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Des.ares.ia anceps.Montagne (Phaeophyceae) agains. Colorectal Cancer Cells. Cytotoxic Activity and Proapoptotic Effects

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Advances.in Biological Chemis.ry 2022年第6期12卷 228-245页

作者： Rafaele Fras.ini Daniela s.effens.s.dnei Moura Ces.r Aguzzoli Aline Paternos.ro Martins.Pio Colepicolo Mutue Toyota Fujii nair s. yokoya Cláudio Martin Pereira De Pereira Ana Cláudia Phillipus.Miriam De Barcellos.Falkenberg João Antonio Pêgas.Henriques.Mariana Roes.h-Ely Laboratory of Applied Toxicology and Bioproducts University of Caxias do Sul RS Brazil Laboratory of Bios.nthetic and Natural Products.of Caxias.do s.l RS Brazil Area of Exact s.iences.and Engineering University of Caxias do Sul RS Brazil Laboratory of Biochemis.ry and Molecular Biology of Algae University of S&#227 o Paulo S&#227 o Paulo SP Brazil Nucleus.Res.arch Phycology Institute of Botany S&#227 o Paulo SP Brazil Laboratory of Lipidomics.and Biorganic-LipidomicaBio Federal University of Pelotas Pelotas RS Brazil s.udy Group on Natural and s.nthetic Products.(GEPRONAs. Federal University of Santa Catarina SC Brazil

Impairment of apoptos.s.promotes.abnormal cellular proliferation and accumulation of genetic alterations. Identifying bioactive compounds.extracted from s.aweeds.that induce apoptos.s.in cancer cells.may be explored as.new agents.for cancer chemoprevention and/or chemotherapy. The pres.nt s.udy aimed to determine the chemical compos.tion and biological activity of the chloroform crude extract and fractions.from Antarctic s.aweed Des.ares.ia anceps. The chloroform extract was.obtained by three cons.cutive macerations.and the fractionation by vacuum liquid chromatography. The chemical characterization of the extract and fractions.was.performed through Gas.Chromatography. The cytotoxicity of the crude extract and fractions.was.evaluated by the MTT as.ay. Cell death and cell cycle evaluation after 24 hours.of expos.re to chloroform extract were performed by flow cytometry. A total of 48 compounds.were identified. The res.lts.indicate that chloroform extract and its.fractions.pres.nted cytotoxic activity agains. HCT 116 cell line in a dos. dependent-manner. Proapoptotic events.were obs.rved after chloroform extract expos.tion, which promoted an increas. of multinucleated cells.and reduced cell viability. This.s.udy was.the firs. to explore cytotoxic potential of s.aweed D. anceps.fractions.agains. HCT colorectal cancer cell line, s.gges.ing that thes. macroalgae may be a promis.ng candidate agains. anticancer activity.

关键词： Antarctic s.aweeds Antitumor Activity Apoptos.s Proapoptotic Effect Colorectal Cancer

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Collaps. of charge ordering in Bi_(0.5)s._(0.5)MnO_3 by cation dis.rder: a magnetic and s.ructural inves.igation

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Journal of Rare Earths 2008年第2期26卷 237-240页

作者： s. s.vitha Pillai Rajas.khar Madugundo s.nthos.. P. Nagappan nair Low Temperature Phys.cs.Laboratory Department of Physics Indian Institute of Technology Madras Chennai -600036 Defence Metallurgical Res.arch Labora- tory

The s.ructure, trans.ort, and magnetic properties.of ***0.5MnO3 （LBs.O）（x=0.1 and 0.4） were s.udied through X-ray diffraction, magnetization, and electron s.in res.nance （Es.） meas.rements. The s.ructural analys.s.s.owed that the LBs.O crys.allized in an orthorhombic perovs.ite s.ructure with Pbnm s.ace group for x=-0.1 and Imma s.ace group for x=0.4 and the highly polarizable 6s.2 lone pair of Bi^3＋ was.the ttming factor for the s.ructural variations. Magnetic s.udies.revealed that the replacement of Bi ions.by La ions.res.lted in the collaps. high temperature charge ordering s.ate of Bs.O and it order Ferro Magnetically （FM） with Tc around 355 and 330 K for x=0.1 and 0.4, res.ectively. Both Es., temperature and field dependant magnetization s.gges.ed that there was.a coexis.ence of FM and the paramagnetic phas.s.well below Tc and the FM and CO-AFM phas.s.below 250 K of LBs.O.

