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Fluid Dynamics & Materials Processing 2024年第8期20卷 1731-1741页

作者： nannan liu Hengchen Qi Hui Xu Yanfeng He School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou213164China

Low salinity water containing sulfate ions can significantly alter the surface wettability of carbonate ***,the impact of sulfate concentration on the desorption of oil film on the surface of carbonate rock is still *** study examines the variations in the wettability of the surface of carbonate rocks in solutions containing varying amounts of sodium sulfate and pure *** problem is addressed in the framework of molecular dynamics simulation(Material Studio software)and *** experiment’s findings demonstrate that sodium sulfate can increase the rate at which oil moisture is turned into water *** final contact angle is smaller than that of pure *** results of the simulations show that many water molecules travel down the water channel under the influence of several powerful forces,including the electrostatic force,the van der Waals force and hydrogen bond,crowding out the oil molecules on the calcite’s surface and causing the oil film to *** relative concentration curve of water and oil molecules indicates that the separation rate of the oil film on the surface of calcite increases with the number of sulfate ions.

关键词： Carbonate rocks wettability sulfate ions concentration molecular simulation desorption

A Note on the Signless Laplacian Spectral Ordering of Graphs with Given Size

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Journal of Mathematical Research with Applications 2024年第3期44卷 304-312页

作者： nannan liu Shuguang GUO School of Mathematics and Statistics Qinghai Normal University School of Mathematics and Statistics Yancheng Teachers University

Abstract For a simple undirected graph G with fixed size m≥2k （k∈Z+） and maximum degree?（G）≤m-k,we give an upper bound on the signless Laplacian spectral radius q（G）of *** two connected graphs G1and G2with size m≥8,employing this upper bound,we prove that q（G1）>q（G2） if?（G1）>?（G2）+1 and■.For triangle-free graphs,we prove two stronger *** an application,we completely characterize the graph with maximal signless Laplacian spectral radius among all graphs with size m and circumference c for m≥max{2c,c+9},which partially answers the question proposed by Chen et ***[Linear Algebra Appl.,2022,645:123–136].

关键词： signless Laplacian spectral radius upper bound ordering size circumference

Log interpretation of carbonate rocks based on petrophysical facies constraints

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Energy Geoscience 2024年第3期5卷 39-51页

作者： Hui Xu Hongwei Xiao Guofeng Cheng nannan liu Jindong Cui Xing Shi Shangping Chen School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhouJiangsu213164China Exploration and Development Research Institute of Daqing Oilfield Co. Ltd.DaqingHeilongjiang163712China Changqing Oilfield No.5 Oil Production Plant PetroChinaXi'anShannxi710000China

The complex pore structure of carbonate reservoirs hinders the correlation between porosity and *** view of the sedimentation,diagenesis,testing,and production characteristics of carbonate reservoirs in the study area,combined with the current trends and advances in well log interpretation techniques for carbonate reservoirs,a log interpretation technology route of“geological information constraint+deep learning”was *** principal component analysis(PCA)was employed to establish lithology identification criteria with an accuracy of 91%.The Bayesian stepwise discriminant method was used to construct a sedimentary microfacies identification method with an accuracy of 90.5%.Based on production data,the main lithologies and sedimentary microfacies of effective reservoirs were determined,and 10 petrophysical facies with effective reservoir characteristics were *** by petrophysical facies,the mean interpretation error of porosity compared to core analysis results is 2.7%,and the ratio of interpreted permeability to core analysis is within one order of magnitude,averaging *** research results demonstrate that deep learning algorithms can uncover the correlation in carbonate reservoir well logging *** geological and production data and selecting appropriate machine learning algorithms can significantly improve the accuracy of well log interpretation for carbonate reservoirs.

