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克罗恩病中骨桥蛋白η-1的上调对t.1免疫反应调节

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 37-38页

作者： Sat. t. nakai t. t.mura N. t. Hibi 郑世成 Division of Gast.oent.rology Department of Internal Medicine Keio University School or Medicine 35 Shinanomachi Shinjukuku Tokyo 160- 8582 Japan Dr.

Background and aims: t.e pat.ogenesis of Crohn’ s disease (CD), a chronic inflammat.ry bowel disease charact.rised by a t.1 immune response, remains unclear. Ost.opont.n (OPN) is a phosphoprot.in known as an adhesive bone mat.ix prot.in. Recent.st.dies have shown t.at.OPN playsan import.nt.role in lymphocyt. migrat.on, granuloma format.on, and int.rleukin 12 (IL- 12) product.on. t.e present.st.dy invest.gat.d expression and t.e pat.ophysiological role of OPN in CD. Met.ods: Plasma OPN concent.at.on was measured by enzyme linked immunosorbent.assay. Expression of OPN in human int.st.nal mucosa was det.rmined using reverse t.anscript.on- polymerase chain react.on and west.rn blot. and localisat.on of OPN was examined by immunohist.chemist.y. Expression of int.grin β 3, an OPN recept.r, on lamina propria mononuclear cells (LPMC)was assessed by flow cyt.met.y. Funct.onal act.vat.on of OPN in LPMC was invest.gat.d by measuring t.e product.on of cyt.kines. Result.: Plasma OPN concent.at.on was significant.y higher in pat.ent. wit. CD compared wit. normal cont.ols or pat.ent. wit. ulcerat.ve colit.s (UC). OPN was upregulat.d in int.st.nal mucosa from UC and CD pat.ent.. OPN producing cells were epit.elial or IgG producing plasma cells, or part.al macrophages. OPN was det.ct.d in areas surrounding granuloma from mucosa in CD. Int.grin β 3 expressing macrophages infilt.at.d inflamed mucosa in UC and CD; in cont.ast. t.ere was no expression of int.grin β 3 on int.st.nal macrophages in normal mucosa. OPN induced product.on of IL- 12 from LPMC in CD but.not.in normal cont.ols or UC. Conclusions: Increased OPN expression facilit.t.s cyt.kine product.on and is closely involved in t.e t.1 immune response associat.d wit. CD.

关键词：克罗恩病 t.1 免疫反应骨桥蛋白肠黏膜炎症性肠病骨基质蛋白黏膜固有层溃疡性结肠炎巨噬细胞

In Vit.o Infect.ous Risk Assessment.of Heliot.is virescens ascovirus 3j(HvAV-3j) t.ward Non-t.rget.Vert.brat. Cells

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Virologica Sinica 2019年第4期34卷 423-433页

作者： Huan Yu Yi-Yi Ou-Yang Ni Li Madoka nakai Guo-Hua Huang Hunan Provincial Key Laborat.ry for Biology and Cont.ol of Plant.Diseases and Insect.Pest. Hunan Agricultural UniversityChangsha 41012& China College of Plant.Prot.ct.on Hunan Agricultural UniversityChangsha 41012& China t.kyo Universit. of Agricult.re and t.chnology SaiwaiFuchuTokyo 183-8509Japan

As specific pat.ogens of noct.id pest.,including Spodopt.ra exigua,***,Helicoverpa armigera,and Myt.imna separat.,ascoviruses are suit.ble for t.e development.of *** t.is st.dy,t.e infect.vit. of Heliot.is virescens ascovirus 3j(HvAV-3j)on insect.and mammalian cells was ***-3j infect.on induced drast.c morphological changes in Sf9,HzAMl,SeFB,and HaFB cells,including swelling and det.chmen Not.bly,t.e lat.er phenomena did not.occur in HvAV-3j-inoculat.d mammalian cells(HEK293,7402,HePG2,PK15,St.and t.3).Mt. assays indicat.d t.at.HvAV-3j inhibit.d t.e growt. of host.insect.cells from t.e 6t. hpi,but.no effect. were det.ct.d in t.e HvAV-3j-inoculat.d mammalian ***,viral DNA replicat.on,gene t.anscript.on,and prot.in expression were invest.gat.d,and t.e result. consist.nt.y suggest.d t.at.HvAV-3j viruses were not.able t. replicat. t.eir genomic DNA,t.anscribe,or express t.eir prot.ins in t.e non-t.rget.vert.brat. *** HvAV-3j genes were only t.anscribed and expressed in t.e four insect.cell *** result. indicat.d t.at.HvAV-3j was infect.ous t. cells derived from ***,***,***,and *** but.not.t. cells derived from human,pig,and mouse,suggest.ng t.at.ascoviruses are safe t. nont.rget.vert.brat. cells.

关键词： Infect.ous risk Heliot.is virescens ascovirus 3j(HvAV-3j) Mammalian cells Insect cells

Present.St.t.s and Fut.re Prospect. of Laser Fusion Research at.ILE Osaka Universit.

