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A study of aqueous humour proteins in patients of primary open angle glaucoma

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Advances in Bioscience and Biotechnology 2010年第2期1卷 110-114页

作者： Meena Zaidi Azra Jilani Padmawati Bhattacharya najmul islam Shahid Alam 不详

Aims: To investigate the changes in the protein composition of aqueous humour in primary open angle glaucoma patients and non-glaucomatous subjects. Patients and Methods: Case control study was conducted at a university hospital to compare the protein profile of aqueous humour obtained from patients of primary open angle glaucoma with those of non glaucomatous subjects. Protein concentration of the aqueous humour samples collected from both glaucomatous and non-glaucomatous patients at the time of surgery was estimated by the Bradford protein assay method. Sodium dodecylsulfate polyacrylamide gel electrophoresis of the samples was also performed. Results: Geometric mean of protein concentration of the samples was 55.73 mg/dl (range: 31-72) in the test group and 46.46 mg/dl (range: 27-65) in the control group and a statistically significant (p ≤= 0.001) difference in protein concentration of aqueous humour between the two groups was observed. Electrophoretic study revealed differences in the aqueous protein composition of the two groups. The glaucomatous group exhibited protein bands of 10 kDa, 20 kDa, 30 kDa, 50 kDa, 60 kDa, 70 kDa, and 90 kDa while the control subjects demonstrated bands of 6 kDa, 10 kDa, 30 kDa, 70 kDa, 90 kDa. Interestingly, almost all the proteins detected in this study corresponded to the molecular weights of heat shock proteins. Conclusions: Primary open angle glaucoma patients differed in protein compositions and had higher concentration of aqueous humour proteins than non glaucomatous patients.

关键词： Aqueous Humour Open Angle Glaucoma Proteins

An Enhanced Hybrid Model Based on CNN and BiLSTM for Identifying Individuals via Handwriting Analysis

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1689-1710页

作者： Md.Abdur Rahim Fahmid Al Farid Abu Saleh Musa Miah Arpa Kar Puza Md.Nur Alam Md.najmul Hossain Sarina Mansor Hezerul Abdul Karim Department of Computer Science and Engineering Pabna University of Science and TechnologyPabna6600Bangladesh Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia Department of Computer Science and Engineering Bangladesh Army University of Science and TechnologySaidpur5311Bangladesh Department of Mathematics Pabna University of Science and TechnologyPabna6600Bangladesh Department of Electrical Electronic and Communication EngineeringPabnaUniversity of Science and TechnologyPabna6600Bangladesh Department of Electrical and Communication Engineering Pabna University of Science and TechnologyPabna6600Bangladesh

Handwriting is a unique and significant human feature that distinguishes them from one *** are many researchers have endeavored to develop writing recognition systems utilizing specific signatures or symbols for person identification through ***,such systems are susceptible to forgery,posing security *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** innovative method is intricately designed,encompassing five distinct phases:data collection,preprocessing,feature extraction,significant feature selection,and *** key advancement lies in the creation of a novel dataset specifically tailored for Bengali handwriting(BHW),setting the foundation for our comprehensive ***-preprocessing,we embarked on an exhaustive feature extraction process,encompassing integration with kinematic,statistical,spatial,and composite *** meticulous amalgamation resulted in a robust set of 91 *** enhance the efficiency of our system,we employed an analysis of variance(ANOVA)F test and mutual information scores approach,meticulously selecting the most pertinent *** the identification phase,we harnessed the power of cutting-edge deep learning models,notably the Convolutional Neural Network(CNN)and Bidirectional Long Short-Term Memory(BiLSTM).These models underwent rigorous training and testing to accurately discern individuals based on their handwriting ***,our methodology introduces a groundbreaking hybrid model that synergizes CNN and BiLSTM,capitalizing on fine motor features for enhanced individual ***,our experimental results unde

关键词： Bengali handwriting(BHW) person identification convolutional neural network(CNN) BiLSTM

Pharmacological insights into Chukrasia velutina bark:Experimental and computer-aided approaches

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Animal Models and Experimental Medicine 2022年第4期5卷 377-388页

作者： Israt Jahan Shahenur Alam Sakib najmul Alam Mohuya Majumder Sanjida Sharmin A.S.M.Ali Reza Department of Pharmacy International Islamic University ChittagongChittagongBangladesh Department of Pharmacy East West UniversityDhakaBangladesh

Background:Chukrasia velutina is an enthnomedicinally used plant reported to have significant medicinal *** present study aimed to explore the pharmacological activities of bark methanol extract using in vitro,in vivo and in silico ***:The study was designed to investigate the pharmacological effects of methanol extract of Chukrasia velutina bark(MECVB)through in vitro,in vivo and in silico *** activity was tested using formalin-i nduced nociception and acetic acid-i nduced writhing assays while the antipyretic effect was tested using yeast-i nduced hyperthermia in mice *** antioxidant effect was tested using the DPPH and reducing power assay and the cytotoxic screening was tested using the brine shrimp lethality *** addition,in silico studies were conducted using computer aided ***:In the acetic acid-i nduced writhing assay,the extract showed 28.36%and 56.16%inhibition of writhing for doses of 200 and 400 mg/kg,***,a dose-dependent formalin-i nduced licking response was observed in both early and late *** yeast-i nduced pyrexia,the MECVB exhibited(p<0.05)antipyretic *** extract demonstrated an ICvalue of 78.86μg/ml compared with ascorbic acid(IC23.53μg/ml)in the DPPH scavenging *** compounds sitosterol,5,7-dimethoxycoumarin and scopoletin were seen be effective in molecular docking scores against COX-I(2OYE),COX-II(6COX)and human peroxiredoxin 5(1HD2).In ADME/T analysis,5,7-dimethoxycoumarin and scopoletin satisfied Lipinski’s rule of five and thus are potential drug ***:The bark of Chukrasia velutina showed significant analgesic and antipyretic properties and is a potential source of natural anti-oxidative agents.

关键词： anti-nociceptive antioxidant antipyretic Chukrasia velutina cytotoxicity

Paediatric conj oint bicondylar Hoffa fracture with patellar tend on injury: An unusual pattern of injury

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Chinese Journal of Traumatology 2019年第4期22卷 246-248页

作者： Julfiqar najmul Huda Ajay Pant Department of Orthopaedic Surgery Faculty of Medicine J.N.Medical College AMU Aligarh UP India Teerthanker Mahaveer Medical College and Research Centre TMU Moradabad UP India

Epiphyseal injuries of distal femur are rare with an incidence of 1%—6% among all physeal injuries. Prompt diagnosis and appropriate surgical treatment is crucial to achieve satisfactory functional outcomes. A conjoint bicondylar coronal split (Hoffa) fracture with complete transaction of ipsilateral patellar tendon has been reported in a 12 year old child. The injury was managed by open reduction and internal fixation and bone to ten don repair. This case emphasizes the need of accurate intraepiphyseal fixation for the management of these fractures in skeletally immature patients.

关键词： Children Bicondylar Hoffa fracture Patellar tendon injury

Interaction of point defects with twin boundaries in Au: A molecular dynamics study

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Chinese Physics B 2013年第9期22卷 496-504页

作者： Fayyaz Hussain Sardar Sikandar Hayat Zulfiqar Ali Shah najmul Hassan Shaikh Aftab Ahmad Department of Physics The Islamia University of Bahawalpur Department of Physics Hazara University

The molecular dynamics simulation technique with many-body and semi-empirical potentials （based on the embedded atom method potentials） has been used to calculate the interactions of point defects with （1 1 1）, （1 1 3）, and （1 2 0） twin boundaries in Au at different temperatures. The interactions of single-, di-, and tri-vacancies （at on- and off-mirror sites） with the twin interfaces at 300 K are calculated. All vacancy clusters are favorable at the on-mirror arrangement near the （1 1 3） twin boundary. Single- and di-vacancies are more favorable at the on-mirror sites near the （1 1 l） twin boundary, while they are favorable at the oft-mirror sites near the （1 2 0） twin boundary. Almost all vacancy clusters energetically prefer to lie in planes closest to the interface rather than away from it, except for tri-vacancies near the （1 2 0） interface at the off-mirror site and for 3.3 and 3.4 vacancy clusters at both sites near the （1 1 1） interface, which are favorable away from the interface. The interaction energy is high at high temperatures.

