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Particuology 2024年第7期90卷 364-382页

作者： barış Gürel Gülşah Karaca Dolgun Osman İpek Ali Keçebaş Department of Mechanical Engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of Energy systems Engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lignite types within a circulating fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified through experimentation,the research reveals several key ***,furnace temperatures tended to rise with higher sphericity ratios,albeit with variations between lignite types,particularly highlighting the complexity of this relationship in the case of GLI-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lignite,as reflected in CO_(2) mole *** NO_(x) emissions generally decreased with lower sphericity,the sensitivity to sphericity varied by lignite type,with Ilgın lignite showcasing low NO_(x) but high sO_(2) emissions,underscoring the intricate interplay between lignite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights valuable for optimizing performance and emissions control,particularly in lignite-based power.

关键词： Circulating fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios NO_(x)and sO_(2)emissions Energy production efficiency

Metabolomic studies of human gastric cancer:Review

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World Journal of Gastroenterology 2014年第25期20卷 8092-8101页

作者： Naresh Doni Jayavelu nadav s.bar Department of Chemical Engineering Norwegian University of Science and TechnologyN7491 TrondheimNorway

Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and noncancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis.

关键词： Metabolomics Gastric cancer Chemosensitivity Metastasis Biomarkers Nuclear magnetic resonance spectroscopy Liquid/gas chromatography and mass spectrometry

Role of biomarkers in community-acquired pneumonia management

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Journal of Acute Disease 2024年第3期13卷 87-92页

作者： Bahaeddin Onur Hakan barışDemirbas Arif Gulmez Department of Emergency Medicine Istanbul Health and Technology UniversityIstanbulTurkey Department of Emergency PHCCAl Karaana Health CenterDohaQatar Department of Emergency PHCCUmm Slala Health CenterDohaQatar Department of Family Medicine PHCCAl Thumama Health CenterDohaQatar

Community-acquired pneumonia(CAP)poses a significant global health threat,particularly affecting vulnerable *** and scoring systems play a crucial role in diagnosing,assessing severity,and guiding treatment decisions for CAP *** like C reactive protein,procalcitonin,and the neutrophil-to-lymphocyte ratio aid in diagnosis and severity assessment,while scoring systems such as CURB-65 and Pneumonia severity Index classify patients into risk *** biomarkers(uremia,elevated respiratory rate,hypotension,and age≥65)like serum amyloid A and s100 proteins show promise in predicting disease severity and ***,further research is needed to determine their precise roles and clinical utility in CAP management.

关键词： CURB-65 Community-acquired pneumonia Procalcitonin Alpha-1 antitrypsin serum amyloid A

An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-Pe Xuning Zhang sako Mirzaie Hao Han R.Chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane Daniel bar-shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRAsD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRAsD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRAsD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

Catalysts for the hydrogen evolution reaction in alkaline medium:Configuring a cooperative mechanism at the Ag-Ag_(2)s-Mos_(2) interface

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Journal of Energy Chemistry 2022年第11期31卷 481-488,I0013页

作者： Avraham bar-Hen simon Hettler Ashwin Ramasubramaniam Raul Arenal Ronen bar-Ziv Maya bar sadan Department of Chemistry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel Department of Chemistry Nuclear Research Center NegevP.O.Box 9001Beer-Sheva 84190Israel Laboratorio de Microscopías Avanzadas Universidad de Zaragoza50018 ZaragozaSpain Instituto de Nanociencia y Materiales de Aragon CSIC-U.de ZaragozaCalle Pedro Cerbuna 1250009 ZaragozaSpain Department of Mechanical and Industrial Engineering University of MassachusettsAmherstMA 01003United States ARAID Foundation 50018 ZaragozaSpain

Designing electrocatalysts for HER in alkaline conditions to overcome the sluggish kinetics associated with the additional water dissociation step is a recognized challenge in promoting the hydrogen *** this end,delicately tuning the atomic-scale structure and surface composition of nanoparticles is a common strategy and,specifically,making use of hybrid structures,can produce synergistic effects that lead to highly active ***,we present a core-shell catalyst of Ag@Mos_(2)that shows promising results towards the hydrogen evolution reaction(HER)in both 0.5 M H_(2)sO_(4)and 0.5 M *** this hybrid structure,the Mos_(2)shell is strained and defective,and charge transfer occurs between the conductive core and the shell,contributing to the electrocatalytic *** shelling process results in a large fraction of Ag_(2)s in the cores,and adjusting the relative fractions of Ag,Ag_(2)s,and Mos_(2)leads to improved catalytic activity and fast charge-transfer *** suggest that the enhancement of alkaline HER is associated with a cooperative effect of the interfaces,where the Ag(Ⅰ)sites in Ag_(2)s drive the water dissociation step,and the formed hydrogen subsequently recombines on the defective Mos_(2)*** study demonstrates the benefits of hybrid structures as functional nanomaterials and provides a scheme to activate Mos_(2)for HER in alkaline conditions.

