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Journal of Systems Science & Complexity 2024年第5期37卷 1887-1906页

作者： WANG Jinghan SHI Yufeng ZHAO nana Institute for Financial Studies Shandong University Zhiyuan School of Liberal Arts Beijing Institute of Petrochemical Technology

In this paper, the authors study a class of general mean-field BDSDEs whose coefficients satisfy some stochastic conditions. Specifically, the authors prove the existence and uniqueness theorem of solution under stochastic Lipschitz condition and obtain the related comparison theorem. Besides,the authors further relax the conditions and deduce the existence theorem of solutions under stochastic linear growth and continuous conditions, and the authors also prove the associated comparison ***, an asset pricing problem is discussed, which demonstrates the application of the general mean-field BDSDEs in finance.

关键词： Backward doubly stochastic differential equations comparison theorem mean-field stochastic conditions Wasserstein metric

Systematic analysis of α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-UV-ESI-TripleTOF-MS/MS and system pharmacology

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Systematic analysis of α-glucosidase inhibitors from flavon...

A Survey of Synthetic Data Augmentation Methods in Machine Vision

中国化学会第十二届全国天然有机化学学术会议

作者： Le Wang nana tan Wenbo Diwu Xiaoling Wang Shaanxi Key Laboratory of Phytochemistry College of Chemistry and Chemical EngineeringBaoji University of Arts and Sciences

Natural α-glucosidase inhibitors present viable alternatives to the treatment of T2 D .The present study aimed at developing a systematic method to screen and explore the underlying biological mechanisms of α-glucosidase inhibitors from flavonoids of Radix scutellariae(RS),using ultrafiltration UPLC-UV-ESI-TripleTOF-MS/MS coupled with network pharmacology .As a result,32 flavonoids were identified from the n-butanol extract of *** n-butanol extract of RS showed a stronger α-glucosidase inhibition activity(IC=0.551 mg/mL).A total of 17 flavonoids exhibited protein binding activity with boving serum albumin(BSA),and that 13 of them were screened as α-glucosidase inhibitors,including Oroxylin A,Tenaxin I,and so on.A compound-target-pathway network was *** analysis showed that chrysin,wogonin,and 5,8,2’-Trihydroxy-7-methoxyflavone were the main active constituents for the α-glucosidase inhibition effect of RS.A pathway-based protein association network(Figure 1) was built for targets of the α-glucosidase inhibitors,and that MAPK3,MAPK1,and PIK3 R1 were considered as key targets with high centrality values(Figure 2).Moreover,a core network analysis revealed a potential synergistic effect between the three main active *** study provides a novel strategy for the screening and mechanism research of natural products.

关键词： Radix scutellariae α-Glucosidase inhibitors Ultrafiltration System pharmacology

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Machine Intelligence Research 2024年第5期21卷 831-869页

作者： Alhassan Mumuni Fuseini Mumuni nana Kobina Gerrar Cape Coast Technical University Cape CoastDL 50Ghana University of Mines and Technology Tarkwa237Ghana

The standard approach to tackling computer vision problems is to train deep convolutional neural network(CNN)models using large-scale image datasets that are representative of the target ***,in many scenarios,it is often challenging to obtain sufficient image data for the target *** augmentation is a way to mitigate this challenge.A common practice is to explicitly transform existing images in desired ways to create the required volume and variability of training data necessary to achieve good generalization *** situations where data for the target domain are not accessible,a viable workaround is to synthesize training data from scratch,i.e.,synthetic data *** paper presents an extensive review of synthetic data augmentation *** covers data synthesis approaches based on realistic 3D graphics modelling,neural style transfer(NST),differential neural rendering,and generative modelling using generative adversarial networks(GANs)and variational autoencoders(VAEs).For each of these classes of methods,we focus on the important data generation and augmentation techniques,general scope of application and specific use-cases,as well as existing limitations and possible ***,we provide a summary of common synthetic datasets for training computer vision models,highlighting the main features,application domains and supported ***,we discuss the effectiveness of synthetic data augmentation *** this is the first paper to explore synthetic data augmentation methods in great detail,we are hoping to equip readers with the necessary background information and in-depth knowledge of existing methods and their attendant issues.

