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首届中日韩核医学会议

作者： nagara tamaki Hokkaido University Graduated School of Medicine Sapporo

＜正＞Prevalence of coronary artery disease has gradually increased in Asia. Nuclear Medicine has an important role for accurate diagnosis and management of this disease. Tc-99m perfusion imaging agents provided excellent myocardial perfusion images which may enhance diagnostic accuracy in the study of coronary artery disease. In addition, greater photon flux from the tracer permits simultaneous assessment of regional perfusion and function with use of ECG-gated SPECT. We applied gated perfusion SPECT both at rest and under low-dose dobutamine infusion to identify chronic ischemic myocardium. The findings in this study and correlated well with those under low-dose dobutamine echocardiography and FDG-PET on the basis of detection of reversible ischemic myocardium.

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OBSERVATION ON THE EFFECTS OF CHINESE MEDICINE ZHENXUANYIN FOR IMPROVING CEREBRAL BLOOD FLOW IN RATS WITH CEREBRAL ISCHEMIA

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Journal of Traditional Chinese Medicine 1997年第4期17卷 299-303页

作者：王静怡 Yasuhiro Magata Naoya Hattori Yoshiharu Yonekura nagara tamaki Fumiko Tanaka Junji Konishi Seok Rye Choi Shigeru Matsuzaki Department of Nuclear Medicine Faculty of Medicine Kyoto University Japan Chemistry Department of Radio Medicine Faculty of Pharmacy Kyoto University Japan Department of Neurological Internal Medicine Faculty of Medicine Kyoto University Japan Mailing Address of Jingyi Wang: Department of Neurological Internal Medicine Hospital of Traditional Chinese Medicine Xi'an 710001 China

Zhenxuanyin (镇眩饮) is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes’ complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03g kg, 0.3g kg, Ig kg, or 3g/ kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3g/ kg can increase cerebral blood flow (CBF) to the normal level.

关键词：镇眩饮

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Preoperative lymph node staging of oral cancer with FDG-PET

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中国口腔颌面外科杂志 2008年第B5期6卷 72-73页

作者： Yoshimasa Kitagawa Yutaka Yamazaki Hironobu Hata Ken-ichi Oral Notani nagara tamaki Oral Diagnosis and Medicine Oral Diagnosis and Medicine Hokkaido University Sapporo 060-8586 Japan Diagnosis and Medicine Oral Diagnosis and Medicine Nuclear Medicine Hokkaido University Sapporo 060-8586 Japan

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OBSERVATION OF THE EFFECTS OF ZHENXUANYIN ON CBF OF RATS WITH VERTEBROARTERIAL ISCHEMIA AND CBF OF HEALTHY RATS

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Journal of Pharmaceutical Analysis 1999年第2期13卷 133-136,141页

作者： Wang Jingyi,Yasuhiro MagataRadio Pharmacy Department, Faculty of Medicine in Kyoto University., Naoya Hattori  ,Seok Rye ChoiNeurology Department, Faculty of Medicine in Kyoto University., Yoshiharu Yonekura , nagara tamaki , Fumiko Tanaka Department of Neurology Xi'an Chinese Traditional Med. Hosp. Xi'an 710001 China

In order to observe the improvement effects of Zhenxuanyin (ZXY) to the rats vertebral artery infarction, it's prevention ability to the Pulsinelli's 4 vessel occlusion (4VO) rats model and it's influences to the normal rats brain. The infarction of the rats vertebral artery (vertebral 2 VO) and the 4VO rats model were achieved through electrocoagulation. 123 I IMP was used to trace cerebral blood flow (CBF). Except of cerebral cortex, the blood flow of each region decreased. Dosage of ZXY at 0 3 g/kg was able to normalize the decreased blood flows in cerebral regions. Healthy rats were medicated at a daily 0 3 g/kg and 1 g/kg dosage of ZXY. At the end of 1 week, they were made into 4VO model rats. No effective prevention effect was found. ZXY had no obvious effect on the CBF of normal rats. Vertebral 2 vessel occlusion is similar to clinical mild cerebral inefficient blood supply, therefore closer to the model of clinical VID. ZXY is able to normalize this incomplete compensation state, which is consistent with the curative effect on Pulsinelli's 4VO model rats. The best curative dosage of ZXY does not improve normal rats' CBF implied that ZXY used to cure regional cerebral ischemia at the acute stage does not dilate the cerebral blood vessel in the normal region, thus does not cause blood stealing in the brain 〔5〕 , Therefore, ZXY is an ideal CBF improving agent.

关键词： cerebral ischemia/TCM therapy vertebral 2VO Zhenxuanyin (ZXY) ^(123)I-IMP

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