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Effects of estrogen replacement therapy on apoptosis and vascular endothelial growth factor expression in ocular surface epithelial cells:An experimental study

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 64-68页

作者： Fatih zcura Sema Oru Dndar Emel Dikicioglu etin nahit beder Mehmet Dndar Department of Ophthalmology Dumlupinar University School of MedicineKutahyaTurkey Department of Ophthalmology Adnan Menderes University School of MedicineAydinTurkey Department of Pathology Adnan Menderes University School of MedicineAydinTurkey Department of Urology Adnan Menderes University School of MedicineAydinTurkey

AIM:To investigate the effects of estrogen replacement therapy (ERT) on apoptosis and vascular endothelial growth factor (VEGF) expression in ocular surface in an experimental rat model.· METHODS:Forty female,Wistar rats were randomized in 4 groups in the *** ERT (17β-estradiol,10g/kg/day) was administered to the first group without ovariectomy and to the second group with ovariectomy for three *** group had only ovariectomy and fourth group had sham *** rats were sacrificed in estrous cycles determined by vaginal smear test and their right eyes were enucleated at the end of the third *** eyes were analyzed by immunohistochemical method for expressions of caspase-3,bcl-2,VEGF and TUNEL assay.· RESULTS:Caspase-3 expression of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.005),and group 2 (P =0.007).TUNEL score of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.006).TUNEL score of corneal epithelium was significantly higher in group 3 than group 2 (P =0.012),and group 4 (P =0.002).There was no significant difference between groups in that bcl-2 and VEGF expressions.· CONCLUSION:We determined increased apoptosis in ocular surface epithelial cells in ovariectomized *** and endogen estrogen decreased the apoptosis,and did not result in difference in VEGF expression between the *** may be beneficial for the treatment of apoptosis-mediated ocular surface disorders such as dry *** studies are needed on this subject for a better understanding of the role of estrogen and to provide a new insight for treatment and prevention of apoptosis-mediated ocular surface disorders.

关键词： apoptosis conjunctiva cornea estrogen ocular surface vascular endothelial growth factor

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