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Adult neurogenesis in the primate hippocampus

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Zoological Research 2023年第2期44卷 315-322页

作者： Ye Li na-na Xu Zhao-Zhe Hao sheng Liu state Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhouGuangdong 510060China Guangdong Province Key Laboratory of Brain Function and Disease GuangzhouGuangdong 510080China

Adult hippocampal neurogenesis(AHN) is crucial for learning,memory,and *** of AHN may lead to reduced cognitive abilities and neurodegenerative disorders,such as Alzheimer’s *** studies on rodent AHN have clarified the developmental and maturation processes of adult neural stem/progenitor ***,to what extent these findings apply to primates remains *** advances in next-generation sequencing technologies have enabled in-depth investigation of the transcriptome of AHN-related populations at single-cell ***,we summarize studies of AHN in *** suggest that neurogenesis is largely shared across species,but substantial differences also *** gene expression patterns in primates differ from those of *** with rodents,the primate hippocampus has a higher proportion of immature dentate granule cells and a longer maturation period of newly generated granule *** research on species divergence may deepen our understanding of the mechanisms underlying adult neurogenesis in primates.

关键词： Neural precursor cells Immature granule cells sc-Rna-seq

Characterization and evaluation of UV-irradiation aging of urushi by micro-UV/Py-GC/Ms system

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science China(Technological sciences) 2023年第8期66卷 2258-2270页

作者： WANG na GU An LEI Yong Department of Conservation science The Palace MuseumBeijing 100009China

Lacquer is the main raw material of lacquerware,while UV-irradiation is an important factor leading to its *** order to investigate the aging behavior of urushi lacquer film under UV-irradiation,and to propose parameters that can be used to evaluate its aging degree,the micro-UV/Py-GC/Ms system has been applied in the present work to enrich and identify volatile products released by urushi film during aging on the one hand,and to investigate micro-amount and conventional urushi films with different aging degrees on the other hand,in addition,representative historical samples have also been *** products released by urushi film demonstrate that during UV-irradiation,polysaccharides wrapping urushiol polymer would be first degraded to generate furans and alcohols,and then urushiol polymer would undergo photo-oxidation and break of molecular chain,mainly generating oxidation products including aldehydes,organic acids,and ketones,as well as a small number of alkyl benzenes and ***-GC/Ms analysis of micro-amount urushi films with different aging degrees indicates that UVirradiation is more destructive to aliphatic chains in urushiol polymer,but it also can accelerate the polymerization of microamount urushi ***-GC/Ms analysis of conventional urushi films indicates that with the increase of aging degree,the total chromatographic peak area ratio of hydrocarbons to benzene derivatives gradually increases,the peak area ratio of 3-pentadecenyl-catechol to 3-pentadecyl-catechol gradually decreases,and the peak area ratio of aging products of urushiol to 3-pentadecyl-catechol gradually *** above parameters were further used to evaluate the aging degree of two urushicontained samples separately collected from the surface and interior of a carved lacquer panel in the Forbidden City,and evaluation results are in accord with the natural aging law and further verify the reliability of the proposed *** results of the pre

关键词： urushi UV-irradiation aging micro-UV/Py-GC/Ms aging degree evaluation

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Properties of collective flow and pion production in intermediate-energy heavy-ion collisions with a relativistic quantum molecular dynamics model

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Nuclear science and Techniques 2024年第1期35卷 155-169页

作者： si-na Wei Zhao-Qing Feng school of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

The relativistic mean-field approach was implemented in the Lanzhou quantum molecular dynamics transport model(***). Using the ***, the properties of collective flow and pion production were investigated systematically for nuclear reactions with various isospin asymmetries. The directed and elliptic flows of the *** are able to describe the experimental data of sTAR Collaboration. The directed flow difference between free neutrons and protons was associated with the stiffness of the symmetry energy, that is, a softer symmetry energy led to a larger flow difference. For various collision energies, the ratio between the π^(-) and π^(+) yields increased with a decrease in the slope parameter of the symmetry energy. When the collision energy was 270 MeV/nucleon, the single ratio of the pion transverse momentum spectra also increased with decreasing slope parameter of the symmetry energy in both nearly symmetric and neutron-rich ***, it is difficult to constrain the stiffness of the symmetry energy with the double ratio because of the lack of threshold energy correction on the pion production.