关键词： Carbonate reservoir Principal component analysis(PCA) Bayesian stepwise discriminant analysis Petrophysical facies Well log interpretation

Optimization of LPS-Induced Inflammation Model and Its Feasibility as a Fast Screening Model for Cosmetics

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第1期14卷 84-97页

作者： Fanghui Sun Xiaojie Song nannan liu Gang Huo R & D Center OSM Biology Co. Ltd. Huzhou China

Objectives: The existing inflammatory models are concentrated in relatively complex medical fields, and most of them use a single type of cell, and the induction conditions are not uniform, so the current LPS-induced inflammation model is less conducive to the study of skin inflammation. The aim of this research is to enhance the existing LPS-induced inflammation model and establish a skin inflammation model that is suitable for the swift screening of anti-inflammatory agents in the cosmetics industry. Methods: LPS was used to induce inflammatory responses in KC and THP-1 cells. Enzyme-linked immunosorbent assay (ELISA) was employed to assess the levels of IL-1α, IL-8, and TNF-α in the two cell types, while the DCFH-DA probe was utilized to label the levels of reactive oxygen species (ROS) in both cell types. Results: In KC cells, 10 μg/mL of LPS induced a significant upregulation of IL-8 but did not result in elevated expression of IL-1α. However, at 100 μg/mL of LPS, both IL-8 and IL-1α were highly expressed in KC cells. LPS concentrations ranging from 0.01 to 100 μg/mL failed to stimulate TNF-α production in KC cells but induced a gradient increase in ROS levels. In THP-1 cells, LPS concentrations from 0.01 to 100 μg/mL did not induce IL-1α production but significantly elevated IL-8 and led to a gradient increase in TNF-α and ROS. After treatment with 100 μg/mL of LPS, the cosmetic ingredient Rucika KGM mitigated the elevated levels of IL-1α, IL-8, and ROS in LPS-induced KC cells and IL-8 and ROS in THP-1 cells. Conclusion: This study has successfully developed an application-oriented model suitable for investigating skin inflammation, enabling the rapid and comprehensive screening of cosmetic ingredients with anti-inflammatory activity. .

关键词： Cell Culture Anti-Inflammatory Lipopolysaccharide Keratinocytes THP-1 Inflammatory Factors

The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel

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Science China(Life Sciences) 2024年第3期67卷 435-448页

作者： nannan liu Yuanhao Du Shijuan Yan Wei Chen Min Deng Shutu Xu Hong Wang Wei Zhan Wenjie Huang Yan Yin Xiaohong Yang Qiao Zhao Alisdair R.Fernie Jianbing Yan National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Agro-biological Gene Research Center Guangdong Academy of Agricultural SciencesGuangzhou 510640China College of Agronomy Hunan Agricultural UniversityChangsha 410128China College of Agronomy Northwest A&F UniversityXi'an 710000China State Key Laboratory of North China Crop Improvement and Regulation Hebei Sub-center of National Maize Improvement Center of ChinaCollege of AgronomyHebei Agricultural UniversityBaoding 071001China College of Life Sciences South-Central Minzu UniversityWuhan 430070China Plant Science Facility of the Institute of Botany Chinese Academy of SciencesBeijing 100093China National Maize Improvement Center of China Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100093China Shenzhen Key Laboratory of Synthetic Genomics Guangdong Provincial Key Laboratory of Synthetic GenomicsShenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Max Planck Institute of Molecular Plant Physiology Potsdam-Golm 14476Germany

Tocopherol is an important lipid-soluble antioxidant beneficial for both human health and plant growth. Here, we fine mapped a major QTLqVE1 affecting γ-tocopherol content in maize kernel, positionally cloned and confirmed the underlying gene ZmPORB1(por1), as a protochlorophyllide oxidoreductase. A 13.7 kb insertion reduced the tocopherol and chlorophyll content, and the photosynthetic activity by repressing ZmPORB1 expression in embryos of NIL-K22, but did not affect the levels of the tocopherol precursors HGA(homogentisic acid)and PMP(phytyl monophosphate). Furthermore, ZmPORB1 is inducible by low oxygen and light, thereby involved in the hypoxia response in developing embryos. Concurrent with natural hypoxia in embryos, the redox state has been changed with NO increasing and H_(2)O_(2) decreasing, which lowered γ-tocopherol content via scavenging reactive nitrogen species. In conclusion, we proposed that the lower lightharvesting chlorophyll content weakened embryo photosynthesis, leading to fewer oxygen supplies and consequently diverse hypoxic responses including an elevated γ-tocopherol consumption. Our findings shed light on the mechanism for fine-tuning endogenous oxygen concentration in the maize embryo through a novel feedback pathway involving the light and low oxygen regulation of ZmPORB1 expression and chlorophyll content.