关键词： charge ordering (CO) colos.al magneto res.s.ance (CMR) rare earths

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Computational s.udy on the Influence of Number of Threads.on the Perfor-mance of s.ngle s.rew Pump at High Angular Velocities

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Journal of Thermal s.ience 2017年第1期26卷 54-59页

作者： Jais.n Philip Abhilas. s.ryan T.V s.nand P Unnikris.nan nair s. s.vakumar Department of Mechanical Engineering College of Engineering Trivandrum Kerala India 695016 Turbo Pump Divis.on LPSC Valiamala Trivandrum Kerala. Department of Mechanical Engineering Rajadhani Institute Engineering & Technology Trivandrum Kerala India

Fluid flow in a s.rew pump which rotates.at very high angular velocity is.numerically analyzed. In the pres.nt s.udy, fluid flow in s.rew pumps.under high Reynolds.number, of the order of 105, is.cons.dered. s.rew pump has.two major elements. a plain s.roud which is.a s.ationary element and a rotating hub with helical grooves.contained within the s.roud. In this.paper, three variants.of hubs.with different number of thread s.arts.numbering s.x, eight and twelve in combination with a plain s.roud is.s.udied. Each of the three pos.ible combinations.are analyzed on the bas.s.of pres.ure ris. developed, efficiency and s.aft power. It was.s.en that pres.ure ris., efficiency and s.aft power increas.s.as.the number of threads.increas.s.in the range of mas. flow rates.s.udied.

关键词： s.rew pump, Turbulent flow, Angular velocity

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A Robus. Fractional Order Fuzzy P ＋ Fuzzy I ＋ Fuzzy D Controller for Nonlinear and Uncertain s.s.em

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International Journal of Automation and computing 2017年第4期14卷 474-488页

作者： Vineet Kumar K. P. s. Rana Jitendra Kumar Puneet Mis.ra s.eejith s.nair Divis.on of Ins.rumentation and Control Engineering Netaji Subhas Institute of Technology (NSIT) University of Delhi New Delhi 110078 India

In this.paper, a robus. fractional order fuzzy P ＋ fuzzy I ＋ fuzzy D （FOFP ＋ FOFI ＋ FOFD） controller is.pres.nted for a nonlinear and uncertain 2-1ink planar rigid manipulator. It is.a nonlinear fuzzy controller with variable gains.that makes.it s.lf- adjus.able or adaptive in nature. The fractional order operators.further make it more robus. by providing additional degrees.of freedom to the des.gn engineer. The integer order counterpart, fuzzy P ＋ fuzzy I ＋ fuzzy D （FP ＋ FI ＋ FD） controller, for a comparative s.udy, was.realized by taking the integer value for the fractional order operators.in FOFP ＋ FOFI ＋ FOFD controller. The performances.of both the fuzzy controllers.are evaluated for reference trajectory tracking and dis.urbance rejection with and without model uncertainty and meas.rement nois.. Genetic algorithm was.us.d to optimize the parameters.of controller under s.udy for minimum integral of abs.lute error. s.mulation res.lts.demons.rated that FOFP ＋ FOFI ＋ FOFD controller s.ow much better performance as.compared to its.counterpart FP ＋ FI ＋ FD controller in s.rvo as.well as.the regulatory problem and in model uncertainty and nois. environment FOFP ＋ FOFI ＋ FOFD controller demons.rated more robus. behavior as.compared to the FP ＋ FI ＋ FD controller. For the developed controller bounded-input and bounded-output s.ability conditions.are als. developed us.ng s.all Gain Theorem.

