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Chinese Journal of Polymer Science 2017年第2期35卷 269-281页

作者： tao jia nan-nan zheng wan-qing cai jie zhang lei ying 黄飞 yong cao Institute of Polymer Optoeleetronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China

We present a microwave-assisted one-pot polymerization with three-components of alkynes, aldehydes and amines for the synthesis of new amino-functionalized optoelectronic polymers. The polymerization of diynes （la-lc）, dialdehydes （2a and 2b） and dibenzylamine catalyzed by InC13 was carried out smoothly within 1 h under microwave radiation, yielding four soluble polymers with high molecular weights. The resulting polymers P1 and P2 could be easily dissolved in alcohol and thus utilized as the cathode interlayer for polymer solar cells （PSCs）. Compared with the control device, the PSCs with P1 and P2 as the cathode interlayer and PTB7-Th：PC71BM as the photoactive layer exhibited significantly higher power conversion efficiencies （PCEs） of 9.49% and 9.16%, respectively. These results suggest that this polycoupling reaction is an efficient approach to construct three-component polymers for the practical applications.

关键词： One-pot three-component polymerization Polymer solar cells Cathode interlayer

Novel theranostic nanoagent based on CuMo_(2)S_(3)-PEG-Gd for MRI-guided photothermal/photodynamic/chemodynamic therapy

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Rare Metals 2022年第1期41卷 45-55页

作者： nan-nan zheng Wen-Yan Kong Zhi Huang Xi-Jian Liu Shan-Hui Liang Guo-Ying Deng Lin-Jing Zhao Jie Lu School of Chemistry and Chemical Engineering Shanghai University of Engineering ScienceShanghai 201620China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Gynecological Oncology Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Trauma Center Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China

Cancer is a severe disease,which have troubled human being for a long *** development of nanotechnology has provided a new way for cancer *** is a promising strategy to integrate imaging and therapeutic functions into one single nanoplatform to achieve efficient combination of diagnosis and ***,we exploited novel CuMo_(2)S_(3)-PEG-Gd nanocomposites(NCs)for magnetic resonance imaging(MRI),guiding the photothermal therapy(PTT)/photodynamic therapy(PDT)/chemodynamic therapy(CDT).The experimental results showed that CuMo_(2)S_(3)-PEG-Gd NCs have a high photothermal conversion efficiency(40.6%),excellent biocompatibility and good *** CuMo_(2)S_(3)-PEGGd NCs exhibited a clear MRI performance for tumor due to connecting Gd,which can guide in vivo therapy to improve the therapeutic ***,both in vitro and in vivo therapeutic results of CuMo_(2)S_(3)-PEG-Gd NCs exhibited that the PTT/PDT/CDT achieved a remarkably synergistic effect,which could efficiently inhibit the tumor ***,CuMo_(2)S_(3)-PEG-Gd NCs,which integrated imaging with multiple therapies,have a good potential as theranostic agent for tumor.

关键词： Combined therapy Magnetic resonance imaging(MRI) CuMo_(2)S_(3)-PEG-Gd NCs Photothermal therapy(PTT) Chemodynamic therapy(CDT)

Combining protein arginine methyltransferase inhibitor and antiprogrammed death-ligand-1 inhibits pancreatic cancer progression

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World Journal of Gastroenterology 2020年第26期26卷 3737-3749页

作者： nan-nan zheng Min Zhou Fang Sun Man-Xiu Huai Yi Zhang Chun-Ying Qu Feng Shen Lei-Ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Immunotherapy targeting programmed death-1(PD-1)or programmed deathligand-1(PD-L1)has been shown to be effective in a variety of malignancies but has poor efficacy in pancreatic ductal adenocarcinoma(PDAC).Studies have shown that PD-L1 expression in tumors is an important indicator of the efficacy of *** cells usually evade chemotherapy and host immune surveillance by epigenetic *** arginine methylation is a common posttranslational *** arginine methyltransferase(PRMT)1 is deregulated in a wide variety of cancer types,whose biological role in tumor immunity is *** To investigate the combined effects and underlying mechanisms of anti-PD-L1 and type I PRMT inhibitor in pancreatic cancer in *** PT1001B is a novel type I PRMT inhibitor with strong activity and good selectivity.A mouse model of subcutaneous Panc02-derived tumors was used to evaluate drug efficacy,toxic and side effects,and tumor growth in *** flow cytometry,we determined the expression of key immune checkpoint proteins,detected the apoptosis in tumor tissues,and analyzed the immune *** staining for cellular proliferation-associated nuclear protein Ki67,TUNEL assay,and PRMT1/PD-L1 immunofluorescence were used to elucidate the underlying molecular mechanism of the antitumor *** Cultured Panc02 cells did not express PD-L1 in vitro,but tumor cells derived from Panc02 transplanted tumors expressed *** therapeutic efficacy of anti-PD-L1 mAb was significantly enhanced by the addition of PT1001B as measured by tumor volume(1054.00±61.37 mm3 vs 555.80±74.42 mm3,P<0.01)and tumor weight(0.83±0.06 g vs 0.38±0.02 g,P<0.05).PT1001B improved antitumor immunity by inhibiting PD-L1 expression on tumor cells(32.74%±5.89%vs 17.95%±1.92%,P<0.05).The combination therapy upregulated tumorinfiltrating CD8+T lymphocytes(23.75%±3.20%vs 73.34%±4.35%,P<0.01)and decreased PD-1+leukocytes(35.77%±3.30%vs 6.48%±1.08%,

