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Cancer treatment with biosimilar drugs:A review

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Cancer Innovation 2024年第2期3卷 45-62页

作者： Shilpa Malakar Emmanuel Nuah Gontor Moses YDugbaye Kamal Shah Sakshi Sinha Priya Sutaoney nagendra singh chau.an Department of Microbiology Kalinga UniversityRaipurChhattisgarhIndia Institute of Pharmaceutical Research GLA UniversityMathuraUttar PradeshIndia Drug Testing Laboratory Avam Anusandhan KendraRaipurChhattisgarhIndia

Biosimilars are biological drugs created from living organisms or that contain living *** share an identical amino-acid sequence and *** drugs are considered to be cost-effective and are utilized in the treatment of cancer and other endocrine *** primary aim of biosimilars is to predict biosimilarity,efficacy,and treatment costs;they are approved by the Food and Drug Administration(FDA)and have no clinical *** involve analytical studies to understand the similarities and dissimilarities.A biosimilar manufacturer sets up FDA-approved reference products to evaluate *** contribution of next-generation sequencing is evolving to study the organ tumor and its progression with its impactful therapeutic approach on cancer patients to showcase and target rare *** study shall help to understand the future perspectives of biosimilars for use in gastro-entero-logic diseases,colorectal cancer,and thyroid *** also help target specific organs with essential mutational categories and drug prototypes in clinical practices with blood and liquid biopsy,cell treatment,gene therapy,recombinant therapeutic proteins,and personalized *** derivatives such as monoclonal antibodies like trastuzumab and rituximab are common drugs used in cancer *** coli produces more than six antibodies or antibody-derived proteins to treat cancer such as filgrastim,epoetin alfa,and so on.

关键词： biologics biosimilars cancer Escherichia coli monoclonal antibody next-generation sequencing pharmacovigilance

Plants’Steroidal Saponins‑A Review on Its Pharmacology Properties and Analytical Techniques

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 350-385页

作者： Sudha Porte Veenu Joshi Kamal Shah nagendra singh chau.an Center for Basic Sciences Pt.Ravishankar Shukla UniversityRaipurChhattisgarhIndia Institute of Pharmaceutical Research GLA UniversityMathuraUttar PradeshIndia Drugs Testing Laboratory Avam Anusandhan KendraRaipurChhattisgarhIndia

The plant is a rich repository of useful secondary metabolites with profound medicinal ***,one type of bioactive compound,are amphitheatric glycosides with one and more hydrophilic sugar and hydrophobic steroidal and terpenoid *** former is known as steroidal saponin,and the latter is called terpenoid *** saponin is mostly distributed among monocotyledon families such as Asparagaceae,Amaryllidaceae,Dioscoreaceae,Smilacaceae,and *** though it is unusual,it could also be detected to some extent by dicotyledonous angiosperms,such as Plantaginaceae,Zygophyllaceae,Fabaceae,Asteraceae,and *** exhibits diverse pharmacological ability including antimicrobic,anti‑inflammatory,cAMP phosphodiesterase inhibitory,antiadipogenic,bactericide,cardioprotective,antitumor,antidiabetic,cytotoxic activity,antifungal,antiviral,antioxidant,and *** saponin timosaponin AIII from Anemarrhena asphodeloides has been found to possess antitumor ***,another steroidal sapogenin,has the potential of preventing neurological diseases by affecting different signaling pathways,increasing bone formation,and increasing antithrombotic *** A from Liriope platyphylla possesses anti‑inflammatory,antiasthma,and antiosteoclastogenic ***2 from Trillium tschonoskii exhibits anticancer *** cell cycle arrest and ROS‑dependent autophagy are induced by polyphyllin *** diverse biological activities of steroidal saponins are attributed to the variability of their structural *** of steroidal saponins in plant materials mainly utilizes classically and advances thin layer chromatography(TLC)on normal and reverses‑phase(high‑performance thin‑layer chromatography,densitometric TLC),gas chromatography,LC,UPLC,ultra‑high‑performance liquid chromatography(HPLC),supercritical fluid chromatography,and HPLC coupled to ultraviolet detector and diode array *** coupled with

