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Phase Ⅱ study of R-CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma:consortium for improving survival of lymphoma(CISL)study

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Cancer Communications 2019年第1期39卷 526-535页

作者： Sung Yong Oh Won Seog kim Jin Seok kim Seok Jin kim Dok Hyun Yoon Deok-Hwan Yang Won Sik Lee Hyo Jung kim Ho-Young Yhim Seong Hyun Jeong Jong Ho Won Suee Lee Jee Hyun Kong Sung-nam Lim Jun Ho Ji Kyung A.Kwon Gyeong-Won Lee Jae Hoon Lee Ho Sup Lee Ho-Jin Shin Cheolwon Suh Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Division of Hematology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Republic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalHwasun 58128Republic of Korea Department of Hematology Busan Paik HospitalInje University College of MedicineBusan 04511Republic of Korea Department of Internal Medicine Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang 14068Republic of Korea Department of Internal Medicine Chonbuk National University HospitalJeonju 54907Republic of Korea Department of Hematology-Oncology Ajou University School of MedicineSuwon 16499Republic of Korea Department of Internal Medicine Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoul 04401Republic of Korea Division of Hematology-Oncology Department of Internal MedicineWonju Severance Christian HospitalYonsei University College of MedicineWonju 26426Republic of Korea Department of Internal Medicine Haeundae Paik HospitalInje University College of MedicineBusan 48108Republic of Korea Division of Hematology and Oncology Department of Internal MedicineSamsung Changwon HospitalSungkyunkwan University School of MedicineChangwon 51353Republic of Korea Division of Hematology-Oncology Department of Internal MedicineDongnam Institute of Radiological and Medical SciencesBusan 46033Republic of Korea Division of Hematology-Oncology Department of Internal MedicineGyeongsang National University HospitalGyeongsang National University College of MedicineJinju 52727Republic of Korea Department of Internal Medicine Gachon University Gil Medical CenterIncheon 21565Republic of

Background:The response rate and survival improvement for rituximab,a CD20-targeting monoclonal antibody,have been demonstrated in marginal zone lymphoma(MZL)as monotherapy and in combination with chemotherapeutic regimens,yet relapses still occur despite treatment ***,extending the period of remission in MZL patients remains an essential *** multicenter,single-arm,open-label phase II study evaluated the survival efficacy of 2 years of rituximab-maintenance therapy in patients with stage III-IV CD20-positive MZL who had responded to first-line R-CVP(rituximab,cyclophosphamide,vincristine,and prednisolone).The objective of this study was to determine whether rituximab maintenance following R-CVP warrants further ***:Prior to rituximab-maintenance therapy,patients received 6-8 cycles of first-line R-CVP therapy for stage III-IV ***(375 mg/m^(2)),cyclophosphamide(750 mg/m^(2)),and vincristine(1.4 mg/m^(2);maximum 2 mg)were administered via an intravenous infusion on day 1 of each 3-week cycle,while oral prednisolone(100 mg)was given on days 1-5 of each 3-week *** patients who achieved complete response(CR),partial response(PR),or stable disease(SD)to R-CVP treatment,were prescribed rituximab-maintenance therapy which was administered intravenously at a dose of 375 mg/m^(2) every 8 weeks for up to 12 *** primary endpoint was progression-free survival(PFS).Secondary endpoints were overall survival(OS)and treatment ***:47 patients were enrolled,of whom,45(96%)received rituximab-maintenance ***(33%)patients had nodal *** R-CVP first-line therapy,20(44%),22(49%),and 3(7%)patients achieved CR,PR,and SD,*** a median follow-up of 38.2 months,their observed 3-year PFS rate was 81%.During the rituximab-maintenance,6 PR and 1 SD patients achieved CR following the administration of *** LDH and the presence of B symptoms were found to be significant prognostic fac

关键词： Marginal zone Lymphoma Advanced stage Rituximab Cyclophosphamide Vincristine Maintenance Multicenter Open label Survival

