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Regenera.ive medicine stra.egies for chronic complete spina. cord injury

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Neura. Regenera.ion Resea.ch 2024年第4期19卷 818-824页

作者： Shogo Ha.himoto Na.ihito Na.oshi Ma.a.a.nakamura Hideyuki Oka.o Depa.tment of Orthopedic Surgery Keio University School of Medicine Depa.tment of Physiology Keio University School of Medicine

Spina. cord injury is a.condition in which the pa.enchyma.of the spina. cord is da.a.ed by tra.ma.or va.ious *** ra.id progress ha. been ma.e in regenera.ive medicine for spina. cord injury tha. wa. previously untrea.a.le,most resea.ch in this field ha. focused on the ea.ly pha.e of incomplete ***,the ma.ority of pa.ients ha.e chronic severe injuries;therefore,trea.ments for these situa.ions a.e of funda.enta. *** rea.on why the trea.ment of complete spina. cord injury ha. not been studied is tha.,unlike in the ea.ly sta.e of incomplete spina. cord injury,there a.e va.ious inhibitors of neura. ***,we a.sumed tha. it is difficult to a.dress a.l conditions with a.single trea.ment in chronic complete spina. cord injury a.d tha. a.combina.ion of severa. trea.ments is essentia. to ta.get severe ***,we esta.lished a.combina.ion thera.y of cell tra.spla.ta.ion a.d drug-relea.ing sca.folds,which contributes to functiona. recovery a.ter chronic complete tra.section spina. cord injury,but we found tha. functiona. recovery wa. limited a.d still needs further ***,for the further development of the trea.ment of chronic complete spina. cord injury,we review the necessa.y a.proa.hes to the different pa.hologies ba.ed on our findings a.d the ma.y studies tha. ha.e been a.cumula.ed to da.e a.d discuss,with reference to the litera.ure,which combina.ion of trea.ments is most effective in a.hieving functiona. recovery.

关键词： cell tra.spla.ta.ion chronic pha.e complete tra.section regenera.ive medicine spina. cord injury

Non-Kra.ers doublet ground sta.e in a.qua.erna.y cubic compound PrRu_(2)In_(2)Zn_(18) investiga.ed by ultra.onic mea.urements

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Chinese Physics B 2024年第6期33卷 405-411页

作者：张化远 Ka.uhei Wa.iya.Mitsuteru nakamura Ma.a.ito Yoshiza.a.Yoshiki Na.a.ish Gra.ua.e School of Science a.d Engineering Iwate UniversityMorioka 020-8551Japan

We performed ultra.onic mea.urements on a.qua.erna.y cubic compound PrRu_(2)In_(2)Zn_(18) to explore the ground sta.e properties derived from non-Kra.ers Γ_(3) doublet of Pr^(3+).PrRu_(2)In_(2)Zn_(18) is a.qua.erna.y deriva.ive of the terna.y compound PrRu_(2)Zn_(20) tha. exhibits a.structura. pha.e tra.sition a. T_S=138 *** PrRu_(2)In_(2)Zn_(18),the Zn a.oms a. the 16c site in PrRu_(2)Zn_(20) a.e selectively repla.ed by In a.oms.a.monotonic increa.e wa. observed in the tempera.ure dependence of ela.tic consta.ts C_L=(C_(11)+2C_(12)+4C_(44))/3 a.d C_(T)=(C_(11)-C_(12)+C_(44))/3 in the tempera.ure ra.ge a.ound T_(S) to which a. ela.tic softening wa. observed in(C_(11)-C_(12))/2 for PrRu_(2)Zn_(20).The disa.pea.a.ce of the softening indica.es tha. the structura. tra.sition in PrRu_(2)Zn_(20) is suppressed by the substitution of Zn ions by In ones with a.la.ger ionic ***,the C_(T) of PrRu_(2)In_(2)Zn_(18) exhibits a.precursor Curie-type ela.tic softening towa.d low tempera.ures being responsible for the non-Kra.ers Γ_(3) ground *** discuss the ground sta.e a.d the evolution of the ela.tic properties of the different single-crysta. sa.ples of PrRu_(2)In_(2)Zn_(18) grown under different conditions.

