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Efficiency of combining pomegranate juice with low-doses of cisplatin and taxotere on A549 human lung adenocarcinoma cells

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Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 19-24页

作者： Nasser Mohamad Hijazi Akram Sayed Ahmad Bouchra Jamal Eddine Zeinab Ibrahim Sajida Rammal hassan Al Rekaby Abd-El-Ameer Nasser Mouhamad Doctoral School of Science and Technology Research Platform for Environmental Science (PRASE) Lebanese University Université Fédérale de Toulouse Midi-Pyrénées INP-ENSIACET Laboratoire de Chimie Agro-industrielle Al Mustansiriya University College of Science Department of Biology American University of Beirut

Objective: To test the coalescence effect of two chemotherapy drugs at low effective dose(cisplatin and taxotere) combined with pomegranate juice on A549 cancer cells. Methods: Infrared spectroscopy method is a qualitative test that was performed to ensure the existence of the phytochemicals providing the antioxidant activity through the presence of the hydroxyl group(-OH). The viability of A549 cell line and normal MCs was tested using the neutral red uptake, Clonogenic survival, XTT and Cell migration assays. Results: Our results showed that this combination firstly led to a greater decrease in the viability of cells comparing to those treated with chemotherapy drugs alone, and secondly led to a significant reduction in cell migration. Conclusions: These data suggest a synergistic effect between the pomegranate and cisplatin which makes probably this combination a powerful option for treating lung adenocarcinoma and in parallel minimizing the systemic side effects.

关键词： Lung cancer Chemotherapy Cisplatin Taxotere Pomegranate A549 cells

Chemical composition and antioxidant activity of a Lebanese plant Euphorbia macroclada schyzoceras

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 542-548页

作者： Hussein Farhan hassan Rammal Akram Hijazi Ahmad Daher Mohamad Reda Hussein Annan Ali Chokr Ali Bassal Bassam Badran Doctoral School of Science and Technology Research Platform for Environmental Science Lebanese UniversityLebanon Faculty of Agricultural and Veterinary Sciences Lebanese UniversityLebanon Faculty of Sciences-1- Lebanese UniversityLebanon

Objective:To determine the chemical composition,total phenolic and total flavonoid contents ofthe crude extracts from leaves and stems of a Lebanese plantEuphorbia macroclada schyzoceras(***),and to evaluate their antioxidant potential using DPPH,H2O2,and chelating offerrous ions ***:Quantification of the total phenolic and total flavonoid contents ofthe crude extracts from leaves and stems and the antioxidant activities were evaluated usingspectrophotometric *** chemical composition has been estimated using differenttechniques such as IR,LC/MS and ***:Ethanolic extract from leaves *** was better than aqueous extract and showed higher content in total phenolic and total flavonoidthan found in the *** the other hand,using DPPH and H2O2tests,this extract from leavesshowed higher antioxidant capacity than aqueous ***,using the chelating of ferrousions test,the antioxidant activity of the aqueous extract of both stems and leaves was strongerthan that of ethanolic *** chemical composition of the whole plant showed the presence ofsome aromatic compounds and fatty ***:Both ethanolic and water extracts fromboth parts of this plant are effective and have good antioxidant ***,this plant can be usedin the prevention of a number of diseases related to oxidative stress.

关键词： Euphorbia macroclada schyzoceras Total phenolic Total flavonoid Antioxidant potential Chemical composition

Sphingomyelin phosphodiesterase acid like 3B(SMPDL3b)regulates Perilipin5(PLIN5)expression and mediates lipid droplet formation

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Genes & Diseases 2022年第6期9卷 1397-1400页

作者： Shamroop Kumar Mallela Mengyuan Ge Judith Molina Javier Varona Santos Jin-Ju Kim Alla Mitrofanova hassan Al-Ali Brian Marples Sandra Merscher Alessia Fornoni Katz Family Division of Nephrology and Hypertension Department of MedicineUniversity of MiamiMiller School of MedicineMiamiFL 33136USA Peggy and Harold Katz Family Drug Discovery Center University of MiamiMiller School of MedicineMiamiFL 33136USA Department of Radiation Oncology University of RochesterRochesterNY 14627USA

