF contributes significantly to the control of several markers such as HbA1c,blood glucose,triglycerides,low-density lipoprotein,and body weight.

关键词： Type 2 diabetes mellitus Soluble fibers Insoluble fibers Probiotics blood glucose nutrition

Shock index and its variants as predictors of mortality in severe traumatic brain injury

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World Journal of Critical Care Medicine 2024年第1期13卷 40-48页

作者： Randhall b Carteri Mateus Padilha Silvaine Sasso de Quadros Eder Kroeff Cardoso Mateus Grellert Department of nutrition Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of Analysis and Systems Development Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of nutrition Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Department of Physiotherapy Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Institute of Informatics Federal University of Rio Grande do Sul(UFRGS)Porto Alegre 91501-970Rio Grande do SulBrazil

bACKGROUnD The increase in severe traumatic brain injury(sTbI)incidence is a worldwide phenomenon,resulting in a heavy disease burden in the public health systems,specifically in emerging *** shock index(SI)is a physiological parameter that indicates cardiovascular status and has been used as a tool to assess the presence and severity of shock,which is increased in *** the high mortality of sTbI,scrutinizing the predictive potential of SI and its variants is *** To describe the predictive potential of SI and its variants in *** This study included 71 patients(61 men and 10 women)divided into two groups:Survival(S;n=49)and non-survival(nS;n=22).The responses of blood pressure and heart rate(HR)were collected at admission and 48 h after *** SI,reverse SI(rSI),rSI multiplied by the Glasgow Coma Score(rSIG),and Age multiplied SI(AgeSI)were *** comparisons included Shapiro-Wilk tests,and independent samples *** predictive analysis,logistic regression,receiver operator curves(ROC)curves,and area under the curve(AUC)measurements were *** no significant differences between groups were identified for SI,rSI,or *** AgeSI was significantly higher in nS patients at 48 h following admission(S:26.32±14.2,and nS:37.27±17.8;P=0.016).both the logistic regression and the AUC following ROC curve analysis showed that only AgeSI at 48 h was capable of predicting sTbI *** Although an altered balance between HR and blood pressure can provide insights into the adequacy of oxygen delivery to tissues and the overall cardiac function,only the AgeSI was a viable outcome-predictive tool in sTbI,warranting future research in different cohorts.

关键词： Head trauma Critical patient neuro-cardio axis Predictive tool Clinical practice

Using old liver grafts for liver transplantation: Where are the limits?

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World Journal of Gastroenterology 2014年第31期20卷 10691-10702页

作者： Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González Service of General and Digestive Surgery and Abdominal Organ Transplantation "Doce de Octubre" University Hospital

The scarcity of ideal liver grafts for orthotopic liver transplantation (OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis b virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts.

关键词： Old liver donors Liver transplantation Aging liver Liver graft Liver disease Aging Donor management Septuagenarian donors Octogenarian donors

Isochrone Fitting of Galactic Globular Clusters—Ⅵ.High-latitude Clusters nGC 5024 (M53),nGC 5053,nGC 5272 (M3),nGC 5466,and nGC7099 (M30)

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Research in Astronomy and Astrophysics 2024年第6期24卷 170-190页

作者： G.A.Gontcharov S.S.Savchenko A.A.Marchuk C.J.bonatto O.S.Ryutina M.Yu.Khovritchev V.b.Il'in A.V.Mosenkov D.M.Poliakov A.A.Smirnov Central(Pulkovo)Astronomical Observatory Russian Academy of SciencesPulkovskoye chaussee 65/1St.Petersburg 196140Russia Saint Petersburg State University Universitetskij pr.28St.Petersburg 198504Russia Special Astrophysical Observatory Russian Academy of Sciences369167 Nizhnij ArkhyzRussia Departamento de Astronomia Instituto de FísicaUFRGSAv.Bento Gonçalves9500Porto AlegreRSBrazil Saint Petersburg University of Aerospace Instrumentation Bol.Morskaya ul.67ASt.Petersburg 190000Russia Department of Physics and Astronomy Brigham Young UniversityN283 ESCProvoUT 84602USA

