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Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration

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Regenerative Biomaterials 2020年第6期7卷 527-542页

作者： Liwei fu Zhen Yang Cangjian Gao Hao Li Zhiguo Yuan fuxin Wang Xiang Sui Shuyun liu Quanyi Guo School of Medicine Nankai UniversityNo.94 Weijin RoadNankai DistrictTianjin 300071China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLAInstitute of OrthopedicsThe First Medical CenterChinese PLA General HospitalNo.28 Fuxing RoadHaidian DistrictBeijing 100853China Department of Bone and Joint Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityNo.160 Pujian RoadPudong New DistrictShanghai 200127China

Due to the sophisticated hierarchical structure and limited reparability of articular cartilage(AC),the ideal regeneration of AC defects has been a major challenge in the field of regenerative *** defects progress,they often extend from the cartilage layer to the subchondral bone and ultimately lead to *** engineering techniques bring new hope for AC *** meet the regenerative requirements of the heterogeneous and layered structure of native AC tissue,a substantial number of multilayered biomimetic scaffolds have been *** multilayered scaffolds should generate zone-specific functional tissue similar to native AC *** review focuses on the current status of multilayered scaffolds developed for AC defect repair,including design strategies based on the degree of defect severity and the zone-specific characteristics of AC tissue,the selection and composition of biomaterials,and techniques for design and *** challenges and future perspectives of biomimetic multilayered scaffold strategies for AC regeneration are also discussed.

关键词： biomimetic multilayered scaffold articular cartilage regeneration tissue engineering osteochondral

HPLC-ICP-MS测定富硒芦笋中硒代蛋氨酸的不确定度评定

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现代食品 2024年第15期30卷 194-199页

作者：刘贤标刘汉泉温志刚邹辉沈乐丞李枝明付志明吕婷婷赣州市综合检验检测院/江西省富硒产品质量监督检验中心江西赣州341000

目的:对高效液相色谱-电感耦合等离子体质谱法测定富硒芦笋中硒代蛋氨酸含量的不确定度进行分析评定。方法:按照行业标准《粮谷中硒代半胱氨酸和硒代蛋氨酸的测定液相色谱-电感耦合等离子体质谱法》(NY/T 3556—2020)对富硒芦笋中硒代... 详细信息

目的:对高效液相色谱-电感耦合等离子体质谱法测定富硒芦笋中硒代蛋氨酸含量的不确定度进行分析评定。方法:按照行业标准《粮谷中硒代半胱氨酸和硒代蛋氨酸的测定液相色谱-电感耦合等离子体质谱法》(NY/T 3556—2020)对富硒芦笋中硒代蛋氨酸的含量进行检测,依据《测量不确定度评定和表示》(GB/T 27418—2017)和《化学分析中测量不确定度评估指南》(RB/T 030—2020)对引入的各类不确定度分量进行分类,通过构建数学模型精确评价测定过程中的测量不确定度。结果:当富硒芦笋中硒代蛋氨酸含量为0.558 mg·kg^(-1)时,在95%的置信区间下,扩展不确定度为0.034 mg·kg^(-1)(k=2)。影响检测结果不确定度的主要因素为试样提取回收率、标准溶液配制和标准曲线拟合。结论:在测定过程中,应保证标液和器具质量,并严格按照标准化流程操作,以降低测量不确定度,获得更加准确的测量结果。

关键词：富硒芦笋硒代蛋氨酸高效液相色谱-电感耦合等离子体质谱不确定度

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锑精矿制备乙二醇锑工艺研究

兰州石化职业技术大学学报 2024年第3期24卷 17-20页

作者：胡小明鲁兴武殷勤生何乃勇刘瑛鑫李银丽白银新大孚科技化工有限公司甘肃白银730900 西北矿冶研究院甘肃白银730900 白银有色集团股份有限公司甘肃白银730900 中南大学冶金与环境学院湖南长沙410083

指出了锑精矿制备三氯化锑的工艺思路,研究了三氯化锑法合成乙二醇锑的工艺条件。通过单因素实验的探索,初步确定了适宜的反应温度为70℃,反应时间为90min,物料配比为50。

关键词：锑精矿聚酯三氯化锑乙二醇乙二醇锑。

GS6, A Member of the GRAS Gene Family,Negatively Regulates Grain Size in Rice

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Journal of Integrative Plant Biology 2013年第10期55卷 938-949页

