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铁道勘测与设计 2006年第6期 41-44页

作者： Hidetoshi Honma Toshishige nagao 叶芹禄（译）杨铭（译）不详铁道第四勘察设计院设备处武汉430063

通过对远程监控系统、列车维护管理系统、车辆段管理系统和维护工作现代化系统的介绍，阐述了改善车辆段运营维护的方法与途径。

关键词：车辆段远程监控系统(rMS) 列车维护管理系统(MMS) 车辆段管理系统(DMS) 维护工作现代化系统

Portal vein thrombosis in liver cirrhosis

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World Journal of Hepatology 2014年第2期6卷 64-71页

作者： Nao Kinjo Hirofumi Kawanaka Tomohiko Akahoshi Yoshi-hiro Matsumoto Masahiro Kamori Yoshihiro nagao Naotaka Hashimoto Hideo Uehara Morimasa Tomikawa Ken Shirabe Yoshihiko Maehara Department of Surgery and Science Graduate School of Medical Sciences Kyushu University Department of Gastroenterological Surgery National Kyushu Cancer Center

Portal vein thrombosis(PVT) is considered to be a frequent complication of liver cirrhosis. However, unlike PVT in patients without cirrhosis, very few data are available on the natural history and management of PVT in cirrhosis, despite its association with potentially life-threatening conditions, such as gastroesophageal bleeding and acute intestinal ischemia. Moreover, no consensus regarding PVT in cirrhosis exists. Suggested causes of PVT in cirrhosis include reduced portal blood flow velocity, multiple congenital or acquired thrombophilic factors, inherited or acquired conditions, and derangement of liver architecture. However, the understanding of PVT in cirrhosis is incomplete. In addition, information on the management of PVT in cirrhosis is inadequate. The aims of this review are to:(1) assemble data on the physiopathological mechanism, clinical findings, diagnosis and management of PVT in cirrhosis;(2) describe the principal factors most frequently involved in PVT development; and(3) summarize the recent knowledge concerning diagnostic and therapeutic procedures.

关键词： Portal vein thrombosis Liver cirrhosis Thrombophilic factors Anticoagulation Splenectomy

Preliminary study of photodynamic diagnosis using 5-aminolevulinic acid in gastric and colorectal tumors

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World Journal of Gastroenterology 2015年第21期21卷 6706-6712页

作者： Munetaka Nakamura Jun Nishikawa Kouichi Hamabe Atsushi Goto Junichi Nishimura Hiroaki Shibata Misato nagao Sho Sasaki Shinichi Hashimoto Takeshi Okamoto Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine

AIM:To investigate the utility of photodynamic diagnosis(PDD) using 5-aminolevulinic acid(5-ALA) to detect gastric/colorectal ***:This prospective single-center study investigated inter-subject variability in patients with early-stage gastric/colorectal tumor indicated for endoscopic *** were patients with gastric or colorectal tumors who had undergone endoscopic resection between November 2012 and November *** criteria included age 20-80 years,either sex,and provision of informed *** were orally administered 20 mg/kg of 5-ALA enteric-coated capsules(SBI ALApromo Co.,Tokyo,Japan).Administration of5-ALA was followed by endoscopic resection of gastric or colorectal tumors,and the resected specimens were examined using a video autofluorescence processor and a fluorescence endoscope(SAFE-3000 and EB-1970 AK,respectively;Pentax,Tokyo,Japan).The primary endpoint was the presence of fluorescence in ***,macroscopic,and histopathologic findings of tumors were *** also evaluated adverse events of the present procedure as a secondary endpoint and examined each patient for the presence of known adverse effects of 5-ALA,namely,hematocytopenia,liver dysfunction,hypotension,nausea,and ***:We enrolled 10 patients(7 men,3 women)(n = 13 lesions:10 gastric/3 colorectal tumors).Fluorescence was detected in 7/13(53.8%) *** significant differences in sex(male:55.6%vs female:50.5%,P = 1.00),age(67.1 ± 1.9 years vs 65.0 ±2.0 years,P= 0.45),tumor color(reddish:60.0%vs discolored:33.3%,P = 0.56),tumor diameter(15.0± 2.1 mm vs 14.2 ± 2.3 mm,P= 0.80),macroscopic type(protruded:70.0%vs depressed 0%,P = 0.07),histologic type(differentiated type:58.3%vs 0%,P = 0.46),invasion depth(mucosal layer:55.6%vs submucosal layer:33.3%,P = 1.00),lymphatic invasion(present:33.3%vs absent:50.0%,P= 1.00),venous invasion(present:0%vs absent:54.5%,P= 1.00) or procedure time of endoscopic resection(36.3 ± 8.3 min v