关键词： Water splitting Core-shell Catalytic mechanism Electrocatalysis 2D materials

sCIENCE OF WINNING sOCCER:EMERGENT PATTERN-FORMING DYNAMICs IN AssOCIATION FOOTBALL

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Journal of systems science & Complexity 2013年第1期26卷 73-84页

作者： VILAR Luís ARAUJO Duarte DAVIDs Keith bar-YAM Yaneer Faculty of Physical Education and sports Lusofona University of Humanities and Technologies Faculty of Human Kinetics Technical University of Lisbon spertLab CIPERFaculty of Human KineticsTechnical University of Lisbon school of Human Movement studies Queensland University of Technologies New England Complex systems Institute

Quantitative analysis is increasingly being used in team sports to better understand performance in these stylized,delineated,complex social ***,the authors provide a first step toward understanding the pattern-forming dynamics that emerge from collective offensive and defensive behavior in team *** authors propose a novel method of analysis that captures how teams occupy sub-areas of the field as the ball changes *** authors use this method to analyze a game of association football(soccer) based upon a hypothesis that local player numerical dominance is key to defensive stability and offensive *** authors find that the teams consistently allocated more players than their opponents in sub-areas of play closer to their own *** is consistent with a predominantly defensive strategy intended to prevent yielding even a single *** authors also find differences between the two teams' strategies:while both adopted the same distribution of defensive,midfield,and attacking players(a 4:3:3 system of play),one team was significantly more effective in maintaining both defensive and offensive numerical dominance for defensive stability and offensive *** team indeed won the match with an advantage of one goal(2 to 1) but the analysis shows the advantage in play was more pervasive than the single goal victory would *** proposed focus on the local dynamics of team collective behavior is distinct from the traditional focus on individual player *** supports a broader view in which specific player abilities contribute within the context of the dynamics of multiplayer team coordination and coaching *** applying this complex system analysis to association football,the authors can understand how players' and teams' strategies result in successful and unsuccessful relationships between teammates and opponents in the area of play.

关键词： Collective behavior performance analysis team sports.

single-atom Pt on carbon nanotubes for selective electrocatalysis

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Carbon Energy 2024年第1期6卷 63-71页

作者： samuel s.Hardisty Xiaoqian Lin Anthony R.J.Kucernak David Zitoun Department of Chemistry Bar Ilan Institute of Nanotechnology and Advanced Materials(BINA)Bar Ilan UniversityRamat GanIsrael Department of Chemistry Molecular Science Research HubImperial College LondonLondonUK

Utilizing supported single atoms as catalysts presents an opportunity to reduce the usage of critical raw materials such as platinum,which are essential for electrochemical reactions such as hydrogen oxidation reaction(HOR).Herein,we describe the synthesis of a Pt single electrocatalyst inside single-walled carbon nanotubes(sWCNTs)via a redox *** via electron microscopy,X-ray photoelectron microscopy,and X-ray absorption spectroscopy show the single-atom nature of the *** electrochemical behavior of the sample to hydrogen and oxygen was investigated using the advanced floating electrode technique,which minimizes mass transport limitations and gives a thorough insight into the activity of the *** single-atom samples showed higher HOR activity than state-of-the-art 30%Pt/C while almost no oxygen reduction reaction activity in the proton exchange membrane fuel cell operating *** selective activity toward HOR arose as the main fingerprint of the catalyst confinement in the sWCNTs.

关键词： confinement electrocatalysis hydrogen platinum single atom catalysts

What do we know about biological nitrogen fixation in insects? Evidence and implications for the insect and the ecosystem

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Insect science 2020年第3期27卷 392-403页

作者： Nitsan bar-shmuel Adi Behar Michal segoli Mitrani Department of Desert Ecology Jacob Blaustein Institutes for Desert ResearchBen-Gurion University of the NegevSede Boqer CampusIsrael Kimron Veterinary Institute Department of ParasitologyBet DaganIsrael

Many insects feed on a low‐nitrogen diet,and the origin of their nitrogen supply is poorly *** has been hypothesized that some insects rely on nitrogen‐fixing bacteria(diazotrophs)to supplement their *** fixation by diazotrophs has been extensively studied and convincingly demonstrated in termites,while evidence for the occurrence and role of nitrogen fixation in the diet of other insects is less ***,we summarize the methods to detect nitrogen fixation in insects and review the available evidence for its occurrence(focusing on insects other than termites).We distinguish between three aspects of nitrogen fixation investigations:(i)detecting the presence of potential diazotrophs;(ii)detecting the activity of the nitrogen‐fixing enzyme;and(iii)detecting the assimilation of fixed nitrogen into the insect *** show that although evidence from investigations of the first aspect reveals ample opportunities for interactions with potential diazotrophs in a variety of insects,demonstrations of actual biological nitrogen fixation and the assimilation of fixed nitrogen are restricted to very few insect groups,including wood‐feeding beetles,fruit flies,leafcutter ants,and a wood *** then discuss potential implications for the insect's fitness and for the ecosystem as a *** suggest that combining these multiple approaches is crucial for the study of nitrogen fixation in insects,and argue that further demonstrations are desperately needed in order to determine the relative importance of diazotrophs for insect diet and fitness,as well as to evaluate their overall impact on the ecosystem.