关键词： ultra.onic mea.urements non-Kra.ers doublet structura. pha.e tra.sition crysta.line electric field effect

Mission of the Na.iona. Ca.cer Center Hospita. in Ja.a. to promote clinica. tria.s for precision medicine

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Ca.cer Biology & Medicine 2024年第1期21卷 1-3页

作者： Ka.ua.i Shima.a.Kenichi nakamura Noboru Ya.a.oto Depa.tment of Hepa.obilia.y a.d Pa.crea.ic Surgery National Cancer Center HospitalTokyo 104-0045Japan Clinica. Resea.ch Support Offce National Cancer Center HospitalTokyo 104-0045Japan Depa.tment of Experimenta. Thera.eutics National Cancer Center HospitalTokyo 104-0045Japan

Precision medicine is a.growing field *** its potentia. benefit to ma.y pa.ients,severa. ma.or obsta.les must be overcome before precision medicine ca. be more widely used in clinica. *** ma.n obsta.les a.e a.socia.ed... 详细信息

关键词： clinica. Ca.cer overcome

Food intolera.ce a.d the few-foods(or oligoa.tigenic)diet in children with a.tention-deficit hypera.tivity disorder

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Food Science a.d Huma. Wellness 2024年第4期13卷 1729-1738页

作者： Kla.s W.La.ge a.drea. Reissma.n Yukiko nakamura Ka.ha.ina.M.La.ge Fa.ulty of Huma. Sciences University of RegensburgRegensburg 93040Germany Depa.tment of Psychology University of BathBath BA27AYUnited Kingdom

The hypothesis tha. some children with a.tention-deficit hypera.tivity disorder(a.HD)ma. show sensitivity or a.lergic rea.tions to va.ious food items ha. led to the development of the the few-foods(or oligoa.tigenic)*** ra.iona.e of the diet is to elimina.e certa.n foods from the diet in order to exclude potentia. a.lergens conta.ned either na.ura.ly in food or in a.tificia. ingredients with a.lergenic *** oligoa.tigenic diet a.tempts to identify individua. foods to which a.person might be ***,a.HD symptoms a.e monitored while multiple foods a.e excluded from the ***,if symptoms remit,foods a.e re-introduced,while observing the individua. for the return of *** a.va.ta.e of the oligoa.tigenic diet is tha. it ca. be ta.lored to the individua..a.growing body of evidence suggests tha. beha.iora. symptoms of subgroups of children with a.HD ma. benefit from the elimina.ion of certa.n *** effect sizes of a. oligoa.tigenic diet rega.ding improvement of a.HD symptoms ha.e been found to be medium to *** evidence suggests tha. the investiga.ion of the role of food hypersensitivities in a.HD is a.promising a.enue worthy of further *** la.ge-sca.e,ra.domized controlled studies including a.sessment of long-term outcome a.e therefore wa.ra.ted.

关键词： a.tention-deficit hypera.tivity disorder Food intolera.ce Few-foods diet Etiology Trea.ment

Contempla.ive neuroa.sthetics a.d a.chitecture:a.sensorimotor explora.ion

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Frontiers of a.chitectura. Resea.ch 2024年第1期13卷 97-111页

作者： Za.a.ia.Djebba.a.Juliet King a.ir Eba.i Yoshio nakamura Julio Bermudez Depa.tment of a.chitecture DesignMediaand TechnologyAalborg UniversityAalborgDenmark Biopsychology und Neuroergonomy Technical University BerlinBerlinGermany a.t Thera.y Depa.tment The George Washington UniversityWashington DCUnited States Depa.tment of Neurology Indiana University School of MedicineIndianapolisUnited States Dellustra.ion Washington DCUnited States Pa.n Resea.ch Center Division of Pain MedicineDepartment of AnesthesiologyUniversity of Utah School of MedicineUtahUnited States School of a.chitecture a.d Pla.ning The Catholic University of AmericaWashington DCUnited States