关键词： Photodynamic diagnosis 5-aminolevulinicacid Protoporphyrin IX, Gastric tumor Colorectaltumor

首例由酒曲菌属非接合孢子引起的皮肤毛霉菌病

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 40-41页

作者： Fujimoto A. nagao K. Tanaka K. 刘艳 Department of Dermatology Keio University School of Medicine 35 ShinanomachiShinjuku-kuTokyo 160-8582 Japan

A rapidly enlarging leg ulcer appeared in a 54-year-old woman with systemic lupus erythematosus receiving aggressive immunosuppressive therapy. Skin biopsy revealed proliferation of hyphae in the midst of a neutrophilic abscess. Culture yielded rhizopus azygosporus. As no organ involvement was detected by thorough examination, the patient was diagnosed as having primary cutaneous mucormycosis. Although intravenous amphotericin B therapy seemed to be very effective, it had to be discontinued due to nephrotoxicity. She unfortunately died of subsequent disseminated fungal infection and cerebral infarction in which the primary cause could not be determined. Minimum inhibitory concentrations of several antifungal drugs to the isolate were examined and amphotericin B proved to be the only agent that may potentially reach the effective plasma concentration. This is the first case report of cutaneous mucormycosis caused by r. azygosporus.

关键词：皮肤毛霉菌病接合孢子酒曲菌属播散性真菌感染嗜中性皮肤活检系统性红斑狼疮二性霉素粒细胞浸润抗真菌药物

Association between the Consumption of Carbonated Beverages and Out-of-Hospital Cardiac Arrests of Cardiac Origin in Japan

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World Journal of Cardiovascular Diseases 2015年第12期5卷 361-372页

作者： Masaki Tokunaga Yasunori Suematsu Shin-ichiro Miura Takashi Kuwano Atsushi Iwata Hiroaki Nishikawa Bo Zhang Naohiro Yonemoto Hiroshi Nonogi Ken nagao Takeshi Kimura Keijiro Saku Department of Cardiology Fukuoka University School of Medicine Fukuoka Japan The AIG Collaborative research Institute of Cardiovascular Medicine Fukuoka University Fukuoka Japan Department of Biochemistry Fukuoka University School of Medicine Fukuoka Japan Department of Epidemiology and Biostatistics National Center of Neurology and Psychiatry Tokyo Japan Hospital Deputy Shizuoka General Hospital Shizuoka Japan Department of Cardiology Resuscitation and Emergency Cardiovascular Care Surugadai Nihon University Hospital Nihon University School of Medicine Tokyo Japan Department of Cardiovascular Medicine Graduate School of Medicine Kyoto University Kyoto Japan

Background: The consumption of carbonated beverages has been shown to increase the risk of developing metabolic syndrome. The associations between the consumption of carbonated beverages and left arterial dimension or left ventricular mass are believed to be likely related to the greater body weight of carbonated beverage drinkers relative to non-drinkers. Nonetheless, little is known about the association between the consumption of carbonated beverages and out-of-hospital cardiac arrests (OHCAs) in Japan. Methods: We compared the age-adjusted incidence of OHCAs to the expenditures on various beverages per person between 2005 and 2011 in the 47 prefectures of Japan. Patients who suffered from OHCAs of cardiac and non-cardiac origin were enrolled in All-Japan Utstein registry of the Fire and Disaster Management Agency. The expenditures on various beverages per person in the 47 prefectures in Japan were obtained from data published by the Ministry of Health, Labour and Welfare of Japan. results: There were 797,422 cases of OHCA in the All-Japan Utstein registry between 2005 and 2011, including 11,831 cases who did not receive resuscitation. Among these 785,591 cases of OHCA, 435,064 (55.4%) were classified as cardiac origin and 350,527 (44.6%) were non-cardiac origin. Non-cardiac origin included cerebrovascular disease, respiratory disease, malignant tumor, and exogenous disease (4.8%, 6.1%, 3.5%, and 18.9%, respectively). The expenditures on carbonated beverages were significantly associated with OHCAs of cardiac origin (r = 0.30, p = 0.04), but not non-cardiac origin (r = -0.03, p = 0.8). Expenditures on other beverages, including green tea, tea, coffee, cocoa, fruit or vegetable juice, fermented milk beverage, milk beverage, and mineral water, were not significantly associated with OHCAs of cardiac origin. Conclusion: Carbonated beverage consumption was significantly and positively associated with OHCAs of cardiac origin in Japan, indicating that beverage habits mi

