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ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development

Journal of Integrative Plant Biology 2015年第12期57卷 1089-1098页

作者： Valentina Cecchetti Patrizia Brunetti nadia napoli Laura Fattorini Maria Maddalena Altamura Paolo Costantino Maura Cardarelli IBPM-CNR Institute of Molecular Biology and Pathology National Research Council Sapienza University of Rome Department of Biology and Biotechnology Sapienza University of Rome Department of Environmental Biology Sapienza University of Rome

Arabidopsis abcbl abcb19 double mutants defective in the auxin transporters ABCB1/PGP1 and ABCB19/PGP19 are altered in stamen elongation, anther dehiscence and pollen maturation. To assess the contribution of these transporters to stamen development we performed phenotypic, histological analyses, and in situ hybridizations on abcbl and abcbl9 single mutant flowers. We found that pollen maturation and anther dehiscence are precocious in the abcbl but not in the abcb19 mutant. Accordingly, endothecium ligniflcation is altered only in abcbl anthers. Both abcbl and abcb1 abcb19 stamens also show altered early development, with asynchronous anther Iocules and a multilayer tapetum. DAPI staining showed that the timing of meiosis is asynchronous in abcbl abcb19 anther Iocules, while only a small percentage of pollen grains are non- viable according to Alexander＇s staining. In agreement, TAM （TARDY ASYNCHRONOUS MEIOSIS）, as well as BAM2 （BARELY ANY MERISTEM）involved in tapetal cell development--areoverexpressed in abcbl abcb19 young flower buds. Corre- spondingly, ABCB1 and ABCB19 mRNA localization supports the observed phenotypes of abcbl and abcbl abcb19 mutant anthers. In conclusion, we provide evidence that auxin transport plays a significant role both in early and late stamen development： ABCB1 plays a major role during anther development, while ABCB19 has a synergistic role.

关键词： Anther development Arabidopsis auxin transport endothecium lignification tapetum differentiation

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Non-invasive prenatal testing can detect silent cancers in expecting mothers

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Genes & Diseases 2024年第2期11卷 585-588页

作者： Alessandro Ottaiano Monica Ianniello nadia Petrillo Mariachiara Santorsola Luigia De Falco Salvatore Giovanni Castaldi Maria Antonietta Castaldi Valentina Giudice Carmine Selleri Giovanni Savarese Unit of Innovative Therapies for Abdominal Metastases Istituto Nazionale Tumori di NapoliIRCCS “G.Pascale”Via Mariano SemmolaNapoli 80131Italy AMES Centro Polidiagnostico Strumentale SRLVia Padre Carmine Fico 24Casalnuovo Di Napoli 80013Italy Specialization School of Clinical Pathology Università degli Studi di SalernoVia Giovanni Paolo II 132Fisciano 84084Italy Unit of High-Risk Pregnancy and Prenatal Diagnosis University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Hematology and Transplant Center University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Department of Medicine Surgery and Dentistry“Scuola Medica Salernitana”Via Salvador Allende 43Baronissi 84081Italy

Pregnancy is a unique physiological state in which several changes *** of the most important aspects is the maternal immune system,which sets to tolerate the presence of thedeveloping fetus(a semi-allogeneic organism),while at the same time providing protection against pathogens.1 Pregnancy has long been known to affect the risk of certain cancers including breast cancer in the short term,gestational trophoblastic disease(GTD),cervical cancer,and melanoma.2,3 The reasons for the increased risk of these cancers during pregnancy are not fully understood,but several hypotheses have been proposed as the hormonal and immune system changes.

关键词： mother cancers fetus

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Limb lengthening with PRECICE magnetic nail in pediatric patients: A systematic review

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World Journal of Orthopedics 2021年第8期12卷 575-583页

作者： Giulia Masci Osvaldo Palmacci Raffaele Vitiello nadia Bonfiglio Maria Beatrice Bocchi Valerio Cipolloni Giulio Maccauro Enrico Pola Department of Orthopaedics and Traumatology Fondazione Policlinico Universitario A.Gemelli IRCCSRome 00168Italy Policlinico di napoli University Hospital Universitàdella Campania Luigi Vanvitelli School of MedicineNapoli 80100Italy

BACKGROUND Limb lengthening techniques play an increasingly important role in the pediatric orthopedic *** principles of the osteogenesis distraction bonded traditionally with external fixators;however,the recent deployment of fully implantable systems has been able to overcome severities related to external *** PRECICE®is an implantable limb lengthening intramedullary nail system that is remotely controlled and magnetically *** To review the current literature available on this matter in order to assess the PRECICE clinical and radiological outcomes and its possible complications in a population of pediatric patients undergoing limb *** Only five studies met the inclusion criteria and were consequently included in the review for a total of 131 patients and 135 *** clinical and radiological outcomes of interest were:the main lengthening obtained,the distraction rate,the period of time to full weight bearing,the consolidation index,and the Association for the Study and Application of Methods of Ilizarov *** In conclusion,data collected from the articles under investigation were comparable with the exception of the consolidation ***,the study population was too small and the patients’follow-up was too short to make definitive *** This review shows that the PRECICE Nail System is still a therapeutic challenge in limb lengthening for pediatric orthopedic surgeons;however,careful preoperative planning and an accurate surgical technique could allow the correction of more complex deformities with a low rate of complications.