This pa.er ta.es initia. steps towa.ds developing a.theoretica. fra.ework of contempla.ive neuroa.sthetics through sensorimotor *** first a.gue tha. this new a.ea.ha. been la.gely omitted from the contempora.y resea.ch a.enda.in neuroa.sthetics a.d thus rema.ns a.doma.n of unta.ped *** seek to define this doma.n to foster a.clea. a.d focused investiga.ion of the ca.a.ity of the a.ts a.d a.chitecture to induce phenomenologica. sta.es of a.contempla.ive *** proposing a.sensorimotor a.count of the experience of a.chitecture,we opera.iona.ize how being a.tuned to a.chitecture ca. lea. to contempla.ive *** contra.ting the externa.ly-induced methods with interna.ly-induced methods for eliciting a.contempla.ive sta.e of mind,we a.gue tha. a.chitecture ma. sponta.eously a.d effortlessly lea. to such sta.es a. certa.n built fea.ures na.ura.ly resona.e with our sensorimotor *** suggest tha. becoming sensible of the resona.ce a.d a.tunement process between interna. a.d externa. sta.es is wha. crea.es a. occa.ion for a. externa.lyinduced contempla.ive ***,we review neuroscientific studies of a.chitecture,ela.ora.e on the bra.n regions involved in such a.sthetic contempla.ive responses,provide a.chitectura. exa.ples,a.d point a. the contributions tha. this new a.ea.of inquiry ma. ha.e in fields such a. the evidence-ba.ed design movement in a.chitecture.

关键词： Neuropheno menology Neuroa.sthetics Contempla.ive sta.es a.chitectura. experience Well-being

Prognosis va.ue of hea.-shock proteins in esopha.ea. a.d esopha.oga.tric ca.cer:a.systema.ic review a.d meta.a.a.ysis

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World Journa. of Ga.trointestina. Oncology 2024年第4期16卷 1578-1595页

作者： Eric Toshiyuki nakamura a.a.da.Pa.k Ma.ina.a.essa.dra.Pereira.Da.iel Kika.a.Fra.cisco Tustumi Depa.tment of Ga.troenterology Instituto do CâncerHospital das Clínicas da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Depa.tment of Scientific Initia.ion Universidade Mogi das CruzesSão Paulo 08780911Brazil Depa.tment of Evidence-Ba.ed Medicine Centro Universitário LusíadaCentre for Evidence-Based MedicineCentro Universitário Lusíada(UNILUS)SantosBrazil Depa.tment of Surgery Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil

Ba.KGROUND Hea. shock proteins(HSPs)a.e molecula. cha.erones tha. pla. a. importa.t role in cellula. protection a.a.nst stress events a.d ha.e been reported to be overex-pressed in ma.y *** prognostic significa.ce of HSPs a.d their regula.ory fa.tors,such a. hea. shock fa.tor 1(HSF1)a.d CHIP,a.e poorly *** To investiga.e the rela.ionship between HSP expression a.d prognosis in esopha.ea. a.d esopha.oga.tric *** a.systema.ic review wa. conducted in a.corda.ce with PRISMa.recommend-a.ions(PROSPERO:CRD42022370653),on Emba.e,PubMed,Cochra.e,a.d ***,ca.e-control,a.d cross-sectiona. studies of pa.ients with eso-pha.us or esopha.oga.tric ca.cer were ***-positive pa.ients were compa.ed with HSP-nega.ive,a.d the endpoints a.a.yzed were lymph node meta.ta.is,tumor depth,dista.t meta.ta.is,a.d overa.l surviva.(OS).HSPs were stra.ified a.cording to the HSP fa.ily,a.d the summa.y risk difference(RD)wa. ca.cula.ed using a.ra.dom-effect *** The fina. selection comprised 27 studies,including esopha.ea. squa.ous cell ca.cinoma.21),esopha.oga.tric a.enoca.cinoma.5),a.d mixed neopla.ms(1).The pooled sa.ple size wa. 3465 ***40 a.d 60 were a.socia.ed with a.higher 3-yea. OS[HSP40:RD=0.22;95%confidence interva.(CI):0.09-0.35;HSP60:RD=0.33;95%CI:0.17-0.50],while HSF1 wa. a.socia.ed with a.poor 3-yea. OS(RD=-0.22;95%CI:-0.32 to-0.12).The other HSP fa.ilies were not a.socia.ed with long-term ***1 wa. a.socia.ed with a.higher proba.ility of lymph node meta.ta.is(RD=-0.16;95%CI:-0.29 to-0.04).HSP40 wa. a.socia.ed with a.lower proba.ility of lymph node dissemina.ion(RD=0.18;95%CI:0.03-0.33).The expression of other HSP fa.ilies wa. not significa.tly rela.ed to tumor depth a.d lymph node or dista.t *** The expression levels of certa.n fa.ilies of HSP,such a. HSP40 a.d 60 a.d HSF1,a.e a.socia.ed with long-term surviva. a.d lymph node dissemina.ion in pa.ients with esopha.ea. a.d esopha.oga.tric ca.cer.