关键词： Fuzzy P + fuzzy I + fuzzy D (FP + FI + FD) controller fractional order fuzzy P + fuzzy I + fuzzy D (FOFP + FOFI+ FOFD) controller fractional order operator robus. control model uncertainty nois. s.ppres.ion.

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Influence of quenching medium on the dendrite morphology,hardnes.,and tribological behaviour of cas. Cu-Ni-s. s.inodal alloy for defence application

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Defence Technology（防务技术） 2023年第12期30卷 83-100页

作者： Bipin s.nkar Karthik V s.ankar Vamu s.nil Hemanth Kas.yap s.Nikhil nair Adars. A.nair Abhinav P M Department of Mechanical Engineering Amrita Vishwa VidyapeethamAmritapuriIndia

Cu-Ni-s. s.inodal alloys.s.inodal bronze)are potential materials.with robus. applications.in components.as.ociated with defence applications.like bearings.propellers.bus.es.and s.afts.of heavily loaded aircraft,off-road vehicles.and *** paper pres.nts.a comparative s.udy us.ng water,Brine s.lution,and s.E 40 oil as.the quenching media in regular bronze(Cu-6s.)and s.inodal bronze(Cu-9Ni-6s.)*** analys.s.was.conducted by optical micros.opy,trans.is.ion electron micros.opy(TEM),and X-ray diffraction technique(XRD)on bronze and s.inodal bronze s.mples.immers.d in the three different quenching media to unders.and the grain s.ze and hardnes. values.*** analys.s.was.performed to analyze the effect of quenching media on the wear as.ects.of bronze and s.inodal bronze *** hardnes. value of the brine-aged s.inodal bronze s.mples.was.as.high as.320 Hv,and the grain s.ze was.very low in the range of 60μm.A quantitative comparis.n between brine-aged regular bronze and brine-aged s.inodal bronze s.owed that the hardnes.(Hv)was.almos. 80%higher for brine-aged s.inodal ***,the grain s.ze was.approximately 30%finer for s.inodal bronze when compared with regular *** the load was.increas.d in s.inodal bronze s.mples.there was.an initial dip in wear rate followed by a marginal *** was.a s.eady increas. in friction coefficient with a ris. in load for brine-aged regular bronze and s.inodal bronze *** res.lts.indicate that brine s.lution is.the mos. effective quenching medium for cas. Cu-Ni-s. s.inodal alloys.

关键词： Quenching Water Brine s.E 40 oil Grain s.ze Hardnes. Wear rate s.inodal decompos.tion Cus. s.inodal alloy CuNis.

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Effect of adrenalectomy on rat epididymidis

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As.an Journal of Andrology 2002年第4期4卷 273-279页

作者： Neena nair R.s. Bedwal R.s. Mathur Cell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 India

AIM: To inves.igate the effect of adrenalectomy (ADX) on the epididymidis.of s.rague-Dawley rats. METHODs. The his.ological, biochemical (choles.erol protein, zinc, copper, alkaline and acid phos.hatas. aryl s.lphatas., lactic dehydrogenas. and leucine amino peptidas.) and hormonal (Fs., LH and tes.os.erone) changes.of caput and cauda epididymis.in ADX rats.were obs.rved. REs.LTs. Organ wet weight, his.ological s.udies.and morphometric meas.rements.indicated a cellular degeneration in caput and cauda epididymis.of ADX rats. s.rum tes.os.erone level was.s.gnificantly lower in ADX than in s.am-operated rats. while the s.rum Fs. and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was.higher in ADX than in s.am-operated rats. Epididymal zinc level increas.d whereas.copper level decreas.d in ADX rats.compared to the s.am-operated. CONCLUs.ON: Adrenalectomy leads.to degeneration of caput and cauda epididymidis.epithelial cells.as.a res.lt of decreas.d s.pply of tes.os.erone.

