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Phytochemical analysis, antioxidant, acetylcholinesterase, and α-amylase inhibitors from Hippeastrum hybridum extract

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Journal of Traditional Chinese Medicine 2024年第3期44卷 496-504页

作者： Naila Sher Mushtaq Ahmed nadia Mushtaq Department of Biotechnology University of Science and Technology Department of Botany University of Science and Technology

OBJECTIVE:To investigate the effects of Hippeastrum hybridum（HH） as a free radical scavenger,and an inhibitor of the two enzymes i-e Alpha-amylase（α-amylase） and acetylcholinesterase（AChE）.METHODS:In this study,HH plant was preliminary analyzed for phytochemical screening and then tested for its antioxidant,anti-α-amylase,and anti-AChE efficiency via standard ***:Phytochemical analysis shows the existence of different compounds;while Coumarins and quinones were *** total phenolic,flavonoid,and tannins content were found to be（78.52±0.69） mg GAE/g,（2.01±0.04） mg RUE/g,and（58.12±0.23） mg TAE/g of plant extract respectively.28.02%±0.02% alkaloid and 2.02%±0.05% saponins were present in the HH *** HH extract showed the anti-oxidant property with IC50（50%inhibition） of（151.01±0.13）(HH),（79.01±0.04）(Ascorbic acid) for ferric reducing,（91.48±0.13）(HH),（48.02±0.11）(Ascorbic acid) against Ammonium molybdenum,（156.02±0.31）(HH),（52.38±0.21）(Ascorbic acid) against DPPH,136.01±0.21（HH）,52.02±0.31（Ascorbic acid） against H2O2,and 154.12±0.03（HH）,（40.05±0.15）(Ascorbic acid)μg/mL against ABTS *** analysis indicated that HH caused a competitive type of inhibition of α-amylase(Vmaxremained constant and Km increases from 10.65 to84.37%) while Glucophage caused the un-competitive type of inhibition i-e both Km and Vmaxdecreased from40.49 to 69.15%and 38.86 to 69.61%*** Ki,（inhibition constant）;KI,（dissociation constant）,Km,（Michaelis-Menten constant）,and IC50 were found to be62,364,68.1,and 38.08±0.22 for HH and 12,101.05,195,34.01±0.21 for ***,HH causes an anon-competitive type of inhibition of AChE i-e Km remains constant while Vmaxdecreases from 60.5%to74.1%.The calculated Ki,KI,Km,and IC50 were found to be 32,36.2,0.05,and 18.117±***:From the current results,it is concluded that HH extract contains bioactive compounds,and could be a good alternative to controlling oxidants,Alzheimer‘s and T

关键词： Hippeastrum hybridum acetylcholinesterase alpha-amylase antioxidant phytochemicals

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SAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1429-1432页

作者： Ishant Khurana Scott Maxwell Simon Royce Prabhu Mathiyalagan Tom Karagiannis nadia mazarakis Jitraporn Vongsvivut Harikrishnan K.N. Jun Okabe Keith Al-Hasani Chrishan Samuel Assam El-Osta Human Epigenetics Program Department of DiabetesCentral Clinical SchoolMonash UniversityMelbourneVICAustralia Cardiovascular Disease Program Monash Biomedicine Discovery Institute and Department of PharmacologyMonash UniversityClaytonVICAustralia Infrared Microspectroscopy Beamline ANSTO-Australian SynchrotronClaytonVICAustralia Department of Medicine and Therapeutics The Chinese University of Hong Kong(CUHK)Hong Kong SARHong Kong Institute of Diabetes and ObesityCUHKHong Kong SARPrince of Wales HospitalLi Ka Shing Institute of Health SciencesCUHKShatinHong KongChina University College Copenhagen Faculty of HealthDepartment of TechnologyBiomedical Laboratory ScienceCopenhagenDenmark

Dear Editor,Takotsubo syndrome(TS)is a stress-induced non-ischaemic cardiomyopathy that is more common in women,but is associated with higher morbidity and mortality in *** known as broken-heart syndrome,TS is characterised by transient left ventricular(LV)dysfunction independent of obstructive coronary artery *** is a polygenic condition and nowhere is this more evident than the use of positive inotropes,such as isoprenaline(ISO)in pre-clinical models.1 There is no standard therapy for broken-heart syndrome because the mechanisms underlying the condition remain ***,there is no consensus on predisposition for Takotsubo2 and our goal was to better understand the regulatory mechanism as a first step towards improved treatment *** acid or SAHA,a drug approved for cancer treatment by the US Food and Drug Administration has previously been shown to improve cardiopulmonary function.3 We tested the hypothesis that the cardioprotective benefit of SAHA in a pre-clinical model of Takotsubo is conferred by an epigenetic acetylation/deacetylation(Ac/Dc)axis.