关键词： Steroidal Saponins Glycosides Antitumour Antioxidant Analytical techniques

Pharmacological, Ethnomedicinal, and Evidence-Based Comparative Review of Moringa oleifera Lam.(Shigru) and Its Potential Role in the Management of Malnutrition in Tribal Regions of India, Especially Chhattisgarh

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World Journal of Traditional Chinese Medicine 2022年第3期8卷 314-338页

作者： Kishor Sonewane Sharda Swaroop Chouhan Mariappan Rajan nagendra singh chau.an Om Prakash Rout Awanish Kumar Gyanendra singh Baghel Prashant Kumar Gupta Department of Kaumarabhritya-Balaroga Shri NPA Government Ayurveda CollegeRaipurChhattisgarhIndia Department of Natural Chemistry Madurai Kamraj UniversityMaduraiTamil NaduIndia Drug Testing Lab Avam Anushandhan Kendra Department of AYUSHChhattisgarhIndia Department of Dravya Guna Shri NPA Government Ayurveda CollegeRaipurChhattisgarhIndia Department of Biotechnology National Institute of TechnologyRaipurChhattisgarhIndia

Moringa oleifera Lam.(Shigru)(Moringaceae family) is a traditional medicine used for control of diabetes, obesity, asthma, and cardiac,liver, gastrointestinal, infective, and brain disorders, such as depression and Alzheimer's disease. In Ayurvedic literature, Shigru is among few drugs having Balya(nourishing) as well as Medohara(antiobesity) property. This review focuses on valid connections between the properties documented in ancient literature and current pharmacological knowledge of Moringa, including pharmacological actions, phytochemistry,botanical description, and how Moringa can tackle malnutrition in India, especially Chhattisgarh. All information about M. oleifera was obtained from electronic scientific databases such as PubMed, Web of Science, Scopus, ScienceDirect, Elsevier, Google Scholar, Traditional Knowledge Digital Library, and Indian Traditional Books(Ancient Ayurveda literatures, The Wealth of India, and The Ayurvedic Formulary of India), postgraduate/doctoral thesis, and googling the keyword M. oleifera. M. oleifera have anti-oxidant, antimicrobial, anti-diabetic,anti-obesity, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, gastroprotective, wound-healing properties and it can potentially tackle malnutrition. This review describes the key information related to botanical description of M. oleifera, phytochemistry,pharmacological actions, clinical studies, toxicological studies, better utilization as food therapeutics, and ethnobotanical and evidence-based comparative review of M. oleifera. M. oleifera can effectively tackle malnutrition in India, especially Chhattisgarh. The authors emphasize the need for future in-depth ethnopharmacological lead-based research and clinical studies to expand M. oleifera pharmacological activities,clinical efficacy, and safety.

关键词： Ethnobotanical practices ethnomedicine Moringa oleifera phytochemicals pharmacological action

Investigation of Tablet Defects by AI Based Terahertz Technology

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Open Journal of Antennas and Propagation 2023年第2期11卷 26-35页

作者： nagendra P. Yadav Guozhen Hu Rakesh Kumar singh School of Electrical and Electronics Information Engineering Hubei Polytechnic University Huangshi China Shambhunath Institute of Engineering and Technology (SIET) Prayagraj India

Recently a lot of medical tablets with special packets in the global market are available. For the safety and purity of the tablet, we need to scan it by developed scanner technology, which should be not more expensive and easily available in the market. The THz technology is one of them. In the proposed work, we have tasted tablet images with the help of the THz super-resolution scanner, which is already available in our lab. The AI machine learning data concept has been investigated. Good resolution of images has been obtained. Furthermore, the challenging research problems are discussed. Finally, it summarizes the recent updates in terahertz technology for drug inspection and medical applications with potential research challenges.