关键词： Hea.-shock proteins Hea.-shock response Prognosis Esopha.ea. neopla.ms Meta.a.a.ysis

a.Survey of Digita. Content Required for STD Prevention Educa.ion Ta.ght by School Nurses

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Hea.th 2024年第4期16卷 350-370页

作者： Tomoko nakamura Fa.ulty of Nursing Hyogo University Kakogawa Japan

Purpose: In recent yea.s, there ha. been concern in Ja.a. a.out the increa.e in STDs a.ong a.olescents a.ed 15 - 19. In order to prevent STDs a.d guide a.olescents towa.d desira.le sexua. beha.ior, this study’s goa. wa. to exa.ine the a.tua. sta.e of STD prevention educa.ion ta.ght by school nurses a. pa.t of the school curriculum, a. well a. the kinds of digita. content they wish to ha.e for tea.hing on the subject. Method: a. a.onymous, self-a.ministered questionna.re wa. distributed by ema.l a.d lea.let. Ta.geting the 100 va.id responses received from the surveyed school nurses, descriptive sta.istics were ma.e for ea.h survey item a.d compa.isons were ma.e between the ea.ly- a.d mid-ca.eer groups ba.ed on yea.s of experience. Results: 70.0% of respondents reported tea.hing a.out STDs in Hea.th & Physica. Educa.ion cla.ses. School nurses in the ea.ly-ca.eer group used rea.y-ma.e ma.eria.s, while the mid-ca.eer group used both rea.y-ma.e a.d self-ma.e ma.eria.s. 95% of respondents reported tha. they ha. little or no knowledge of STDs, while 84% reported tha. they were “good” or “fa.rly good” a. tea.hing cla.ses on sexua.ity. Both groups reported difficulty with the topics of “phimosis” a.d “nocturna. emissions” in the physiologica. ca.egory, “sexua. beha.ior” in the “sex-a.ja.ent” ca.egory, a.d “sexua. a.d reproductive issues” in the psychosocia. ca.egory. Respondents expressed a.need for digita. content covering the topics of “sexua. violence”, “sexua. a.use”, “sexua.ly tra.smitted disea.es”, a.d “how to turn down sex”. The mid-ca.eer group desired digita. content for more items tha. the ea.ly-ca.eer group, with significa.t differences in the pa.hogens involved in sexua.ly tra.smitted disea.es a.d sex-a.ja.ent items. 32.0% of respondents a.swered tha. they ha. done self-study for sex educa.ion cla.ses in the pa.t three yea.s, a.d both groups desired self-study on “sexua.ly tra.smitted disea.es”, with the mid-ca.eer group significa.tly higher tha. the ea.ly-ca.eer

关键词： High School Students Sexua.ly Tra.smitted Disea.es Digita. Content School Nurses

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动态化学放大内镜在胃肿瘤诊断中的应用研究

世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 30-31页

作者： Ya.i K a.uga.Y nakamura a. 尹勇 Depa.tment of Interna. Medicine Niigata-Prefectural Yoshida Hospital Yoshida-machi Niigata-ken 959-0242 JapanDr.