关键词： SAHA Takotsubo protective

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Pro-fertility effect of Ficus carica fruit extract in streptozotocin-induced male rats

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Asian pacific Journal of Reproduction 2024年第1期13卷 34-41页

作者： Mat Noor Mahanem Subramaniam Puvaratnesh AbuBakar Umarqayum Shamsusah nadia A Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Institute of Biological Sciences Faculty of ScienceUniversity Malaya50603 Kuala LumpurMalaysia Department of Earth Sciences and Environment Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600Malaysia

Objective:To explore the impact of Ficus carica fruit aqueous extract on fertility parameters in streptozotocin(STZ)-induced male ***:Twenty-four male Sprague-Dawley rats were divided into four different *** groups except a normal control group were induced with 50 mg/kg of streptozotocin(STZ)intravenously to induce diabetes.A positive control group was treated with an antidiabetic drug,metformin(500 mg/kg)whereas a negative control group remained untreated throughout the ***,another diabetic rat group received treatment with 400 mg/kg of aqueous Ficus carica fruit *** in the treatment group were administered Ficus carica fruit aqueous extract daily through forcefeeding via oral gavage for a 21-day *** included the sperm quality(count,motility and morphology),histology of the testes,serum testosterone and fasting blood glucose(FBG)***:The FBG level of the Ficus carica-treated rats exhibited a significant decrease compared to the negative control group(P<0.05).Sperm quality analysis also indicated that the aqueous Ficus carica extract had significant positive effects on sperm count and motility(P<0.05).The histology of the testes in Ficus caricatreated rats revealed an improved cell arrangement in the germinal cell ***,serum testosterone level showed an increment in the Ficus carica treatment group in comparison to the negative control ***:Our findings provide compelling evidence for the profertility and anti-hyperglycemic properties of aqueous Ficus carica fruit extract in diabetic-induced male rats.

关键词： Ficus carica fruit Male fertility parameter Diabetes mellitus Anti-hyperglicemic

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Survey of current practices in the management of cervical cancer by Moroccan radiotherapists

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Radiation Medicine and Protection 2024年第2期5卷 124-130页

作者： Bouchra Amaoui Slimane Semghouli Hanane El Kacemi Issam Lalya nadia Benchekroune Fatima Safini Sanae Abbaoui Biotechnology and Medicine(BioMed)Laboratory Faculty of Medicine and PharmacyIbn Zohr UniversityAgadirMorocco Souss Massa University Hospital Center AgadirMorocco Higher Institute of Nursing Professions and Health Techniques AgadirMorocco Mohammed-V University RabatMorocco National Institute of Oncology(INO) RabatMorocco Mohammed-V Military Instruction Hospital RabatMorocco Hassan II University CasablancaMorocco Mohammed VI Oncology Center-Casablanca University Hospital CasablancaMorocco Regional Oncology Center AgadirMorocco

Objective:To assess the applicability degree of the international guidelines by Moroccan radiotherapists,in order to improve the management of cervical cancer(CC),since CC is the second most common cancer for women in ***:This cross-sectional study was carried out using a questionnaire sent online to Moroccan *** questionnaire covered participants'characteristics,initial assessment and treatment preparation,techniques and indications for radiotherapy and brachytherapy,dose and indications,as well as on the protocol adopted in the intermediate stages and the location of adjuvant treatments and assessments'***:74 radiotherapists out of 300 have responded to the *** 27.0%of practitioners reported discussing patient records systematically in a multidisciplinary consultation meeting(MCM).For the initial assessment,77.0%requested pelvic magnetic resonance imaging(MRI).It is significantly less requested in regional oncology centers(ROCs)than in university hospital centers(UHCs)or the private sector(P<0.001).Furthermore,Clinicians in ROCs do not have access to new techniques of *** 83.8%of cases,the most prescribed radiotherapy protocols were 45–46 Gy in 1.8–2 Gy per ***-dimensional gynaecological brachytherapy high-throughput dose guided by dosimetric scanner was available in 75.5%of structures while interstitial gynaecological brachytherapy was only available in 23%of *** two most prescribed dose protocols were 47 Gy and 37 Gy in 74.4%and 21.6%of cases,***,monitoring during the first two years was based mainly on pelvic MRI(82.2%)while PET/CT was recommended by only less than 10%.Conclusions:The findings obtained show that our radiotherapists generally comply with international guidelines for the cervical cancer ***,they should still enhance their practices for the first staging evaluation,the use of systematic MCMs,the doses and treatment techniques used,and