关键词： THz Radiation Nano Drugs Tablets Sample Covid-19 Medical Application 3D Imaging Layer in Tablet AI

Influence of Withania somnifera on obsessive compulsive disorder in mice

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Asian Pacific Journal of Tropical Medicine 2012年第5期5卷 380-384页

作者： Bhanu PS Kaurav Manish M Wanjari Amol Chandekar nagendra singh chau.an Neeraj Upmanyu Department of Pharmacology R.K.D.F.College of PharmacyBhopal M.P.India Department of Pharmacology Central Research Institute(ay.) AmkhoGwaliorM.P.India Department of Pharmaceutical Sciences.Doctor Hari Singh Gour Vishwavidyalaya Sagar-470003(M.P.) India Department of Pharmaceutical Sciences Doctor Hari Singh Gour Vishwavidyalaya Sagar-470003(M.P.) India

Objective:To study the influence of methanolic and aqueous extract of Withania somnifera (***) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive ***:Mice were divided in different groups(n=6).Fluoxetine(5,10,15 mg/kg), (10,25,50,100 mg/kg) and melhanolic extract ***(MEWS)(10,25,50,100 mg/kg) were administered i.p.30 *** to the assessment of marble burying behavior and locomotor *** control group received vehicle of the ***:Administration of aqueous extracts ***(AEWS) and MEWS(50 mg/kg) successively decreaesed the marble burying behavior activity without affecting motor *** effect of AEWS and MEWS was comparable to standard fluoxetine,ritanserin and ***:*** extract is effective in treating obsessive compulsive disorder.

关键词： Withania somnifera Fluoxetine Ritanserin Parachlorophenylalanine Obsessive compulsive behavior

Plants Used as Antihypertensive

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Natural Products and Bioprospecting 2021年第2期11卷 155-184页

作者： Tarawanti Verma Manish Sinha Nitin Bansal Shyam Raj Yadav Kamal Shah nagendra singh chau.an I.K.Gujral Punjab Technical University(IKGPTU) JalandharPunjabIndia Laureate Institute of Pharmacy KathogJwalamukhiKangraHimachal PradeshIndia Department of Pharmacology ASBASJSM College of PharmacyBELARoparPunjabIndia Department of Chemistry S.P.Jain College(Veer Kunwar Singh UniversityAra)SasaramBiharIndia Institute of Pharmaceutical Research GLA UniversityNH#2MathuraUttar Pradesh 281406India Drugs Testing Laboratory Avam Anusandhan Kendra 1st Floor Govt.Ayurvedic Hospital BuildingGovt.Ayurvedic College Campus G.E.RoadRaipurChhattisgarh 492010India

Hypertension is a critical health problem and worse other cardiovascular *** is mainly of two types:Primary or essential hypertension and Secondary *** is the primary possibility feature for coronary heart disease,stroke and renal vascular *** medicines have been used for millions of years for the management and treatment of hypertension with minimum side *** aim to write this review is to collect information on the anti-hypertensive effects of natural herbs in animal studies and human involvement as well as to recapitulate the underlying mechanisms,from the bottom of cell culture and ex-vivo tissue *** to WHO,natural herbs/shrubs are widely used in increasing order to treat almost all the ailments of the human *** are the regular industrial units for the invention of chemical constituents,they used as immunity booster to enhance the natural capacity of the body to fight against different health prob-lems as well as herbal medicines and food products *** percent population of the world(around 5.6 billion people)consume medicines from natural plants for major health *** review provides a bird’s eye analysis primarily on the traditional utilization,phytochemical constituents and pharmacological values of medicinal herbs used to normalize hypertension *** sabdariffa,Allium sativum,Andrographis paniculata,Apium graveolens,Bidenspilosa,Camel-lia sinensis,Coptis chinensis,Coriandrum sativum,Crataegus spp.,Crocus sativus,Cymbopogon citrates,Nigella sativa,Panax ginseng,Salviaemiltiorrhizae,Zingiber officinale,Tribulus terrestris,Rauwolfiaserpentina,Terminalia arjuna etc.

