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Protective effects of Achyranthes bidentata polypeptides on retinal ganglion cells post-optic nerve crush in rats

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Neural Regeneration Research 2011年第15期6卷 1164-1168页

作者： nan hu Qi Zhao Fangling Zhang Junfang Zhang Xiaosong Gu Medical School of Soochow University Suzhou 215123 Jiangsu Province China Department of Ophthalmology Affiliated Hospital of Nantong University Nantong 226001 Jiangsu Province China Jiangsu Key Laboratory of Neuroregeneration Nantong University Nantong 226001 Jiangsu Province China

Achyranthes bidentata polypeptides（ABPP） have been reported to inhibit apoptosis of retinal ganglion cells（RGCs）.The present study investigated the protective effects of ABPP on RGCs in a rat model of optic nerve *** prolonged injury time,RGC densities were gradually ***（5 μg） significantly increased RGC densities and upregulated growth associated protein 43 expression in rats with optic nerve *** demonstrate that ABPP can protect RGCs and promote axonal growth after optic nerve crush.

关键词： Achyranthes bidentata polypeptides optic nerve crush retinal ganglion cells growth associated protein 43 neural regeneration

Integrating ecological civilization concept into the environmental legal institution

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Ecological Economy 2015年第2期8卷 110-117页

作者： WANG Xu QIN Shu-sheng hu nan School of Marxism Northeast University of China

Integrating the ecological civilization concept into many aspects such as environmental legislation and judicial enforcement is an important measure of constructing ecological civilization. It has three aspects. In the aspect of the legislation, we should take the ecological civilization concept into the environmental legislation in order to construct perfect environmental legislation institution, to strengthen the coordination of environmental legislation related regulations, and then to improve the operability of the environmental legislation. In the aspect of the environmental judice, we must strength the construction of environmental legal institution, promote establishing environmental courts, strength the judicial personnel construction and improve the level of environmental justice. In the aspect of the enforcement of the law, we must establish environmental management institution immediately, i.e., to establish environmental administrative law enforcement questioning mode, and to strength cooperation between environmental law enforcement and enhance their law enforcement responsibility.

关键词： ecological civilization environmental law institution construction

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法经济学视野下的金融监管法正义性分析

法制与社会发展 2006年第5期12卷 118-126页

作者：李晗湖南大学法学院湖南长沙410079

正义历来是法律所追求的价值目标之一,但其从来都不是空洞和抽象的,需要用具体的方法和标准对其进行诠释和分析。在金融全球化趋势日益加深的今天,从法经济学的视角,对金融监管法的正义性价值目标进行分析和诠释,对于进一步完善我国金... 详细信息

正义历来是法律所追求的价值目标之一,但其从来都不是空洞和抽象的,需要用具体的方法和标准对其进行诠释和分析。在金融全球化趋势日益加深的今天,从法经济学的视角,对金融监管法的正义性价值目标进行分析和诠释,对于进一步完善我国金融监管法体系,维护我国金融安全与稳定意义深远。运用法经济学的分析方法,从立法、执法和司法三个方面对我国现行的金融监管法进行分析,以促进我国金融监管法正义价值目标的最终实现。

关键词：法经济学金融监管法正义

An fMRI Study of Words Processing in Chinese Language

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Journal of Biosciences and Medicines 2016年第3期4卷 9-14页

作者： Pei Xu Bing Sun Chunqi Chang nan hu School of Electronic and Information Engineering Soochow University Suzhou China School of Biomedical Engineering Shenzhen University Shenzhen China

Using the blood oxygen levels dependent technology of magnetic resonance imaging (BLOD-fMRI), we aimed to explore the brain activation after visual stimulation by Chinese words. In the current study, 24 healthy volunteers (12 males, 12 females, right-handed, mean age 26 ± 2 years) were prospectively included. The event related design was used in the current fMRI study when participants silently read all words appearing in the middle of the screen. Images were processed with Statistical Parametric Mapping 8 (SPM8) software, by using a general linear model (GLM). Group activations were extracted from the 2nd level group analysis with a threshold of p < 0.001, and it was shown that the main activated areas by silent reading tasks were regions involved in brain semantic processing, including middle temporal gyrus, fusiform gyrus, supplementary motor area, inferior frontal gyrus, cingulate gyrus, superior parietal lobule and inferior parietal lobule. It was also learnt that superior parietal lobule and middle temporal gyrus are related with semantic understanding, lenticular nucleus are related with semantic processing. This means, in addition to the cerebral cortex, subcortical nuclei is also very important to the processing of words in Chinese language.

