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Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years： from the Korean Transradial Intervention Prospective Registry

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Journal of Geriatric Cardiology 2017年第2期14卷 81-86页

作者： Hoyoun Won Wang Soo Lee Sang-Wook Kim Byung Ryul Cho young Jin youn young-Hyo Lim Min-Ho Lee Jae-Hwan Lee Seung-Woon Rha Cardiovascular & Arrhythmia Center Chung-Ang University Hospital Chung-Ang University College of Medieine Seoul South Korea Division of Cardiology Kangwon National University Hospital Chuncheon South Korea Division of Cardiology Yonsei University Wonju College of Medicine Wonju South Korea Division of Cardiology College of Medicine Hanyang University Seoul South Korea Department of Cardiology Soonchunhyang University College of Medicine Seoul South Korea Department of Cardiology Chungnam National University Hospital Daejeon South Korea Department of Cardiology Korea University Guro Hospital Seoul South Korea

Background Radial artery access for coronary procedures is a safe and beneficial technique. However, elderly patients have been considered as a higher risk group of access site related complications compared to younger patients. This study was conducted to investigate the feasibility and safety oftransradial coronary angiography or intervention in the elderly. Methods A total of 6132 patients from Korean Transradial Intervention Prospective Registry at 20 centers were analyzed. Patients were divided into the non-elderly group （n = 5667） and the elderly （_〉 80 years） group （n = 465）. Using propensity score matching, the elderly group （n = 465） was compared with one-to-one matched the non-elderly group （n = 465）. Results After propensity score matching, mean age was 64.3 ＋ 10.3 years in the non-elderly group and 83.5 -4- 3.3 years in the elderly group. There was no difference of procedural characteristics, procedural and fluoroscopic times. Access site cross-over rate was not different between the non-elderly group and elderly group （7.5% vs. 6.2%, P = 0.074）. Bleeding compli- cations occurred similarly in two groups （2.6% of the non-elderly group vs. 1.9% of the elderly group, P -~ 0.660）. Access site complications were 1.9% of the non-elderly group and 0.9% of the elderly group （P = 0.263）. Both of in hospital death and cardiovascular death for one year were also similar between two groups. Conclusions Transradial angiography or intervention was safe and feasible in elderly patients. Complication rates and clinical outcomes in elderly patients were comparable with those in non-elderly patients.

关键词： The elderly patients Transmdial coronary angiography Transradial coronary intervention

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Colonic lipoma covered by hyperplastic epithelium: Case report

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World Journal of Clinical Cases 2013年第3期1卷 124-127页

作者： Ju-Ok Yeom Sun-young Kim Eun-Chul Jang Ji-youn Yu Eun Deok Chang young-Seok Cho Division of Gastroenterology Department of Internal MedicineUijeongbu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea Departement of Cilinical Pathology Uijeong-bu St. Mary’s Hospitalthe Catholic University of Korea College of MedicineUijeongbu 480-717South Korea

Colonic lipomas are submucosal nonepithelial tumors covered by intact or eroded mucosa. In rare cases, alterations in the mucosa covering a lipoma include hyperplasia, adenoma, atrophy, ulceration, and necrosis. Here, we report a case of a colonic lipoma covered by hyperplastic epithelium in a 68-year-old woman. Based on the colonoscopy findings, a snare polypectomy was performed for a presumptive diagnosis of an epithelial lesion; however, the histological examination revealed a colonic submucosal lipoma with overlying hyperplastic epithelium.

关键词： Lipoma Colonic lipomas Hyperplastic Colonoscopy

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Risk factors of electrocoagulation syndrome after esophageal endoscopic submucosal dissection

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World Journal of Gastroenterology 2018年第10期24卷 1144-1151页

作者： Dae Won Ma young Hoon youn Da Hyun Jung Jae Jun Park Jie-Hyun Kim Hyojin Park Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