关键词： Out-of-Hospital Cardiac Arrest Utstein registry Carbonated Beverage Ecological Study

Historical Cohort Study of the Efficacy and Safety of Piperacillin/Tazobactam Versus Fourth-Generation Cephalosporins for Empirical Treatment of Febrile Neutropenia in Patients with Hematological Malignancies

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International Journal of Clinical Medicine 2011年第1期2卷 18-22页

作者： Takashi Saito Tatsuo Ichinohe Junya Kanda Miki nagao Shunji Takakura Yutaka Ito Yoshitsugu Iinuma Kouhei Yamashita Tadakazu Kondo Takayuki Ishikawa Takashi Uchiyama Satoshi Ichiyama 不详

We retrospectively evaluated the efficacy and safety of the combination drug piperacillin/tazobactam (PIPC/TAZ) in comparison with those of fourth-generation cephalosporins (4th Cephs) as initial empirical treatment in hematological malignancies patients with febrile neutropenia (FN). Among 200 patients assessed in this study, 49 had received PIPC/TAZ and 151 4th Cephs. Patient background characteristics were comparable between the two treatment groups. The overall efficacy rate in those receiving 4th Cephs and PIPC/TAZ was 57.0% (86/151 patients) and 59.2% (29/49 patients), respectively, with no significant difference detected between the two treatment regimens (P = 0.78). Treat-ment did not need to be discontinued or interrupted due to development of adverse drug reactions in any of the patients. Therefore in this study the efficacy and safety of PIPC/TAZ as initial antimicrobial treatment for FN in patients with hematological malignancies were not inferior to those of 4th Cephs. Based on the preliminary data obtained in this study, we propose to conduct a multicenter, prospective, controlled study to compare PIPC/TAZ versus CFPM given as empirical antimicrobial treatment against FN in patients with hematological malignancies.

关键词： Febrile Neutropenia Piperacillin/Tazobactam Fourth-Generation Cephalosporins Safety Efficacy

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对VAN方法信号识别判据的独立检验

世界地震译丛 1997年第3期28卷 4-8页

作者： T.nagao M.Uyeshima S.Uyeda 卢军国家地震局地球物理研究所

为了检验VAN研究组对地震电信号(SES)识别所提出的判据的普遍性,我们对原始VAN地电位记录作了独立检验。(1)确认了艾奥尼纳(IOA)台3个月(1988年7月19日至10月18日)共338个异常变化。在应用VAN判据后,仅8个异常变化幸存下来作为可能的地... 详细信息

为了检验VAN研究组对地震电信号(SES)识别所提出的判据的普遍性,我们对原始VAN地电位记录作了独立检验。(1)确认了艾奥尼纳(IOA)台3个月(1988年7月19日至10月18日)共338个异常变化。在应用VAN判据后,仅8个异常变化幸存下来作为可能的地震电信号,其中7个异常与VAN研究组当时发布的成功预报所用异常相同。(2)对IOA台28.5个月(1988年4月30日至1990年9月15日)进行了类似的检验。从3000多个异常变化中挑选41个变化作为可能的地震电信号。在这期间,VAN研究组共发布18次预报;VAN小组所用地震电信号中的14个变化与我们挑选的地震电信号是完全相同的,而4个变化我们认为是干扰。在两组资料中,共同的地震电信号一般要更强些。

关键词： VAN法信号识别判据独立检验地震电信号

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c9,t11-共轭亚油酸异构体的分离纯化

河北农业大学学报 2007年第3期30卷 101-104页

作者：杨丽华永尾寿浩内蒙古农业大学生物工程学院内蒙古呼和浩特010018 大阪市立工业研究所

为进一步研究c9,t11-共轭亚油酸的生理生化特性,需获得高纯度的c9,t11-共轭亚油酸异构体。利用假丝酵母脂肪酶两步选择性酯化可以提高c9,t11-共轭亚油酸异构体的含量。采用分子蒸馏装置来分离纯化大量样品,最后得到纯度92.2 wt%的c9,t11... 详细信息