关键词： Protein arginine methyltransferase Programmed death-ligand-1 blockade Pancreatic cancer Combination therapy Tumor microenvironment Pancreatic ductal adenocarcinoma

Changes in posterior corneal elevation after small incision lenticule extraction for different myopic diopters

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 491-498页

作者： Xiao-Tong Sun Yang Zhang Xiao-Kun Mei nan-nan zheng Ling-Zhi Niu Xiao-Li Qu Ai-Ping Song Jian Zhuo Department of Ophthalmology the First Affiliated Hospital of Shandong First Medical UniversityShandong Provincial Qianfoshan HospitalJinan 250014Shandong ProvinceChina

●AIM:To study the changes and effect factors of posterior corneal surface after small incision lenticule extraction(SMILE)with different myopic diopters.●METHODS:Ninety eyes of 90 patients who underwent SMILE were included in this retrospective *** were allocated into three groups based on the preoperative spherical equivalent(SE):low myopia(SE≥-3.00 D),moderate myopia(-3.00 D>SE>-6.00 D)and high myopia(SE≤-6.00 D).Posterior corneal surfaces were measured by a Scheimpflug camera preoperatively and different postoperative times(1wk,1,3,6mo,and 1y).Posterior mean elevation(PME)at 25 predetermined points of 3 concentric circles(2-,4-,and 6-mm diameter)above the best fit sphere was analyzed.●RESULTS:All surgeries were completed uneventfully and no ectasia was found through the *** difference of myopia group was significant at the 2-mm ring at 1 and 3mo postoperatively(1mo:P=0.017;3mo:P=0.018).The effect of time onΔPME was statistically significant(2-mm ring:P=0.001;4-mm ring:P<0.001;6-mm ring:P<0.001).The effect of different corneal locations onΔPME was significant except 1wk postoperatively(1mo:P=0.000;3mo:P=0.000;6mo:P=0.001;1y:P=0.001).Posterior corneal stability was linearly correlated with SE,central corneal thickness,ablation depth,residual bed thickness,percent ablation depth and percent stromal bed thickness.●CONCLUSION:The posterior corneal surface changes dynamically after *** protrusion is observed on the posterior corneal surface in patients with different degrees of myopia within one year after *** has good stability,accuracy,safety and predictability.

关键词： myopia posterior corneal elevation corneal ectasia small incision lenticule extraction

Effect of photodynamic therapy with(17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt on pancreatic cancer cells in vitro and in vivo

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World Journal of Gastroenterology 2018年第46期24卷 5246-5258页

作者： Yu-Jie Shen Jia Cao Fang Sun Xiao-Lei Cai Ming-Ming Li nan-nan zheng Chun-Ying Qu Yi Zhang Feng Shen Min Zhou Ying-Wei Chen Lei-Ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

AIM To investigate the antitumor effects and underlying mechanisms of(17 R,18 R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt(YLG-1)-induced photodynamic therapy(PDT) on pancreatic cancer in vitro and in *** YLG-1 is a novel photosensitizer extracted from spirulina. Its phototoxicity, cellular uptake and localization, as well as its effect on reactive oxygen species(ROS) production, apoptosis, and expression of apoptosis-associated proteins were detected in vitro. An in vivo imaging system(IVIS), the Lumina K imaging system, and mouse models of subcutaneous Panc-1-bearing tumors were exploited to evaluate the drug delivery pathway and pancreatic cancer growth in *** YLG-1 was localized to the mitochondria, and the appropriate incubation time was 6 h. Under 650 nm light irradiation, YLG-1-PDT exerted a potent cytotoxic effect on pancreatic cancer cells in vitro, which could be abolished by the ROS scavenger N-acetyl-L-cysteine(NAC). The death mode caused by YLG-1-PDT was apoptosis, accompanied by upregulated Bax and cleaved Caspase-3 and decreased Bcl-2 expression. The results from the IVIS images suggested that the optimal administration route was intratumoral(IT) injection and that the best time to conduct YLG-1-PDT was 2 h post-IT injection. Consistent with the results in vitro, YLG-1-PDT showed great growth inhibition effects on pancreatic cancer cells in a mouse *** YLG-1 is a potential photosensitizer for pancreatic cancer PDT via IT injection, the mechanisms of which are associated with inducing ROS and promoting apoptosis.