关键词： Radiotherapy Brachytherapy Cervical cancer Morocco

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Nonlinear Study on the Mechanical Performance of Built-Up Cold-Formed Steel Concrete-Filled Columns under Compression

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3435-3465页

作者： Oulfa Harrat Yazid Hadidane S.M.Anas Nadhim Hamah Sor Ahmed Farouk Deifalla Paul O.Awoyera nadia Gouider Civil Engineering Laboratory Faculty of TechnologyDepartment of Civil EngineeringBadji Mokhtar-Annaba UniversityP.O.Box 12Annaba23000Algeria Department of Civil Engineering Faculty of Engineering and TechnologyJamia Millia Islamia(A Central University)New Delhi110025India Civil Engineering Department University of GarmianKalar46021Iraq Department of Civil Engineering Harran UniversitySanliurfa63510Turkey Structural Engineering and Construction Management Department Future University in EgyptNew Cairo11835Egypt Department of Civil Engineering Covenant UniversityOta112233Nigeria

Given their numerous functional and architectural benefits,such as improved bearing capacity and increased resistance to elastic instability modes,cold-formed steel(CFS)built-up sections have become increasingly developed and used in recent years,particularly in the construction *** paper presents an analytical and numerical study of assembled CFS two single channel-shaped columns with different slenderness and configurations(backto-back,face-to-face,and box).These columns were joined by double-row rivets for the back-to-back and box configurations,whereas they were welded together for the face-to-face *** built-up columns were filled with ordinary concrete of good *** element models were applied,using ABAQUS software,to assess mechanical performance and study the influence of assembly techniques on the behavior of cold-formed columns under axial *** approaches based on Eurocode 3 and Eurocode 4 recommendations for un-filled and concrete-filled columns respectively were followed for the numerical analysis,and concrete confinement effects were also considered per American Concrete Institute(ACI)standards for face-to-face and box *** obtained results indicated a good correlation between the numerical results and the proposed analytical methodology which did not exceed 8%.The failure modes showed that the columns failed due to instabilities such as local and global buckling.

关键词： Cold-formed steel built-up sections slenderness rivets welded axial compression analytical approaches confinement buckling

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Non-invasive prenatal testing can detect silent cancers in expecting mothers

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Genes & Diseases 2024年第2期11卷 585-588页

作者： Alessandro Ottaiano Monica Ianniello nadia Petrillo Mariachiara Santorsola Luigia De Falco Salvatore Giovanni Castaldi Maria Antonietta Castaldi Valentina Giudice Carmine Selleri Giovanni Savarese Unit of Innovative Therapies for Abdominal Metastases Istituto Nazionale Tumori di NapoliIRCCS “G.Pascale”Via Mariano SemmolaNapoli 80131Italy AMES Centro Polidiagnostico Strumentale SRLVia Padre Carmine Fico 24Casalnuovo Di Napoli 80013Italy Specialization School of Clinical Pathology Università degli Studi di SalernoVia Giovanni Paolo II 132Fisciano 84084Italy Unit of High-Risk Pregnancy and Prenatal Diagnosis University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Hematology and Transplant Center University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Department of Medicine Surgery and Dentistry“Scuola Medica Salernitana”Via Salvador Allende 43Baronissi 84081Italy

Pregnancy is a unique physiological state in which several changes *** of the most important aspects is the maternal immune system,which sets to tolerate the presence of thedeveloping fetus(a semi-allogeneic organism),while at the same time providing protection against pathogens.1 Pregnancy has long been known to affect the risk of certain cancers including breast cancer in the short term,gestational trophoblastic disease(GTD),cervical cancer,and melanoma.2,3 The reasons for the increased risk of these cancers during pregnancy are not fully understood,but several hypotheses have been proposed as the hormonal and immune system changes.