Ba.kground: We a.sessed the usefulness of a.etic a.id-enha.ced ma.nifying endoscopy in the dia.nosis of ga.tric neopla.ia. Methods: Forty-five pa.ients (27 men, 18 women; media. a.e 61.6 yea.s)with ga.tric ca.cinoma.or a.enoma.ere enrolled in a.prospective tria. of enha.ced ma.nifying endoscopy a.ter instilla.ion of 1.5%a.etic a.id. a.etic a.id-enha.ced ma.nified views of ca.cinoma.or a.enoma.a.d the surrounding non-neopla.tic mucosa.were observed, a.d the dura.ion of whitening time of ea.h lesion wa. recorded. Observa.ions: Ma.nified views of ca.cinoma.showed a.minute, gra.n-like pa.tern tha. differed from the surrounding nonca.cerous mucosa. The histopa.hologic dia.nostic criteria.were ba.ed on the Vienna.cla.sifica.ion of GI epithelia. neopla.ia. The mea. dura.ion of whitening differed with ea.h histologic type: low-gra.e a.enoma.94 seconds; high-gra.e a.enoma.24.3 seconds; noninva.ive ca.cinoma. 20.1 seconds; inva.ive intra.ucosa. ca.cinoma. 3.5 seconds; a.d submucosa. ca.cinoma.or beyond, 2.5 seconds. The dura.tion in the non-neopla.tic surrounding mucosa.wa. 90 seconds. a.ter the disa.pe a.a.ce of whitening in the ca.cinoma. the irregula. pa.tern of the ca.cinoma.rea.ppea.ed, a.d the contra.t between ca.cinoma.ous microvessels a.d the whitened no n-neopla.tic tissue beca.e very clea. on ma.nifying endoscopy. In a.corda.ce wi th the dura.ion of whitening, more tha. 1 minute wa. termed “continuous whiteni ng," from 31 to 60 seconds wa. “dela.ed disa.pea.a.ce of whitening," from 30 to 6 seconds wa. “ea.ly disa.pea.a.ce of whitening," a.d 0 to 5 seconds wa. “no response." Conclusions: a.etic a.idenha.ced ma.nifying endoscopy wa. useful for the dia.nosis of ga.tric a.enoca. cinoma. The dura.ion of whitening differed a.ong gra.es of neopla.ia. a.d it wa. possible to observe cha.ges in the whitening with time. a.etic a.id-enha.ced ma.nifying endoscopy, therefore, ca. be termed “dyna.ic chemica. ma.nifying endo scopy."

关键词：胃肿瘤胃腺瘤放大内镜检查非浸润性癌应用研究浸润深度周围黏膜胃腺癌持续时间黏膜内癌

Impa.ts of multiple dema.d-side ma.a.ement stra.egies on microgrids pla.ning: a.litera.ure survey

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CLEa. ENERGY 2024年第1期8卷 36-54页

作者： Ela.a., Ra.ha.a.delna.y, a.med T. a.i, a. a. Helwa. Univ Fac Engn Elect Power & Machines Dept Cairo Egypt

Dema.d-side ma.a.ement (DSM) schemes pla. a.crucia. role in ma.a.ing renewa.le energy genera.ion a.d loa. fluctua.ions by utilizing dema.d-response progra.mes (DRPs). This pa.er a.ms to provide a.deta.led overview of DRPs tha. help microgrid opera.ors to keep costs a.d relia.ility within a.cepta.le ra.ges. a.ditiona.ly, this review pa.er provides a.deta.led economic loa. model for DRPs ba.ed on initia. loa., dema.d-response (DR) incentive, DR pena.ty a.d ela.ticity coefficients. This a.ticle a.so a.ms to guide resea.chers in identifying resea.ch ga.s in DSM a.plica.ions in microgrids by compa.ing va.ious DSM schemes from different countries a.d regions in terms of DSM stra.egies, objective functions a.d optimiza.ion techniques. Furthermore, this study a.a.yses the impa.t of DRPs on microgrid configura.ion from the perspective of utilities a.d customers, considering technica. a.d economic performa.ce metrics. a. a.result, it ca. be concluded tha. none of the studied ca.es provides models or guidelines for choosing a.propria.e DSM schemes tha. consider different consumer interests or loa.-type fea.ures. Furthermore, a.few resea.chers ha.e a.dressed the fea.ures of a.modern price-ba.ed DR stra.egy, renewa.le genera.ion-ba.ed dyna.ic pricing DR, which offers higher customer sa.isfa.tion tha. tra.itiona. DRPs. [GRa.HICS] .

关键词： dema.d-side ma.a.ement optima. sizing dema.d-response stra.egies renewa.le genera.ion-ba.ed dyna.ic pricing TIME-OF-USE ENERGY Ma.a.EMENT RENEWa.LE ENERGY RESPONSE PROGRa. RELIa.ILITY Pa.TICIPa.ION TECHNOLOGY CHa.LENGES OPERa.ION SYSTEMS