AIM To investigate post endoscopic submucosal dissection electrocoagulation syndrome(PEECS) of the *** We analyzed 55 consecutive cases with esophageal endoscopic submucosal dissection for superficial esophageal squamous neoplasms at a tertiary referral hospital in South Korea. Esophageal PEECS was defined as "mild" meeting one of the following criteria without any obvious perforation: fever(≥ 37.8 ℃), leukocytosis(> 10800 cells/μl), or regional chest pain more than 5/10 points as rated on a numeric pain intensity scale. The grade of PEECS was determined as "severe" when meet two or more of above *** We included 51 cases without obvious complications in the analysis. The incidence of mild and severe esophageal PEECS was 47.1% and 17.6%, respectively. Risk factor analysis revealed that resected area, procedure time, and muscle layer exposure were significantly associated with PEECS. In multivariate analysis, a resected area larger than 6.0 cm^2(OR = 4.995, 95%CI: 1.110-22.489, P = 0.036) and muscle layer exposure(OR = 5.661, 95%CI: 1.422-22.534, P = 0.014) were independent predictors of esophageal PEECS. All patients with PEECS had favorable outcomes with conservative management approaches, such as intravenous hydration or *** Clinicians should consider the possibility of esophageal PEECS when the resected area exceeds 6.0 cm^2 or when the muscle layer exposure is noted.

关键词： Electrocoagulation Endoscopic submucosal dissection Esophageal neoplasm Syndrome

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Effects of torrefied wood chip and vermicompost application on vegetation growth and nutrient uptake in the Saemangeum reclaimed land

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Ecological Processes 2020年第1期9卷 74-82页

作者： Aung Aung Jeong Min Seo Si Ho Han Ji young An Huong Thi Thuy Dao Woo Bin youn Byung Bae Park Department of Environment and Forest Resources College of Agriculture and Life SciencesChungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Environmental Conservation Department Ministry of Natural Resources and Environmental ConservationNaypyitaw 15011Myanmar Institute of Agricultural Science College of Agriculture and Life SciencesChungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea.

Background:In reclaimed land,the growth environment for plants may be unfavorable and the initial establishment and growth of seedlings could be limited because of low nutrient and water *** and control of understory vegetation that competes with seedlings may be of help in ameliorating soil physical and chemical properties,resulting in better seedling growth and reclamation ***,the amount of nutrients understory vegetation absorbs in this ecological process has been rarely ***,we aimed to investigate the effect of soil amendment on biomass production and nutrient uptake by weeds in the nutrient-poor reclaimed *** applied three levels of torrefied wood chip(TWC;0,2.5,and 5 Mg ha^(−1))and two levels of vermicompost(VC;0 and 2.7 Mg ha^(−1))as soil physical improvements and organic soil amendments in reclaimed land in the Republic of Korea,with Populus euramericana used as the crop ***:TWC did not influence weed biomass,but 2.7 Mg ha^(−1) VC significantly increased weed biomass by 21%compared to 0 Mg ha^(−1) VC ***(N),phosphorus(P),potassium(K),calcium(Ca),magnesium(Mg),and sodium(Na)concentrations in weeds were the highest in control,but there was no statistical difference among ***,VC treatment did marginally increase nutrient uptake in weeds,especially P,K,Ca,and *** treatments influenced crop tree ***:We conclude that VC can be used as an organic source of nutrients in reclaimed soil and that weed management is necessary to increase treatment effects on crop trees in this salt-affected reclaimed land.

关键词： Nutrient content Populus euramericana Saemangeum Soil amendment Weed biomass

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An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats

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Neural Regeneration Research 2014年第14期9卷 1351-1357页

作者： Ji Yeong Kim Woo Joo Jeon Dong Hwee Kim Im Joo Rhyu young Hwan Kim Inchan youn Jong Woong Park Department of Orthopedic Surgery Seoul Paik HospitalInje UniversitySeoulKorea Department of Orthopedic Surgery Korea UniversitySeoulKorea Department of Physical Medicine & Rehabilitation KoreaUniversitySeoulKorea Department of Anatomy Korea UniversitySeoulKorea Biomedical Research Center Korea Institute of Science and TechnologySeoulKorea

Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with plateletrich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.

关键词： nerve regeneration peripheral nerve injury sciatic nerve platelet-rich plasma in-side-out vein autografi myelinated axons axon diameter myelin sheath thickness histology sciaticnerve index neural regeneration

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Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

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Nano Research 2015年第7期8卷 2340-2350页

作者： Doo-Won Lee Jinhwan Lee II Yung Sohn Bo-Yeong Kim young Min Son Hunyoung Bark JaehyuckJung Minseok Choi Tae Hyeong Kim Changgu Lee nae-Eung Lee Department of Advanced Materials Science & Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Department of Mechanical Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST) Sungkyunkwan University Suwon Gyeonggi-do 440-746 Republic of Korea New Materials Team Future Device R&D Department LG Electronics Advanced Research Institute Seou1137-724 Republic of Korea These authors contributed equally to this work.