Lipid droplets(LDs)are lipid storage organelles with a central hydrophobic core of neutral lipids that is enclosed in a monolayer of *** the storage of lipids,mainly cholesterol and triglycerides,was thought to be the primary function of LDs,studies have shown that they have important functions in maintaining lipid homeostasis and modulating various signaling *** lipid accumulation has been recognized as a key feature in several human diseases such as obesity,diabetes,cancer,neurological diseases,cardiovascular diseases,insulin resistance,liver diseases and kidney *** play an important role in innate immunity,in the fight against infections,and in the replication of *** a tight regulation of LD metabolism is essential for proper functioning of a cell.

关键词： metabolism immunity Lipid

Race and colorectal cancer screening compliance among persons with a family history of cancer

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World Journal of Gastrointestinal Endoscopy 2015年第18期7卷 1300-1305页

作者： Adeyinka O Laiyemo Nicole Thompson Carla D Williams Kolapo A Idowu Kathy Bull-Henry Zaki A Sherif Edward L Lee hassan Brim hassan Ashktorab Elizabeth A Platz Duane T Smoot Division of Gastro-enterology Department of Medicine Howard University College of Medicine Howard University Cancer Center Department of Medicine Georgetown Univer-sity Department of Biochemistry and Molecular Biology Howard University College of Medicine Department of Pathology Howard University Department of Epidemiology Johns Hopkins Bloomberg School of Public Health the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Department of Medicine Meharry Medical Center

AIM: To determine compliance to colorectal cancer(CRC) screening guidelines among persons with a family history of any type of cancer and investigate racial differences in screening ***: We used the 2007 Health Information National Trends Survey and identified 1094(27.4%)respondents(weighted population size = 21959672) without a family history of cancer and 3138(72.6%) respondents(weighted population size = 58201479) with a family history of cancer who were 50 years and older. We defined compliance with CRC screening as the use of fecal occult blood testing within 1 year, sigmoidoscopy within 5 years, or colonoscopy within 10 years. We compared compliance with CRC screening among those with and without a family member with a history of cancer. RESulTS: Overall, those with a family member with cancer were more likely to be compliant with CRC screening(64.9% vs 55.1%; OR = 1.45; 95%CI: 1.20-1.74). The absolute increase in screening rates associated with family history of cancer was 8.2% among whites. Hispanics had lowest screening rates among those without family history of cancer 41.9% but had highest absolute increase(14.7%) in CRC screening rate when they have a family member with cancer. Blacks had the lowest absolute increase in CRC screening(5.3%) when a family member has a known history of cancer. However, the noted increase in screening rates among blacks and Hispanics when they have a family member with cancer were not higher than whites without a family history of cancer:(54.5% vs 58.7%; OR = 1.16; 95%CI: 0.72-1.88) for blacks and(56.7% vs 58.7%; OR = 1.25; 95%CI: 0.72-2.18) for ***: While adults with a family history of any cancer were more likely to be compliant with CRC screening guidelines irrespective of race/ethnicity, blacks and Hispanics with a family history of cancer were less likely to be compliant than whites without a family history. Increased burden from CRC among blacks may be related to poor uptake of screening

关键词： Colon cancer Health disparities Screening Fecal bl

Effect of Plumeria alba＇s Bioactive Extract against Colletotrichum gleosporoides in Vitro and in Vivo

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Journal of Agricultural Science and Technology(B) 2014年第3期4卷 195-199页

作者： Maryana Mohamad Nor Husna Hawa Mohd. hassan Nik Hairiah Nik Mohamad Ravi Muhammad Nor Omar Department of Biotechnology International Islamic University Malaysia (IIUM) Kuantan 25200 Pahang Malaysia Department of Food Technology Polytechnic of Sultan Haji Ahmad Shah (POLISAS) Kuantan 25352 Pahang Malaysia

