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A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

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Frontiers in Biology 2016年第3期11卷 256-259页

作者： m. A. Bottelier A. Schrantee g. van Wingen H. g. Ruhe m. B. de Ruiter L. Reneman Department of Child-andAdolescentPsychiatry Triversum Alkmaar The Netherlands Brain Imaging Center Academic Medical Center University of Amsterdam Amsterdam The Netherlands Department of Radiology Academic Medical Center Amsterdam The Netherlands Department of Psychiatry Academic Medical Center Amsterdam The Netherlands Program for mood and Anxiety Disorders Department of Psychiatry University Medical Center Groningen University of GroningenGroningen The Netherlands

Treatment of adolescents with antidepressants may induce an increased risk for suicidality in this population. The activity of the amygdala during processing of emotional faces with functional magnetic Resonance Imaging （fmRI） is a well-known measure of emotional dysregulation. Based upon data of our prematurely ended randomized clinical trial with fluoxetine （NTR3103） in anxious and or depressed girls （12-14 years of age） we calculated that with the found effect size of r = 0.66, compared to placebo, only 8 subjects are heeded to demonstrate increased amygdala activity following 16 weeks of treatment with fluoxetine.

关键词： amygdala reactivity SSRI adverse effects anxiety depression

<i>In Vitro </i>Effects of Oil’s Fatty Acids on T-Cell Function of Obese men

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Food and Nutrition Sciences 2017年第2期8卷 277-293页

作者： Asmaa meraou Hafida merzouk Amel saidi Amel medjdoub Sid Ahmed merzouk mohamed Bénali Slimane Belbraouet Laboratory of Physiology Physiopathology and Biochemistry of Nutrition Department of Biology Faculty of Natural and Life Sciences Earth and Universe University of Abou-Bekr Belka&#239 d Tlemcen Algeria Laboratory of Biotoxicology Djilali Liabes University Sidi Bel Abbès Algeria Department of Technical Sciences Faculty of Engineering University of Abou-Bekr Belka&#239 d Tlemcen Algeria école de Nutrition Université de Moncton New Brunswick Canada

Background: Dietary fatty acids have important homeostatic functions in regulating the immune response and may exert beneficial effects on immune alterations during obesity. Objective: To assess the in vitro effects of oil fatty acids, different oils (olive, linseed, Nigel, sunflower) were tested on T-lymphocyte proliferation, Th1- and Th2-type cytokine production, and intracellular oxidant/antioxidant status in obese patients. methods: Peripheral blood lymphocytes were isolated using Histopaque and were in vitro cultured and stimulated by Con A in the presence or absence of the oils. Cell proliferation, interleukin-2, interleukin-4 and interferon-γ (INFγ) secretions and intracellular oxidative status (glutathione (gSH), malondialdehyde (mDA), carbonyl protein levels, catalase activity and micronuclei frequency) were investigated. Results: Abnormalities in lymphocyte function and intracellular oxidative stress were observed in obesity. Linseed oil induced a reduction in T-lymphocyte proliferation and IL-2 production while Nigel oil increased them in both obese and control groups. In addition, Nigel oil enhanced IFNγ and IL-4 secretion. Olive and sunflower oils had no effect on lymphocyte proliferation and cytokine secretion in both groups. Linseed and Nigel oils induced an increase in T cell gSH concentrations and catalase activity with a concomitant decrease in mDA, carbonyl protein contents and micronuclei frequency especially in obese patients. Conclusion: Linseed and Nigel oils had beneficial effects on lymphocyte proliferation, cytokines secretions and redox status, while olive and sunflower oils had no effects on immune cell function in obesity.

关键词： Obesity Lymphocytes Olive Oil Linseed Oil Nigel Oil Sunflower Oil Cytokines Oxidant/Antioxidant Status

Temperature and Pressure Behaviours of methanol, Acetonitrile/Water mixtures on Chromatographic Systems

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American Journal of Analytical Chemistry 2011年第8期2卷 934-937页

作者： Talal Aburjai muhammed alzweiri Yusuf m. al-Hiari 不详

Temperature and pressure were shown to vary significantly with solvent mixing, showing maxima at differ-ent solvent ratios. Acetonitrile/water mixing resulted in temperature reduction of solutions whereas metha-nol/water mixing caused temperature increases. On the other hand, maximum recorded chromatographic pressure of acetonitrile:water mixtures occurred at a solvent ratio of 1:6 compared with methanol:water, which showed a maximum pressure at a solvent ratio of 1:1. These findings can be of use in stabilizing re-tention time shifts during HPLC-based studies associated with compound identification based on retention time such as analysis of complex mixtures.

