检索结果-南通市图书馆

Role of intestinal ultrasound in ulcerative colitis: A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Meta-Analysis 2024年第3期12卷 42-67页

作者： Partha Pal Mohammad Abdul Mateen Kanapuram Pooja Nandhakumar Rajadurai Rajesh Gupta Manu Tandan nages.war reddy duvvuru Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500082India Department of Diagnostic Radiology and Imaging Asian Institute of GastroenterologyHyderabad 500082India

BACKGROUND Intestinal ultrasound(IUS)is an emerging,non-invasive,and highly sensitive diagnostic tool in inflammatory bowel disease(IBD),including ulcerative colitis(UC).Despite its potential,its adoption in clinical practice is limited due to a lack of standardization and *** To perform a comprehensive scoping review based on a systematic literature review on IUS in UC to inform current *** Ninety-nine original articles about ultrasonography in UC were identified among 7608 citations searching PubMed and EMBASE databases for systematic *** IUS can be useful as an initial diagnostic strategy in patients with suspected IBD/*** UC,IUS can predict endoscopic response,histologic healing,and steroid responsiveness in acute severe *** can predict response to biologics/small molecules(as early as 2 wk).IUS correlates well with ileocolonoscopy,but IUS could miss rectal,jejunal,and upper GI lesions in suspected IBD and colon polyps or extra-intestinal manifestations in known *** is useful in special situations(children,pregnancy,and postoperative Crohn's disease).Inter-observer agreement is acceptable and trained physicians have comparable diagnostic ***-of-care ultrasound impacted management in 40%-60%of ***-held IUS has excellent agreement with conventional *** IUS is a non-invasive,highly sensitive tool in the diagnosis and monitoring of UC,offering excellent patient ***-of-care ultrasound by IBD physicians can significantly impact clinical decision-making.

关键词： Ulcerative colitis Intestinal ultrasound Inflammatory bowel disease Diagnosis Monitoring

Capsule endoscopy:Current status in obscure gastrointestinal bleeding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第34期13卷 4551-4553页

作者： R Gupta duvvuru nages.war reddy Asian Institute of Gastroenterology 6-3-652 Somajiguda Hyderabad 500082 India

Capsule endoscopy (CE) is a safe, non invasive diagnostic modality for the evaluation of small bowel lesions. Obscure gastrointestinal bleeding (OGIB) is one of the most important indications of capsule endoscopy. Capsule endoscopy has a very high diagnostic yield especially if the bleeding is ongoing. This technique appears to be superior to other techniques for the detection of suspected lesions and the source of bleeding. Capsule endoscopy has been shown to change the outcome in patients with obscure gastrointestinal (GI) bleed.

关键词： Capsule endoscopy Obscure gastrointestinalbleeding Luminal endoscopy Diagnostic yield Smallbowel study

Management of hepatitis B and C in special population

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第40期27卷 6861-6873页

作者： Anand V Kulkarni nages.war reddy duvvuru Department of Hepatology Asian Institute of GastroenterologyHyderabad 500032TelanganaIndia Department of Gastroenterology Asian Institute of GastroenterologyHyderabad 500032TelanaganaIndia

Chronic viral hepatitis is one of the leading causes of cirrhosis *** hepatitis B is more common in the Asia-Pacific region due to the larger population and lower screening *** C predominates in the west due to injection drug *** discovery of(oral)direct-acting antiviral agents(DAAs)has changed the landscape of chronic hepatitis C(CHC)***(t)ide analogs(NUCs)have also changed the approach to the treatment of chronic hepatitis B(CHB).Oral NUCs and DAAs have excellent efficacy and patient acceptance as well as a lower risk of ***,certain populations have no robust data and safety and efficacy of such oral drugs is still *** this review,we provide an overview of the management of CHB and CHC in special populations,such as those with chronic kidney disease,pregnant women,healthcare workers,and those undergoing chemo-or immunosuppressive therapy.

