Metabolomic studies of human gastric cancer:Review

作     者：Naresh Doni Jayavelu Nadav S Bar 

作者机构：Department of Chemical EngineeringNorwegian University of Science and TechnologyN7491 TrondheimNorway 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第25期

页      面：8092-8101页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Research Council of Norway NO.70174300 

主　　题：Metabolomics Gastric cancer Chemosensitivity Metastasis Biomarkers Nuclear magnetic resonance spectroscopy Liquid/gas chromatography and mass spectrometry 

摘      要：Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and noncancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis.