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Novel Treatment of Hepatitis C Virus Infection for Patients with Renal Impairment

Journal of Clinical and Translational Hepatology 2016年第4期4卷 320-327页

作者： Goki Suda Koji Ogawa Megumi Kimura Masato Nakai Takuya Sho Kenichi Morikawa naoya sakamoto Department of Gastroenterology and Hepatology Graduate School of Medicine Hokkaido University Hokkaido Japan

Prevalence of hepatitis C virus (HCV) infection is high in patients with end-stage renal dysfunction,including patients undergoing hemodialysis (HD).The HCV infection itself can cause glomerulonephritis and puts individuals at increased risk of developing end-stage renal disease;fortunately,successful HCV eradication sometimes restore HCV-related renal ***,the prognosis of dialysis patients infected with HCV is significantly worse and the renal allograft survival in HCV-infected patients is also worse than in dialysis patients without HCV *** life prognosis is favorable,therefore,anti-HCV therapy is strongly recommended for HCV-infected patients with severe renal *** standard therapy for HCV-infected patients with severe renal dysfunction has historically been interferon-based ***,this therapy remains ineffective in achieving high,sustained viral response rates and the rate of adverse events and treatment discontinuation due to treatment-induced adverse events continues to be high in patients with severe renal *** and effective anti-HCV therapies are urgently needed,and crucial,for patients with severe renal ***,direct-acting antivirals (DAAs) that specifically target viral proteins have been developed,and these targets include the NS3,NS5A,and NS5B of *** trials have revealed high efficacy and safety of the DAA-based therapies,but patients with severe renal dysfunction were not included in the majority of these ***,several recent reports have shown high efficacy and safety for some regimens of DAA combination therapy for HCV-infected patients with severe renal *** this review,we discuss novel treatments for HCV-infected patients with severe renal dysfunction and the pharmacokinetics of these drugs.

关键词： DAAs HCV Hemodialysis CKD

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Preliminary study of automatic gastric cancer risk classification from photofluorography

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World Journal of Gastrointestinal Oncology 2018年第2期10卷 62-70页

作者： Ren Togo Kenta Ishihara Katsuhiro Mabe Harufumi Oizumi Takahiro Ogawa Mototsugu Kato naoya sakamoto Shigemi Nakajima Masahiro Asaka Miki Haseyama Graduate School of Information Science and Technology Hokkaido UniversityHokkaido 060-0814Japan Department of Gastroenterology National Hospital Organization Hakodate HospitalHokkaido 041-8512Japan Medical Examination Center of the Yamagata City Medical Association Yamagata 990-2473Japan Department of Gastroenterology Hokkaido University Graduate School of MedicineHokkaido 060-8648Japan Department of General Medicine Japan Community Healthcare Organization Shiga HospitalShiga 520-0846Japan Health Sciences University of Hokkaido Hokkaido 061-0293Japan

AIM To perform automatic gastric cancer risk classificationusing photofluorography for realizing effective mass screening as a preliminary study. METHODS We used data for 2100 subjects including X-ray images, pepsinogen Ⅰ and Ⅱ levels, PGⅠ/PGⅡ ratio, Helicobacter pylori (H. pylori) antibody, H. pylori eradication history and interview sheets. We performed two-stage classification with our system. In the first stage, H. pylori infection status classification was performed, and H. pylori-infected subjects were automatically detected. In the second stage, we performed atrophic level classification to validate the effectiveness of our *** Sensitivity, specificity and Youden index(YI) of H. pylori infection status classification were 0.884, 0.895 and 0.779, respectively, in the first stage. In the second stage, sensitivity, specificity and YI of atrophic level classification for H. pylori-infected subjects were 0.777, 0.824 and 0.601, respectively. CONCLUSION Although further improvements of the system are needed, experimental results indicated the effectiveness of machine learning techniques for estimation of gastric cancer risk.

关键词： Gastric cancer Helicobacter pylori Mass screening Photofluorography Automatic data processing

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Recent advances in endoscopic ultrasonography-guided biliary interventions

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World Journal of Gastroenterology 2015年第32期21卷 9494-9502页

作者： Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Shuhei Kawahata Yoko Abe Yoshimasa Kubota Kimitoshi Kubo Hiroyuki Isayama naoya sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Department of Gastroenterology Graduate School of Medicine The University of Tokyo

Interventional endoscopic ultrasonography(EUS) based on EUS-guided fine-needle aspiration has rapidly spread as a minimally invasive procedure. Especially in patients with failed endoscopic retrograde cholangiopancreatography, EUS-guided biliary intervention is reported to be useful as salvage therapy. EUS-guided biliary interventions are carried out using three techniques: EUS-guided bilioenteric anastomosis, EUS-guided rendezvous procedure, and EUS-guided antegrade treatment. Although interventional EUS is not yet a standardized procedure, there have been recent advances in this field that address various biliary diseases. Here, we summarize the indications, techniques, clinical results of previous studies, and future perspectives.