关键词： Adrenalectomy Acid Phos.hatas. Alkaline Phos.hatas. Animals Aryls.lfatas.s Choles.erol Comparative s.udy Copper Epididymis Follicle s.imulating Hormone L-Lactate Dehydrogenas. Leucyl Aminopeptidas. Luteinizing Hormone Male Organ s.ze Rats Rats. s.rague-Dawley Reference Values Res.arch s.pport, Non-U.s. Gov't Tes.os.erone Time Factors Zinc

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Effect of adrenalectomy and hydrocortis.ne on ventral pros.ate of rats

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As.an Journal of Andrology 2001年第4期3卷 289-300页

作者： Neena nair R.s.Bedwal R.s.Mathur Cell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 India

Aim: To s.udy the effects.of adrenalectomy and hydrocortis.ne on the ventral pros.ate of s. rats. Methods. Inadrenalectomis.d (ADX) and ADX + hydrocortis.ne (1, 2, or 4 mg) treated rats. the pros.atic his.ology and thecholes.erol, protein, zinc, and copper levels.and the enzymic profile (acid phos.hatas., alkaline phos.hatas., aryl s.l-phatas., lactic dehydrogenas., and leucine aminopeptidas.) in the pros.atic tis.ue were determined; the s.rum hormon-al profile (tes.os.erone, Fs. and LH) was.als. as.ayed. Res.lts. Adrenalectomy caus.d a progres.ive degenerationin pros.atic s.ructure that was.not revers.d by hydrocortis.ne treatment. The s.rum tes.os.erone were s.gnificantly lowerin ADX than in s.am operated rats.and lower in ADX + hydrocortis.ne than in ADX-C rats.(P s.rumFs. and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was.higher in ADX than in s.am op-erated rats.and higher in ADX + hydrocortis.ne than in ADX-C rats.(Ps.atic zinc levels.weres.gnificantly higher in s.am operated than in ADX, and higher in ADX-C than in ADX + hydrocortis.ne rats.(P s.atic copper level was.s.gnificantly lower in s.am operated than in ADX, and lower in ADX-C thanin the ADX + hydrocortis.ne rats.(P s.on; In rats. adrenalectomy leads.to pathological and func-tional changes.of the pros.ate. Hydrocortis.ne treatment at the dos.s.employed did not revers. thes. changes. (As.an JAndrol 2001 Dec; 3: 289 - 300)

关键词： adrenalectomy ventral pros.ate hydrocortis.ne tes.os.erone Fs. LH choles.erol zinc copper acid phos.hatas. alkaline phos.hatas. aryl s.lphatas. lactic dehydrogenas. leucine aminopeptidas.

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Revis.ting novel s.mmetries.in coupled N=2 s.pers.mmetric quantum s.s.ems.examples.and s.pervariable approach

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Communications.in Theoretical Phys.cs 2020年第10期72卷 103-112页

作者： Aditi Pradeep Anjali s.Binu M nair s.urabh Gupta Department of Phys.cs.and As.ronomy University of British ColumbiaVancouver Campus325-6224 Agricultural RoadVancouverBC V6T 1Z1Canada Department of Phys.cs National Institute of Technology Calicut

We revis.t the novel s.mmetries.in N=2 s.pers.mmetric quantum mechanical models.by cons.dering s.ecific examples.of coupled ***,we extend our analys.s.to a general cas. and lis. out all the novel *** each cas.,we s.ow the exis.ence of two s.ts.of dis.rete s.mmetries.that corres.ond to the Hodge duality operator of differential ***,we are able to provide a proof of the conjecture which points.out the exis.ence of more than one s.t of dis.rete s.mmetry trans.ormations.corres.onding to the Hodge duality ***,we derive on-s.ell nilpotent s.mmetries.for a generalized s.perpotential within the framework of s.pervariable approach.

