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Adult female syphilis prevalence,congenital syphilis case incidence and adverse birth outcomes,Mongolia 2000e2016:Estimates using the Spectrum STI tool

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Infectious Disease Modelling 2018年第1期3卷 13-22页

作者： Erdenetungalag Enkhbat Eline L.Korenromp Jugderjav Badrakh Setsen Zayasaikhan Purevsuren Baya Enkhjargal Orgiokhuu Narantuya Jadambaa Sergelen Munkhbaatar Delgermaa Khishigjargal Narantuya Khad Guy Mahiane naoko ishikawa Davaalkham Jagdagsuren Melanie M.Taylor Mongolia National Centre for Communicable Disease AIDS/STI Surveillance and Research DepartmentUlaanbaatar210648Bayanzurkh DistrictNam-Yan-Ju StreetMongolia Avenir Health GenevaSwitzerland1 route de Morillons/150 Route de Ferney(WCCOffice 164)PO Box 2100CH-1211 Geneva 2Switzerland World Health Organization Post Box 663Ulaanbaatar-13Mongolia Mongolia Global Fund Supported Project on AIDS and TB Peace Avenue 13/3Sukhbaatar DistrictUlaanbaatarMongolia Mongolia Center for Health Development Enkhtaivan Street-13bSukhbaatar DistrictUlaanbaatarMongolia Avenir Health 655 Winding Brook DriveGlastonburyCTCT-06033USA World Health Organization Western Pacific Regional OfficePO Box 2932(United Nations Avenue)1000 ManilaPhilippines World Health Organization Department of Reproductive Health and Research8 Avenue Appia(L152)1211 GenevaSwitzerland Centers for Disease Control and Prevention Atlanta GAUSA

Introduction:Mongolia's health ministry prioritizes control of Sexually Transmitted Infections,including syphilis screening and treatment in antenatal care(ANC).Methods:Adult syphilis prevalence trends were fitted using the Spectrum-STI estimation tool,using data from ANC surveys and routine screening over *** were combined with programmatic data to estimate numbers of treated and untreated pregnant women with syphilis and associated incidence congenital syphilis(CS)and CS-attributable adverse birth outcomes(ABO),which we compared with CS case ***:Syphilis prevalence in pregnant women was estimated at 1.7%in 2000 and 3.0%in *** estimated 652 CS cases,of which 410 ABO,in *** larger,annually increasing numbers of CS cases and ABO were estimated to have been prevented:1654 cases,of which 789 ABO in 2016thanks to increasing coverages of ANC(99%in 2016),ANC-based screening(97%in 2016)and treatment of women diagnosed(81%in 2016).The 42 CS cases reported nationally over 2016(liveborn infants only)represented 27%of liveborn infants with clinical CS,but only 7%of estimated CS cases among women found syphilis-infected in ANC,and 6%of all estimated CS cases including those born to women with undiagnosed ***/Conclusion:Mongolia's ANC-based syphilis screening program is reducing CS,but maternal prevalence remains *** eliminate CS(target:<50 cases per 100,000 live births),Mongolia should strengthen ANC services,limiting losses during referral for treatment,and under-diagnosis of CS including still-births and neonatal deaths,and expand syphilis screening and prevention programs.

关键词： Syphilis Congenital syphilis Surveillance Screening Antenatal care Epidemiological modelling

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Infrequent p53 gene mutation and expression of the cardia adenocarcinomas from a high-incidence area of Southwest China

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World Journal of Gastroenterology 2000年第5期6卷 750-753页

作者： naoko lida Hideaki Oda Shigetoshi Aiso Takatoshi ishikawa Department of Molecular Pathology Faculty of Medicinethe University of TokyoHongoTokyo 113Japan

INTRODUCTIONAdenocarcinomas of the cardia are the lesionsarising from the proximal stomach or within 3 cm ofthe gastroesophageal *** cancerstended to be advanced at the time of presentation,usually with poor *** recent decade,the incidence of adenocarcinoma of gastric eardiaand esophagus are increasing steadily,while therehas been a decrease in the proportion of the cancersarising from the distal ***

关键词： cardia adenocarcinoma/etiology protein P53 gene expression mutation genes p53 polymerase chain reaction DNA risk factors

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Rice-Specific Mitochondrial Iron-Regulated Gene （MIR） Plays an Important Role in Iron Homeostasis

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Molecular Plant 2009年第5期2卷 1059-1066页

作者： Yasuhiro Ishimaru Khurram Bashir Masaru Fujimoto Gynheung An Reiko Nakanishi Itai Nobuhiro Tsutsumi Hiromi Nakanishi naoko K Nishizawa Graduate School of Agricultural and Life Sciences The University of Tokyo 1-1-1 Yayoi Bunkyo-Ku Tokyo 113-8657 Japan Department of Life Sciences Pohang University of Science and Technology Pohang 790-784 Republic of Korea Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University Ishikawa 921-8836 Japan

Mitochondria utilize iron （Fe）, but the proteins involved in mitochondrial Fe regulation are not characterized in plants. We cloned and characterized a mitochondrial iron-regulated （MIR） gene in rice involved in Fe homeostasis. MIR, when expressed in tobacco BY-2 cells, was localized to the mitochondria. MIR transcripts were greatly increased in response to Fe deficiency in roots and shoot tissue. MIR is not homologous to any known protein, as homologs were not found in the rice or Arabidopsis genome databases, or in the EST database for other organisms. Growth in the MIR T-DNA knockout rice mutant （mir） was significantly impaired compared to wild-type （WT） plants when grown under Fe-deficient or -sufficient conditions. Furthermore, mir plants accumulated more than twice the amount of Fe in shoot and root tissue compared to WT plants when grown under either Fe-sufficient or -deficient conditions. Despite the high accumulation of Fe in roots and shoots, mir plants triggered the expression of Fe-deficiency-inducible genes, indicating that mir may not be able to utilize Fe for physiological functions. These results clearly suggest that MIR is a rice-specific mitochondrial protein, recently evolved, and plays a significant role in Fe homeostasis.

关键词： Fe-deficiency-regulated gene Fe homeostasis mitochondria Oryza sativa.

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