关键词： Chronic kidney disease Pregnancy Hepatitis B Hepatitis C Health care professionals Tenofovir

Favipiravir-induced Liver Injury in Patients with Coronavirus Disease 2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2021年第2期9卷 276-278页

作者： Pramod Kumar Anand Kulkarni Mithun Sharma Padaki Nagaraja Rao duvvuru nages.war reddy Department of Hepatology and Liver Transplantation Asian Institute of Gastroenterology HospitalsHyderabadIndia Department of Gastroenterology Asian Institute of Gastroenterology HospitalsHyderabadIndia

Favipiravir,an antiviral,was given restricted emergency use approval to treat coronavirus disease 2019(COVID-19)in many *** the clinical efficacy of favipiravir in COVID-19 remains uncertain,the approval was based on findings from in vitro studies and a clinical trial.1 Limited data from studies of the Ebola virus and influenza disease showed a favorable safety profile.2 Herein,we provide the first report of drug-induced liver injury(DILI)due to favipiravir in patients treated for COVID-19.

关键词： clinical approval Liver

Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2016年第20期8卷 827-837页

作者： Vishnubhotla Venkata Ravi Kanth Mitnala Sasikala Mithun Sharma Padaki Nagaraja Rao duvvuru nages.war reddy Asian Healthcare Foundation a Research Wing of Asian Institute of Gastroenterology Asian Institute of Gastroenterology

Genetics plays an important role in determining the susceptibility of an individual to develop a disease. Complex, multi factorial diseases of modern day(diabetes, cardiovascular disease, hypertension and obesity) are a result of disparity between the type of food consumed and genes, suggesting that food which does not match the host genes is probably one of the major reasons for developing life style diseases. Non-alcoholic fatty liver is becoming a global epidemic leading to substantial morbidity. While various genotyping approaches such as whole exome sequencing using next generation sequencers and genome wide association studies have identified susceptibility loci for non-alcoholic fatty liver disease(NAFLD) including variants in patatin-like phospholipase domain containing 3 and transmembrane 6 superfamily member 2 genes apart from others; nutrient based studies emphasized on a combination of vitamin D, E and omega-3 fatty acids to manage fatty liver disease. However majority of the studies were conducted independent of each other and very few studies explored the interactions between the genetic susceptibility and nutrient interactions. Identifying such interactions will aid in optimizing the nutrition tailor made to an individual's genetic makeup, thereby aiding in delaying the onset of the disease and its progression. The present topic focuses on studies that identified the genetic susceptibility for NAFLD, nutritional recommendations, and their interactions for better management of NAFLD.

关键词： Transmembrane 6 superfamily member 2 gene Patatin-like phospholipase domain containing 3 gene Genotyping Nutrient interactions Non-alcoholic fatty liver disease Genetic susceptibility

Pooled genetic analysis in ultrasound measured non-alcoholic fatty liver disease in Indian subjects:A pilot study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2014年第6期6卷 435-442页

作者： Vishnubhotla Venkata Ravi Kanth Mitnala Sasikala Padaki Nagaraja Rao Urmila Steffie Avanthi Kalashikam Rajender Rao duvvuru nages.war reddy Asian Healthcare Foundation Hyderabad 500082India Asian Institute of Gastroenterology Hyderabad 500082India Division of Endocrinology and Metabolism National Institute of NutritionTarnakaHyderabad 500082India