关键词： Hypertension Antihypertensive herbs Blood pressure Vasodilatation Herbal medicines Blood pressure regulation

Genetic gains with genomic versus phenotypic selection for drought and waterlogging tolerance in tropical maize(Zea mays L.)

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The Crop Journal 2021年第6期9卷 1438-1448页

作者： Reshmi Rani Das Madhumal Thayil Vinayan Kaliyamoorthy Seetharam Manish Patel Ramesh Kumar Phagna Shyam Bir singh Jai Prakash Shahi Akashi Sarma nagendra Sarma Barua Raman Babu Pervez Haider Zaidi International Maize and Wheat Improvement Center(CIMMYT) ICRISAT CampusPatancheru 502324HyderabadIndia Main Maize Research Station Anand Agriculture UniversityAnand 388001GujaratIndia ICAR-Indian Institute of Maize Research Ludhiana141001BiharIndia Institute of Agricultural Sciences Banaras Hindu UniversityVaranasi 221005Uttar PradeshIndia Assam Agricultural University Jorhat 785013AssamIndia

Erratic rainfall often results in intermittent drought and/or waterlogging and limits maize(Zea mays L.)productivity in many parts of the Asian *** climate-resilient maize germplasm possessing tolerance to these key abiotic stresses without a yield penalty under optimal growing conditions is a challenge for breeders working in stress-vulnerable agro-ecologies in the *** stress-resilient maize for rainfed stress-prone ecologies is identified as one of the priority areas for CIMMYT-Asia maize *** applied rapid cycle genomic selection(RCGS)on two multiparent yellow synthetic populations(MYS-1 and MYS-2)to improve grain yield simultaneously under drought and waterlogging conditions using genomic-estimated breeding values(GEBVs).Also,the populations were simultaneously advanced using recurrent phenotypic selection(PS)by exposing them to managed drought and waterlogging and intermating tolerant plants from the two selection *** cycles per se(C1,C2,and C3)of the two populations developed using RCGS and PS approach and their test-cross progenies were evaluated separately in multilocation trials under managed drought,waterlogging,and optimal moisture *** genetic gains were observed with both GS and PS,except with PS in MYS-2 under drought and with GS in MYS-1 under *** genetic gains from GS were relatively higher under drought conditions(110 and 135 kg ha^(-1) year^(-1))compared to waterlogging(38 and 113 kg ha^(-1) year^(-1))in both MYS-1 and MYS-2,***,under waterlogging stress PS showed at par or better than GS as gain per year with PS was 80 and 90 kg ha^(-1),whereas with GS it was 90 and 43 kg ha^(-1) for MYS-1 and MYS-2,*** findings suggested that careful constitution of a multiparent population by involving trait donors for targeted stresses,along with elite highyielding parents from diverse genetic background,and its improvement using RCGS is an effe

关键词： Drought Genomic selection Maize Phenotypic selection Waterlogging

Enhanced thermoelectric performance in p-type ZrCoSb based half-Heusler alloys employing nanostructuring and compositional modulation

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Journal of Materiomics 2019年第1期5卷 94-102页

作者： nagendra S.chau.an Sivaiah Bathula Avinash Vishwakarma Ruchi Bhardwaj Kishor Kumar Johari Bhasker Gahtori Ajay Dhar Academy of Scientific&Innovative Research(AcSIR) CSIR-National Physical LaboratoryNew Delhi 110012India Division of Advanced Materials and Devices Metrology CSIR-National Physical LaboratoryDr.K.S.Krishnan MargNew Delhi 110012India