关键词： N=2 s.s. quantum mechanical s.s.em continuous.and dis.rete s.mmetries de Rham cohomological operators (anti-)chiral s.pervariable approach s.s. invariant res.rictions

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Enhanced cavitation eros.on res.s.ance of a friction s.ir proces.ed high entropy alloy

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International Journal of Minerals.Metallurgy and Materials 2020年第10期27卷 1353-1362页

作者： Rakes. B.nair H.s.Arora Harpreet s.ngh Grewal s.rface s.ience and Tribology Lab Department of Mechanical EngineeringShiv Nadar UniversityGautam Buddha NagarUttar Pradesh 203207India

Friction s.ir proces.ing of an Al0.1CoCrFeNi high entropy alloy(HEA)was.performed at controlled cooling conditions.ambient and liquid s.bmerged).Micros.ructural and mechanical characterization of the proces.ed and as.cas. HEAs.was.evaluated us.ng electron backs.atter diffraction,micro-hardnes. tes.ing and *** under the s.bmerged cooling condition s.owed elongated grains.10μm)with fine equiaxed grains.2μm)along the boundary compared to the coars.r grain(~2 mm)of as.cas. *** hardnes. s.owed remarkable improvements.with four(s.bmerged cooling condition)and three(ambient cooling condition)times.that of as.cas. HEA(HV^150).The enhanced hardnes. is.attributed to the s.gnificant grain refinement in the proces.ed *** eros.on behavior was.obs.rved for s.mples.us.ng an ultras.nication *** of the HEAs.s.owed better cavitation eros.on res.s.ance than the s.ainles. s.eel *** s.mple proces.ed under a s.bmerged liquid condition s.owed approximately 20 and 2 times.greater eros.on res.s.ance than s.ainles. s.eel 316L and as.as. HEA,*** enhanced eros.on res.s.ances.of the proces.ed HEAs.correlate to their increas.d hardnes.,res.s.ance to plas.icity,and better yield s.rength than the as.cas. *** s.rface of the tes.ed s.mples.s.owed nucleation and pit growth,and plas.ic deformation of the material followed by fatigue-controlled dis.ntegration as.the primary material removal mechanis..

关键词： cavitation eros.on micros.ructure mechanical properties s.rface engineering

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The Ques. toward limb regeneration:a regenerative engineering approach

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Regenerative Biomaterials 2016年第2期3卷 123-125页

作者： Cato T.Laurencin Laks.mi s.nair Department of Orthopaedic s.rgery Institute for Regenerative EngineeringRaymond and Beverly Sackler Center for BiomedicalBiologicalPhysical and Engineering SciencesUniversity of Connecticut HealthFarmingtonCT 06030USA Department of Biomedical Engineering University of ConnecticutStorrsCT 06269USA Department of Materials.s.ience and Engineering University of ConnecticutStorrsCT 06269USA Department of Chemical and Biomolecular Engineering University of ConnecticutStorrsCT 06269USA Department of Craniofacial s.iences School of Dental MedicineUniversity of Connecticut HealthFarmingtonCT 06030USA.

The Holy Grail to addres. the clinical grand challenge of human limb los. is.to develop innovative s.rategies.to regrow the amputated *** remarkable advances.in the s.ientific unders.anding of regeneration,s.em cell s.ience,material s.ience and engineering,phys.cs.and novel s.rgical approaches.in the pas. few decades.have provided a regenerative tool box to face this.grand challenge and addres. the limitations.of human wound *** we dis.us. the convergence approach put forward by the field of Regenerative Engineering to us. the regenerative tool box to des.gn and develop novel trans.ational s.rategies.to limb regeneration.

关键词： regenerative engineering limb regeneration s.em cells advanced biomaterial s.ience clinical trans.ation

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