作者： Lianjun Sun Xiaojiao Li Yongcai fu Zuofeng Zhu Lubin Tan Fengxia liu Xianyou Sun Xuewen Sun Chuanqing Sun State Key Laboratory of Plant Physiology and Biochemistry National Center for Evaluation of Agricultural Wild Plants (Rice) MOE Key Laboratory of Crop Heterosis and Utilization Key Laboratory of Crop Genetic Improvement Department of Plant Genetics and Breeding China Agricultural University State Key Laboratory of Plant Physiology and Biochemistry National Center for Evaluation of Agricultural Wild Plants(Rice) MOE Key Laboratory of Crop Heterosis and Utilization Key Laboratory of Crop Genetic Improvement Department of Plant Genetics and Breeding China Agricultural University

Grain size is an important yield-related trait in rice. Intensive artificial selection for grain size during domestication is evidenced by the larger grains of most of today＇s cultivars compared with their wild relatives. However, the molecular genetic control of rice grain size is still not well characterized. Here, we report the identification and cloning of Grain Size 6 （GS6）, which plays an important role in reducing grain size in rice. A premature stop at the ＋348 position in the coding sequence （CDS） of GS6 increased grain width and weight significantly. Alignment of the CDS regions of GS6 in 90 rice materials revealed three GS6 alleles. Most japonica varieties （95%） harbor the Type I haplotype, and 62.9% of indica varieties harbor the Type II haplotype. Association analysis revealed that the Type I haplotype tends to increase the width and weight of grains more than either of the Type II or Type III haplotypes. further investigation of genetic diversity and the evolutionary mechanisms of GS6 showed that the GS6 gene was strongly selected in japonica cultivars. In addition, a ＂ggc＂ repeat region identified in the region that encodes the GRAS domain of GS6 played an important historic role in the domestication of grain size in rice. Knowledge of the function of GS6 might aid efforts to elucidate the molecular mechanisms that control grain development and evolution in rice plants, and could facilitate the genetic improvement of rice yield.

关键词： Domestication GS6 , grain size haplotype Oryza sativa rice.

Graphitic carbon nitride based single-atom photocatalysts

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Frontiers of physics 2020年第3期15卷 13-26,M0001页

作者： Junwei fu Shuandi Wang Zihua Wang Kang liu Huangjingwei Li Hui liu Junhua Hu Xiaowen Xu Hongmei Li Min liu School of Physics and Electronics State Key Laboratory of Powder MetallurgyHunan Provincial Key Laboratory of Chemical Power SourcesCentral South UniversityChangsha410083China School of Metallurgy and Environment Central South UniversityChangsha410083China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China

Single-atom photocatalysts,due to their high catalysis activity,selectivity and stability,become a hotspot in the field of *** carbon nitride(g-C3N4)is known as both a good support for single atoms and a star *** g-C3N4-based single-atom photocatalysts exhibits great potential in improving the photocatalytic *** this review,we summarize the recent progress in g-C3N4-based single-atom photocatalysts,mainly including preparation strategies,characterizations,and their photocatalytic *** significant roles of single atoms and catalysis mechanism in g-C3N4-based single-atom photocatalysts are *** last,the challenges and perspectives for exploring high-efficient g-C3N4-based single-atom photocatalysts are presented.

关键词： graphitic carbon nitride single atoms atomically dispersed sites site-isolated catalysts photocatalysis

MonkeyTrail:A scalable video-based method for tracking macaque movement trajectory in daily living cages

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Zoological Research 2022年第3期43卷 343-351页

作者： Meng-Shi liu Jin-Quan Gao Gu-Yue Hu Guang-fu Hao Tian-Zi Jiang Chen Zhang Shan Yu Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijing 100190China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 101408China Technology Management Center SAFE Pharmaceutical Technology Co.Ltd.Beijing 100176China Model R&D Center Beijing Life Biosciences Co.Ltd.Beijing 100176China Key Laboratory for NeuroInformation of Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduSichuan 611731China Department of Neurobiology School of Basic Medical SciencesBeijing Key Laboratory of Neural Regeneration and Repairand Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100069China Current address:School of Computing National University of SingaporeSingapore 119077Singapore

Behavioral analysis of macaques provides important experimental evidence in the field of *** recent years,video-based automatic animal behavior analysis has received widespread ***,methods capable of extracting and analyzing daily movement trajectories of macaques in their daily living cages remain underdeveloped,with previous approaches usually requiring specific environments to reduce interference from occlusion or environmental ***,we introduce a novel method,called MonkeyTrail,which satisfies the above requirements by frequently generating virtual empty backgrounds and using background subtraction to accurately obtain the foreground of moving *** empty background is generated by combining the frame difference method(FDM)and deep learning-based model(YOLOv5).The entire setup can be operated with low-cost hardware and can be applied to the daily living environments of individually caged *** test MonkeyTrail performance,we labeled a dataset containing>8000 video frames with the bounding boxes of macaques under various conditions as *** showed that the tracking accuracy and stability of MonkeyTrail exceeded that of two deep learningbased methods(YOLOv5 and Single-Shot MultiBox Detector),traditional frame difference method,and na?ve background subtraction *** MonkeyTrail to analyze long-term surveillance video recordings,we successfully assessed changes in animal behavior in terms of movement amount and spatial ***,these findings demonstrate that MonkeyTrail enables low-cost,large-scale daily behavioral analysis of macaques.