关键词： Endosonography-guided biliary intervention Choledo

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Visualization and Management Platform with Augmented Reality for Wireless Sensor Networks

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Wireless Sensor Network 2015年第1期7卷 1-11页

作者： Kenya Sato naoya sakamoto Hideki Shimada Department of Information Systems Design Doshisha University Kyoto Japan

Recently a ubiquitous sensor network which collects our environmental information gets increasingly popular, a visualization application is necessary for users to manage complicated wireless networks, however, these applications are developed individually for wireless communication standard or a type of wireless device. Therefore, users are forced to adopt and use the application individually according to the target of the wireless network. In this paper, we propose a visualization platform for wireless network environments using augmented reality technology, and evaluate the effectiveness of the platform. From the result of the evaluation, we have confirmed the proposed platform has availability for visualization and management of wireless networks.

关键词： Network Management Visualization Augmented Reality

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Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism

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World Journal of Gastroenterology 2020年第39期26卷 6047-6056页

作者： Masaki Inoue Yuichi Shimizu Marin Ishikawa Satoshi Abiko Yoshihiko Shimoda Ikko Tanaka Sayoko Kinowaki Masayoshi Ono Keiko Yamamoto Shoko Ono naoya sakamoto Department of Gastroenterology and Hepatology Graduate School of Medicine and Faculty of MedicineHokkaido UniversitySapporoHokkaido 060-0808Japan of Endoscopy Hokkaido University HospitalSapporoHokkaido 060-8648Japan Department of Cancer Pathology Hokkaido University Graduate School of MedicineSapporoHokkaido 060-0808Japan Department of Gastroenterology Hokkaido University HospitalSapporoHokkaido 060-8648Japan Department of Gastroenterology and Hepatology Hakodate Municipal HospitalHakodateHokkaido 041-8680Japan

BACKGROUND It is well known that an alcohol consumption habit together with inactive heterozygous aldehyde dehydrogenase-2(ALDH2)is an important risk factor for the development of esophageal squamous cell carcinoma(ESCC).It remains controversial whether human papillomavirus(HPV)infection contributes to the occurrence/development of *** has been no study in which the relationship between ESCC and HPV in addition to alcohol dehydrogenase-1B(ADH1B)and ALDH2 genotypes was *** To evaluate relationships between HPV infection and development of esophageal cancer,particularly early esophageal cancer,based on ADH1B/ALDH2 *** We conducted an exploratory retrospective study using new specimens,and we enrolled 145 patients who underwent endoscopic resection for superficial ESCC and had been observed for more than two years by both physical examination and endoscopic examination in Hokkaido University *** was collected to analyze genetic polymorphisms of ADH1B/*** performed in situ hybridization for resected specimens to detect HPV by using an HPV type 16/18 *** HPV was detected in 15(10.3%)of the 145 patients with ***-positive rates in inactive ALDH2*1/*2 and ALDH2*1/*1+*2/*2 were 10.8%and 9.8%,respectively(P=1.00).HPV-positive rates in slow-metabolizing ADH1B*1/*1 and ADH1B*1/*2+*2/*2 were 12.0%and 10.0%,respectively(P=0.72).HPV-positive rates in the heavy or moderate alcohol consumption group and the light or rare consumption group were 11.1%and 8.7%,respectively(P=0.68).HPV-positive rates in the heavy smoking group and the light or no smoking group were 11.8%and 8.3%,respectively(P=0.59).The 3-year incidence rates of secondary ESCC or head and neck cancer after initial treatment in the HPV-positive and HPVnegative groups were 14.4%and 21.4%(P=0.22),*** In the present situation,HPV status is considered to be less important than other risk factors,such as alcohol consumption,smoking habit,AD

关键词： Human papillomavirus Esophageal squamous cell carcinoma Early esophageal cancer Alcohol dehydrogenase-1B Aldehyde dehydrogenase-2 Endoscopic resection

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Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance

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World Journal of Gastroenterology 2014年第13期20卷 3620-3627页

作者： Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Kazunori Eto Shuhei Kawahata Yoko Abe Manabu Onodera Nobuyuki Ehira Hiroaki Yamato Shin Haba Kazumichi Kawakubo naoya sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of MedicineSapporo 060-8638Japan

AIM: To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in a cohort of pancreatic cancer patients.

