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Sex-Dependent Glial Signaling in Pathological Pain:Distinct Roles of Spinal Microglia and Astrocytes

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neuroscience Bulletin 2018年第1期34卷 98-108页

作者： Gang Chen Xin Luo M.Yawar qadri Temugin Berta Ru-Rong Ji Department of Anesthesiology Duke University Medical Center Key Laboratory of neuroregeneration of Jiangsu and the Ministry of Education Co-Innovation Center of Neuroregeneration Nantong University Pain Research Center Department of AnesthesiologyUniversity of Cincinnati Medical Center Department of neurobiology Duke University Medical Center

Increasing evidence suggests that spinal micro- glia regulate pathological pain in males. In this study, we investigated the effects of several microglial and astroglial modulators on inflammatory and neuropathic pain follow- ing intrathecal injection in male and female mice. These modulators were the microglial inhibitors minocycline and ZVEID （a caspase-6 inhibitor） and the astroglial inhibitors L-α-aminoadipate （L-AA, an astroglial toxin） and car- benoxolone （a connexin 43 inhibitor）, as well as U0126 （an ERK kinase inhibitor） and D-JnKI-1 （a c-Jun n-terminal kinase inhibitor）. We found that spinal administration of minocycline or ZVEID, or Caspase6 deletion, reduced formalin-induced inflammatory and nerve injury-induced neuropathic pain primarily in male mice. In contrast, intrathecal L-AA reduced neuropathic pain but not inflam- matory pain in both sexes. Intrathecal U0126 and D-JnKI- 1 reduced neuropathic pain in both sexes. nerve injury caused spinal upregulation of the astroglial markers GFAP and Connexin 43 in both sexes. Collectively, our data confirmed male-dominant microglial signaling but also revealed sex-independent astroglial signaling in the spinal cord in inflammatory and neuropathic pain.

关键词： Astrocytes - Microglia Sex difference Spinal cord

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一种新型被动扑翼的流固耦合实验研究

一种新型被动扑翼的流固耦合实验研究

Growth Pattern and Morphological Variation of Labeo calbasu Found in Indus River, Sindh-Pakistan

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作者：唐辉 M.n.Mumtaz qadri 赵福旺香港理工大学机械工程系

本文通过水洞实验研究了一种新型的、可从水流中萃取能量的被动扑翼机构及其复杂的流固耦合现象。首先我们设计并建造了一个能在水洞里运行的实验装置。这个装置的主要部件是一个可同时进行升沉和俯仰、具有两个自由度的水翼。该水翼能... 详细信息

本文通过水洞实验研究了一种新型的、可从水流中萃取能量的被动扑翼机构及其复杂的流固耦合现象。首先我们设计并建造了一个能在水洞里运行的实验装置。这个装置的主要部件是一个可同时进行升沉和俯仰、具有两个自由度的水翼。该水翼能够仅在水流的驱动下进行周期性的升沉和俯仰运动,从而实现了将水流的动能转换成水翼的机械能。在雷诺数约为10的条件下,我们测量了该水翼的运动和受力,并研究了它们之间的关系。并且,我们还研究了水翼的几个重要参数的影响:升沉幅度,俯仰幅度和柔性变形。本研究让我们对该新型能量萃取装置的动力特性有了更深的理解,为下一步进行流场定量测量和进一步改进该装置提供了指导。

关键词：被动扑翼清洁能源流固耦合

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Journal of Fisheries Science 2019年第2期1卷 20-25页

作者： Sumeera Malik Ayaz Hussain.qadri M.Y.Laghari P.K.Lashari Hameeda Kalhoro A.R.Khooharo n.T.narejo Department of Zoology University of SindhJamshoroPakistan Department of Freshwater Biology and Fisheries University of SindhJamshoroPakistan Centre of Excellence in Marine Biology University of KarachiSindhPakistan

The present work reports the length–weight relationships(LWR)and condition factor relationships for Labeo calbasu collected from Upstream(Matyari)Kotri barrage at,River Indus,Pakistan,because stock assessment helps the fisheries managers to conserve the commercially important *** characters of fish as well as Length-weight relationship are an important tool for fishery *** results of LWR(W=aLb),for L *** negative allometric growth *** and condition factor relationships were found significantly correlated.A total of 200 and 190 specimens from upstream and downstream were collected,*** assessed values of length-weight correlation and condition factor were calculated as Kn=39.663(LeCren),and K=11.915(Fulton)for upstream and Kn=44.066 and K=13.872 for ***-weight was found with a strong correlation of n=2.892,a=0.0235 with r2=0.934 for upstream population then the downstream *** results of this work would be beneficial for sustainable management as well as fishery managers.

