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Estimation of boswellic acids in herbal formulations containing Boswellia serrata extract and comprehensive characterization of secondary metabolites using UPLC-Q-Tof-MS^e

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Journal of Pharmaceutical Analysis 2019年第6期9卷 414-422页

作者： Kumar Katragunta Bandi Siva Niharika Kondepudi PRrao Vadaparthi nadendla rama rao Ashok Kumar Tiwari Katragadda Suresh Babu Centre for Natural Products and Traditional Knowledge CSIR-Indian Institute of Chemical TechnologyHyderabad500007India Chalapathi Institute of Pharmaceutical Sciences LamGuntur522034India College of Pharmaceutical Sciences Acharya Nagarjuna UniversityNagarjuna NagarGuntur522510India

Boswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quanti cation of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto-boswellic acid(2),-b Boswellic acid(3),-Boswellic acid(4),3-O-Acetyl--boswellic acid(5)and 3-O-Acetyl--boswellic acid b(6)in commercial herbal products containing *** as an *** UPLCbwith Q-Tof-MS/MS makes the better identi cation of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quanti cation of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituenBoswellia serrata is a widely used herb in Indian systems of medicine and is well known for its potential medicinal properties.A chromatographic method was developed for the analysis and quantification of six boswellic acid marker compounds,i.e.,keto boswellic acid(1),3-O-Acetyl 11-keto b-boswellic acid(2),ɑ-Boswellic acid(3),b-Boswellic acid(4),3-O-Acetyl-ɑ-boswellic acid(5)and 3-O-Acetyl-b-boswellic acid(6)in commercial herbal products containing *** as an *** UPLC with Q-Tof-MS/MS makes the better identification of secondary metabolites and adulterants in the herbal formulations containing *** in rapid time using fragmentation approach than the traditional *** this study quantification of boswellic acids with UPLC-PDA method was performed as per the pharmacopeia ***,minor phytochemical constituents were identified and characterized with the help of LC-Q-Tof-MS/MS fragmentation data and various isoforms of boswellic acids and tirucallic acids in *** oleo-gum-resin extract were *** were identi ed and characterized with the help of LC-Q-Tof-MS/MS

关键词： Boswellia serrata Herbal formulations Quantification UPLC-Q-tof-MSe Boswellic acids Tirucallic acids

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An Intelligent Big Data Security Framework Based on AEFS-KENN Algorithms for the Detection of Cyber-Attacks from Smart Grid Systems

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Big Data Mining and Analytics 2024年第2期7卷 399-418页

作者： Sankaramoorthy Muthubalaji Naresh Kumar Muniyaraj Sarvade Pedda Venkata Subba rao Kavitha Thandapani Pasupuleti rama Mohan Thangam Somasundaram Yousef Farhaoui Department of Electrical and Electronics Engineering CMR College of Engineering&TechnologyHyderabad 501401India Department of Electronics and Communication Engineering Vardhaman College of Engineering KacharamShamshabad 501218India Department of Electronics and Communication Engineering Sreenidhi Institute of Science and TechnologyHyderabad 501301India Department of Electronics and Communication Engineering Vel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600062India Department of Electrical and Electronics Engineering Bharat Institute of Engineering and TechnologyHyderabad 501510India Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidhyapeethamBengaluru 560035India T-IDMS Department of Computer ScienceFaculty of Sciences and TechniquesMoulay Ismail UniversityErrachidia 52000Morocco

Big data has the ability to open up innovative and ground-breaking prospects for the electrical grid,which also supports to obtain a variety of technological,social,and financial *** is an unprecedented amount of heterogeneous big data as a consequence of the growth of power grid technologies,along with data processing and advanced *** main obstacles in turning the heterogeneous large dataset into useful results are computational burden and information *** original contribution of this paper is to develop a new big data framework for detecting various intrusions from the smart grid systems with the use of AI ***,an AdaBelief Exponential Feature Selection(AEFS)technique is used to efficiently handle the input huge datasets from the smart grid for boosting ***,a Kernel based Extreme Neural Network(KENN)technique is used to anticipate security vulnerabilities more *** Polar Bear Optimization(PBO)algorithm is used to efficiently determine the parameters for the estimate of radial basis ***,several types of smart grid network datasets are employed during analysis in order to examine the outcomes and efficiency of the proposed AdaBelief Exponential Feature Selection-Kernel based Extreme Neural Network(AEFS-KENN)big data security *** results reveal that the accuracy of proposed AEFS-KENN is increased up to 99.5%with precision and AUC of 99%for all smart grid big datasets used in this study.