关键词： Data augmentation generative modelling neural rendering data synthesis synthetic data neural style transfer(NsT)

Design of an automated robotic microinjection system for batch injection of zebrafish embryos and larvae

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Microsystems & Nanoengineering 2024年第1期10卷 89-103页

作者： Zhongyi Guo nana Ai Wei Ge Qingsong Xu Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Department of Biomedical Sciences and Centre of Reproduction Development and Aging(CRDA)Faculty of Health SciencesUniversity of MacaoMacaoChina

This paper presents the design of a vision-based automated robotic microinjection system for batch injection of both zebrafish embryos and larvae.A novel visual recognition algorithm based on an automatic threshold and excessive dilatation is introduced to accurately identify the center of zebrafish embryos and larval yolks.A corresponding software system is developed using the producer-consumer model as the framework structure,and a friendly user interface is designed to allow operators to choose from a range of desired functions according to their different *** addition,a novel microstructural agarose device is designed and fabricated to simultaneously immobilize mixed batches of embryos and ***,a prototype microinjection system is fabricated by integrating hardware devices with visual *** experimental study is conducted to verify the performance of the robotic microinjection *** results show that the reported system can accurately identify zebrafish embryos and larvae and efficiently complete batch microinjection tasks of the mixtures with an injection success rate of 92.05%in 13.88 s per *** with manual and existing microinjection systems,the proposed system demonstrates the merits of versatility,excellent efficiency,high success rate,high survival rate,and sufficient stability.

关键词： zebra automated hardware

Inverse-time Backup Protection Based on Unified Characteristic Equation for Distribution Networks with High Proportion of Distributed Generations

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 202-212页

作者： nana Chang Guobing Song Zhongxue Chang Yuping Zheng Xingang Yang the School of Electrical Engineering Xi’an Jiaotong UniversityXi’anChina State Key Laboratory of Smart Grid Protection and Control NARI Group CorporationNanjingChina Electric Power Research Institute of State Grid Shanghai Electric Power Company ShanghaiChina

The setting work of backup protection using steady-state current is tedious,and mismatches occasionally occur due to the increased proportion of distributed generations(DGs)connected to the power ***,there is a practical need to study a backup protection technology that does not require step-by-step setting and can be adaptively *** paper proposes an action sequence adaptive to fault positions that uses only positive sequence fault component(PSFC)*** the influence of DGs,the unified time dial setting can be obtained by selecting specific *** protection performance is improved by using the adjacent upstream and downstream protections to meet the coordination time interval in the case of metallic faults at the near-and far-ends of the ***,the expression and implementation scheme for inverse-time backup protection(ITBP)based on the unified characteristic equation is *** results show that this scheme can adapt to DG penetration scenarios and can realize the adaptive coordination of multi-level relays.

关键词： Inverse-time backup protection(ITBP) distributed generation(DG) positive sequence fault component(PSFC)voltage unified characteristic equation adaptive coordination

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A unique role of the pyrimidine de novo synthesis enzyme ODCase in Lysobacter enzymogenes

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Journal of Integrative Agriculture 2024年第9期23卷 3066-3077页

作者： Mingming Yang Yunxiao tan Jiabing Ma Yingjia Zhao Xia Yan nana Wang Pingping Wang Jiaqi tan Suilong Ai Xiaofei Liang Bangshuai Chang Obadah E.A.Yousif Chao Zhao Bo Wang Guoliang Qian Lili Huang State Key Laboratory for Crop Stress Resistance and High-Efficiency Production Northwest A&F UniversityYangling 712100China College of Plant Protection Northwest A&F UniversityYangling 712100China College of Life Sciences Northwest A&F UniversityYangling 712100China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China Shaanxi Provincial Tobacco Corporation of China National Tobacco Corporation Xi’an 710061China Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210014China College of Plant Protection Laboratory of Plant ImmunityNanjing Agricultural UniversityNanjing 210095China

Bacterial species of the genus Lysobacter are environmentally ubiquitous with strong antifungal biocontrol ***-stable antifungal factor(HSAF)secreted by the biocontrol bacterium Lysobacter enzymogenes OH11 has broad-spectrum and highly efficient antifungal *** the biosynthetic regulations of HSAF would lay an important foundation for strain engineering toward improved HSAF *** this work,we demonstrate that Le0752,an orotidine-5´-phosphate decarboxylase enzyme(ODCase)catalyzing a pivotal step of the UMP de novo biosynthesis pathway,is vital for HSAF-mediated antimicrobial activities and growth of *** OH11,but not for twitching *** gene regulates the production of HSAF by affecting the expression of lafB,a key gene in the HSAF biosynthesis operon,through the transcription factor ***,bioinformatics analysis revealed that Le0752 belongs to the Group III ODCases,whereas its homologs in the closely related genera Xanthomonas and Stenotrophomonas belong to Group I,which contains most ODCases from Gram-positive bacteria,Gram-negative bacteria and ***,the Group I ODCase PXO_3614 from the Xanthomonas oryzae *** PXO99A strain complemented the Le0752 mutant in regulating HSAF-mediated antagonistic ***,these results highlight the important requirement of de novo pyrimidine biosynthetic enzymes for antibiotic HSAF production in ***,which lays an important foundation for improving HSAF production via metabolic flow design and for dissecting the regulatory functions of bacterial ODCases.