AIM: To investigate genetic susceptibility in Indian subjects with non-alcoholic fatty liver disease(NAFLD) by performing a pooled genetic ***: Study subjects(n = 306) were recruited and categorized into NAFLD and control groups based on ultrasound findings of fatty infiltration. Of the 306 individuals, 156 individuals had fatty infiltration and thus comprised the NAFLD group. One hundred and fifty(n = 150) individuals were normal, without fatty infiltration of the liver, comprising the control group. Blood samples, demographic and anthropometric data from the individuals were collected after obtaining informed consent. Anthropometric data, blood glucose, lipids and liver function tests were estimated using standard methods. Genome wide association stud-ies done to date on NAFLD were identified, 19 single nucleotide polymorphisms(SNPs) were selected from these studies that were reported to be significantly associated with NAFLD and genotyping was performed on the Sequenom platform. Student's t test for continuous variables and χ2 test was applied to variant carriers from both groups. Required corrections were applied as multiple testing was *** The mean age of the control group was 39.78 ± 10.83 and the NAFLD group was 36.63 ± 8.20 years. The waist circumference of males and females in the control and NAFLD groups were 80.13 ± 10.35; 81.77 ± 13.65 and 94.09 ± 10.53; 92.53 ± 8.27 respectively. The mean triglyceride and alanine transaminase(ALT) levels in the control and NAFLD groups were 135.18 ± 7.77; 25.39 ± 14.73 and 184.40 ± 84.31; 110.20 ± 67.05 respectively. When χ2 test was applied to the number of individuals carrying the variant risk alleles between the control and NAFLD group, a significant association was seen between rs738409 of the patatin-like phospholipase domain containing 3(PNPLA3) gene(P = 0.001), rs2073080 of the PARVB gene(P = 0.02), rs2143571 of SAMM50 gene(P = 0.05) and rs6487679 of the pregnancy zone protein(PZP) gene(P = 0.0

关键词： Non-alcoholic fatty liver disease Genome wide association studies Genetic association Hepatic steatosis Genotyping Single nucleotide polymorphisms Susceptibility

Transcriptome Profiles and Gene Expression of Min6 Cells Are Altered by Pancreatic Stellate Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Bioscience and Biotechnology 2018年第6期9卷 273-288页

作者： Ratnakar reddy Bynigeri Sasikala Mitnala Ravikanth Vishnubhotla Rupjyoti Talukdar Surya Satyanarayana Singh nages.war reddy duvvuru Asian Healthcare Foundation Hyderabad India Asian Institute of Gastroenterology Hyderabad India Osmania University Hyderabad India

Aim: To identify the influence of pancreatic stellate cell (PSCs) secretions on gene expression profiles of Min6 cells by whole transcriptome sequencing. Methods: Pancreatic stellate cells (PSCs) were isolated from C57BL6J mice and propagated in vitro to acquire the activated phenotype. Total RNA was isolated from monocultured (MC) and PSC cocultured (CC) Min6 cells to prepare cDNA libraries, which were subjected to whole transcriptome sequencing for identifying differential expression of β-cell transcription factors (Pdx-1, Rfx6 and NeuroD1) related to insulin gene transcription and GSIS related genes such as Glut2, Gck, Abcc8, Kcnj11 and L-type Ca2+ channels (Cacnb2, Cacna1c). qRT-PCR was used to validate the gene expression. GSIS of Min6 cells was examined by estimating insulin levels in response to high glucose challenge. Results: Transcriptome analysis of discovery set revealed that coculture of Min6 cells with PSCs caused increased expression of β-cell specific genes (Ins1, Rfx6 and NeuroD1) concomitant with decreased expression of Pdx-1, MafA and Nkx2-2. Expression of GSIS associated genes (Glut2, Gck, Abcc8, Kcnj11 and Cacnb2) was decreased in such conditions. Validation by qRT-PCR in Min6 cells cocultured with PSCs revealed increased significant expression of Ins1 (2.1 ± 0.22 folds;p ≤ 0.001), Rfx6 (1.68 ± 0.23 folds;p ≤ 0.002) and NeuroD1 (0.96 ± 0.11 folds;p ≤ 0.01), accompanied by downregulation of Cacnb2 (-0.93 ± 0.57 folds;p ≤ 0.05). PSC secretions did not restore the GSIS from glucose unresponsive higher passage Min6 cells (MC: 1.33 ± 0.42;CC: 1.55 ± 0.72 pmol/mg protein;p = ns) upon high glucose stimulation. However, glucose responsive higher passage Min6 cells cocultured with PSCs presented increased insulin secretion (MC: 7.025 ± 0.64;CC: 14.84 ± 1.01 pmol/mg protein;p ≤ 0.04) concomitant with marginal increase of insulin contents. Conclusion: PSC secretions increase Ins1, Rfx6 and NeuroD1 gene expression, GSIS from glucose responsive Min6 cells, b