关键词： Retention Time Pressure Temperature methanol and Acetonitrile

Anti-inflammatory effects of mangifera indica *** in a model of colitis

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World Journal of gastroenterology 2010年第39期16卷 4922-4931页

作者： Lucía márquez Beatriz g Pérez-Nievas Icíar gárate Borja garcía-Bueno José Lm madrigal Luis menchén gabino garrido Juan C Leza Department of Pharmacology School of MedicineUniversity Complutense and Centro de Investigación en Red de Salud Mental(CIBERSAM) Pharmaceutical Chemistry Center and University of La Habana Health Research Institute Hospital 12 de Octubre(I+12) gastroenterology Service Hospital General Universitario Gregorio Maraón and CIBEREHD Department of Chemistry and Pharmacy University Católica del Norte

AIm:To investigate the effect of aqueous extract from mangifera indica L.(mIE)on dextran sulfate sodium (DSS)-induced colitis in ***:mIE(150 mg/kg)was administered in two different protocols:(1)rectally,over 7 d at the same time as DSS administration;and(2)once daily over 14 d (by oral gavage,7 d before starting DSS,and rectally for 7 d during DSS administration).general observations of clinical signs were ***-inflammatory activity of mIE was assessed by myeloperoxidase(mPO)activity. Colonic lipid peroxidation was determined by measuring the levels of thiobarbituric acid reactive substances (TBARS).Reduced glutathione(gSH)levels,expression of inflammatory related mediators[inducible isoforms of nitric oxide synthase(iNOS)and cyclooxygenase (COX)-2,respectively]and cytokines[tumor necrosis factor(TNF)-αand TNF receptors 1 and 2]in colonic tissue were also ***(IL)-6 and TNF-α serum levels were also measured. RESULTS:The results demonstrated that mIE has anti-inflammatory properties by improvement of clinical signs,reduction of ulceration and reduced mPO activity when administered before *** addition,administration of mIE for 14 d resulted in an increase in gSH and reduction of TBARS levels and iNOS,COX-2, TNF-αand TNF R-2 expression in colonic tissue,and a decrease in IL-6 and TNF-αserum levels. CONCLUSION:mIE has anti-inflammatory activity in a DSS-induced rat colitis model and preventive administration(prior to DSS)seems to be a more effective protocol.

关键词： Oxidative stress Ulcerative colitis Inflammation Polyphenols mangifera indica Antioxidants

Viability of Bifidobacteria in frozen yogurt made from camel milk

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Journal of Agricultural Science and Technology 2009年第8期3卷 17-21页

作者： A. A. m. metwalli al-Saleh, A. A. Department of Food Science and Nutrition King Saud University Riyadh 11451 Saudi Arabia

The purpose of this research was to incorporate Bifidobacterium angulatum and Bifidobacterium infantis in frozen fermented dairy desserts made from camel or cow milk and to determine their viability during freezing and storage at .20℃. To meet this objective, ice cream mixtures were formulated using camel or cow milk constituents, inoculated with regular yogurt starter （Lactobacillus delbruecldi ssp bulgaricus and streptococcus thermophilus） and incubated at 42℃ till a pH value of 5.0 was attained. The fermented mixes were heated to 80℃ for 5 min in water bath to inhibit yogurt organisms. Bifidobacteria were then added at 2 g/kg mix （1 gram from each Bifidobacterium strain）. The results showed that the initial counts of Bifidobacteria before freezing were 7.3 × 10^8 and 7.1 × 108 cfu/g for camel and cow mix respectively and decreased to 1.06× 10^8 and 1.1×10^8 in the same order （about 0.8 log reduction in the count of Bifidobacteria was observed） after freezing and storage for one day. No significant changes in counts of Bifidobaeteria were found during storage at -20℃ for 17 weeks. Changes in pH and titratable acidity were also studied. No significant changes in titratable acidities of frozen yogurt made from camel or cow milk constituents during storage period were observed.

关键词： Bifidobacteria: viability: camel milk: frozen yogurt

Biomechanical mechanisms for chronic discogenic back pain

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中华物理医学与康复杂志 2012年第12期34卷 910-910页

作者： Stefanakis m al-Abbasi m Harding I

BACKgROUND AND PURPOSE:Closely linked to discogenic back pain are annulus fissures and the ingrowth of nerves and blood *** fluid pressure normally extends from the nucleus into the inner and middle annulus,it would be expected to collapse any blood *** pressure within a fissure could,therefore,provide a route for ingrowth of blood vessels and *** addition,proteoglycans have been shown to inhibit the growth of *** loss of proteoglycans from within an annulus fissure may therefore increase their attractiveness to ingrowing vessels and *** study was designed to better understand whether fissures in the annulus of degenerated human discs are conducive to the ingrowth of nerves and blood ***:Cadaveric and surgically removed discs were used to per-

关键词：物理医学康复医学临床 mETHODS

Exploring the dynamics of a Holling-Tanner model with cannibalism in both predator and prey population

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International Journal of Biomathematics 2018年第1期11卷 225-253页

作者： aladeen al Basheer Rana D. Parshad Emmanuel Quansah Shengbin Yu Ranjit Kumar Upadhyay mathematics Department The University of Georgia 240A Riverbend Rd Athens GA 30602 USA Department of mathematics Clarkson University Potsdam New York 13699 USA Pacific Source Health PlansSpringfield Oregon 97477 USA Department of Basic Teaching and ResearchYango University Fuzhou Fujian 350015 P. R. China Department of Applied mathematicsIndian Institute of Technology (ISm) Dhanbad 826004 Jharkhand India