关键词： Functional Magnetic Resonance Imaging (fMRI) Brain Functional Area Brain Activation

MH-STRALP:A scoring system for prognostication in patients with upper gastrointestinal bleeding

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 790-806页

作者： Jun-nan hu Fei Xu Ya-Rong Hao Chun-Yan Sun Kai-Ming Wu Yong Lin Lan Zhong Xin Zeng Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Gastroenterology Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China

BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment *** To develop a new scoring system to predict its *** In this retrospective study,692 patients with UGIB were enrolled from two cen-ters and divided into a training(n=591)and a validation cohort(n=101).The clinical data were collected to develop new prognostic prediction *** en-dpoint was compound outcome defined as(1)demand for emergency surgery or vascular intervention,(2)being transferred to the intensive care unit,or(3)death during *** models’predictive ability was compared with previously esta-blished scores by receiver operating characteristic(ROC)*** Totally 22.2%(131/591)patients in the training cohort and 22.8%(23/101)in the validation cohort presented poor *** on the stepwise-forward Lo-gistic regression analysis,eight predictors were integrated to determine a new post-endoscopic prognostic scoring system(MH-STRALP);a nomogram was de-termined to present the *** with the previous scores(GBS,Rock-all,ABC,AIMS65,and PNED score),MH-STRALP showed the best prognostic prediction ability with area under the ROC curves(AUROCs)of 0.899 and 0.826 in the training and validation cohorts,*** to the calibration cur-ve,decision curve analysis,and internal cross-validation,the nomogram showed good calibration ability and net clinical benefit in both *** removing the endoscopic indicators,the pre-endoscopic model(pre-MH-STRALP score)was ***,the pre-MHSTRALP score showed better predictive value(AUROCs of 0.868 and 0.767 in the training and validation cohorts,respectively)than the other pre-endoscopic *** The MH-STRALP score and pre-MH-STRALP score are simple,convenient,and accurate tools for prognosis prediction of UGIB,and may be applied for early decision on its management strategies.

关键词： Upper gastrointestinal bleeding Prognosis prediction Retrospective study Nomogram Post-endoscopic model Pre-endoscopic model

Constructing a highly bioactive tendon-regenerative scaffold by surface modification of tissue-specific stem cell-derived extracellular matrix

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Regenerative Biomaterials 2022年第1期9卷 81-92页

作者： Liang-Ju Ning Jing Cui Shu-Kun He Ruo-nan hu Xuan Yao Yi Zhang Wei Ding Yan-Jing Zhang Jing-Cong Luo Ting-Wu Qin Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041P.R.China Department of Orthopedic Surgery Orthopedic Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Core Facility West China HospitalSichuan UniversityChengduSichuan 610041P.R.China

Developing highly bioactive scaffold materials to promote stem cell migration,proliferation and tissue-specific differentiation is a crucial requirement in current tissue engineering and regenerative *** previous work has demonstrated that the decellularized tendon slices(DTSs)are able to promote stem cell proliferation and tenogenic differentiation in vitro and show certain pro-regenerative capacity for rotator cuff tendon regeneration in *** this study,we present a strategy to further improve the bioactivity of the DTSs for constructing a novel highly bioactive tendon-regenerative scaffold by surface modification of tendon-specific stem cell-derived extracellular matrix(tECM),which is expected to greatly enhance the capacity of scaffold material in regulating stem cell behavior,including migration,proliferation and tenogenic *** prove that the modification of tECM could change the highly aligned surface topographical cues of the DTSs,retain the surface stiffness of the DTSs and significantly increase the content of multiple ECM components in the *** a result,the tECM-DTSs dramatically enhance the migration,proliferation as well as tenogenic differentiation of rat bone marrow-derived stem cells compared with the ***,this strategy would provide a new way for constructing ECMbased biomaterials with enhanced bioactivity for in situ tendon regeneration applications.