We fit various color–magnitude diagrams(CMDs) of the high-latitude Galactic globular clusters nGC 5024(M53),nGC 5053,nGC 5272(M3),nGC 5466,and nGC 7099(M30) by isochrones from the Dartmouth Stellar Evolution Database and bag of Stellar Tracks and Isochrones for α–enrichment [α/Fe] = +*** the CMDs,we use data sets from Hubble Space Telescope,Gaia,and other sources utilizing,at least,25 photometric filters for each *** obtain the following characteristics with their statistical uncertainties for nGC 5024,nGC 5053,nGC 5272,nGC 5466,and nGC 7099,respectively:metallicities [Fe/H] =-1.93 ± 0.02,-2.08 ± 0.03,-1.60 ± 0.02,-1.95 ± 0.02,and-2.07 ± 0.04 dex with their systematic uncertainty 0.1 dex;ages 13.00 ± 0.11,12.70 ± 0.11,11.63 ± 0.07,12.15 ± 0.11,and 12.80 ± 0.17 Gyr with their systematic uncertainty 0.8 Gyr;distances(systematic uncertainty added) 18.22 ± 0.06 ± 0.60,16.99 ± 0.06 ± 0.56,10.08 ± 0.04 ± 0.33,15.59 ±0.03 ± 0.51,and 8.29 ± 0.03 ± 0.27 kpc;reddenings E(b-V) = 0.023 ± 0.004,0.017 ± 0.004,0.023 ± 0.004,0.023 ± 0.003,and 0.045 ± 0.002 mag with their systematic uncertainty 0.01 mag;extinctions AV= 0.08 ± 0.01,0.06 ± 0.01,0.08 ± 0.01,0.08 ± 0.01,and 0.16 ± 0.01 mag with their systematic uncertainty 0.03 mag,which suggest the total Galactic extinction AV= 0.08 across the whole Galactic dust to extragalactic objects at the north Galactic *** horizontal branch morphology difference of these clusters is explained by their different metallicity,age,mass-loss efficiency,and loss of low-mass members in the evolution of the core-collapse cluster nGC 7099 and loose clusters nGC 5053 and nGC 5466.

关键词： (stars:)Hertzsprung Russell and C-M diagrams (ISM:)dust extinction (Galaxy:)globular clusters:general (Galaxy:)globular clusters:individual(nGC 5024,nGC 5053,nGC 5272,nGC 5466,nGC7099)

Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes

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Journal of Geriatric Cardiology 2019年第2期16卷 121-128页

作者： Miquel Vives-borras Manuel Martinez-Selles Albert Ariza-Sole Maria T.Vidan Francesc Formiga Hector bueno Juan Sanchis Oriol alegre Albert Duran-Cambra Ramon Lopez-Palop Emad Abu-Assi Alessandro Sionis LOnGEVO-SCA Investigators Department of Cardiology Hospital de la Santa Creu i Sant PauInstitute of Biomedical Research I1B Sant PauCIBERCVUniversitat Autonoma de BarcelonaBarcelonaSpain department of Cardiology Hospital General Universitario Gregorio MarahonC1BERCVUniversidad ComplutenseUniversidad EuropeaMadridSpain Hospital Universitari de bellvitge L'Hospitalet de LlobregatBarcelonaSpain Hospital General Universitario Gregorio Maranon IiSGMCIBERFESUniversidad ComplutenseMadrid.Spain Hospital Doce de Octubre Centro Nacional de Investigaciones CardiovascularesMadridSpain Hospital Clinico de Valencia INCLIVAUniversidad de ValenciaCIBERCVSpain Hospital Universitario San Juan AlicanteSpain Hospital Alvaro Cunqueiro VigoSpain 不详

background Elderly patients with non-ST-segment elevation acute coronary syndromes(nSTE-ACS)may present delirium but its clinical relevance is *** study aimed at detennining the clinical associated factors,and prognostic implications of delirium in old-aged patients admitted for *** LOnGEVO-SCA is a prospective multicenter registry including unselected patients with nSTE-ACS aged>80 *** variables and a complete geriatric evaluation were assessed during *** association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding *** also analysed its association with 6-month bleeding and cognitive or functional *** Among 527 patients included,thirty-seven(7%)patients presented delirium during the *** was more frequent in patients with dementia or depression and in those from nursing homes(27.0%vs.3.1%,24.3%vs.11.6%,and 11.1%V5.2.2%,respectively;all Pnificantly associated with in-hospital infections(27.0%vs.5.3%,Pnd usage of diuretics(70.3%vs.49.8%,P=0.02).Patients with delirium had longer hospitalizations[median 8.5(5.5-14)vs.6.0(4.0-10)days,P=0.02]and higher incidence of 6-month bleeding and mortality(32.3%vs.10.0%and 24.3%vs.10.8%,respectively;both Pbut similar cognitive or functional *** was independently associated with 6-month mortality(HR=1.47,95%CI:1.02-2.13,P=0.04)and 6-month bleeding events(OR=2.87;95%CI:1.98-4」6,Pnclusions In-hospital delirium in elderly patients with nSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality.