关键词： ODCase pyrimidine de novo synthesis secondary metabolite HSAF Lysobacter enzymogenes

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Generalized Laws of Importation and Cross-Migrativity Based on(D, N)-Implications

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Journal of Mathematical Research with Applications 2024年第5期 583-595页

作者： nana MA School of Mathematics Xi'an University of Finance and Economics

In the present article we study the generalized laws of importation and crossmigrativity based on(D, N)-implications. On the one hand, we consider the generalized law of importation I(T(x, α), y) = I(x, J(α, y)), when T is concretized as a fuzzy conjunction C, I and J are concretized as(D, N)-implications generated by a fuzzy disjunction D and a fuzzy negation N. On the other hand, we discuss the cross-migrativity of fuzzy disjunctions over fuzzy implications, that is, I(x, D(y, z)) = D(y, I(x, z)), where I is a fuzzy implication, D is a fuzzy disjunction. In addition, we study the relationship between the(α-)cross-migrative of(I, D) and the(α-)cross-law of importation(I, ID,N, C).

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Impact of Local Climate Zones on the Urban Heat and Dry Islands in Beijing:Spatial Heterogeneity and Relative Contributions

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Journal of Meteorological Research 2024年第1期38卷 126-137页

作者： Zuofang ZHENG Fu LUO nana LI Hua GAO Yuanjian YANG Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089 School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Key Laboratory of Urban Meteorology China Meteorological AdministrationBeijing 100089

Based on the building height and density data on a 100-m resolution,hourly 2-m temperature and humidity data at83 automatic weather stations,and gridded local climate zone(LCZ)data on a 120-m resolution in urban Beijing in2020,this study first employs the semivariogram combined with building parameters to calculate spatial correlations and has identified an LCZ grid resolution of 500 m suitable for best usage of the available observation ***,how the spatially heterogeneous LCZs affect and contribute to the canopy urban heat island intensity(UHII)and urban dry island intensity(UDII)are quantitatively *** is found that UHII is high in winter and low in summer with a unimodal diurnal variation while UDI is low in winter but high in summer with a bimodal diurnal *** LCZ with compact mid-rise(open high-rise)buildings exhibits the highest UHII(UDII),followed by the compact high-rise(compact low-rise),while the LCZ of scattered trees presents both the lowest UHII and the lowest *** most significant difference in the UHII(UDII)among the nine LCZ types in the urban area of Beijing is2.62℃(1.1 g kg^(-1)).Area-weighted averaging analysis reveals that the open mid-rise LCZ is the most significant contributor to the UHII(UDII),immediately followed by compact mid-rise(open low-rise),with the least contribution from bare rock or paved(scattered trees).The results also indicate that beyond the intrinsic physical properties of the LCZs of a city,their area proportions cannot be overlooked in evaluating their impact on the UHI and *** quantitatively findings could help urban planners to create a livable urban climate and environment by adjusting the relevant land use.

关键词： local climate zone(LCZ) urban heat island(UHI) urban dry island(UDI) distribution pattern contribution rate Beijing

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IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

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Genes & Diseases 2024年第1期11卷 464-478页

作者： Mengtian Fan nana Geng Xingyue Li Danyang Yin Yuyou Yang Rong Jiang Cheng Chen Naibo Feng Li Liang Xiaoli Li Fengtao Luo Huabing Qi Qiaoyan tan Yangli Xie Fengjin Guo Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Laboratory of Stem Cells and Tissue Engineering School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Department of Orthopedics The 1st Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(PTHrP-PTH1R)feedback loop is *** inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBP1s)branch of the unfolded protein response(UPR)is essential for normal cartilage ***,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains ***,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone ***1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth *** deficiency interrupted PTHrP/PTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and ***1s,produced by p-IRE1α-mediated splicing,binds and up-regulates PTH1R and IHH,which coordinate cartilage ***,ER stress cannot be activated normally in ERN1-deficient *** conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and PTHrP/PTH1R feedback loop and ER ***1 may have a potential role as a new target for cartilage growth and maturation.

关键词： Cartilage development ER stress ERN1 IHH PTHrP/PTH1R