关键词： smart grid Machine Learning(ML) big data analytics AdaBelief Exponential Feature Selection(AEFS) Polar Bear Optimization(PBO) Kernel Extreme Neural Network(KENN)

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Comparative Efficacy of <i>Tagetes erecta</i>and <i>Centella asiatica</i>Extracts on Wound Healing in Albino Rats

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Chinese Medicine 2011年第4期2卷 138-142页

作者： Sandipan Chatterjee Tigari Prakash Dupadahalli Kotrsha nadendla rama rao Divakar Goli 不详

The study was undertaken to evaluate the comparative efficacy of hydroalcoholic extracts of leaves of Tagetes erecta (T. erecta) and aerial parts of Centella asiatica (C. asiatica) on Excision, Incision and Dead space wound models in albino rats. Extract of T. erecta and C. asiatica (P T. erecta extract (250 and 500 mg/kg) showed significantly increased the wound breaking strength in incision wound model and wet and dry granulation tissue weights, breaking strength in a dead space wound model compare to control and C. asiatica treated group (P T. erecta extract showed potent wound healing activity then the reported C. asiatica in different wound parameters.

关键词： Centella asiatica Tagetes erecta Excision Incision Dead Space Wound Model

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Tumor microenvironment pathways:Cross regulation in breast cancer metastasis

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Genes & Diseases 2022年第2期9卷 310-324页

作者： rama rao Malla P.Kiran Cancer Biology Lab Department of Biochemistry and BioinformaticsInstitute of ScienceGITAM(Deemed to be University)Visakhapatnam 530045India

The tumor microenvironment(TME)is heterogeneous and contains a multiple cell population with surrounded immune cells,which plays a major role in regulating *** multifunctional pathways,Hedgehog(Hh),Wnt,Notch,and NF-kB,cross-regulates metas-tasis in breast *** review presents substantial evidence for cross-regulation of TME components and signaling pathways,which makes breast TME more heterogeneous and com-plex,promoting breast cancer progression and metastasis as a highly aggressive *** discoursed the importance of stromal and immune cells as well as their crosstalk in bridging the *** also discussed the role of Hh and Notch pathways in the intervention be-tween breast cancer cells and macrophages to support TME;Notch signaling in the bidirec-tional communication between cancer cells and components of TME;Wnt signal pathway in controlling the factors responsible for EMT and NF-kB pathway in the regulation of genes con-trolling the inflammatory *** also present the role of exosomes and their miRNAs in the cross-regulation of TME cells as well as pathways in the reprogramming of breast TME to support ***,we examined and discussed the targeted small molecule inhibitors and natural compounds targeting developmental pathways and proposed small molecule nat-ural compounds as potential therapeutics of TME based on the multitargeting *** conclu-sion,the understanding of the molecular basis of the cross-regulation of TME pathways and their inhibitors helps identify molecular targets for rational drug discovery to treat breast can-cers.

关键词： Breast cancer Cross-regulation Hedgehog NF-kB Notch Tumor microenvironment Wnt

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A novel monocrystalline PV array configuration for enhancing the maximum power under partial shading conditions

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Clean Energy 2023年第4期7卷 783-794页

作者： Sarayu Vunnam M.Vanithasri rama Koteswara rao Alla Research Scholar Department of Electrical EngineeringAnnamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Assistant Professor Department of Electrical and Electronics EngineeringRVR&JC College of EngineeringGunturAndhra Pradesh-522019India Associate Professor Department of Electrical EngineeringAnnamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Associate Professor Department of Electrical and Electronics EngineeringRVR&JC College of EngineeringGunturAndhra Pradesh-522019India

Solar photovoltaic(PV)systems have gained importance as a promising renewable energy source in recent *** arrays are prone to variable irradiance levels under partial shading conditions due to non-uniform *** a result,there will be a decrease in the amount of power produced and hotspots will *** overcome these issues,it is essential to select an appropriate PV material and a suitable array *** obtain the maximum output power from a PV array under partial shading conditions,this paper suggests a novel triple-series–parallel ladder topology with monocrystalline PV *** short and wide,long and wide,short and narrow,long and narrow,middle and diagonal shading situations,a 6×6-sized array has been considered and compared with other existing configurations such as total cross-tied,bridge-link,honeycomb,series–parallel and series–parallel *** proposed configuration has an optimal number of cross ties to produce maximum *** has 4 cross ties fewer than a honeycomb,3 cross ties fewer than a bridge link,16 cross ties fewer than a total cross-tied and 7 cross ties fewer than series–parallel cross-tied *** proposed configuration has an improvement in power of 0.1%to 20%compared with other configurations under the considered shading scenarios.