A field-effect transistor （FET） with two-dimensional （2D） few-layer MoS2 as a sensing-channel material was investigated for label-free electrical detection of the hybridization of deoxyribonucleic acid （DNA） molecules. The high-quality MoS2-channel pattern was selectively formedthrough the chemical reaction of the Mo layer with H2S gas. The MoS2 FET was very stable in an electrolyte and inert to pH changes due to the lack of oxygen-containing functionalities on the MoS2 surface. Hybridization of single-stranded target DNA molecules with single-stranded probe DNA molecules physically adsorbed on the MoS2 channel resulted in a shift of the threshold voltage （Vt,） in the negative direction and an increase in the drain current. The negative shift in Vth is attributed to electrostatic gating effects induced by the detachment of negatively charged probe DNA molecules from the channel surface after hybridization. A detection limit of 10 fM, high sensitivity of 17 mWdec, and high dynamic range of 106 were achieved. The results showed that a bio-FET with an ultrathin 2D MoS2 channel can be used to detect very small concentrations of target DNA molecules specifically hybridized with the probe DNA molecules.

关键词： two-dimensional(2D)materials, MoS2,field-effect transistor, biosensor,deoxyribonucleic acid (DNA) hybridization

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Dietary sophorolipid accelerates growth by modulation of gut microbiota population and intestinal environments in broiler chickens

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Journal of Animal Science and Biotechnology 2022年第1期13卷 256-264页

作者： Min-Jin Kwak Min-young Park Yong-Soon Choi Junghwan Cho Duleepa Pathiraja Jonggun Kim Hanbae Lee In-Geol Choi Kwang-youn Whang Department of Biotechnology Korea University145 Anam-roSeoul 02841Republic of Korea Pathway Intermediates Seoul 02841Republic of Korea

Background:Gut is a crucial organ for the host’s defense system due to its filtering action of the intestinal membrane from hazardous foreign *** strategy to strengthen the gut epithelial barrier function is to upregulate beneficial microflora populations and their ***(SPL),which is a glycolipid biosurfactant,could increase beneficial microflora and decrease pathogenic bacteria in the gastrointestinal ***,herein,we conducted an experiment with broiler chickens to investigate the fortifying effects of SPL on the host’s gut defense system by modulating the microbiota ***:A total of 5401-day-old chicks(Ross 308)were used,and they were immediately allotted into three treatment groups(6 replications with 30 chicks/pen)according to their initial body *** dietary treatments consisted of CON(basal diet),BAM(10 mg/kg bambermycin),and SPL(10 mg/kg SPL).During the experiment,birds freely accessed feed and water,and body weight and feed intake were measured at the end of each *** d 35,birds(one bird/pen)were sacrificed to collect jejunum and cecum ***:Dietary SPL and BAM supplementation significantly accelerated birds’growth and also significantly improved feed efficiency compared to *** microbial community was significantly separated by dietary SPL supplementation from that of CON,and dietary SPL supplementation significantly increased Lactobacillus *** Akkermansia ***,birds fed with dietary SPL also showed the highest concentration of cecal butyrate among all treatment *** morphological analysis showed that dietary SPL significantly increased villus height,ratio of villus height to crypt depth,goblet cell numbers,and the gene expression levels of claudin-1 and mucin ***,dietary SPL significantly decreased the mRNA expression level of pro-inflammatory cytokine,interleukin-6,and increased that of anti-inflammatory cytokine,interleukin-10,compared

关键词： Broilers Gut microbiota Gut morphology Local inflammation Mucus barrier Sophorolipids

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Serial evaluation of myocardial function using the myocardial performance index in Kawasaki disease

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World Journal of Pediatrics 2018年第3期14卷 259-268页

作者： Eun Song Song Somy Yoon Joo Hyun Cho Eun Mi Yang Hwa Jin Cho young youn Choi Jae Sook Ma Gwang Hyeon Eom young Kuk Cho Department of Pediatrics Chonnam National University HospitalChonnam National University Medical School42 Jebong-roDong-guGwangju 501-757South Korea Department of Pharmacology and Medical Research Center for Gene Regulation Chonnam National University Medical School160 Baekseo-roDong-guGwangju 61469South Korea Department of Pediatrics KS HospitalGwangjuSouth Korea

