Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism

作     者：Masaki Inoue Yuichi Shimizu Marin Ishikawa Satoshi Abiko Yoshihiko Shimoda Ikko Tanaka Sayoko Kinowaki Masayoshi Ono Keiko Yamamoto Shoko Ono Naoya Sakamoto 

作者机构：Department of Gastroenterology and HepatologyGraduate School of Medicine and Faculty of MedicineHokkaido UniversitySapporoHokkaido 060-0808Japan of EndoscopyHokkaido University HospitalSapporoHokkaido 060-8648Japan Department of Cancer PathologyHokkaido University Graduate School of MedicineSapporoHokkaido 060-0808Japan Department of GastroenterologyHokkaido University HospitalSapporoHokkaido 060-8648Japan Department of Gastroenterology and HepatologyHakodate Municipal HospitalHakodateHokkaido 041-8680Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第39期

页      面：6047-6056页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Human papillomavirus Esophageal squamous cell carcinoma Early esophageal cancer Alcohol dehydrogenase-1B Aldehyde dehydrogenase-2 Endoscopic resection 

摘      要：BACKGROUND It is well known that an alcohol consumption habit together with inactive heterozygous aldehyde dehydrogenase-2(ALDH2)is an important risk factor for the development of esophageal squamous cell carcinoma(ESCC).It remains controversial whether human papillomavirus(HPV)infection contributes to the occurrence/development of *** has been no study in which the relationship between ESCC and HPV in addition to alcohol dehydrogenase-1B(ADH1B)and ALDH2 genotypes was *** To evaluate relationships between HPV infection and development of esophageal cancer,particularly early esophageal cancer,based on ADH1B/ALDH2 *** We conducted an exploratory retrospective study using new specimens,and we enrolled 145 patients who underwent endoscopic resection for superficial ESCC and had been observed for more than two years by both physical examination and endoscopic examination in Hokkaido University *** was collected to analyze genetic polymorphisms of ADH1B/*** performed in situ hybridization for resected specimens to detect HPV by using an HPV type 16/18 *** HPV was detected in 15(10.3%)of the 145 patients with ***-positive rates in inactive ALDH2*1/*2 and ALDH2*1/*1+*2/*2 were 10.8%and 9.8%,respectively(P=1.00).HPV-positive rates in slow-metabolizing ADH1B*1/*1 and ADH1B*1/*2+*2/*2 were 12.0%and 10.0%,respectively(P=0.72).HPV-positive rates in the heavy or moderate alcohol consumption group and the light or rare consumption group were 11.1%and 8.7%,respectively(P=0.68).HPV-positive rates in the heavy smoking group and the light or no smoking group were 11.8%and 8.3%,respectively(P=0.59).The 3-year incidence rates of secondary ESCC or head and neck cancer after initial treatment in the HPV-positive and HPVnegative groups were 14.4%and 21.4%(P=0.22),*** In the present situation,HPV status is considered to be less important than other risk factors,such as alcohol consumption,smoking habit,AD