关键词： Heavy-ion collision Collective flow Pion production symmetry energy Relativistic mean field

Multi-Attribute Preferences Mining Method for Group Users with the Process of Noise Reduction

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Journal of Computer science & Technology 2021年第4期36卷 944-960页

作者： Qing-Mei Tan Xu-na Wang College of Economic and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China Research Base for Civilian-Military Integration Development in Jiangsu Province Nanjing 211106China

Traditional researches on user preferences mining mainly explore the user’s overall preferences on the project,but ignore that the fundamental motivation of user preferences comes from their attitudes on some attributes of the *** addition,traditional researches seldom consider the typical preferences combination of group users,which may have influence on the personalized service for group *** solve this problem,a method with noise reduction for group user preferences mining is proposed,which focuses on mining the multi-attribute preference tendency of group ***,both the availability of data and the noise interference on preferences mining are considered in the algorithm *** the process of generating group user preferences,a new path is used to generate preference keywords so as to reduce the noise ***,the Gibbs sampling algorithm is used to estimate the parameters of the ***,using the user comment data of several online shopping websites as experimental objects,the method is used to mine the multi-attribute preferences of different *** proposed method is compared with other methods from three aspects of predictive ability,preference mining ability and preference topic *** results show that the method is significantly better thap other existing methods.

关键词： preferences mining group user multi-attribute noise reduction noise interference

Testing High-Dimensional Nonparametric Behrens-Fisher Problem

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Journal of systems science & Complexity 2022年第3期35卷 1098-1115页

作者： MENG Zhen LI na YUAN Ao Academy of Mathematics and systems science Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of sciences Beijing 100049China Department of Biostatistics Bioinformatics and BiomathematicsGeorgetown UniversityWashington 20057USA

For high-dimensional nonparametric Behrens-Fisher problem in which the data dimension is larger than the sample size,the authors propose two test statistics in which one is U-statistic Rankbased Test(URT)and another is Cauchy Combination Test(CCT).CCT is analogous to the maximumtype test,while URT takes into account the sum of squares of differences of ranked samples in different dimensions,which is free of shapes of distributions and robust to *** asymptotic distribution of URT is derived and the closed form for calculating the statistical significance of CCT is *** simulation studies are conducted to evaluate the finite sample power performance of the statistics by comparing with the existing *** simulation results show that our URT is robust and powerful method,meanwhile,its practicability and effectiveness can be illustrated by an application to the gene expression data.

关键词： Cauchy combination test nonparametric Behrens-Fisher problem rank-based test U-statistic

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Effect of a Traffic speed Based Cruise Control on an Electric Vehicle’s Performance and an Energy Consumption Model of an Electric Vehicle

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IEEE/CAA Journal of Automatica sinica 2020年第2期7卷 386-394页

作者： Anil K.Madhusudhanan Xiaoxiang na Department of Engineering University of Cambridge

This paper proposes a cruise control system(CCs)to improve an electric vehicle's range,which is a significant hurdle in market penetration of electric vehicles.A typical driver or a conventional adaptive cruise control(ACC)controls an electric vehicle(EV)such that it follows a lead vehicle or drives close to the speed *** driving behaviour may cause the EV to cruise significantly above the average traffic *** may later require the EV to slow down due to the traffic ripples,wasting a part of the EV's kinetic *** addition,the EV will also waste higher speed dependent dissipative energies,which are spent to overcome the aerodynamic drag force and rolling *** paper proposes a CCs to address this *** proposed CCs controls an EV's speed such that it prevents the vehicle from speeding significantly above the average traffic *** addition,it maintains a safe inter-vehicular distance from the lead *** design and simulation analysis of the proposed CCs were in a MATLAB simulation *** simulation environment includes an energy consumption model of an EV,which was developed using data collected from an electric bus operation in *** the simulation analysis,the proposed system reduced the EV's energy consumption by approximately 36.6%in urban drive cycles and 15.4%in motorway drive ***,the experimental analysis using a Nissan e-NV200on two urban routes showed approximately 30.8%energy savings.

