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3D reconstruction size effect on the quantification of solid oxide fuel cell nickel-yttria-stabilized-zirconia anode microstructural information using scanning electron microscopy-focused ion beam technique

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Science Bulletin 2016年第17期61卷 1317-1323页

作者： Zhenjun Jiao naoki Shikazono Institute of Industrial Science The University of Tokyo

Self-made conventional nickel-yttria-stabilized zirconia composite anodes after reduction and 500 h operation were analyzed by three-dimensional microstructure reconstruction based on focused ion beam-scanning electron microscopy *** area,threephases-boundary density and phase volume fraction were measured based on the three-dimensional microstructure reconstruction to quantitatively study the statistical characterization of solid oxide fuel cell nickel-yttria-stabilizedzirconia anode microstructure before and after *** is found that for anode operated with long time,it is necessary to increase the corresponding three-dimensional reconstruction size to suppress the influence of microstructure variation caused by Ni agglomeration in order to obtain more accurate microstructural quantification information.

关键词： FIB-SEM 3D reconstruction TPB density Tetragonal mesh

Cathodoluminescence of diamond synthesized from silicon-carbide

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Chinese Science Bulletin 1996年第3期41卷 208-212页

作者：洪时明 kanda Hisao 芶立 National Institute for Research in Inorganic Materials Namiki 1-1 Tsukuba Ibaraki 305 Japan

As a wide energy gap semiconductor, diamond is expected to play a role in UV light-emitting diode or laser. However, the impurities and vacancies in diamond exert a great influence on optical properties of the crystals. It is important, therefore, to study the relation between impurities and the optical properties, and furthermore, to study the control of the impurities.

关键词： high pressure synthesis diamond cathodoluminescence optical centre.

Emerging evidence of the molecular landscape specific for hematogenous metastasis from gastric cancer

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World Journal of Gastrointestinal Oncology 2018年第6期10卷 124-136页

作者： Dai Shimizu Mitsuro kanda Yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of MedicineNagoya 466-8550Japan

Gastric cancer(GC) is one of the most frequentlydiagnosed cancers in the world. Most GC patients are diagnosed when the cancer is in an advanced stage, and consequently, some develop metastatic lesions that generally cause cancer-related death. Metastasis establishment is affected by various conditions, such as tumor location, hemodynamics and organotropism. While digestive cancers may share a primary site, certain cases develop hematogenous metastasis with the absence of peritoneal metastasis, and vice versa. Numerous studies have revealed the clinicopathological risk factors for hematogenous metastasis from GC, such as vascular invasion, advanced age, differentiation, Borrmann type 1 or 2 and expansive growth. Recently, molecular mechanisms that contribute to metastatic site determination have been elucidated by advanced molecular biological techniques. Investigating the molecules that specifically participate in metastasis establishment in distinct secondary organs will lead to the development of novel biomarkers for patient stratification according to their metastatic risk and strategies for preventing and treating distinct metastases. We reviewed articles related to the molecular landscape of hematogenous metastasis from GC.

关键词： Gastric cancer Hematogenous metastasis Hepatic metastasis Molecular mechanism Biomarker Premetastatic niche

Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer

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World Journal of Gastroenterology 2019年第22期25卷 2743-2751页

作者： Koki Nakanishi Mitsuro kanda Yasuhiro Kodera Department of Gastroenterological Surgery(Surgery Ⅱ) Nagoya University Graduate School of Medicine

Gastrectomy with radical lymph node dissection is the most promising treatment avenue for patients with gastric cancer. However, this procedure sometimes induces excessive intraoperative blood loss and requires perioperative allogeneic blood transfusion. There are lasting discussions and controversies about whether intraoperative blood loss or perioperative blood transfusion has adverse effects on the prognosis in patients with gastric cancer. We reviewed laboratory and clinical evidence of these associations in patients with gastric cancer. A large amount of clinical evidence supports the correlation between excessive intraoperative blood loss and adverse effects on the prognosis. The laboratory evidence revealed three possible causes of such adverse effects: anti-tumor immunosuppression, unfavorable postoperative conditions, and peritoneal recurrence by spillage of cancer cells into the pelvis. Several systematic reviews and meta-analyses have suggested the adverse effects of perioperative blood transfusions on prognostic parameters such as all-cause mortality, recurrence, and postoperative complications. There are two possible causes of adverse effects of blood transfusions on the prognosis: Anti-tumor immunosuppression and patient-related confounding factors (e.g., preoperative anemia). These factors are associated with a worse prognosis and higher requirement for perioperative blood transfusions. Surgeons should make efforts to minimize intraoperative blood loss and transfusions during gastric cancer surgery to improve patients’ prognosis.