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韩国家长教育参与政策的历史发展过程与特征

现代教育论丛 2022年第1期 26-40,111页

作者：李秀广吴在吉韩国京畿道研究院韩国利川17416 韩国上岘初等学校韩国龙仁16928

本研究的目的是分析韩国家长教育参与政策的历史发展过程与特征。在金泳三政府推动“5.31教育改革”前,家长被视为学校的支持者和志愿者。改革后,家长的社会和法律地位得到改善,开始被认可为教育的权利主体。引入学校管理委员会制度后,... 详细信息

本研究的目的是分析韩国家长教育参与政策的历史发展过程与特征。在金泳三政府推动“5.31教育改革”前,家长被视为学校的支持者和志愿者。改革后,家长的社会和法律地位得到改善,开始被认可为教育的权利主体。引入学校管理委员会制度后,家长开始参与学校管理。此外,韩国政府还出台了各种赋权家长的支持政策。然而,这些政策存在如下几个问题:一是学校(教师)和家长之间的“固定关系”(不平衡的权力结构)持续存在;二是政策、规范与环境存在不协调(discord)问题;三是提高教师“协作领导力”的政策力度不够;四是建立双向沟通体制的政策不足;五是家长教育热用作战略资源的政策不足。

关键词：家长地位教育主权者家长赋权政策双向互动机制

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Wnt1表达细胞系Nell-1缺失导致颅面部骨发育不足及出生后脑积水

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Wnt1表达细胞系Nell-1缺失导致颅面部骨发育不足及出生后脑积水

粳稻“龙锦1号／香软米1578”F3家系群糙米矿质元素含量变异及相关性分析

2020年中华口腔医学会口腔生物医学专业委员会第十次全国口腔生物医学学术年会暨第六次全国口腔杰青优青论坛

作者：陈小燕王慧明俞孟流 Jong Kil kim 齐慧川 Pin Ha Wenlu Jiang Eric Chen Xiangyou Luo Ryan Brent Needle Lloyd Baik Cathryn Yang 施洁珺 Jin Hee Kwak Kang Ting Xinli Zhang Chia soo 浙江大学医学院附属口腔医院中日友好医院种植科 School of Dentistry University of California 吉林大学口腔医院正畸科四川大学华西口腔医院 UCLA Division of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center University of California

目的:Nell-1蛋白表达增加与人类颅缝早闭(Craniosynostosis,CS)有关,此结果已在Nell-1过表达的转基因小鼠模型中得到验证。N-乙基-N-亚硝基脲(ENU)诱变的全身Nell-1敲除小鼠出生死亡率增加,并通常伴有骨骼异常,其中包括颅骨锁骨闭合发...

目的:Nell-1蛋白表达增加与人类颅缝早闭(Craniosynostosis,CS)有关,此结果已在Nell-1过表达的转基因小鼠模型中得到验证。N-乙基-N-亚硝基脲(ENU)诱变的全身Nell-1敲除小鼠出生死亡率增加,并通常伴有骨骼异常,其中包括颅骨锁骨闭合发育不良(CCD)样颅骨骨缺损。由于颅神经嵴细胞(CNCCs)在颅面组织发育过程中发挥着重要作用,本研究拟通过通过利用Nell-1在Wnt1表达细胞系中的特异性敲除转基因小鼠,进一步明确了Nell-1在颅面骨骼形成中的作用。

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中国水稻科学 2008年第3期22卷 290-296页

作者：孙明茂杨昌仁李点浩崔仁守曹桂兰李圭星金弘烈于元杰李英泰韩龙植中国农业科学院作物科学研究所/国家农作物基因资源与基因改良重大科学工程/农业部作物种质资源与生物技术重点开放实验室北京100081 韩国农村振兴厅作物科学院山东农业大学农学院山东泰安271018

利用粳稻品种间杂交组合"龙锦1号/香软米1578"的196份F3家系,对糙米中Fe、Se、Zn、Cu、Mn、Ca、Mg、K、Na和P等10种矿质元素含量的变异及其相关性进行了分析。10种矿质元素在F3家系间均有较大的变异,其中Na含量变异最大,Zn含量变异最小... 详细信息