关键词： Cruise control electric vehicle(EV) energy performance safety traffic

Partial Linear Model Averaging Prediction for Longitudinal Data

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Journal of systems science & Complexity 2024年第2期37卷 863-885页

作者： LI na FEI Yu ZHANG Xinyu Faculty of science Kunming University of Science and TechnologyKunming 650500China school of statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221China Academy of Mathematics and systems science Chinese Academy of SciencesBeijing 100190China

Prediction plays an important role in data *** averaging method generally provides better prediction than using any of its *** though model averaging has been extensively investigated under independent errors,few authors have considered model averaging for semiparametric models with correlated *** this paper,the authors offer an optimal model averaging method to improve the prediction in partially linear model for longitudinal *** model averaging weights are obtained by minimizing criterion,which is an unbiased estimator of the expected in-sample squared error loss plus a *** properties,including asymptotic optimality and consistency of averaging weights,are established under two scenarios:(i)All candidate models are misspecified;(ii)Correct models are available in the candidate *** studies and an empirical example show that the promise of the proposed procedure over other competitive methods.

关键词： Asymptotic optimality longitudinal data model averaging estimator partially linear model prediction

sYNTHEsIs AND PROPERTIEs OF BIFUNCTIOnaL MAGNETIC-OPTICAL naNOMATERiaLs:Fe_2O_3@PDMAEMA-CAPPED Ⅱ－Ⅵ sEMICONDUCTOR QUANTUM DOTs naNOCOMPOsITEs

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Chinese Journal of Polymer science 2013年第9期31卷 1233-1241页

作者： na-na Zhao Wei Nie Jun Mao Wei-cai Wang Xiang-ling Ji state Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

A facile route to synthesize a new type of multifunctional nanocomposites is reported. Here, PDMAEMA （poly[2- （dimethylamino）ethyl] methacrylate） is a key macromolecule serving as a bridge between magnetic FeaO3 nanoparticles and luminescent quantum dots. Both Fe203 nanoparticles and II-VI semiconductor quantum dots with a narrow size distribution are synthesized through a two-phase thermal approach. subsequently, the atom transfer radical polymerization （ATRP） technique was applied to prepare magnetic Fe203@PDMAEMA core-shell nanoparticles. The thickness of PDMAEMA shell can be easily controlled by adjusting the reaction time. Finally, the ligand exchange method was exploited to modify II-VI quantum dot with amine-containing polymer of PDMAEMA, which led to quantum dot securely bound by Fe203@PDMAEMA core-shell nanoparticle to form a multifunctional nanocomposite. The resulting nanocomposite remains variable emission by tuning the II-VI semiconductor type and particle size and shows/arc at 49 kA/m and Tb at 16 K from Fe2O3 nanoparticles. The self-assembled behavior for the resulting samples is also discussed.

关键词： Bifunctional nanocomposite Magnetic-optical PDMAEMA semiconductor ATRP Two-phase method.

A Review on nanomaterial-based strategies for Manipulating Tumor Microenvironment to Enhance Chemodynamic Therapy

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Chemical Research in Chinese Universities 2024年第2期40卷 202-212页

作者： CAO Mengyu XING Xiner sHEN Xiaotong OUYANG Jin na na Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing100875P.R.China Department of Chemistry College of Arts and SciencesBeijing Normal University at ZhuhaiZhuhai519087P.R.China state Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan430074P.R.China

Cancer is a leading cause of death worldwide,and a series of strategies has been reported for tumor-specific ***,chemodynamic therapy(CDT)has become a research hotspot for antitumor treatment due to its advantages of high specificity,endogenous stimulation,and high ***,the therapeutic effects of CDT are normally limited in the complex tumor microenvironment(TME),such as insufficient acidity,tumor hypoxia,low hydrogen peroxide(H2O2),and high glutathione(GsH).Consequently,different kinds of multifunctional nanomaterials have been designed to manipulate TME conditions,which provided more opportunities to improve the efficiency of *** review focuses on nanomaterial-based strategies for enhancing CDT through manipulating *** CDT enhancements,this review would provide a reference for the future development of efficient CDT nanomaterials.

关键词： Chemodynamic therapy Tumor microenvironment nanomaterial Manipulating strategy Fenton/Fenton-like reaction