关键词： Gastric cancer Blood loss Prognosis Transfusion Adverse effect Immunosuppression Mortality Recurrence Complication

Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers

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World Journal of Gastroenterology 2014年第28期20卷 9229-9236页

作者： Tatsuo kanda Xia Jiang Osamu Yokosuka Department of Gastroenterology and Nephrology Chiba UniversityGraduate School of Medicine

Hepatocellular carcinoma (HCC) and pancreatic cancer remain difficult to treat, and despite the ongoing development of new treatments, the overall survival rate has only modestly improved over the past decade. Liver and pancreatic progenitors commonly develop from endoderm cells in the embryonic foregut. A previous study showed that HCC and pancreatic cancer cell lines variably express androgen receptor (AR), and these cancers and the surrounding tissues also express AR. AR is a ligand-dependent transcription factor that belongs to the nuclear receptor superfamily. Androgen response element is present in regulatory elements on the AR-responsive target genes, such as transforming growth factor beta-1 (TGF beta-1) and vascular endothelial growth factor (VEGF). It is well known that the activation of AR is associated with human carcinogenesis in prostate cancer as well as HCC and pancreatic cancer and that GRP78, TGF beta, and VEGF all play important roles in carcinogenesis and cancer development in these cancers. HCC is a male-dominant cancer irrespective of its etiology. Previous work has reported that vertebrae forkhead box A 1/2 are involved in estrogen receptors and/or AR signaling pathways, which may contribute to the gender differences observed with HCC. Our recent work also showed that AR has a critical role in pancreatic cancer development, despite pancreatic cancer not being a male dominant cancer. Aryl hydrocarbon (or dioxin) receptor is also involved in both HCC and pancreatic cancer through the formation of complex with AR. It is possible that AR might be involved in their carcinogenesis through major histocompatibility complex class I chain-related gene A/B. This review article describes AR and its role in HCC and pancreatic cancer and suggests that more specific AR signaling-inhibitors may be useful in the treatment of these “difficult to treat” cancers.

关键词： Androgen receptor Gender difference Hepatocellular carcinoma Male-dominant Pancreas

Novel Phase Transition in BaPr_2Mn_2O_7

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Journal of Rare Earths 2006年第Z2期24卷 1-3页

作者： Hiromi Nakano naoki Kamegashira Ryukoku University SetaOtsu 520-2194Japan Toyohashi University of Technology Tenpaku-choToyohashi 441-8580Japan

The rare earth manganite BaLn2Mn2O7(Ln = rare earth element) has a Sr3Ti2O7-type layered perovskite structure with double-block oxygen octahedra belonging to the Ruddlesden-Popper-type homologous series AO(ABO3)2. In Pr-manganite, a novel phase transition was first observed in situ at 1040 K by a thermal transmission electron microscope. At 1040 K, reflections began to split along the c-direction in the selected area diffraction pattern. This indicates that a new phase appears in the original phase matrix; the c length of the new phase is 1.5% longer than that of the original phase. After about 5 min, the original phase disappears. No change in the crystal symmetry (space group 14/mmm) is observed above 1040 K.

关键词： rare earth manganite phase transition transmission electron microscope (TEM)

Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

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Frontiers of Chemical Science and Engineering 2018年第1期12卷 184-193页

作者： Kimthet Chhouk Wahyudiono Hideki kanda Shin-Ichro Kawasaki Motonobu Goto Department of Chemical Engineering Nagoya University Nagoya 464-8603 Japan Department of Chemical Engineering and Food Technology Institute of Technology of Cambodia Phnom Penh Cambodia Department of Materials Process Engineering Nagoya University Nagoya 464-8603 Japan Research Institute for Chemical Engineering Process Technology National Institute of Advanced Industrial Science and Technology Sendai 983-8551 Japan

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and antimicrobial activity. In this employed to produce the work, a swirl mixer was micronized curcumin with polyvinylpyrrolidone （PVP） by the supercritical antisolvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO2 flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1：30, feed concentration of 5 mg·mL^-1, temperature of 40 ℃, pressure of 15 MPa, and CO2 flow rate of 15 mL·min^-1. Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

关键词： micronization curcumin polyvinylpyrrolidone supercritical anti-solvent swirl mixer

Effects of bile acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis

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World Journal of Gastroenterology 2014年第21期20卷 6541-6546页

作者： naoki Hashimoto Department of Surgery Kinki UniversityOsaka 589-8511Japan

AIM: To examine the expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in rat esophageal lesions induced by reflux of duodenal contents.

关键词： Bile acids Cyclooxygenase-2 Prostaglandin E2 Esophageal cancer Esophagoduodenal anastomosis

基于固有应变的旧钢桥加固焊接应力和变形分析

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合肥工业大学学报（自然科学版） 2024年第7期47卷 1003-1008页

作者：杜洋华罗宇赵晟大沢直樹上海交通大学船舶海洋与建筑工程学院上海200240

文章针对某大型桥梁实际加固修复焊接,利用独自开发的焊接变形分析系统软件,预测不同工艺和工况条件下大桥的应力和变形,获得不同条件下桥梁变形和应力的分布规律,确认该大型桥梁加固焊接施工方案的安全性。同时,该文为实际焊接工艺的... 详细信息

文章针对某大型桥梁实际加固修复焊接,利用独自开发的焊接变形分析系统软件,预测不同工艺和工况条件下大桥的应力和变形,获得不同条件下桥梁变形和应力的分布规律,确认该大型桥梁加固焊接施工方案的安全性。同时,该文为实际焊接工艺的优化提供了技术解决方案。

关键词：桥梁焊接加固焊接应力变形固有应变数值模拟焊接工艺