关键词： mother cancers fetus

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Exploring the Contribution of Pharmacists in Addressing the Opioid Crisis through Naloxone Prescriptions and Pharmacist-Led Interventions

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Pharmacology & Pharmacy 2024年第2期15卷 27-38页

作者： Michelle Krey Sophia Villa nadia Gharibyar Haroon Mesdaq Just Health Experts Thornton CO USA

The opioid epidemic in the United States continues to take the lives of many individuals, with overdoses continuing to rise every year. Naloxone is an opioid antagonist that is efficacious in temporarily reversing opioid overdoses. Pharmacists play an important role in the accessibility and education of naloxone in both the community and health system settings. Recent efforts, such as co-dispensing naloxone with opioid prescriptions, naloxone training programs, and approval of naloxone to be over-the-counter, have been implemented in hopes to better control the opioid epidemic. Despite the efforts to make naloxone more accessible, there are still some barriers to overcome such as lack of training, cost, stigma, and patient refusal. This review aims to explore the contributions pharmacists have made thus far and define the barriers that still have to be resolved.

关键词： Naloxone Narcan Opioid Crisis Opioid Epidemic Pharmacy Pharmacist Interventions

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西尔维斯特·雷维尔塔斯的《小提琴与钢琴三曲》的演奏诠释

西尔维斯特·雷维尔塔斯的《小提琴与钢琴三曲》的演奏诠释

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作者： nadia Citlali Cano Casta(?)eda 成都大学

学位级别：硕士

西尔维斯特·雷维尔塔斯于1899年出生在一个艺术家世家。他在墨西哥革命时期长大并接受了那个时期的教育。1917年他被派往美国,在芝加哥音乐学院完成了他的小提琴学习,并且一直在这个国家担任小提琴演奏家,直到1928年。到墨西哥后,他成... 详细信息

西尔维斯特·雷维尔塔斯于1899年出生在一个艺术家世家。他在墨西哥革命时期长大并接受了那个时期的教育。1917年他被派往美国,在芝加哥音乐学院完成了他的小提琴学习,并且一直在这个国家担任小提琴演奏家,直到1928年。到墨西哥后,他成为了这个国家最重要的作曲家之一。尽管他创作的作品曲目有限,但涵盖了重要的作品,如管弦乐作品、电影音乐、室内乐和声乐作品。他的创作美学特点在于融合了他所在的那个时代的现代音乐元素和传统的墨西哥音乐元素,创造出具有创新性的音乐。西尔维斯特·雷维尔塔斯的《小提琴与钢琴三曲》聚集了他作品中最独特的作曲元素。作为他最后的小提琴和钢琴作品,他在他的弦乐四重奏所建立起来的探索基础上继续发展,呈现了他在作曲和表演风格上的重要元素。这份文件提供了产生作曲家作品的历史背景,并对《小提琴与钢琴三曲》中的每一首曲目进行了分析。此外,它根据对作品和小提琴技术分析的技术和解释性建议。

关键词：墨西哥音乐西尔维斯特音乐分析历史背景拼贴画

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Severe asthma exacerbation:Changes in patient characteristics,management,and outcomes from 1997 to 2016 in 40 ICUs in the greater Paris area

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Journal of Intensive Medicine 2024年第2期4卷 209-215页

作者： Romy Younan Jean Loup Augy Bertrand Hermann Bertrand Guidet Philippe Aegerter Emmanuel Guerot Ana Novara Caroline Hauw-Berlemont Amer Hamdan Clotilde Bailleul Francesca Santi Jean-Luc Diehl Nicolas Peron nadia Aissaoui Intensive Care Unit AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Intensive Care Unit AP-HPSaint Antoine HospitalUniversités de SorbonneUniversitéPierre et Marie CurieParisFrance INSERM U1136 ParisFrance Versailles Saint-Quentin-en-Yvelines University INSERM U1018Groupe Interrégional de Recherche Clinique et d'InnovationÎle-de-FranceFrance Respiratory Medicine Department AP-HPGeorges Pompidou European HospitalUniversitéde ParisParisFrance Innovative Therapies in Hemostasis INSERM UMR-S1140Universitéde ParisParisFrance Intensive Care Unit and Biosurgical Research Lab(Carpentier Foundation) AP-HPGeorges Pompidou European HospitalParisFrance Paris-Cardiovascular-Research-Center INSERM U970ParisFrance