关键词： Labeo calbasu LWR Condition factor Growth pattern

<i>In Vitro</i>Plant Regeneration of <i>Morus indica</i>L. cv. V1 Using Leaf Explant

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American Journal of Plant Sciences 2013年第10期4卷 2001-2005页

作者： Melur Kodandaram Raghunath Karaba n. nataraja Jyothi Sainath Meghana Radha Sivarajan Sajeevan Mala V. Rajan Syed Mashayak Hussaine qadri Central Sericultural Research and Training Institute Srirampura Mysore India Department of Crop Physiology University of Agricultural Sciences GKVK Bangalore India.

Adventitious bud induction and plantlet regeneration were studied in a popular mulberry variety, V1 using leaf as an explant. Fully expanded leaf explants were cultured on Murashige and Skoog’s (MS) medium supplemented with thidiazuron (TDZ) (0.5-4.0 mg/l), 6-benzylaminopurine (BAP) (0.5-2.0 mg/l), indole acetic acid (IAA) (2.0 mg/l), gibberlic acid (GA3) (1.0-2.0 mg/l) silver nitrate (AgnO3) (2.0 mg/l) and different carbon sources such as sucrose, fructose and glucose (10%-30%) either individually or in combination to induce adventitious buds and regeneration. The highest percentage (63%) of adventitious bud formation and regeneration (68%) was achieved in the medium containing MS with TDZ (1.0 mg/l), IAA (2.0 mg/l) and AgnO3 (2.0 mg/l). For subsequent regeneration and shoot elongation the MS medium having BAP (1.0 mg/l), GA3 (2.0 mg/l) and AgnO3 (2.0 mg/l) was found to be suitable. Amongst the carbon sources tested, the most suitable carbon source was found to be sucrose (3%) followed by fructose (2%) for adventitious bud formation. Excised in vitro shoots were rooted (60%-80%) in half strength MS medium supplemented with indole-3-butyric acid (1.0 mg/l). The well rooted plantlets were hardened in soil + sand + farm yard manure (FYM) mixture with a success rate of 70%-90%. Since in vitro regeneration is highly genotype-dependent in mulberry, the standardized protocol can be effectively used for further improvement of this leading genotype using biotechnological approaches.

关键词： In Vitro Regeneration Adventitious Bud Thidiazuron Mulberry cv. V1 Carbon Source

Characterization of optimal resting tension in human pulmonary arteries

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World Journal of Cardiology 2016年第9期8卷 553-558页

作者： Azar Hussain Robert T Bennett Mubarak A Chaudhry Syed S qadri Mike Cowen Alyn H Morice Mahmoud Loubani Department of Cardiothoracic Surgery Castle Hill Hospital Centre for Cardiovascular and Metabolic Research Hull York Medical SchoolCastle Hill Hospital

AIM To determine the optimum resting tension(ORT) for in vitro human pulmonary artery(PA) ring *** Pulmonary arteries were dissected from disease free sections of the resected lung in the operating theatre and tissue samples were directly sent to the laboratory in Krebs-Henseleit solution(Krebs).The pulmonary arteries were then cut into 2 mm long *** rings were mounted in 25 m L organ baths or 8 m L myograph chambers containing Krebs compound(37 ℃,bubbled with 21% O_2:5% CO_2) to measure changes in isometric *** resting tension was set at 1-gram force(gf) with vessels being left static to equilibrate for duration of one *** contractile reactions to 40 mmol/L KCl were obtained from a resting tension of 1 *** reactions to 40 mmol/L KCl were then obtained from stepwise increases in resting tension(1.2,1.4,1.6,1.8 and 2.0 gf).RESULTS Twenty PA rings of internal diameter between 2-4 mmwere prepared from 4 *** human PA rings incrementing the tension during rest stance by 0.6 gf,up to 1.6 gf significantly augmented the 40 mmol/L KCl stimulated *** enhancement of active tension by 0.4 gf,up to 2.0 gf mitigate the 40 mmol/L KCl stimulated *** Myograph and the organ bath demonstrated identical conclusions,supporting that the radial optimal resting tension for human PA ring was 1.61 *** The radial optimal resting tension in our experiment is 1.61 gf(15.78 m n) for human PA rings.