关键词： β-Cells Gene Expression Islets Pancreatic Stellate Cells Tran-scriptome

Indian task force for celiac disease:Current status

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第48期15卷 6028-6033页

作者： Rajesh Gupta duvvuru nages.war reddy Govind K Makharia Ajit Sood Balakrishnan S Ramakrishna Surender Kumar Yachha Babu Ram Thapa Rupa Banerjee Sekaran Anuradha Usha Dutta Amarender Singh Puri Ajay Kumar Jain Chris JJ Mulder Ajay Kumar Sesikeran Boindala Department of Gastroenterology Asian Institute of Gastro-enterology Department of Gastroenterology AIIMS Department of Gastroenterology Dayanand Medical College Department of Gastrointestinal Sciences Department of Pediatric Gastro-enterology SGPGIMS Department of Pediatric Gastroenterology PGIMER Department of Gastroenterology Asian Institute of Gastroenterology Department of Pathology Asian Institute of Gastroenterology Department of Gastroenterology GB PANT Hospital Department of Gastroenterology Choithram Hospital & Research Centre Department of Gastroenterology VU University Medical Center Department of Gastroenterology Indraprasth Apollo Hospital National Institute of Nutrition

There are limited data on celiac disease(CD) from *** limited knowledge about CD in India might be attributed to several *** fi rst meeting of the Indian Task Force for Celiac Disease was held in the Asian Institute of Gastroenterology,Hyderabad,India in December *** objectives of the meeting were to focus research on prevalence of CD in the wheat-eating Northern vs the rice-eating Southern Indian population,low-budget serological assays to study the underprivileged population,to involve other medical subspecialties in CD,to suggest proper legislation regarding wheat food labeling,and to organize affordable food substitutes for patients with celiac disease.

关键词： Celiac disease Food labeling Gluten-free diet India Legislation Malnutrition Rice Wheat

Epidural anesthesia is effective for extracorporeal shock wave lithotripsy of pancreatic and biliary calculi

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2010年第5期2卷 165-168页

作者： Santosh Darisetty Manu Tandan duvvuru nages.war reddy Rama Kotla Rajesh Gupta Mohan Ramchandani Sandeep Lakhtakia Guduru Venkat Rao Rupa Banerjee Department of Anesthesiology Asian Institute of Gastroenterology Department of Gastroenterology Asian Institute of Gastroenterology

AIM: To evaluate the efficacy of thoracic epidural analgesia for extracorporeal shock wave lithotripsy (ESWL). METHODS: ESWL is an effective, non-invasive technique for the treatment of difficult pancreatic and large bile duct calculi. The procedure is often painful and requires large doses of analgesics. Many different anesthetic techniques have been used. Patients with either large bile duct calculi or pancreatic duct calculi which could not be extracted by routine endoscopic methods were selected. Thoracic epidural anesthesia (TEA) was routinely used in all the subjects unless contraindicated. Bupivacaine 0.25% with or without clonidine was used to block the segments D6 to D12. The dose was calculated depending on the age, height and weight of the patient. It was usually 1-2 mL per segment ***: Ninety eight percent of the 1509 patients underwent ESWL under TEA. The subjects selected were within American Society of Anesthesiologists grade Ⅰ to Ⅲ. ESWL using EA permitted successful elimination of bile duct or pancreatic calculi with minimal morbidity. The procedure time was shorter in patients with TEA than in those who underwent ESWL under total intravenous anesthesia. CONCLUSION: Almost all patients undergoing ESWL with EA had effective blocks with a single catheter insertion and local anesthetic injection.

关键词： Thoracic epidural anesthesia Extracorporeal shock wave lithotripsy Bile duct calculi Pancreatic duct calculi