关键词： maize tocopherol hypoxia photosynthesis ZmPORB1

Mapping of powdery mildew resistance genes transferred to common wheat from wild emmer wheat revealed three functional Pm60 haplotypes

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The Crop Journal 2024年第2期12卷 540-548页

作者： Wenxin Wei nannan liu Shengnan Zhang Jing Zhang Wei Pan Xiaoming Xie Zuhuan Yang Junna Sun Jun Ma Zhaorong Hu Weilong Guo Qiaoling Luo Jingzhong Xie Fei He Yinghui Li Chaojie Xie Qixin Sun Key Laboratory of Crop Heterosis and Utilization(MOE)/Key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijing 100193China Institute of Advanced Agricultural Science Peking UniversityWeifang 261200ShandongChina Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel

Powdery mildew(PM),caused by Blumeria graminis ***(Bgt),is one of the destructive wheat diseases *** emmer wheat(Triticum turgidum ***,WEW),a tetraploid progenitor of common wheat,is a valuable genetic resource for wheat disease resistance breeding *** developed three hexaploid pre-breeding lines with PM resistance genes derived from three WEW *** resistant pre-breeding lines were crossed with susceptible common wheat *** in the F2populations were 3 resistant:1 susceptible,suggesting a single dominant allele in each resistant *** of the resistance gene in each line indicated a single locus on the long arm of chromosome 7A,at the approximate location of previously cloned Pm60 from *** sequencing revealed three different Pm60 haplotypes(Hap 3,Hap 5,and Hap 6).Co-segregating diagnostic markers were developed for identification and selection of each *** resistance function of each haplotype was verified by the virus-induced gene silencing(VIGS).Common wheat lines carrying each of these Pm60 haplotypes were resistant to most Bgt isolates and differences in the response arrays suggested allelic variation in response.

关键词： Alleles Blumeria graminus Marker-assisted selection Molecular marker Triticum dicoccoides

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新基建专项债的就业效应与空间外溢性

世界经济 2024年第2期47卷 152-173页

作者：刘楠楠曾宇西南财经大学财政税务学院

本文手工收集整理2015-2021年专项债和新基建项目等数据,通过双重差分识别策略和双重差分空间杜宾模型,探讨新基建专项债对劳动力市场的就业效应及其空间外溢性。研究发现:(1)新基建专项债对就业具有乘数效应,不仅能够增加专项债指定投... 详细信息

本文手工收集整理2015-2021年专项债和新基建项目等数据,通过双重差分识别策略和双重差分空间杜宾模型,探讨新基建专项债对劳动力市场的就业效应及其空间外溢性。研究发现:(1)新基建专项债对就业具有乘数效应,不仅能够增加专项债指定投向领域3.49%的就业,还通过扩散效应带动非指定投向领域8.34%的地区就业;(2)与传统基建专项债不同,新基建专项债能够产生显著的行业和岗位替代效应,有助于优化劳动力市场的就业结构;(3)新基建专项债的就业结构效应具有正向溢出特征,表现为本地区高技能劳动力流入和低技能劳动力流出。本文对于促进劳动力市场格局转变、减少地区间摩擦性失业有政策参考价值。