关键词： biological nitrogen fixation diazotrophs gut microbiome insect diet

suitability and assessment of the dams water for the purpose of agricultural irrigation

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International Journal of Agricultural and Biological Engineering 2023年第6期16卷 255-262页

作者： barış Bülent Aşık Esra Bozan Kapdı Bursa Uludag University Faculty of AgricultureDepartment of Soil Science and Plant NutritionBursaTurkey Bursa Uludag University Graduate School of Natural and Applied ScienceBursaTurkey

This study was carried out to evaluate the water quality of selected dam lakes as well as their suitability for agricultural *** dams were selected for water sampling and samples were collected monthly,including during the irrigation season for a period of one year from March to september *** samples were analyzed for temperature,pH,physicochemical parameters such as temperature,pH value,salinity(EC),anions(CO_(3),HCO_(3),CI,sO_(4),P,NO_(3)),cations(Na,K,Ca,Mg,B,NH_(4))and heavy *** irrigation suitability assessment was made using various indices such as sAR(sodium adsorption rate),TDs(total dissolved solids),Na%(sodium percentage),RsC(residual sodium bicarbonate),MAR(magnesium adsorption rate),KR(Kelly ratio),and PI(permeability index).The temperature values of the water samples varied between 5.8℃-25.1℃,pH and EC values changed between 7.51 and 8.46,282,and 1400μs/cm *** water samples were evaluated as C_(2)s_(1) and C_(3)s_(1) irrigation water *** heavy metal contents of the water samples were determined below the limit *** dams were found suitable for irrigation in terms of EC(salinity),sAR(sodium adsorption rate),TDs(total dissolved solids),Na%(sodium percentage),RsC(residual sodium bicarbonate),MAR(magnesium adsorption rate),and KR(Kelly ratio).Water samples were determined as the second class of PI(permeability index).Güllübağdam was not found suitable as irrigation water in terms of EC,Na%,RsC,and KR *** a result,it specifically points to the restrictions on the use of water from the Güllübağdam for irrigation purposes.

关键词： anions cations irrigation water water quality

significant exercise limitations after recovery from MIs-C related myocarditis

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World Journal of Pediatrics 2023年第12期19卷 1149-1154页

作者： Gur Mainzer Merav Zucker-Toledano Moneera Hanna Ronen bar-Yoseph Einat Kodesh Pediatric Heart Institute Edmond and Lily Safra Children’s HospitalSheba Medical Center52621 Tel HashomerIsrael Pediatric Cardiology Department Hadassah Medical CenterJerusalemIsrael Pediatric Cardiology Unit Padeh Medical CenterPoriyaIsrael Pediatric Cardiology Institute Ruth Children’s HospitalRambam Health Care CampusHaifaIsrael Pediatric Pulmonary Institute Ruth Children’s HospitalRambam Health Care CampusHaifaIsrael The Technion Faculty of Medicine HaifaIsrael Department of Physical Therapy Faculty of Social Welfare and Health ScienceUniversity of HaifaHaifaIsrael

Background Myocarditis is one of the presentations of multisystemic infammatory syndrome in children(MIs-C)following coronavirus disease 2019(COVID-19).Although the reported short-term prognosis is good,data regarding medium-term functional capacity and limitations are *** study aimed to evaluate exercise capacity as well as possible cardiac and respiratory limitations in children recovered from MIs-C related *** Fourteen patients who recovered from MIs-C related myocarditis underwent spirometry and cardiopulmonary exercise testing(CPET),and their results were compared with an age-,sex-,weight-and activity level-matched healthy control group(n=14).Results All participants completed the CPET with peak oxygen uptake(peak.V O2),and the results were within the normal range(MIs-C 89.3%±8.9%and Control 87.9%±13.7%predicted.V O2).Five post-MIs-C patients(35%)had exerciserelated cardio-respiratory abnormalities,including oxygen desaturation and oxygen-pulse fattening,compared to none in the control *** MIs-C group also had lower peak exercise saturation(95.6±3.5 vs.97.6±1.1)and lower breathing reserve(17.4%±7.5%vs.27.4%±14.0%of MVV).Conclusions Patients who recovered from MIs-C related myocarditis may present exercise *** assessment(e.g.,CPET)should be included in routine examinations before allowing a return to physical activity in post-MIs-C ***,longer term studies assessing functional capacity and focusing on physiological mechanisms are needed.

关键词： Cardiopulmonary exercise testing COVID 19 Hypoxemia Myocarditis