关键词： monocrystalline PV material photo voltaic array series–parallel cross-tied,triple-series–parallel ladder topology

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ETP-AKEP: enhanced three-party authenticated key exchange protocols for data integrity in cloud environments

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Journal of Control and Decision 2023年第1期10卷 126-133页

作者： Kalluri rama Krishna C.V.Guru rao Faculty of Informatics Osmania UniversityHyderabadIndia School of Computer Science&Artificial Intelligence S.R.UniversityWarangalIndia

With key exchange protocols, a secure session key is generated between two remote users, andservers and exchanged between them. It is generally used to prevent unauthorised users fromgaining access to sensitive data. This article presents an enhanced three-party authenticated keyexchange protocols (ETP-AKE) protocol that does not depend on symmetric key encryption andinstead uses asymmetric key encryption. A key component of the proposed ETP-AKE protocol isusing elliptic curve encryption in conjunction with a one-way hash function. Its integrity certificationwas confirmed via the usage of the AVISPA tool package. Our proposed protocol is intendedto protect against various security threats, including the man-in-the-middle assault, the parallelattack, and the key-compromise attack, among others.

关键词： ECC hash function cloud integrity third party key exchange

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A novel PV array configuration for enhancing maximum power from PV array

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Clean Energy 2022年第6期6卷 817-826页

作者： Dharani Kumar Narne T.A.Ramesh Kumar rama Koteswara rao Alla Department of Electrical Engineering Annamalai UniversityAnnamalai NagarChidambaramTamilnadu-608002India Department of Electrical and Electronics Engineering RVR&JC College of EngineeringGunturAndhra Pradesh-522019India

Partial shading conditions(PSC)are unavoidable and are the main reason for the reduction in power from a photovoltaic(PV)*** proper arrangement,the impact of PSC can be somewhat *** are distinct types of configurations,including series,parallel,series-parallel(SP),honeycomb,total cross-tied(TCT),*** article presents a novel SP-TCT configuration to maximize output power from PV panels under different shading *** proposed configuration performance has been examined considering a 4×4 PV array under long-narrow and long-wide,short-narrow,short-wide and uniform shading *** results of the proposed configurations are compared with existing configurations in terms of performance measures such as maximum power,fill factor,efficiency and mismatch *** all the cases,performance of the proposed configuration is nearer to the TCT configuration *** percentage improvement in terms of efficiency for the proposed novel SP-TCT configuration and TCT configuration is nearly 1.6%compared to other methods.

关键词： maximum power shading patterns PV array efficiency

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Millimeter wave dielectric loaded exponentially tapered slot antenna array using substrate integrated waveguide for gigabit wireless communications

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红外与毫米波学报 2015年第5期34卷 513-519页

作者： S Ramesh T rama rao Department of Electronics & communication Engineering Valliammai Engineering College RADMIC Department of Telecommunication EngineeringSRM University

A new and upcoming application is the use of 60 GHz antennas for high date rate point-to-point connections to serve Gigabit(Gi-Fi)w ireless *** design of M illimeter w ave(M m W)antennas has to cope w ith the unadorned influences of manufacturing tolerances and losses at 60 *** this paper,the concept of Substrate Integrated Waveguide(SIW)and Exponentially Tapered Slot(ETS)antenna w ere used together to design a high gain,efficient planar dielectric loaded antenna for M m W Gi-Fi w ireless communications at 60 *** SIW is used to feed the antenna and a dielectric is utilized in front of the antenna to increase the *** dielectric loaded ETS antenna and compact SIW feed w ere fabricated on a single substrate,resulting in low cost and easy *** antenna w ith elliptical shaped dielectric loaded w as fabricated using printed circuit board *** measured gain of the single element antenna is 10.2 dB,w hile the radiation efficiency of 96.84%is obtained at 60 *** Y-junction SIW pow er divider is used to form a 1×4 array structure.M easured gain of the 1×4 array antenna is 13.3 dB,w hile the measured radiation pattern and gain are almost constant w ithin the w ide bandw idth of the antenna.