Plant species in the genus Plumeria of Apocynaceae family are well known for their uses in traditional medicine antimicrobial activity. Plant materials from P. alba were extracted using Soxhlet apparatus and screened for the control of anthracnose disease caused by Colletotrichum gleosporoides on fruit during post harvest storage. For in vitro, the crude extract of P. alba （stem bark and leaves） were completely inhibited conidial germination （sporulation test method） of Colletotrichum gleosporoides at all concentration tested except the lowest concentration （4.4 ul）. In vivo studies show that percentage of infection on fruit after treated with both stem bark （11.11 ± 3.8） and leaves （15.55 ± 3.8） part, at 32,000 mg/L have no significant differences during seven days of storage at ambient temperatures. These results proved that P. alba extracted （stem bark and leaves） were found to be promising as an antifungal agent and to control anthracnose disease in fruits tested.

关键词： P. alba Colletotrichum gleosporoides post harvest.

儿童青少年新诊断糖尿病酮症酸中毒临床、遗传学及随访分析

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蚌埠医学院学报 2023年第3期48卷 311-313,318页

作者：赵武马里奥孙琦杭航高科刘义蚌埠医学院第一附属医院儿科安徽蚌埠233004

目的:分析儿童青少年新诊断糖尿病酮症酸中毒(DKA)的临床表现、遗传学及随访结局。方法:回顾分析23例DKA患儿的临床和随访资料,自愿接受基因检查者给予二代测序。结果:男6例,女17例,中位年龄10.1岁。1型糖尿病(T1DM)22例,2型糖尿病(T2D... 详细信息

目的:分析儿童青少年新诊断糖尿病酮症酸中毒(DKA)的临床表现、遗传学及随访结局。方法:回顾分析23例DKA患儿的临床和随访资料,自愿接受基因检查者给予二代测序。结果:男6例,女17例,中位年龄10.1岁。1型糖尿病(T1DM)22例,2型糖尿病(T2DM)1例。烦渴多饮多尿22例,呼吸深长16例,腹痛恶心呕吐12例,发热5例,意识障碍12例,休克15例。中位随机血糖25.0 mmol/L(11.48~34.72 mmol/L),平均糖化血红蛋白13.62%(9.80%~17.40%),C肽降低22例,平均0.18 ng/mL(0.05~0.37 ng/mL),平均静脉pH 7.06(6.80~7.23),糖尿病自身抗体阳性10例。所有患儿给予补液、小剂量胰岛素持续静脉泵入治疗,1例转院,22例抢救成功。DKA纠正后T1DM患儿给予胰岛素治疗,T2DM患儿口服二甲双胍。随访18例,平均随访26.5月(5~57个月),1例T2DM患儿HbA1c 6.8%,17例T1DM患儿平均HbA1c 8.79%(5.5%~14.4%),中位C肽0.09 ng/mL(0.05~0.50 ng/mL),3例T1DM患儿糖尿病自身抗体转阳性。2例T1DM患儿接受二代测序,其中1例PDE11A外显子2存在c.20_21delGA杂合缺失变异,导致阅读框改变,蛋白质截短(***7ThrfsTer30),父亲为野生型,母亲为杂合携带。结论:儿童青少年新诊断DKA多见于T1DM,临床表现多样,HbA1c达标率低,PDE11A基因突变可能与T1DM有关。

关键词：糖尿病酮症酸中毒基因儿童青少年

Author Correction:Low temperature chemical sintering of inkjet-printed Zn nanoparticles for highly conductive flexible electronic components

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npj Flexible Electronics 2021年第1期5卷 276-276页

作者： Subimal Majee Mikael C.F.Karlsson Pawel Jerzy Wojcik Anurak Sawatdee Mohammad Yusuf Mulla Naveed ul hassan Alvi Peter Dyreklev Valerio Beni David Nilsson Published in partnership with Nanjing Tech University