关键词： Pancreatic cancer Diagnosis Biopsy Endoscopic ultrasound-guided fine-needle aspiration Preoperative diagnosis

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Prospect of lenvatinib for unresectable hepatocellular carcinoma in the new era of systemic chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2076-2087页

作者： Takuya Sho Kenichi Morikawa Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Taku Shigesawa Mugumi Kimura Masato Nakai Goki Suda Mitsuteru Natsuizaka Koji Ogawa naoya sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638HokkaidoJapan

The phase III clinical trial of the novel molecular targeted agent(MTA)lenvatinib for patients with advanced hepatocellular carcinoma(HCC)(REFLECT trial)found that lenvatinib was non-inferior to sorafenib in overall ***,the efficacy of multiple MTAs,including lenvatinib,in practice has been reported,and therapeutic strategies for Barcelona Clinic Liver Cancer(BCLC)intermediate stage HCC are undergoing major *** on these results,lenvatinib could be recommended for patients with transcatheter arterial chemoembolization(TACE)-refractory,ALBI grade 1,within the up-to-seven criteria in the BCLC intermediate *** provides a more favorable outcome than TACE,even in cases with large or multinodular HCC beyond the up-to-seven criteria with Child-Pugh grade *** patients meet the definitions of TACE-refractory or TACE-unsuitable,switching to systemic chemotherapy,including lenvatinib,is for favorable for preserving liver *** initial treatment,including MTA,has a significant therapeutic effect and downstaging of HCC is obtained,additional TACE or surgical resection should be *** also has a therapeutic effect for poorly differentiated type and non-simple nodular type HCC thanks to the survival-prolonging effect of this ***,a significant therapeutic effect is expected in tumors with more than 50%liver involvement or main portal vein invasion,which have traditionally been considered to have a poor prognosis in *** suggests that at the start of lenvatinib treatment,HCC patients with ALBI grade 1 may be able to maintain liver functional reserve.

关键词： Hepatocellular carcinoma Lenvatinib Molecular targeted agent TACE refractory TACE-unsuitable Barcelona Clinic Liver Cancer intermediate stage

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Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

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World Journal of Hepatology 2022年第7期14卷 1480-1494页

作者： Masato Nakai Kenichi Morikawa Shunichi Hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Masatsugu Ohara Takuya Sho Goki Suda Koji Ogawa naoya sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent *** To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage *** In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and *** contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically ***-three patients were HCV-positive and 77 were *** In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after *** HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative *** In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival ***-sarcopenia contributed to the poor prognosis independently in HCV-negative *** factors might be useful recurrence and prognostic markers for early-stage primary HCC.

关键词： Mac-2 binding protein Mac-2 binding protein glycosylation isomer Pre-sarcopenia Primary hepatocellular carcinoma Radiofrequency ablation

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Anterior mediastinal abscess diagnosed in a young sumo wrestler after closed blunt chest trauma

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Chinese Journal of Traumatology 2015年第6期18卷 360-362页

作者： Tatsuro Sassa Ken-ichiro Kobayashi Masayuki Ota Takuya Washino Mayu Hikone naoya sakamoto Sentaro Iwabuchi Mizuto Otsuji Kenji Ohnishi Department of Infectious Disease Tokyo Metropolitan Bokutoh General Hospital 4-23-15 kohtohbashi Sumida City Tokyo 130-0022 Japan

Most mediastinal abscesses result from infections after thoracotomy, esophageal perforation or pene- trating chest trauma. This disease is rarely caused by closed blunt chest trauma. All previously reported such cases after closed blunt chest trauma presented with hematoma and sternal osteomyelitis resulting from sternal fracture. Here we report a 15-year-old sumo wrestler who presented with an anterior mediastinal abscess without any mediastinal fracture. The mediastinal abscess resulted from the he- matogenous spread of Staphylococcus aureus to a hematoma that might have been caused by a closed blunt chest trauma incurred during sumo wrestling exercises.

关键词： Mediastinal abscess Staphylococcus aureus Sumo wrestler Chest trauma

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Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma

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World Journal of Gastrointestinal Endoscopy 2016年第9期8卷 385-390页

作者： Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa Kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera naoya sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Sapporo 0608638Japan

AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar ***:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and *** retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative *** risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related *** risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral ***:In total,137 complications were observed in92(78%)*** reintervention was required in 83(70%)*** was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)*** absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral *** sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral ***:The endoscopic management of hilar cholangiocarcinoma is *** should be selected as a temporary drainage method because of its low risk of complications.

关键词： Hilar cholangiocarcinoma Endoscopic nasobiliary drainage Endoscopic biliary stenting Endoscopic sphincterotomy Complications

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