关键词： Movement trajectory tracking Video-based behavioral analyses Background subtraction Virtual empty background Occlusion

Pleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors

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Cellular & Molecular Immunology 2011年第2期8卷 172-180页

作者： Qin Li Li Li Yun liu Xiaoying fu Dan Qiao Hui Wang Suihua Lao Fengyu Huang Changyou Wu Department of Immunology Zhongshan School of MedicineKey Laboratory of Tropical Disease Control Research of Ministry of EducationSun Yat-Sen UniversityGuangzhouChina Chest Hospital of Guangzhou GuangzhouChina Department of Gynecology and Obstetrics The Secondary Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina

Immunosuppressive mediators in tuberculosis pleurisy(pleural fluid(PF))are associated with the course of disease,but they remain poorly *** study the local immune status of patients with tuberculosis pleurisy,we examined the effect of PF on the functions of T cells and the differentiation of Th1 *** could inhibit the ability of T cells to produce ***,tumor-necrosis factor(TNF)-a derived from non-T cells was not *** analysis indicated that cell activation and cell cycle progression were also ***,PF could inhibit Th1 cell ***,we found that inhibitors of indoleamine 2,3-dioxygenase(IDO)and adenosine and neutralizing antibodies against IL-10 and transforming growth factor(TGF)-b could reverse cytokine production,suggesting that IDO,adenosine,IL-10 and Transforming growth factor–b1 in PF might take part in impairing T-cell *** together,our data demonstrate for the first time that several immunopathological factors participate in the downregulation of T-cell functions in local PF.

关键词： suppressive factors Th1 cytokine Th1 differentiation tuberculosis pleurisy

Lentivirus carrying the Atoh1 gene infects normal rat cochlea

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Neural Regeneration Research 2013年第17期8卷 1551-1559页

作者： Song Pan Jingzhi Wan Shaosheng liu Song Zhang Hao Xiong Jun Zhou Wu Xiong Kunfei Yu Yong fu Department of Otolaryngology Guangming New District People's Hospital Department of Surgery Hubei University of Science and Technology Department of Otolaryngology Beilun Branch of the First Affiliated Hospital College of Medicine Zhejiang University Department of Otolaryngology Second Affiliated Hospital Sun Yat-sen University Department of Otolaryngology First Affiliated Hospital College of Medicine Zhejiang University

Lentivirus carrying the Atohl gene can infect Corti＇s organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. Lentivirus acts as a carrier that can stably and continuously express genes. In this study, the cochlear structure and hearing level were not affected, and Atohl gene carried by lentivirus promoted the production of hair-like cells in the cochlear supporting cell area. This led to expression of the hair-like cell surface marker myosin 7a 30 days after lentivirus carrying Atohl was microinjected into the cochlear round window of rats.

关键词： neural regeneration gene therapy Atohl lentivirus hair cells myosin 7a cochlea auditorythreshold grants-supported paper neuroregeneration

Long-term deformation analysis of Shuibuya concrete face rockfill dam based on response surface method and improved genetic algorithm

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Water Science and Engineering 2019年第3期12卷 196-204页

作者： fu-hai Yao Shao-heng Guan He Yang Yuan Chen Huan-feng Qiu Gang Ma Qi-wen liu School of Water Resources and Hydropower Engineering Wuhan University Wuhan 430072 China School of Civil Engineering and Architecture Wuhan University Wuhan 430070 China Guiyang Engineering Corporation Limited Guiyang 550081 China

Due to the size effects of rockfill materials, the settlement difference between numerical simulation and in situ monitoring of rockfill dams is a topic of general *** constitutive model parameters obtained from laboratory triaxial tests often underestimate the deformation of high rockfill ***, constitutive model parameters obtained by back analysis were used to calculate and predict the long-term deformation of rockfill *** of using artificial neural networks (ANNs), the response surface method (RSM) was employed to replace the finite element simulation used in the optimization *** 27 training samples were required for RSM, improving computational efficiency compared with ANN, which required 300 training *** can be used to describe the relationship between the constitutive model parameters and dam *** inversion results of the Shuibuya concrete face rockfill dam (CFRD) show that the calculated settlements agree with the measured data, indicating the accuracy and efficiency of RSM.

关键词： Shuibuya rockfill dam Parameter back analysis Response surface method Duncan EB model Time-dependent deformation