关键词： molecular dynamics twin boundaries vacancy clusters gold

Quantitative analysis of cefixime via complexation with palladium(Ⅱ) in pharmaceutical formulations by spectrophotometry

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Journal of Pharmaceutical Analysis 2013年第4期3卷 248-256页

作者： Syed najmul Hejaz Azmi Bashir Iqbal Nada Said Hassan Al-Humaimi Iman Rashid Saif Al-Salmani Noora Ali Saad Al-Ghafri Nafisur Rahman Department of Applied Sciences Chemistry SectionHigher College of Technology Department of Chemistry Aligarh Muslim University

An optimized and validated spectrophotometric method has been developed for the determination of cefixime in pharmaceutical formulations. The method is based on the complexa- tion reaction between cefixime and palladium ion in the presence of acidic buffer solution （pH 3） in ethanol-distilled water medium at room temperature. The complex absorbed maximally at 352 nm. Beer＇s law is obeyed in the working concentration range of 2.5-35 μg/mL with apparent molar absorptivity of 1.015×104 L/mol cm and Sandell＇s sensitivity of 0.001 μg/cm2/0.001 absorbance unit. The limits of detection and quantitation for the proposed method are 0.175 and 0.583μg/mL, respectively. The effect of common excipients used as additives has been studied in the determination of cefixime. The proposed method has been successfully applied for the determina- tion of cefixime in pharmaceutical formulations. The results obtained by the proposed method were statistically compared with the reference method using t and F values and found no significant difference between the two methods.

关键词： Spectrophotometry Cefixime Palladium ion Pd(II)-cefixime complex

A Comparative Study on the Fixed Bed Pyrolysis of Different Biomass Solid Wastes

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Journal of Energy and Power Engineering 2013年第7期7卷 1250-1256页

作者： Mohammad Nurul islam Mustafizur Rahman Sheikh Mohammad najmul Hoque Department of Mechanical Engineering Institute Technology Brunei Darussalam BE 1410 Brunei Department of Mechanical Engineering Rajshahi University of Engineering & Technology Rajshahi 6204 Bangladesh

Biomass in the form of nutshell, hay of catkin, wheat straw and linseed residue in particles have been pyrolyzed in laboratory scale fixed bed reactor which yielded liquid oil, solid char and gas. The variation of oil yield for different biomass feedstock with reactor bed temperature and feed size is presented in this paper. A maximum liquid yield of 55 wt% of dry feedstock is obtained at an optimum temperature of 500 °C for a feed size of 300-600 μm with a running time of 55 min for nutshell as the feedstock while the minimum liquid oil yield is found to be 30 wt% of feedstock at an optimum temperature of 400 °C for a feed size of 2.36 mm with a running time of 65 min for linseed residue as the feedstock. A comparison on the product yields is highlighted in this study. The pyrolysis liquid products are characterized and compared for some of the fuel properties like HHV (higher heating value), viscosity, density and specific gravity.

关键词：固定床反应器生物质热解固体废物生物质原料最佳生长温度液体产品运行时间实验室规模

Development of Cu Nanoparticle Loaded Oil Palm Fibre Reinforced Nanocomposite

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Advances in Nanoparticles 2013年第4期2卷 358-365页

作者： Ridzuan Ramli Maksudur Rahman Khan najmul Kabir Chowdhury Mohammad Dalour Hossen Beg Rohaya Mohamed Halim Astimar Abdul Aziz Zawawi Ibrahim Nahrul Hayawin Zainal Engineering and Processing Division Malaysian Palm Oil Board (MPOB) Kajang Selangor Malaysia Faculty of Chemical and Natural Resources Engineering University of Malaysia Pahang (UMP) Kuantan Malaysia

Functionalized copper nanoparticles (FCuNPs) have been synthesized by chemical reduction method and polyvinyl alcohol (PVA) performed as a stabilizer in that medium. Analysis observed that the average size of the synthesized FCuNPs was 3.5 nm. The obtained FCuNPs were loaded in the oil palm empty fruit bunch (EFB) natural fibre. Before the loading of FCuNPs in EFB fibres, the surface of the fibres is tailored by the cationic agent CHPTAC since they have a natural tendency to exhibit negatively charged surface owing to the presence of large amount of hydroxyl groups. Thereafter, different types of composite were developed and their properties were studied. The composites were developed by using the untreated empty fruit bunch (UEFB) fibres and FCuNPs loaded EFB (NP-CAEFB) fibres with commercially available unsaturated polyester resin (UPER). The synthesized composites were characterized through FTIR, FESEM, XRD, DSC, tensile strength tests, etc. The obtained biodegradation results indicated that significant weight loss was not observed for neat PER and PER/FNP-CAEFB nanocomposite, whereas, the UEFB/VUPER composite showed ca. 21.4% weight loss at 90 days, which was considered rationally due to the preferential degradation of the fibre.

关键词： Biodegradation Nano-Composite Nanoparticle Natural Fibre Polyester Resin