Cannibalism is an intriguing life history trait, that has been considered primarily in the predator, in predator-prey population models. Recent experimental evidence shows that prey cannibalism can have a significant impact on predator-prey population dyna- mics in natural communities. motivated by these experimental results, we investigate a ratio-dependent Holling-Tanner model, where cannibalism occurs simultaneously in both the predator and prey species. We show that depending on parameters, whilst prey or predator cannibalism acting alone leads to instability, their joint effect can actually stabilize the unstable interior equilibrium. Furthermore, in the spatially explicit model, we find that depending on parameters, prey and predator cannibalism acting jointly can cause spatial patterns to form, while not so acting individually. We discuss ecologicalconsequences of these findings in light of food chain dynamics, invasive species control and climate change.

关键词： Holling-Tanner model prey cannibalism predator cannibalism stability global attraction Turing instability.

Elaboration and validation of Crohn's disease anoperineal lesions consensual definitions

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World Journal of gastroenterology 2017年第29期23卷 5371-5378页

作者： Clémence Horaist Vincent de Parades Laurent Abramowitz Paul Benfredj guillaume Bonnaud Dominique Bouchard nadia Fathallah Agnès Sénéjoux Laurent Siproudhis ghislain Staumont manuelle Viguier Philippe marteau Department of Digestive Disease Centre Hospitalier Intercommunal Le Raincy-Montfermeil Department of Proctology Hopital Saint-Joseph Institut Léopold Bellan Department of Proctology and Digestive Diseases University Hospital Bichat Department of Digestive Diseases Clinique des Cèdres Department of Proctology Hopital Bagatelle Department of Proctology Centre Hospitalier Privé Rennes de Saint-Grégoire Department of Digestive Diseases Pontchaillou University Hospital Department of Proctology Clinique St Jean Languedoc AP-HP H0pital Saint Louis Dermatology and Denis Diderot-Paris 7 University Sorbonne Universités UPMC Univ Paris 06 75005 Paris France INSERm-ERL 1157 CHU Saint-Antoine 27 75012 Paris France CNRS UMR7203 75012 Paris France APHP Hépatologie et Gastroentérologie Hopital Saint Antoine

To establish consensual definitions of anoperineal lesions of Crohn’s (APLOC) disease and assess interobserver agreement on their diagnosis between experts. mETHODSA database of digitally recorded pictures of APLOC was examined by a coordinating group who selected two series of 20 pictures illustrating the various aspects of APLOC. A reading group comprised: eight experts from the Société Nationale Française de Colo Proctologie group of study and research in proctology and one academic dermatologist. all members of the coordinating and reading groups participated in dedicated meetings. The coordinating group initially conducted a literature review to analyse verbatim descriptions used to evaluate APLOC. The study included two phases: establishment of consensual definitions using a formal consensus method and later assessment of interobserver agreement on the diagnosis of APLOC using photos of APLOC, a standardised questionnaire and Fleiss’s kappa test or descriptive statistics. RESULTSTerms used in literature to evaluate visible APLOC did not include precise definitions or reference to definitions. most of the expert reports on the first set of photos agreed with the main diagnosis but their verbatim reporting contained substantial variation. The definitions of ulceration (entity, depth, extension), anal skin tags (entity, inflammatory activity, ulcerated aspect), fistula (complexity, quality of drainage, inflammatory activity of external openings), perianal skin lesions (abscess, papules, edema, erythema) and anoperineal scars were validated. For fistulae, they decided to follow the American gastroenterology Association’s guidelines definitions. The diagnosis of ulceration (κ = 0.70), fistulae (κ = 0.75), inflammatory activity of external fistula openings (86.6% agreement), abscesses (84.6% agreement) and erythema (100% agreement) achieved a substantial degree of interobserver reproducibility. CONCLUSIONThis study constructed consensual definitions of APLOC and the

关键词： Crohn’s disease Anoperineal lesions Fistula Interobserver agreement

Proteomics:Concepts and applications in human medicine

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World Journal of Biological Chemistry 2021年第5期12卷 57-69页

作者： Safa al-Amrani Zaaima al-Jabri Adhari al-Zaabi Jalila alshekaili murtadha al-Khabori Department of microbiology and Immunology Sultan Qaboos UniversityMuscat 123Oman Department of Human and Clinical Anatomy Sultan Qaboos UniversityMuscat 123Oman Department of microbiology and Immunology Sultan Qaboos University HospitalMuscat 123Oman of Hematology Sultan Qaboos UniversityMuscat 123Oman

Proteomics is the complete evaluation of the function and structure of proteins to understand an organism’s *** spectrometry is an essential tool that is used for profiling proteins in the ***,biomarker discovery remains the major challenge of proteomics because of their complexity and ***,combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease ***,most studies have investigated a small part of the proteins in the *** review highlights the types of proteomics,the available proteomic techniques,and their applica-tions in different research fields.

关键词： Proteomics Biomarker mass spectrometry Two-dimensional electrophoresis Drug discovery