Influence of Withania somnifera on obsessive compulsive disorder in mice

作     者：Bhanu PS Kaurav Manish M Wanjari Amol Chandekar Nagendra Singh Chauhan Neeraj Upmanyu 

作者机构：Department of PharmacologyR.K.D.F.College of PharmacyBhopal M.P.India Department of PharmacologyCentral Research Institute(ay.) AmkhoGwaliorM.P.India Departmentof Pharmaceutical Sciences.Doctor Hari Singh Gour Vishwavidyalaya Sagar-470003(M.P.) India Department of Pharmaceutical SciencesDoctor Hari Singh Gour Vishwavidyalaya Sagar-470003(M.P.) India 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第5期

页      面：380-384页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：Withania somnifera Fluoxetine Ritanserin Parachlorophenylalanine Obsessive compulsive behavior 

摘      要：Objective:To study the influence of methanolic and aqueous extract of Withania somnifera (***) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive ***:Mice were divided in different groups(n=6).Fluoxetine(5,10,15 mg/kg), (10,25,50,100 mg/kg) and melhanolic extract ***(MEWS)(10,25,50,100 mg/kg) were administered i.p.30 *** to the assessment of marble burying behavior and locomotor *** control group received vehicle of the ***:Administration of aqueous extracts ***(AEWS) and MEWS(50 mg/kg) successively decreaesed the marble burying behavior activity without affecting motor *** effect of AEWS and MEWS was comparable to standard fluoxetine,ritanserin and ***:*** extract is effective in treating obsessive compulsive disorder.