Background Despite advances in asthma treatments,severe asthma exacerbation(SAE)remains a life-threatening condition in adults,and there is a lack of data derived from adult patients admitted to intensive care units(ICUs)for *** current study investigated changes in adult patient characteristics,management,and outcomes of SAE over a 20-year period in 40 ICUs in the greater Paris *** In this retrospective observational study,admissions to 40 ICUs in the greater Paris area for SAE from January 1,1997,to December 31,2016 were *** primary outcome was the proportion of ICU admissions for SAE during 5-year *** outcomes were ICU and hospital mortality,and the use of mechanical ventilation and *** analysis was performed to assess factors associated with ICU *** A total of 7049 admissions for SAE were *** each 5-year period,the proportion decreased over time,with SAE accounting for 2.84%of total ICU admissions(n=2841)between 1997 and 2001,1.76%(n=1717)between 2002 and 2006,1.05%(n=965)between 2007 and 2011,and 1.05%(n=1526)between 2012 and *** median age was 46 years(interquartile range[IQR]:32–59 years),55.41%were female,the median Simplified Acute Physiology Score II was 20(IQR:13–28),and 19.76%had mechanical *** use of mechanical ventilation remained infrequent throughout the 20-year period,whereas the use of catecholamine *** and hospital mortality rates *** associated with ICU mortality were renal replacement therapy,catecholamine,cardiac arrest,pneumothorax,acute respiratory distress syndrome,sepsis,and invasive mechanical ventilation(IMV).Non-survivors were older,had more severe symptoms,and were more likely to have received *** ICU admission for SAE remains uncommon,and the proportion of cases decreased over *** a slight increase in symptom severity during a 20-year period,ICU and hospital mortality *** requirin

关键词： Epidemiology Intensive care unit Mechanical ventilation Severe asthma exacerbation

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模拟训练在提高肿瘤护理质量和患者安全中的应用:范围综述

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International Journal of Nursing Sciences 2024年第2期11卷 187-196,I0002页

作者： nadia Al Wachami Mohamed Chahboune Ibtissam Youlyouz-marfak Mohamed Reda Mesradi Hajar Lemriss Abderraouf Hilali Hassan First University of Settat Higher Institute of Health SciencesLaboratory of Sciences and Health TechnologiesSettatMorocco

目的模拟训练(simulation-based training,SBT)是一种有效的教育方法,广泛应用于包括肿瘤学在内的多种临床环境中。该文对肿瘤学中与SBT相关的研究进行了范围综述,全面了解SBT在提高医护人员技能方面的作用,从而提高护理质量和患者安全... 详细信息

目的模拟训练(simulation-based training,SBT)是一种有效的教育方法,广泛应用于包括肿瘤学在内的多种临床环境中。该文对肿瘤学中与SBT相关的研究进行了范围综述,全面了解SBT在提高医护人员技能方面的作用,从而提高护理质量和患者安全。方法根据Arksey和O’Malley提出的范围综述方法框架,在Medline、Scopus和Web of Science数据库中检索于2012年至2022年发表的,与SBT在提高肿瘤科医护人员技能方面的相关研究文献,仅纳入经过同行评审的英文或法语文献。由2名研究员独立进行文献的筛选、提取和分析。结果检索出1013篇文章,共纳入29篇文献。其中25篇文献侧重于非技术技能,如决策技能、沟通和团队合作技能以及认知能力;13篇文献侧重于技术技能。纳入文献研究结果表明,通过SBT项目,肿瘤科医护人员的技能得到了显著提高。其中14篇文献对SBT的应用进行了主观评估,9篇文献对其进行了客观评估,6篇文献采用了主观和客观相结合的评估方法。结论SBT是提高肿瘤科医护人员技能的有效方法,支持和推广SBT对提供高质量的医疗服务和确保患者安全至关重要。

关键词：护士肿瘤科患者安全卫生保健质量模拟训练

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