关键词： millimeter waves 60 GHz exponentially tapered slot antenna dielectric loading substrate integrated waveguide

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Hydro-elastic computational analysis of a marine propeller using two-way fluid structure interaction

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Journal of Ocean Engineering and Science 2022年第3期7卷 280-291页

作者： V.rama Krishna Srinivas Prasad Sanaka N.Pardhasaradhi B.Raghava rao Naval Science&Technological Laboratory Visakhapatnam532007India Department of Mechanical Engineering V.R.Siddhartha Engineering CollegeVijayawada520007India

Marine propellers have complex geometry and their performance is determined by costly and time consuming open water *** of numerical techniques helps researchers in effective design of *** approaches are used that predicted either hydrodynamic and acoustic response or structural ***-way fluid-structure interaction(FSI)analysis is a very useful approach providing all three responses which helps in the design,analysis and optimization of a *** objective of this paper is to predict the hydro-elastic response of a propeller using two-way FSI on a 0.2m diameter,DTMB-4119 propeller using ANSYS ***-way FSI analysis is carried out using system coupling approach that transfers the data between the structural and fluid *** turbulence effects are captured using the large-eddy simulation(LES)model and the Ffowcs Williams Hawkings(FWH)acoustic model is used for evaluating the sound pressure level(SPL)generated by *** is extended to evaluate the hydro-elastic and acoustic response of the propeller after validating the hydrodynamic performance with the experimental result in the *** results from Two-way FSI analysis are in close agreement when compared with the one-way FSI ***-way FSI can accommodate the peak value of stress and deformation developed during the initial part of the transient solution which is important in the design of *** study reveals that metallic(NAB)propeller can be replaced by a composite *** acoustic response from two-way FSI analysis will be more realistic due to the consideration of hydro-elastic effect of propeller.

关键词： Advance ratio Coupled analysis CFD Marine propeller Hydrodynamic parameters Two-way fluid structure interaction

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Structural,electrical and magnetic properties of cobalt ferrite with Nd^(3+) doping

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Rare Metals 2022年第1期41卷 240-245页

作者： Regaty Anitha Reddy Kattepogu rama rao Bitra Rajesh Babu Guthikonda Kiran Kumar Cherukupalli Rajesh Anindita Chatterjee Nadella Krishna Jyothi Department of Physics Koneru Lakshmaiah Education FoundationVaddeswaramGunturAndhra Pradesh 522502India Department of Physics Andhra UniversityVisakhapatnamAndhra Pradesh 530003India Department of Physics G.V.P.College of Engineering for WomenVisakhapatnamAndhra Pradesh 530048India Department of Physics Raghu College of Engineering(A)BheemunipatnamVisakhapatnamAndhra Pradesh 531162India Department of Physics Gayatri Vidya Parishad College of Engineering(Autonomous)VisakhapatnamAndhra Pradesh 530048India Department of Chemistry Raghu College of Engineering(A)BheemunipatnamVisakhapatnamAndhra Pradesh 531162India

A systematic study on the influence of Nd^(3+) substitution on structural,magnetic and electrical properties of cobalt ferrite nanopowders obtained by sol–gel auto-combustion routewas *** formation of spinel phasewas confirmed by X-ray diffraction(XRD)data,and percolation limit ofNd3?into the spinel lattice was also *** transform infrared spectroscopy(FTIR)bands observed ≈580 and ≈390 cm^(-1 ) support the presence of Fe^(3+) at A andBsites in the spinel *** variation in microstructure was investigated by scanning electronmicroscopy(SEM),and the average grain size varies from 5.3 to 3.3 *** substitution of Nd^(3+) significantly affects the formation of pores and grain size of cobalt ***-temperature saturation magnetization and coercivity decrease from 60 to 30 mA·m^(2)·g^(-1) and 19.9–17.8 mT,respectively,with Nd^(3+) substitution *** decreases in magnetic properties are explained based on the presence of non-magnetic nature of Nd^(3+) concentration and the dilution of super-exchange interaction in the spinel *** room-temperature direct-current electrical resistivity increases with Nd^(3+) concentration increasing,which is due to the unavailability of Fe^(2+) at octahedral B sites.

关键词： Co-Nd ferrite Saturation magnetization DC resistivity

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