关键词： Photodynamic therapy Pancreatic neoplasm (17R,18R)-2-(1-hexyloxyethyl)-2-devinyl chlorine E6 trisodium salt Antitumor effect

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang nan zheng Qingming Lin Yan You zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Single-puncture Method of Laparoscopic Herniorrhaphy in Children

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Chinese Medical Journal 2016年第16期129卷 2015-2016页

作者： Xue-Qiang Yan Hou-Fang Kuang nan-nan zheng Jun Yang Xu-Fei Duan Zhen-Chuang Zhu Hong-Qiang Bian Department of Pediatric Surgery Wuhan Medical and Health Center for Women and Children Wuhan Hubei 430016 China Department of Radiology Wuhan Medical and Health Center for Women and Children Wuhan Hubei 430016 China

To the Editor： Pediatric inguinal hernia repair is a common surgical procedure performed in pediatric patients. Laparoscopic herniorrhaphy has several advantages over conventional open herniotomy： most of them related to the evaluation of possible contralateral patent processus vaginalis （PPV） and avoidance of trauma to the vas deferens and spermatic vessels.

关键词：创伤和损伤评价研究输精管细小病毒科胰岛素疝腹股沟儿童人类

Incidence and Concurrent Laparoscopic Repair of ypertrophic Pyloric Stenosis and Patent Processus Vaginalis

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Chinese Medical Journal 2015年第7期128卷 982-984页

作者： Xue-Qiang Yan nan-nan zheng Fu-Zhong Xing Lei YU Wei Lu Xu-Fei Duan Jun Yang Hong-Qiang Bian Department of General Surgery Wuhan Medical and Health Center for Women and Children Wuhan Hubei 430016 China Department of Radiology Wuhan Medical and Health Center for Women and Children Wuhan Hubei 430016 China Department of Neonatal Surgery Wuhan Medical and Health Center for Women and Children Wuhan Hubei 430016 China

INTRODUCTIONAlthough laparoscopic herniorrhaphy is the most common procedure performed by pediatric surgeons at present, herniorrhaphy with an asymptomatic patent processus vaginalis （PPV） remains controversial. The incidence of contralateral PPV on laparoscopy in previous studies was reported as 20%-50%, but it is believed to approach 100% in premature infants. It has been reported that 4%-34% patients have the risk of developing subsequent metachronous contralateral hernia after a repair of an ipsilateral *** If this is true, then the identification and closure of a PPV at the time of ipsilateral hernia repair will obviate the need for a second operation in thousands of children every year. With recent advances in minimally invasive surgery, transinguinal diagnostic laparoscopy has emerged as a safe and effective method for evaluating a pediatric patient with PPV. Meanwhile, the laparoscopy has been widely used to manage the infantile hypertrophic pyloric stenosis （IHPS）, due to equally high success rate, minimal complications, and a shorter hospital stay.

关键词： Herniorrhaphy Hypertrophic Pyloric Stenosis Inguinal Hernia Internal Ring Laparoscopy: Patent Processus Vaginalis:Pediatric

双向地震动下单层偏心体系基于IDA的地震易损性分析

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大连民族大学学报 2018年第3期20卷 249-253页

作者：王丰王楠楠郭中正大连民族大学土木工程学院辽宁大连116650

考虑实际地震动的多维性以及偏心引起结构多分量反应的耦合作用,建立了屈服准则符合二维屈服函数三自由度的单层偏心体系模型。选取了24组双向地震动记录作为水平激励进行增量动力分析。以地震峰值加速度为地震强度参数,分别以x分量的... 详细信息

考虑实际地震动的多维性以及偏心引起结构多分量反应的耦合作用,建立了屈服准则符合二维屈服函数三自由度的单层偏心体系模型。选取了24组双向地震动记录作为水平激励进行增量动力分析。以地震峰值加速度为地震强度参数,分别以x分量的延性系数μ和扭转分量的最大扭转角θ为抗震性能参数建立平动能力曲线和扭转能力曲线。分析了偏心率e/r、频率比Ω_θ和场地类别等对两种能力曲线的影响。结果表明:e/r和Ω_θ对单层偏心体系平动反应的影响可忽略不计,但对扭转反应的影响明显。失效指标相同的前提下,场地土越硬,相同地震强度下的单层偏心体系抗震失效的概率越低。

关键词：增量动力分析地震易损性分析双向地震动延性系数偏心率

Novel Magnesium Alloys Developed for Biomedical Application:A Review

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Journal of Materials Science & Technology 2013年第6期29卷 489-502页

作者： nan Li Yufeng zheng State Key Laboratory for Turbulence and Complex System and Department of Materials Science and Engineering College of EngineeringPeking University

There is an increasing interest in the development of magnesium alloys both for industrial and biomedical applications. Industrial interest in magnesium alloys is based on strong demand of weight reduction of transportation vehicles for better fuel efficiency, so higher strength, and better ductility and corrosion resistance are required. Nevertheless, biomedical magnesium alloys require appropriate mechanical properties, suitable degradation rate in physiological environment, and what is most important, biosafety to human body. Rather than simply apply commercial magnesium alloys to biomedical field, new alloys should be designed from the point of view of nutriology and toxicology. This article provides a review of state-of-the-art of magnesium alloy implants and devices for orthopedic, cardiovascular and tissue engineering applications. Advances in new alloy design, novel structure design and surface modification are overviewed. The factors that influence the corrosion behavior of magnesium alloys are discussed and the strategy in the future development of biomedical magnesium alloys is proposed.

关键词： Biomaterials Magnesium alloys Biodegradation Mechanical property Biocompatibility