The original version of this Article omitted from the author list the 3rd author Pawel Jerzy Wojcik from redoxme AB,Research&Development Department,Norrköping,Sweden(Affiliation#3)and 7th author Peter Dyreklev from RI... 详细信息

关键词： ping Nor Sweden

Beverage intake preference and bowel preparation laxative taste preference for colonoscopy

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第3期6卷 84-88页

作者： Adeyinka O Laiyemo Clinton Burnside Maryam A Laiyemo John Kwagyan Carla D Williams Kolapo A Idowu hassan Ashktorab Angesom Kibreab Victor F Scott Andrew K Sanderson Department of Medicine Howard University College of Medicine Howard University Cancer Center Department of Biological Sciences College of Arts and Sciences Howard University Georgetown-Howard Universities Center for Clinical and Translations Science

AIM: To examine whether non-alcoholic beverage intake preferences can guide polyethylene glycol(PEG)-based bowel laxative preparation selection for ***: We conducted eight public taste test sessions using commercially procured(A) unflavored PEG,(B) citrus flavored PEG and(C) PEG with ascorbate(Moviprep). We collected characteristics of volunteers including their beverage intake preferences. The volunteers tasted the laxatives in randomly assigned orders and ranked the laxatives as 1st, 2nd, and 3rd based on their taste preferences. Our primary outcome is the number of 1st place rankings for each preparation. RESulTS: A total of 777 volunteers completed the study. Unflavored PEG was ranked as 1st by 70(9.0%), flavored PEG by 534(68.7%) and PEG with ascorbate by173(22.3%) volunteers. Demographic, lifestyle characteristics and beverage intake patterns for coffee, tea, and carbonated drinks did not predict PEG-based laxative ***: Beverage intake pattern was not a useful guide for PEG-based laxative preference. It is important to develop more tolerable and affordable bowel preparation laxatives for colonoscopy. Also, patients should taste their PEG solution with and without flavoring before flavoring the entire gallon as this may give them more opportunity to pick a pattern that may be more tolerable.

关键词： Bowel preparation Laxatives Colonoscopy Taste tests Colon cancer Screening

High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence

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World Journal of Gastroenterology 2022年第35期28卷 5217-5229页

作者： Essa A Mohamed Nasra H Giama Abubaker O Abdalla hassan M Shaleh Abdul M Oseini Hamdi A Ali Fowsiyo Ahmed Wesam Taha Hager Ahmed Mohammed Jessica Cvinar Ibrahim A Waaeys Hawa Ali Loretta K Allotey Abdiwahab O Ali Safra A Mohamed William S Harmsen Eimad M Ahmmad Numra A Bajwa Mohamud D Afgarshe Abdirashid M Shire Joyce E Balls-Berry Lewis R Roberts Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55905United States Center for Clinical and Translational Science Mayo ClinicRochesterMN 55905United States School of Nursing University of MinnesotaMinneapolisMN 55455United States Division of Digestive Diseases Emory School of MedicineAtlantaGA 30322United States Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine NewYork-Presbyterian QueensFlushingNY 11355United States Department of Pediatrics University of Nevada Las VegasLas VegasNV 89154United States Department of Quantitative Health Sciences Mayo ClinicRochesterMN 55905United States Department of Medicine Gargar Urgent Care and ClinicMinneapolisMN 55406United States Office of the Director Shire ScientificMinneapolisMN 55405United States Department of Neurology Washington University School of Medicine in St LouisSt LouisMO 63130United States Knight Alzheimer Disease Research Center Washington University School of MedicineSt LouisMO 63130United States

BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and *** previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in *** To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening *** We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV *** Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV *** age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,*** participants developed incident HCC during follow *** Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States ***-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients.

关键词： Viral hepatitis Liver disease Community engagement African Immigrant health