关键词： Limbs lengthening PRECICE Nail Pediatric Dysmetria Deformities

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Gelatin-biofermentative unsulfated glycosaminoglycans semi-interpenetrating hydrogels via microbial-transglutaminase crosslinking enhance osteogenic potential of dental pulp stem cells

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Regenerative Biomaterials 2021年第3期8卷 110-123页

作者： Annalisa La Gatta Virginia Tirino Marcella Cammarota Marcella La Noce Antonietta Stellavato Anna Virginia Adriana Pirozzi Marianna Portaccio nadia Diano Luigi Laino Gianpaolo Papaccio Chiara Schiraldi Dipartimento di Medicina Sperimentale Universita`della Campania“Luigi Vanvitelli”via L.De Crecchio 7Naples 80138Italy Dipartimento Multidisciplinare di Specialita’Medico-Chirurgiche e Odontoiatriche via Luigi De Crecchio6Napoli 80138Italy

Gelatin hydrogels by microbial-transglutaminase crosslinking are being increasingly exploited for tissue engineering,and proved high potential in bone *** study aimed to evaluate,for the first time,the combination of enzymatically crosslinked gelatin with hyaluronan and the newly developed biotechnological chondroitin in enhancing osteogenic *** enzymatic crosslinking was carried out in the presence of hyaluronan or of a hyaluronan–chondroitin mixture,obtaining semi-interpenetrating *** latter proved lower swelling extent and improved stiffness compared to the gelatin matrix alone,whilst maintaining high *** heteropolysaccharides were retained for 30 days in the hydrogels,thus influencing cell response over this *** evaluate the effect of hydrogel composition on bone regeneration,materials were seeded with human dental pulp stem cells and osteogenic differentiation was *** expression of osteocalcin(OC)and osteopontin(OPN),both at gene and protein level,was evaluated at 7,15 and 30 days of *** electron microscopy(SEM)and two-photon microscope observations were performed to assess bone-like extracellular matrix(ECM)deposition and to observe the cell penetration *** the presence of the heteropolysaccharides,OC and OPN expression was upregulated and a higher degree of calcified matrix formation was *** with hyaluronan and chondroitin improved both the biophysical properties and the biological response of enzymatically crosslinked gelatin,fastening bone deposition.

关键词： hydrogels gelatin hyaluronan biotechnological chondroitin bone regeneration human dental pulp stem cells

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Influence of dietary hydrogenated palm oil supplementation on serum biochemistry and progesterone levels in dairy goats

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Animal Nutrition 2019年第3期5卷 286-289页

作者： Raffaella Tudisco nadia Musco Maria E.Pero Valeria M.Morittu Micaela Grossi Vincenzo Mastellone Gina Cavaliere Metha Wanapat Federico Infascelli Pietro Lombardi Department of Veterinary Medicine and Animal Production University of Naples Federico IINapoli80137Italy Department of Health Science University Magna Graecia of CatanzaroCatanzaro88100Italy Department of Biology University of Naples Federico IINapoli80134Italy Tropical Feed Resources Research and Development Center(TROFREC) Department of Animal ScienceFaculty of AgricultureKhon Kaen UniversityKhonKaen40260Thailand

The aim of this research was to investigate the influence of hydrogenated palm oil(HPO)added to a dairy goat diet on serum biochemistry and progesterone *** pregnant Cilentana dairy goats were equally divided into 2 groups(control [CTR]and HPO groups).After kidding,concentrated feed for both groups was gradually increased up to 400 g/(animal d).and the HPO group received 50 g/(animal·d)of *** with HPO significantly increased cholesterol levels(mg/dL, 63.80 vs.54.68 at 30 d.P<0.05;78.20 vs.58.00 at 60 d.P<0.05;83.80 vs.57.83 at 120 d.P<0.01)compared with the CTR group although no significant differences were detected for liver and kidney function ***,other biochemical parameters were not affected by HPO supplementation thus suggesting no change occurred in lipid and protein ***,a significant correlation was found between progesterone levels and serum cholesterol(r = 0.65,P≤0.01)although these were not significantly higher in HPO supplemented *** dose and time of HPO supplementation appears critical as regards assessing the limits between the risks and benefits of HPO supplementation in dairy *** the tested *** was well tolerated by the animals and may represent a useful tool to increase energy availability during highly demanding periods.

关键词： Goat Hydrogenated palm oil Metabolism Progesterone

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