关键词： tendon-regenerative scaffold extracellular matrix bioactive material tissue-specific stem cell

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政府债务规模对政府稳定影响的实证研究

湖南师范大学社会科学学报 2017年第4期46卷 71-77页

作者：胡穗胡南湖南工学院马克思主义学院中山大学数据科学与计算机学院软件工程与应用研究所

政府债务规模对政府稳定具有重要影响。通过对41个国家(地区)16年的面板数据进行回归发现:政府债务规模越高的国家(地区),政府稳定指数越低。总体而言,政府债务规模每提高1%,政府稳定指数相应降低约0.03。研究还发现:人均GDP增长率与政... 详细信息

政府债务规模对政府稳定具有重要影响。通过对41个国家(地区)16年的面板数据进行回归发现:政府债务规模越高的国家(地区),政府稳定指数越低。总体而言,政府债务规模每提高1%,政府稳定指数相应降低约0.03。研究还发现:人均GDP增长率与政府稳定指数呈现显著正相关,人均GDP增长率每提高1%,政府稳定指数相应提高约0.07;失业率、腐败指数与政府稳定指数呈现负相关。为提高我国政府稳定指数,一要加强监管,严防政府债务增速过快,准确判断、防范和化解政府债务风险,牢牢守住不发生政府债务系统性风险底线。二要科学选择政策工具,加快供给侧结构性改革,稳定并维持适度的GDP增长率。三要反腐挽民心,民生换民心,严惩腐败,提高就业率,巩固和优化政府执政资源。

关键词：政府债务规模政府稳定人均GDP增长率失业率腐败

带多个切换的Filippov系统极限环在扰动下的保持性

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四川大学学报（自然科学版） 2013年第4期50卷 698-702页

作者：胡楠四川大学数学学院

本文讨论了一类含有有限多条切换线的平面Filippov系统极限环在扰动下的保持性.假设该类平面Filippov系统的未扰系统含有一个极限环且它分别与每一条切换线横截相交一次,作者应用Diliberto定理和由此引出的变分引理导出了极限环的特征... 详细信息

本文讨论了一类含有有限多条切换线的平面Filippov系统极限环在扰动下的保持性.假设该类平面Filippov系统的未扰系统含有一个极限环且它分别与每一条切换线横截相交一次,作者应用Diliberto定理和由此引出的变分引理导出了极限环的特征指标的计算公式,并利用该公式讨论了系统极限环的稳定性及其在扰动下保持的条件.

关键词： Filippov系统极限环切换

三维层级花状活性氧化铝纳米材料的制备及其除砷性能研究

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无机材料学报 2019年第5期34卷 553-559页

作者：李荣辉郏义征胡楠楠天津力神电池股份有限公司力神研究院天津300384 四川建筑职业技术学院德阳618000

以硝酸铝和尿素为原料,通过简单的水热和高温煅烧法自组装形成三维层级花状活性氧化铝。这种结构既保留了氧化铝丰富的纳米级别活性位点,同时具有微米级的三维尺寸,在柱吸附除砷实验中起到骨架支撑作用,而其较大的比表面积可以确保水中... 详细信息

以硝酸铝和尿素为原料,通过简单的水热和高温煅烧法自组装形成三维层级花状活性氧化铝。这种结构既保留了氧化铝丰富的纳米级别活性位点,同时具有微米级的三维尺寸,在柱吸附除砷实验中起到骨架支撑作用,而其较大的比表面积可以确保水中的砷酸根离子与吸附位点充分接触,从而有效吸附水中砷酸根离子,相较商用活性氧化铝具有更好的除砷性能,且不会对水体产生二次污染。对制备的活性氧化铝材料的除砷动力学进行了分析,明确了吸附动力学准一级和准二级模型的应用条件和范围。通过对该材料吸附砷酸根前后Zeta电位的变化的研究和离子强度实验进一步验证发现,γ-Al2O3对As(V)的吸附机理遵循内球配位模型,而对As(III)的吸附机理遵循外球配位模型。

关键词：三维层级花状氧化铝晶体生长吸附动力学吸附模型机理