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Biomimetic glycosaminoglycan-based scaffolds improve skeletal muscle regeneration in a Murine volumetric muscle loss model

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Bioactive Materials 2021年第4期6卷 1201-1213页

作者： naagarajan narayanan Zhihao Jia Kun Ho Kim Liangju Kuang Paul Lengemann Gabrielle Shafer Victor Bernal-Crespo Shihuan Kuang Meng Deng Department of Agricultural and Biological Engineering Purdue UniversityWest LafayetteIN47906United States Bindley Bioscience Center Purdue UniversityWest LafayetteIN47906United States Department of Animal Science Purdue UniversityWest LafayetteIN47906United States Center for Comparative Translational Research Purdue UniversityWest LafayetteIN47906United States School of Materials Engineering Purdue UniversityWest LafayetteIN47906United States Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteIN47906United States

Volumetric muscle loss(VML)injuries characterized by critical loss of skeletal muscle tissues result in severe functional *** treatments involving use of muscle grafts are limited by tissue availability and donor site *** this study,we designed and synthesized an implantable glycosaminoglycan-based hydrogel system consisting of thiolated hyaluronic acid(HA)and thiolated chondroitin sulfate(CS)cross-linked with poly(ethylene glycol)diacrylate to promote skeletal muscle regeneration of VML injuries in *** HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation,myogenic differentiation and expression of myogenic markers MyoD,MyoG and ***,in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7+satellite cells,de novo myofiber formation,angiogenesis,and innervation with minimized scar tissue formation during 4-week *** hydrogel-treated and autograft-treated mice showed similar functional improvements in treadmill performance as early as 1-week post-implantation compared to the untreated *** together,our results demonstrate the promise of HA-CS hydrogels as regenerative engineering matrices to accelerate healing of skeletal muscle injuries.

关键词： Hyaluronic acid Chondroitin sulfate Hydrogels Volumetric muscle loss Myoblasts Skeletal muscle tissue engineering

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