ZrCoSb based half-Heusler(HH)alloys have been widely studied as a p-type thermoelectric(TE)material for power generation applications in the mid-temperature ***,their intrinsically high thermal conductivity has been found to be detrimental for the improvement in their thermoelectric figure-of-merit(ZT),which presently is far below *** the current work,a state-of-the-art ZT~1.1 at 873 K was realized in an optimized composition of nanostructured Zr1-xHfxCoSb_(0.9)Sn_(0.1) HH alloys by employing compositional modulation ***-by-grain compositional variations,which leads to a substantial increase in its power factor coupled with a concurrent decrease in its thermal *** reduction in the phonon mean-free-path is observed on Hf substitution,which is comparable to the average crystallite size(~25 nm),thus leading to a very low thermal conductivity of~2.2Wm^(-1)K^(-1) at 873 K,which is amongst the lowest reported in HH *** TE device characteristics,estimated using cumulative temperature dependence model for quantitative evaluation of TE performance,yielded an output power density of~10 Wcm2 with a leg efficiency of~10%in the optimized composition of nanostructured Zr_(1-x)Hf_(x)CoSb_(0.9)Sn_(0.1) HH alloys,which is comparable to the reported efficiencies of other state-of-the-art TE materials.

关键词： Half Heuslers Iso-electronic Waste heat recovery Mid-temperature Efficiency Compositional modulation

A Comprehensive Transcriptome Assembly of Pigeonpea （Cajanus cajan L.） using Sanger and Second-Generation Sequencing Platforms

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Molecular Plant 2012年第5期5卷 1020-1028页

作者： Himabindu Kudapa Arvind K. Bharti Steven B. Cannon Andrew D. Farmer Benjamin Mulaosmanovi Robin Kramer Abhishek Bohra Nathan T. Weeks John A. Crow Reetu Tuteja Trushar Shah Sutapa Dutta Deepak K. Gupta Archana singh Kishor Gaikwad Tilak R. Sharma Gregory D. May nagendra K. singh Rajeev K. Varshney International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) Patancheru 502324 india National Center for Genome Resources (NCGR) Santa Fe NM 87505 USA United States Department of Agriculture-Agricultural Research Service (USDA-ARS) Corn Insects and Crop Genetics Research Unit Ames IA USA National Research Centre on Plant Biotechnology (NRCPB) Indian Agricultural Research Institute New Delhi 110 012 India Department of Agronomy Iowa State University Amens IA USA CGIAR Generation Challenge Programme (GCP) c/o ClMMYT 06600 Mexico DF Mexico

A comprehensive transcriptome assembly for pigeonpea has been developed by analyzing 128.9 million short Illumina GA IIx single end reads, 2.19 million single end FLX/454 reads, and 18 353 Sanger expressed sequenced tags from more than 16 genotypes. The resultant transcriptome assembly, referred to as CcTA v2, comprised 21 434 transcript as- sembly contigs （TACs） with an N50 of 1510 bp, the largest one being -8 kb. Of the 21 434 TACs, 16 622 （77.5%） could be mapped on to the soybean genome build 1.0.9 under fairly stringent alignment parameters. Based on knowledge of intron junctions, 10 009 primer pairs were designed from 5033 TACs for amplifying intron spanning regions （ISRs）. By using in silico mapping of BAC-end-derived SSR loci of pigeonpea on the soybean genome as a reference, putative mapping posi- tions at the chromosome level were predicted for 6284 ISR markers, covering all 11 pigeonpea chromosomes. A subset of 128 ISR markers were analyzed on a set of eight genotypes. While 116 markers were validated, 70 markers showed one to three alleles, with an average of 0.16 polymorphism information content （PIC） value. In summary, the CcTA v2 transcript assembly and ISR markers will serve as a useful resource to accelerate genetic research and breeding applications in pigeonpea.

关键词： Cajanus cajan (L.) second-generation sequencing transcriptome assembly intron spanning region (ISR)markers.