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Plasma Science and t.chnology 2004年第1期6卷 2179-2184页

作者： K.Mima K.A.t.naka R.Kodama t.Johzaki H.Nagat.mo H.Shiraga Y.Sent.ku N.Miyanaga H.Azechi M.nakai t.Norimat. K.Nagai J.Sunahara K.Nishihara t.t.guchi H.Sakagami Inst.t.t. of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanInstitute of Laser Engineering Osaka University 2-6 Yamada-oka Suita Osaka 565-0871 JapanSetunan University Neyagawa Osaka JapanHimeji Institute of technology Himeji Hyougo Japan

Reviewed are t.e present.st.t.s and fut.re prospect. of t.e laser fusionresearch at.t.e ILE Osaka. t.e Gekko XII and Pet. Wat. laser syst.m have been operat.d forinvest.gat.ng t.e implosion hydrodynamics, fast.ignit.on, and t.e relat.vist.c laser plasmaint.ract.ons and so on. In part.cular, t.e fast.ignit.on experiment. wit. cone shell t.rget.havebeen in progress as t.e UK and US-Japan collaborat.on programs. In t.e experiment., t.e implodedhigh densit. plasmas are heat.d by irradiat.ng 500 J level pet.-wat. laser pulse. t.e t.ermalneut.on yield is found t. increase by t.ree orders of magnit.de by inject.ng t.e pet.-wat. laserint. t.e cone shell t.rget. t.e Rayleigh-t.ylor inst.bilit. experiment.result. are also reviewed ist.is paper.

关键词： laser fusion present.st.t.s fut.re prospect.

Opt.cal Beam Cont.olin Gekko Ⅻ Glass Laser

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光电子·激光 1989年第2期 76-77页

作者： M.NAKAt.UKA t.JIt.UNO t.KANABE Y.KAt. K.MIMA K.NISHIHARA t.SASAKI H.t.KABE t.YAMANAKA K.YOSHIDA S.nakai Inst.t.t. of Laser engineering Osaka Universit. Suit.

Aft.r const.uct.ons of 10 t. 100 KJ glass laser drivers in t.e world for t.e inert.al confinement.fusion, t.e rapid ext.nsion of t.e experiment.l researches of t.e high densit. compression up t. 100 t.mes solid densit., t.e efficient.coupling of about.5% bet.een t.e laser energy t. compressed fuel energy have been obt.ined 1). t.e key issues of recent.development. 2). of t.e promissing implosion relevant.o t.e energy driver are as follows;

关键词： Glass Laser Opt.cal Beam Cont.olin Gekko

MAGNEt.C BEHAVIORS OF AMORPHOUS Gd2t.(t.Co,Ni and Cu)

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MAGNETIC BEHAVIORS OF AMORPHOUS Gd2T (T=Co,Ni and Cu)

Re-Os and Lu-Hf isot.pe evidence for crust.l mat.rials in t.e source of t.e Ont.ng Java Plat.au?

t.e 2nd Int.rnat.onal Symposium on Physics of Magnet.c Mat.rials

作者： Ikuo nakai Depart.ent.of Physics Faculty of General EducationTottori UniversityTottori 680JAPAN

We report.st.dies of precise magnet.zat.on measurement. on amorphous Gdt.t.Co,Ni and Cu) alloys bet.een 4.2 K and 300 K under a magnet.c field of 5.0 t.A form for t.mperat.re changes in magnet.zat.on is proposed from t.e viewpoint.of fluct.at.ons of t.e local magnet.c *** magnet.zat.on of t.e amorphous GdNi and GdCu ferromagnet. obeys t.e simple spin wave t.*** t.e amorphous QdCo alloy,on t.e ot.er hand,we have found t.e St.ner-t.pe t.cont.ibut.on t. t.e magnet.zat.on as well as t.e spin wave t.t.rm.

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Re-Os and Lu-Hf isotope evidence for crustal materials in th...

LSHELLELECt.ONPOPULAt.ONSOF95MeVArIONSINPASSINGt.ROUGHt.ICKSOLIDt.RGEt.

Int.rnat.onal Conference on Cont.nent.l Volcanism

作者： M.L. G. t.jada K.Suzuki t. Hanyu J. Mahoney Y.t.t.umi S. nakai IFREE JAMSTECJapanNIGSUniv. of the Philippines. Philippines IFREE JAMSTECJapan IFREE JAMSTECJapan SOESt Univ. of HawaiiUSA IFREE. JAMSt.C Japan ERI Univ. of TokyoJapan

＜正＞Re-Os and Lu-Hf analyses of samples from t.e 4-km-t.ick sect.on of -120 Ma sout.ern Ont.ng Java Plat.au （OJP） crust.in Cent.al Malait., Solomon Islands, show t.at.t.e Singgalo and underlying Kwaimbait. Fm. lavas, charact.rized by dist.nct.Pb-Nd-Sr isot.pic composit.ons （t.jada et.al., 2002） also exhibit.cont.ast.ng Os and Hf isot.pic values. For samples wit. （?） 10 ppt.Os, Singgalo Fm. lavas have markedly higher age-correct.d I87Os/I88Os （0.1808 - 0.6030） t.an t.e Kwaimbait. Fm. lavas (0.1216 - 0.1654, except.for one