利用粳稻品种间杂交组合"龙锦1号/香软米1578"的196份F3家系,对糙米中Fe、Se、Zn、Cu、Mn、Ca、Mg、K、Na和P等10种矿质元素含量的变异及其相关性进行了分析。10种矿质元素在F3家系间均有较大的变异,其中Na含量变异最大,Zn含量变异最小,变异系数分别为77.69%和12.04%。各矿质元素含量的变异系数大小顺序为Na>Se>Cu>Fe>Mg>Mn>Ca>P>K>Zn。不同矿质元素含量也有较大的差异,F3家系群各矿质元素含量平均值高低排序为P>K>Mg>Ca>Fe>Mn>Zn>Na>Cu>Se。糙米中10种矿质元素含量在F3家系群中均表现为正态分布,为由多基因控制的数量性状。Zn与Fe、Cu,Mn与Mg、Ca、K、P,Ca与Mg、K、Na、P,Mg与K、P,P与K、Na含量呈显著或极显著正相关,而Fe与Se、Mn与Na、Mg与Na含量呈显著或极显著负相关。Mn、Ca、Mg、K、P含量与其他矿质元素含量间的相关关系较Fe、Se、Cu、Zn含量与其他矿质元素含量间的相关关系更为密切。

关键词：水稻矿质元素家系遗传变异相关性

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MRI三维测量口腔舌鳞状细胞癌病人肿瘤厚度的临床意义

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国际医学放射学杂志 2016年第3期 327-327页

作者： M.Kwon H.Moon S.nam J.Lee J.kim Y.Lee 王奕 Department of Otorhinolaryngology Gyeongsang National University HospitalSchool of Medicine

摘要目的为明确口腔舌鳞状细胞癌病人(OTSCC)原发肿瘤厚度(TT)及其方向的临床意义,在MRI横断面/冠状面/矢状面影像上测量肿瘤厚度并评估其意义。方法共纳入53例OTSCC病人,均进行了术前三维MRI扫描以及手术治疗。分别在横断面(内外侧方向... 详细信息

摘要目的为明确口腔舌鳞状细胞癌病人(OTSCC)原发肿瘤厚度(TT)及其方向的临床意义,在MRI横断面/冠状面/矢状面影像上测量肿瘤厚度并评估其意义。方法共纳入53例OTSCC病人,均进行了术前三维MRI扫描以及手术治疗。分别在横断面(内外侧方向)、冠状面(上下方向)以及矢

关键词：肿瘤厚度隐匿性淋巴结转移口腔舌鳞状细胞癌 MRI 病人临床意义

梗阻性前列腺癌病人可回收自膨式带倒钩金属支架的放置

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国际医学放射学杂志 2013年第3期 290-290页

作者： H.Y.Song C.S.kim I.G.Jeong D.Yoo J.H.kim D.H.nam 田凤娟 Departments of Radiology and Research Institute of Radiology University of Ulsan College of Medicine

目的评价梗阻性前列腺癌病人放置可回收自膨式带倒钩金属支架的技术可行性和临床疗效。方法带8个倒钩的可回收自膨式金属支架连续置入8例梗阻性前列腺癌病人体内。病人年龄55;6岁（平均69岁）。8例病人先前都接受过激素治疗,其中3例病... 详细信息

目的评价梗阻性前列腺癌病人放置可回收自膨式带倒钩金属支架的技术可行性和临床疗效。方法带8个倒钩的可回收自膨式金属支架连续置入8例梗阻性前列腺癌病人体内。病人年龄55;6岁（平均69岁）。8例病人先前都接受过激素治疗,其中3例病人曾行姑息性经尿道前列腺切除术。出现并发症时这些支架通过一个21F支架移除装置回收。结果所有支架均成功置入,而且所有病人都能耐受。其中1例严重尿失禁自然好转,另有2例病人的肉眼血尿在4d后自然消失。支架植入1个月后病人最大尿流率和膀胱残余尿量分别是5.6;0.2mL/s（平均:8.3mL/s）和5;5mL（平均:27mL）。经过平均约192d（39;32d）的随访,1例病人在232d后因支架内结石形成需要移除支架。由于支架移除后肿块好转而不需要进一步介入治疗。结论初步结果表明带8个倒钩的可回收自膨式金属支架在梗阻性前列腺癌病人中的应用具有可行性和有效性。要点①可回收金属尿道支架对梗阻性前列腺癌病人有帮助。②带8个倒钩的可回收自膨式支架是可行的、有效的。③这些支架显然解决了支架移动的问题。④移去这些支架是安全的,不需要外科手术,局部麻醉即可。