关键词： Pulmonary hypertension Pulmonary artery Optimal resting tension Pulmonary artery rings Human

Phosphorous and Foliar Applied nitrogen Improved Productivity and Quality of Potato

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American Journal of Plant Sciences 2015年第1期6卷 144-149页

作者： Rashid Waseem Khan.qadri Imran Khan Muhammad Muzammil Jahangir Umair Ashraf Ghufrana Samin Ammara Anwer Muhammad Adnan Mohsin Bashir Institute of Horticultural Sciences University of Agriculture Faisalabad Pakistan Department of Agronomy University of Agriculture Faisalabad Pakistan Department of Crop Science and Technology College of Agriculture South China Agricultural University Guangzhou China University of Engineering and Technology (Lahore) Faisalabad Campus Faisalabad Pakistan

Growth, yield and quality of potato are greatly affected by its nutritional management. Foliar application of urea reduces nitrogen losses and increases plant nitrogen use efficiency. This study was therefore planned to evaluate the effect of soil applied phosphorus (DAP) and foliar application of nitrogenous fertilizer (urea) on growth, yield and quality of potato. Experiment was comprised of four different treatments of phosphorus (DAP, 46% P) and nitrogen (urea, 46% n) including a control. Treatments were T0 (DAP 160 + Urea 300 kg/acre), T1 (DAP 160 + Urea 5 kg/acre), T2 (DAP 100 + Urea 6 kg/acre) and T3 (DAP 120 + Urea 8 kg/acre). DAP fertilizer was given as basal dressing at the time of sowing. Foliar applications of nitrogenous fertilizer (urea) were given after 30 of sowing with one week interval in five split doses. Results indicated that T3 remained better regarding productivity and quality of potato. The overall fertilizer efficacy regarding yield and quality was: T3 > T2 > T1 > T0. However, Vitamin C was found maximum in T0.

关键词： nitrogen Potato Tuber Phosphorous Quality Yield

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磷酸二酯酶3A与动脉高血压

中华高血压杂志 2020年第7期28卷 623-623页

作者：周卫(译) 叶鹏(摘/审校) Ercu M MarkóL Schachterle C Tsvetkov D Cui Y Maghsodi S Theda UP.Bartolomaeus Maass PG Zühlke K Gregersen n Hübner n Hodge R Mühl A Pohl B Molé-Illas R Geelhaar A Walter S napieczynska H Schelenz S Taube M Heuser A Anistan YM qadri F Todiras M Plehm R Popova E Langanki R Eichhorst J Lehmann M Wiesner B Russwurm M Forslund SK Kamer I Müller Dn Gollasch M Aydin A Bohring S Bader M Luft FC Klussmann E 不详

高血压是全球心血管病死亡的主要危险因素。高血压伴短指(趾)畸形综合征在临床上类似于耐盐性原发性高血压,常导致患者在50岁之前因脑卒中而死亡。然而,最近研究者应用磷酸二酯酶3A(phosphodiesterase 3A,PDE3A)编码基因技术进行体内遗... 详细信息

高血压是全球心血管病死亡的主要危险因素。高血压伴短指(趾)畸形综合征在临床上类似于耐盐性原发性高血压,常导致患者在50岁之前因脑卒中而死亡。然而,最近研究者应用磷酸二酯酶3A(phosphodiesterase 3A,PDE3A)编码基因技术进行体内遗传缺陷模型研究,显示突变体PDE3A并未参与其中作用。方法:通过遗传图谱,测序,转基因技术.

关键词：动脉高血压遗传缺陷心血管病原发性高血压主要危险因素脑卒中转基因技术遗传图谱