为进一步研究c9,t11-共轭亚油酸的生理生化特性,需获得高纯度的c9,t11-共轭亚油酸异构体。利用假丝酵母脂肪酶两步选择性酯化可以提高c9,t11-共轭亚油酸异构体的含量。采用分子蒸馏装置来分离纯化大量样品,最后得到纯度92.2 wt%的c9,t11-共轭亚油酸。

关键词：假丝酵母脂肪酶共轭亚油酸分离纯化分子蒸馏

多西紫杉醇和卡铂联合治疗晚期或复发宫颈癌:一项初步研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第7期1卷 41-42页

作者： nagao S. Fujiwara K. Oda T. 战媛 Dept. of Obstetrics and Gynecology Kawasaki Medical School 577 Matsushima Kurashiki- City 701- 0192 Japan

Objectives. This is a pilot study for a future trial to assess the efficacy and safety of combination chemotherapy with docetaxel and carboplatin in advanced or recurrent uterine cervix cancer. Methods. The patients eligible for this study had histologically confirmed, advanced (stage IB2- IV) or recurrent uterine cervix cancer. Eligible patients had measurable lesions and must have sufficient bone marrow, renal, and liver functions. Docetaxel was administered intravenously (IV) at 60 mg/m2 followed by IV carboplatin administration based on AUC = 6. Chemotherapy was repeated in 1- 6 courses depending on the purpose of the therapy. The response was evaluated based on rECIST criteria. The toxicity grade was determined by NCI- CTC version 2. results. During January 2001 and April 2004, 17 patients were entered in this study. The distribution of stage was IB2, 3; IIB, 8; IIIB, 3; IVB, 1; recurrent, 2. There were 9 squamous cell carcinomas, 6 adenocarcinomas, 1 adenosquamous cell carcinoma, and 1 small cell carcinoma. The overall response rate was 76% (2 Cr, 11 Pr, and 4 SD). No progression of disease was observed. All 5 adenocarcinoma patients in the neoadjuvant chemotherapy group responded including 1 pathological Cr. The incidences of grade 3/4 toxicities were 76% for neutrocytopenia, 12% for thrombocytopenia, and 6% for anemia. No grade 3/4 neurotoxicity was observed. Conclusions. The combination of docetaxel and carboplatin is an effective and safe treatment for uterine cervix cancer. Further evaluation particularly targeted on cervical adenocarcinoma is warranted.

关键词：联合化疗新辅助化疗小细胞癌腺鳞癌静脉给药毒性反应鳞状细胞癌肾功能神经毒性可测量

Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine

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World Journal of Gastroenterology 2015年第1期21卷 177-186页

作者： Toshihide Ueda ryota Hokari Masaaki Higashiyama Yuichi Yasutake Koji Maruta Chie Kurihara Kengo Tomita Shunsuke Komoto Yoshikiyo Okada Chikako Watanabe Shingo Usui Shigeaki nagao Soichiro Miura Department of Internal Medicine National Defense Medical CollegeSaitama 359-8513Japan

AIM: To investigate the effect of a fat rich diet onnon-steroidal anti-inflammatory drug(NSAID)-induced mucosal damage in the murine small ***: C57BL6 mice were fed 4 types of diets with or without *** group was fed standard laboratory *** other groups were fed a fat diet consisting of 8% w/w fat,beef tallow(rich in SFA),fish oil,(rich in omega-3 PUFA),or safflower oil(rich in omega-6 PUFA).Indomethacin(3 mg/kg) was injected intraperitoneally from day 8 to day *** day 11,intestines and adhesions to submucosal microvessels were ***: In the indomethacin-treated groups,mucosal damage was exacerbated by diets containing beef tallow and fish oil,and was accompanied by leukocyte infiltration(P r in mice fed the safflower oil diet than in mice fed the beef tallow or fish oil diet(P reased monocyte and platelet migration to the intestinal mucosa,whereas safflower oil significantly decreased monocyte and platelet recruitment(P rich in SFA and omega-3 PUFA exacerbated NSAID-induced small intestinal damage via increased leukocyte ***,a diet rich in omega-6-PUFA did not aggravate inflammation as monocyte migration was blocked.

关键词： Non-steroidal anti-inflammatory drugs Small intest