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Journal of Shanghai Jiaot.ng universit.(Science) 1996年第1期1卷 56-59页

作者： Ya-Ming Zou Y. Awaya t. Kambara Y. Kanai M. Oura Y. nakai K. Ando

ＬＳＨＥＬＬＥＬＥＣＴＲＯＮＰＯＰＵＬＡＴＩＯＮＳＯＦ９５ＭｅＶＡｒＩＯＮＳＩＮＰＡＳＳＩＮＧＴＨＲＯＵＧＨＴＨＩＣＫＳＯＬＩＤＴＡＲＧＥＴＳＺｏｕＹａｍｉｎｇ（ＡｐｐｌｉｅｄＰｈｙｓｉｃｓＤｅｐａｒｔｍｅｎｔ，Ｓｈ... 详细信息

ＬＳＨＥＬＬＥＬＥＣＴＲＯＮＰＯＰＵＬＡＴＩＯＮＳＯＦ９５ＭｅＶＡｒＩＯＮＳＩＮＰＡＳＳＩＮＧＴＨＲＯＵＧＨＴＨＩＣＫＳＯＬＩＤＴＡＲＧＥＴＳＺｏｕＹａｍｉｎｇ（ＡｐｐｌｉｅｄＰｈｙｓｉｃｓＤｅｐａｒｔｍｅｎｔ，ＳｈａｎｇｈａｉＪｉａｏｔｏｎｇＵｎｉ...

关键词： shell elect.on Ar ions solid t.rget. fast heavy ions elect.on populat.ons

动态光散射和透射电镜法研究pH和NaCl对丝胶蛋白微观结构的影响

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光谱学与光谱分析 2010年第5期30卷 1391-1395页

作者：吴丽萍冷小京孙雁任发政 nakai Shuryo CAU＆ACC航天食品研究实验室北京市-教育部功能乳品重点实验室中国农业大学食品科学与营养工程学院北京100083 加拿大英属哥伦比亚大学食品、营养与健康系加拿大温哥华市V6T124

应用近红外光谱法、动态光散射法及透射电镜扫描法,研究了pH和NaCl浓度对丝胶蛋白聚集微观结构的影响。近红外光谱显示丝胶蛋白在酰氨Ⅰ带1700～1600cm-1附近有较强吸收峰。通过zet.电势法测定丝胶蛋白的表观等电点为pH3.7。应用动态光... 详细信息

应用近红外光谱法、动态光散射法及透射电镜扫描法,研究了pH和NaCl浓度对丝胶蛋白聚集微观结构的影响。近红外光谱显示丝胶蛋白在酰氨Ⅰ带1700～1600cm-1附近有较强吸收峰。通过zet.电势法测定丝胶蛋白的表观等电点为pH3.7。应用动态光散射法测定了在不同pH和NaCl浓度下丝胶蛋白颗粒的分散粒径,pH4及高NaCl浓度时,丝胶蛋白聚集颗粒粒径大且分散系数大;pH3或pH8及低NaCl浓度时丝胶蛋白聚集颗粒粒径和分散系数相对较小。采用透射扫描电镜观察丝胶蛋白在pH3或pH8条件下聚集形成松散的松针状微观结构,在pH4或者高NaCl浓度下会聚集形成相对紧密的微观结构。pH4时可以观察到丝胶蛋白的椭圆形单聚体大小约为(60±6)nm(n=10)。并探讨了静电斥力、氢键和范德华吸引力对丝胶蛋白微观结构形成的影响,为丝胶蛋白作为生物材料的应用提供了理论依据。

关键词：丝胶聚集微观结构动态光散射透射电镜红外光谱氢键范德华力

马自达汽车公司的新型4缸Skyact.v-D柴油机

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汽车与新动力 2012年第3期 6-10页

作者： t.razawa Y nakai E Kat.oka M Sakono t.张慰

马自达汽车公司推出了新一代Skyact.v-D柴油机。通过优化燃烧室形状、采用两级涡轮增压和减小机械摩擦,使该发动机的效率得以提高。Skyact.v-D柴油机的特点是压缩比为14.0,在不采用氮氧化物催化器或低压废气再循环的情况下仍能达到欧6... 详细信息

马自达汽车公司推出了新一代Skyact.v-D柴油机。通过优化燃烧室形状、采用两级涡轮增压和减小机械摩擦,使该发动机的效率得以提高。Skyact.v-D柴油机的特点是压缩比为14.0,在不采用氮氧化物催化器或低压废气再循环的情况下仍能达到欧6排放标准,此外,它的燃油经济性比现有发动机提高了15%;0%。作为Skyact.v技术的一部分,该发动机具有优异的驾驶性能、良好的环保性和安全性。

关键词：柴油机燃烧室形状压缩比燃油经济性