关键词：可回收自膨式金属支架前列腺癌经尿道前列腺切除术尿潴留倒钩

Autologous Peripheral Blood Stem Cells and <i>γ</i>/<i>δ</i>T Cells May Improve Immunity in Treating Secondary Bacteremic Infection in HIV Infected Patient

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Stem Cell Discovery 2015年第4期5卷 48-61页

作者： Ciro Gargiulo Van Hung Pham Nguyen Thuy Hai Kieu C. D. Nguyen Ngan Duong kim Thinh Nguyen Van An Luu Tuan Kenji Abe Veronica Flores Melvin Shiffman Division of Internal Medicine The Human Medicine International Clinic Ho Chi Minh City Vietnam Molecular Diagnostics Department Nam Khoa-Biotek Laboratory Ho Chi Minh City Vietnam Division of Pathology The Human Medicine International Clinic Ho Chi Minh City Vietnam Department of Pathology National Institute of Infectious Diseases Tokyo Japa Sol Price School of Public Policy University of Southern California Los Angeles CA USA Section of Surgery Newport Specialty Hospital Tustin CA USA

Opportunistic bacteremia in adult HIV-infected patients is a normal co-infectious condition caused by Gram-negative bacilli. Respiratory infections, including cough, shortness of breath, and chest pain and skin infection with eruptions, pustules and itchiness, are common complaints in the setting of late HIV infection. The variety of infections ranges from mild, self-limited viral, bacteremia and fungal infections to severe, life-threatening demanding urgent care and hospitalization. Varicella pneumonia, for instance, is the most severe complication of chickenpox in HIV infected adults, potentially refractory, fulminant respiratory failure can ensue. Patients with impaired immune status and chronic lung disease are at an increased risk. In the United States as well as in Vietnam, bacterial/viral pneumonia and skin infection are the two most common HIV-associated conditions. While globally the incidence of opportunistic infection has decreased since the introduction of highly active antiretroviral therapy during the last 3 decades, HIV-associated diseases remain a significant source of mortality, thus any manifestation must be taken seriously. This study will present the most common HIV-related pulmonary and skin infections and provide an overview of the epidemiology, characteristic clinical and chest radiograph findings, diagnosis, treatment, and prevention globally as well in Vietnam. Though the extensive efforts of the Vietnamese Government during last decade contributed to a valuable decrease, yet epidemic in Vietnam still remains high, ranking Vietnam 5th in the South-East region. The second part of the study focuses on a unique and severe HIV case report of a 35-year-old man, with a rare form of pneumonia caused by Acitenobacter spp. concomitant with a prolonged and disseminating skin infection. The case has been treated with a combination of conventional anti-retroviral medication and autologous peripheral blood stem cells, the results showed that within 5 mon

关键词： Human Peripheral Blood Stem Cells γ/δ T Cells NK Cells Hematopoietic Stem Cells CD4 CD8 HIV

Characterization of arsenic-contaminated groundwater and human health risk assessment in Vietnam

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Chinese Journal Of Geochemistry 2006年第B8期25卷 74-74页

作者： Van Anh Nguyen Sunbaek Bang Kyoung-Woong kim International Environmental Research Center Gist Buk-Gu Gwangju 500-712 South Korea

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肥胖细胞型Ⅱ级星形细胞瘤的肥胖细胞成分和MR影像特征相对于非肥胖细胞型Ⅱ级星形细胞瘤评估预后的作用

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国际医学放射学杂志 2017年第5期 609-609页

作者： Y.J.Heo J.E.Park H.S.kim J.Y.Lee S.J.nam S.C.Jung 董晨风 Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical Center

摘要目的探讨肥胖细胞型Ⅱ级星形细胞瘤(Gem A)相比非肥胖细胞型Ⅱ级星形细胞瘤(non-Gem A),其MRI特征是否与肿瘤进展时间(TTP)更短相关。材料与方法纳入10

关键词：细胞型星形细胞瘤 MR 非肥胖影像特征