Background Kawasaki disease (KD) is known as systemic vasculitis, and more than half of the patients with KD have myo-carditis, which can induce ventricular dysfunction. In this study, we evaluate left ventricular (LV) dysfunction in patients with KD based on the myocardial performance index (MPI) using pulse Doppler (PD) and tissue Doppler imaging (TDI), from the acute to convalescent phases. Methods We retrospectively studied 89 children diagnosed with KD from January 2010 to August 2012. We assessed the presence of coronary artery lesions (CALs) and the LV ejection fraction, PD-MPI, and TDI-MPI at diagnosis, and 2, 14, and 56 days after intravenous immunoglobulin (IVIG) treatment. We enrolled 70 healthy children as a control group. Results The ejection fraction in patients with KD at diagnosis (67.3 ± 0.9%) was lower than that in the control group (69.8 ± 0.8%,P = 0.035), and the LV TDI-MPIs for patients with KD at diagnosis (0.49 ± 0.01) and 2 days after IVIG treatment (0.48 ± 0.01) were higher than those in the control group (0.45 ± 0.01,P = 0.002,P = 0.033, respectively). No signifi cant diff erences were found in the LV dysfunction between the patients with complete and incomplete KD. Septal TDI-MPIs in patients with KD with CAL at diagnosis (0.52 ± 0.02) were higher than those in patients with KD without CAL (0.47 ± 0.01,P = 0.019). Conclusions Transient LV dysfunction occurred in patients with complete and incomplete KD in the acute stage. In patients with KD with CAL at diagnosis, the LV dysfunction was more prominent. The PD-MPI and TDI-MPI are useful parameters for assessing LV function in patients with KD.

关键词： Kawasaki disease Myocardial function Myocardial performance index Tissue Doppler imaging

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Gastric choriocarcinoma admixed with an α-fetoprotein-producing adenocarcinoma and separated adenocarcinoma

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World Journal of Gastroenterology 2009年第40期15卷 5106-5108页

作者： Bang Wool Eom So-youn Jung Hongman Yoon Myeong-Cherl Kook Keun Won Ryu Jun Ho Lee young-Woo Kim Center for Gastric Cancer National Cancer Center

We report a case of gastric choriocarcinoma admixed with an α-fetoprotein (AFP)-producing adeno-carcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomywith D2 lymph node dissection and Billroth gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-producing adenocarcinoma and separated adenocarcinoma. At 2 wk postoperatively, his human chorionic gonadotropin and AFP levels had reduced and six cycles of adjuvant chemotherapy were initiated. No recurrence or distant metastasis was observed at 4 years postoperatively.

关键词： α-fetoproteins Adenocarcinoma Choriocarcinoma Stomach neoplasms

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Performance of Weibull function as a diameter distribution model for Pinus thunbergii stands in the eastern coast of South Korea

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Journal of Mountain Science 2016年第5期13卷 822-830页

作者： ABINO Azyleah Canizares KIM Sung Yong LUMBRES Roscinto Ian Canicosa JANG Mi Na youn Ho doong PARK Ki Hyung LEE young Jin Department of Forest Resources Kongju National UniversityYesanChungnam 340-802South Korea Laguna Lake Development Authority DilimanQuezon City 1101Philippines College of Forestry Benguet State UniversityLa TrinidadBenguet2601Philippines Division of Forest Disaster Management Korea Forest Research InstituteSeou1130-712South Korea

This study was carried out to determine the performance of percentile-based Weibull diameter distribution model for Pinus thunbergii stands thriving along the eastern coast of South Korea. The parameter recovery technique was used to estimate the three parameters of the Weibull model. The analysis demonstrated satisfactory results based on the following test statistics for the principal percentile models： fit index （FI） range from 0.501（minimum diameter） to 0.932 （50th diameter percentiles） and root mean square error （RMSE） range from 0.112 （quadratic mean diameter） to 3.572 （minimum diameter）. The developed model was further evaluated by determining the mean bias （E） in trees per ha （TPH） for each diameter class, and the results showed highest over-prediction in the 20 cm, and under-prediction in the x6 cm and 24 cm diameter classes. The goodness of fit tested by Kolmogorov- Smirnov （KS） test showed no significant differences （P〉0.05） between the observed and predicted diameter distributions for almost all plots. Using site index and aboveground biomass （AGB） models developed for P. thunbergii in South Korea, a model to predict the AGB per ha for each diameter class and subsequently the total AGB of the stand was created. An application guide was also created, which will serve as a decision-support tool for forest managers in quantifying the future total AGB in P. thunbergii stands located in the eastern coast of South Korea and, subsequently, the quantification of potential carbon stocks aside from being a vital input in designing efficient management and protection strategies for these stands.

关键词： Aboveground biomass Weibull distribution Parameter recovery technique Site index Pinus thunbergii Diameter distribution

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