关键词：新基建专项债就业效应空间外溢性

金融强国视域下融资平台债务规模扩张对中小企业融资约束的影响

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中国农村经济 2024年第5期 106-127页

作者：刘楠楠凌语阳西南财经大学财政税务学院中央财经大学中国公共财政与政策研究院

本文构建一个包括银行和企业的两部门模型,将融资平台债务与中小企业融资纳入统一理论框架,并基于2013-2019年中小企业数据、融资平台公司数据和地级市宏观统计数据,探讨融资平台债务规模扩张对中小企业融资约束的影响及其作用机制。研... 详细信息

本文构建一个包括银行和企业的两部门模型,将融资平台债务与中小企业融资纳入统一理论框架,并基于2013-2019年中小企业数据、融资平台公司数据和地级市宏观统计数据,探讨融资平台债务规模扩张对中小企业融资约束的影响及其作用机制。研究发现:融资平台债务规模扩张会推高中小企业的信贷利率水平,降低中小企业的信贷规模,强化中小企业面临的融资约束。同时,链式作用机制检验结果表明:融资平台债务规模扩张主要通过中小企业信贷利率、信贷规模等多条路径共同作用于中小企业融资约束。据此,本文从融资平台公司转型和风险治理视角提出缓解中小企业融资约束问题的政策启示。

关键词：融资平台债务中小企业融资约束信贷利率信贷规模

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儒家伦理道德资源融入高校道德教育研究

扬州大学学报（高教研究版） 2024年第4期28卷 37-46页

作者：刘楠楠黑龙江大学黑龙江哈尔滨150080 牡丹江医学院黑龙江牡丹江157000

儒家文化是崇德的文化,以成为君子为人生追求,这与高校立德树人、培养时代新人的根本任务具有内在一致性。立足新时代,合理挖掘儒家德育资源,将儒家伦理道德资源融入高校道德教育,准确理解其在社会公德、职业道德、家庭美德、个人品德... 详细信息

儒家文化是崇德的文化,以成为君子为人生追求,这与高校立德树人、培养时代新人的根本任务具有内在一致性。立足新时代,合理挖掘儒家德育资源,将儒家伦理道德资源融入高校道德教育,准确理解其在社会公德、职业道德、家庭美德、个人品德教育维度的典型故事。真正领会融入的方法精髓,做到以学生为本,实现儒家传统文化的创造性转化和创新性发展,落实立德树人根本要求。在融入的路径上,要把握思政课堂主渠道,深化道德认知;开展丰富的实践活动,强化道德践履;搭建网络德育新平台,创新道德教育的载体和形式。

关键词：儒家伦理道德观伦理道德资源道德教育

多感官刺激在脑梗死偏瘫失语患者中的应用效果

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中国民康医学 2024年第9期36卷 105-107页

作者：刘南南周口市中心医院康复医学科河南周口466000

目的:观察多感官刺激在脑梗死偏瘫失语患者中的应用效果。方法:选取2021年5月至2023年1月该院收治的64例脑梗死偏瘫失语患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各32例。对照组实施常规康复训练,研究组在对照组基础... 详细信息

目的:观察多感官刺激在脑梗死偏瘫失语患者中的应用效果。方法:选取2021年5月至2023年1月该院收治的64例脑梗死偏瘫失语患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各32例。对照组实施常规康复训练,研究组在对照组基础上进行多感官刺激,比较两组干预前后肢体功能[Fugl-Meyer评定量表(FMA)]、语言功能[汉语失语检查表(ABC)]及神经功能[美国国立卫生研究院卒中量表(NIHSS)]评分。结果:护理后,两组上、下肢各项FMA评分均高于干预前,且研究组高于对照组,差异有统计学意义(P<0.05);两组ABC评分均高于干预前,且研究组高于对照组,差异有统计学意义(P<0.05);两组NIHSS评分均低于干预前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论:多感官刺激联合常规康复训练应用于脑梗死偏瘫失语患者,可提高肢体功能,改善语言功能和神经功能,效果优于单纯常规康复训练。

关键词：多感官刺激常规康复训练脑梗死偏瘫失语肢体功能语言功能