关键词： Acute coronary syndromes Delirium Prognosis The elderly

Estimation of aboveground biomass of arboreal species in the semi-arid region of brazil using SAR(synthetic aperture radar)images

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Journal of Arid Land 2023年第6期15卷 695-709页

作者： Janisson b de JESUS Tatiana M KUPLICH Íkaro D de C bARRETO Fernando L HILLEbRAnD Cristiano n da ROSA Postgraduate Program in Remote Sensing Federal University of Rio Grande do SulCampus ValePorto Alegre 91501970Brazil national Institute for Space Research(InPE) COESU(Southern Spatial Coordination)Santa Maria 97105970Brazil Postgraduate Program biometry and Applied Statistics Rural Federal University of PernambucoRecife 52171900Brazil Federal Institute of Education Science and Technology of Rio Grande do Sul(IFRS)Campus RolanteRolante 95690000Brazil Postgraduate Program in Remote Sensing Polar and Climate CenterFederal University of Rio Grande do SulPorto Alegre 91501970Brazil

The Caatinga biome is an important ecosystem in the semi-arid region of *** has significantly degraded due to human activities and is currently a region undergoing ***,monitoring the variation in the Caatinga biome has become essential for its sustainable ***,traditional methods for estimating aboveground biomass(AGb)are time-consuming and *** sensing,such as optical and radar imaging,can estimate and correlate with ***,radar imaging is still a novelty to be applied in estimating the AGb of this biome,which is an area with little ***,this study aimed to use Sentinel-1 images to estimate the AGb of the Caatinga biome in Sergipe State(northeastern brazil)and to verify its influencing *** sample plots(30 m×30 m)were selected,and the stems of individuals with a circumference at breast height(1.3 m above the ground)equal to or greater than 6.0 cm were measured,and the AGb through an allometric equation was *** Sentinel-1 images from 3 different periods(green,intermediate,and dry periods)were used to consider the phenological conditions of the Caatinga *** the pre-processing and extraction of attributes(co-polarized VV(vertical transmit and vertical receive),cross-polarized VH(vertical transmit and horizontal receive),and band ratio VH/VV backscatter,radar vegetation index,dual polarization synthetic aperture radar(SAR)vegetation index(DPSVI),entropy(H),and alpha angle(α))were performed with Sentinel’s Application *** attributes were used to estimate the AGb through simple and multiple linear regressions and evaluated by the coefficients of determination(R2),correlation(r),and root mean squared error(RMSE).The results showed that the attributes individually had little ability to estimate the AGb of the Caatinga biome in the three *** with multiple regression,we found that the intermediate period presented the equation with the best

关键词： Caatinga tropical dry forest coherent and incoherent attributes C-band Sentinel-1

Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina belén Keingeski bruno de Souza basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho nacional de Desenvolvimento Científico e Tecnológico(CnPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

bACKGROUnD Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEn)in drinking water and Veh gavage],and RIF[HFCD,DEn and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRnAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/b(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,becn1 and Ezh2 were lower in HCC and RIF-groups(Pn HCC compared to RIF(Pn of Mmp9 was higher in HCC in relation to the control;the opposite was observed for p62/Sqstm1(Pn of p62/SQSTM1 protein was lower in the RIF-group compared to the control(P=0.024).There was no difference among groups for Tuba-1c,Aldolase-b,alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(Pb was lower in HCC compared to RIF,and the inverse was observed for miR-224(Pno difference among groups regarding miR-33a,miR-143,miR-155,miR-375 and miR-21(P>0.05).COnCLUSIOn RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

Congenital Gangrene in a Premature newborn: A Case Report

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Open Journal of Pediatrics 2021年第3期11卷 393-397页

作者： Assetou Cissouma Mamadou b. Coulibaly Djibril Kassogué Hachimi A. poma Moussa Diassana bathio Traoré Aly Diallo Layes Touré Ternan Traoré Moussa Kanté Abdoulaye Kissima-Traoré Pediatric Service Sikasso Hospital Sikasso Mali Pediatric Surgery Service Sikasso Hospital Sikasso Mali Pediatric Service Timbuktu Hospital Timbuktu Mali Surgery General Service Sikasso Hospital Sikasso Mali Orthopedic and Trauma Surgery Service Sikasso Hospital Sikasso Mali Anesthesia and Intensive Care Service Sikasso Hospital Sikasso Mali Cardiology Service Sikasso Hospital Sikasso Mali

Introduction: Congenital limb gangrene is a rare pathology. In the majority of cases, no cause is identified and its treatment is not codified. Observation: 29-week premature newborn, female from poorly followed twin ... 详细信息

ng>Introduction:ng> Congenital limb gangrene is a rare pathology. In the majority of cases, no cause is identified and its treatment is not codified. b>Observation:b> 29-week premature newborn, female from poorly followed twin pregnancy. Clinical examination at admission found an unstable neonate, the presence of necrosis of the left hand and forearm well limited, with absent humeral pulse and absence of hand movement. Surgical treatment was scheduled for amputation of the limb after the agreement of the parents whose postoperative follow-ups were simple. b>Conclusion:b> Congenital gangrene remains a rare entity in neonatology.n>n>n>

关键词： Gangrene Upper Limb newborn Prematurity