检索结果-南通市图书馆

维普期刊数据库博看期刊

Clinical efficacy and identification of factors confer resistance to afatinib(tyrosine kinase inhibitor)in EGFR-overexpressing esophageal squamous cell carcinoma

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 3130-3140页

作者： Yanni Wang Chang Liu Huan Chen Xi Jiao Yujiao Wang Yanshuo Cao Jian Li Xiaotian Zhang Yu Sun na zhuo Fengxiao Dong Mengting Gao Fengyuan Wang Liyuan Dong Jifang Gong Tianqi Sun Wei Zhu Henghui Zhang Lin Shen Zhihao Lu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Genecast Biotechnology Co. LtdWuxiPR China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital and InstituteBeijingChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijingChina Precision Scientific(Beijing)Co. Ltd.BeijingChina Generulor Company Bio-X Lab ZhuhaiGuangdongChina Biomedical Innovation Center Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory for Therapeutic Cancer Vaccines Beijing Shijitan HospitalCapital Medical UniversityBeijingChina

Epidermal growth factor receptor(EGFR)is reportedly overexpressed in most esophageal squamous cell carcinoma(ESCC)patients,but anti-EGFR treatments offer limited survival *** preclinical data showed the promising antitumor activity of afatinib in EGFR-overexpressing *** proof-of-concept,phase II trial assessed the efficacy and safety of afatinib in pretreated metastatic ESCC patients(n=41)with EGFR overexpression(NCT03940976).The study met its primary endpoint,with a confirmed objective response rate(ORR)of 39%in 38 efficacy-evaluable patients and a median overall survival of 7.8 months,with a manageable toxicity *** analysis of pretreatment tumors revealed that neurotrophic receptor tyrosine kinase 2(NTRK2)was negatively associated with afatinib sensitivity and might serve as a predictive biomarker,irrespective of EGFR ***,knocking down or inhibiting NTRK2 sensitized ESCC cells to afatinib *** study provides novel findings on the molecular factors underlying afatinib resistance and indicates that afatinib has the potential to become an important treatment for metastatic ESCC patients.

关键词： esophageal squamous expressing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

辐射对药代动力学的影响

中国临床药理学杂志 2024年第13期40卷 1996-2000页

作者：宗杰张海晖窦桂芳孟志云顾若兰吴卓娜朱晓霞胡瑄甘慧军事医学研究院辐射医学研究所北京100850

辐射主要来自医用射线、工业用射线、核废物和天然射线等,分为电离辐射和非电离辐射。研究电离和非电离辐射对药物代谢的影响,了解辐射后药物在机体内的吸收、分布以及辐射条件下消除快慢等情况,可对临床用药进行合理的指导。本文综述... 详细信息

辐射主要来自医用射线、工业用射线、核废物和天然射线等,分为电离辐射和非电离辐射。研究电离和非电离辐射对药物代谢的影响,了解辐射后药物在机体内的吸收、分布以及辐射条件下消除快慢等情况,可对临床用药进行合理的指导。本文综述了辐射对不同药物的药代动力学的影响,阐述辐射状态下不同药代动力学参数的变化,并讨论变化产生的原因。

关键词：药代动力学辐射动力学参数药物代谢酶

Real-Time Co-optimization of Gear Shifting and Engine Torque for Predictive Cruise Control of Heavy-Duty Trucks

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2024年第2期37卷 294-317页

作者： Hongqing Chu Xiaoxiang na Huan Liu Yuhai Wang zhuo Yang Lin Zhang Hong Chen School of Automotive Studies Tongji UniversityShanghaiChina Department of Engineering University of CambridgeCambridgeUK State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchunChina Qingdao Automotive Research Institute Jilin UniversityQingdaoChina Dongfeng Commercial Vehicle Technology Center Dongfeng Motor CorporationWuhanChina

Fuel consumption is one of the main concerns for heavy-duty *** cruise control(PCC)provides an intriguing opportunity to reduce fuel consumption by using the upcoming road *** this study,a real-time implementable PCC,which simultaneously optimizes engine torque and gear shifting,is proposed for heavy-duty *** minimize fuel consumption,the problem of the PCC is formulated as a nonlinear model predictive control(MPC),in which the upcoming road elevation information is *** the solution of the nonlinear MPC is time consuming;thus,a real-time implementable solver is developed based on Pontryagin’s maximum principle and indirect shooting *** programming(DP)algorithm,as a global optimization algorithm,is used as a performance benchmark for the proposed ***,hardware-in-the-loop and real-truck experiments are conducted to verify the performance of the proposed *** results demonstrate that the MPC-based solution performs nearly as well as the DP-based solution,with less than 1%deviation for testing ***,the proposed co-optimization controller is implementable in a real-truck,and the proposed MPC-based PCC algorithm achieves a fuel-saving rate of 7.9%without compromising the truck’s travel time.

关键词： Heavy-duty truck Predictive cruise control Model predictive control Pontryagin’s maximum principle Real-truck implementation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

西藏扎日南木措流域水环境特征及其影响因素

环境科学 2024年第8期45卷 4529-4539页

作者：李志龙张惠芳刘长兵陈旭索娜卓嘎德吉央宗周云桥牛学锐董慧科王小萍兰州大学资源环境学院兰州730000 西藏自治区生态环境监测中心拉萨850000 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101

扎日南木措位于藏西北高寒草原带,为西藏第三大湖,生态环境脆弱,长期以来其流域水环境的研究资料缺乏,为探究其流域地表水环境特征及影响因素,于2021年8月~2022年6月丰、枯、平水期对流域湖泊和入湖河流水环境进行调查,结合数理统计以... 详细信息

扎日南木措位于藏西北高寒草原带,为西藏第三大湖,生态环境脆弱,长期以来其流域水环境的研究资料缺乏,为探究其流域地表水环境特征及影响因素,于2021年8月~2022年6月丰、枯、平水期对流域湖泊和入湖河流水环境进行调查,结合数理统计以及水化学分析、相关分析和主成分分析等方法,对流域水化学特征进行了评价,分析了水质时空差异特征,并对水质影响因素进行了探讨.结果表明:①扎日南木措流域水体呈碱性,湖水离子组成以na^(+)、SO_(4)^(2-)和Cl^(-)为主,河流以Ca^(2+)、HCO_(3)~-和SO_(4)^(2-)为主.②硫酸盐、砷、氯化物和总磷为主要超标污染物,流域水质存在明显时空差异.时间上,硫酸盐、砷和总磷超标均表现为:丰水期>枯水期>平水期,氯化物的水期差异不明显;空间上,河流水质优于湖泊,湖泊中砷、总磷、TDS、硫酸盐、氯化物、K^(+)和na^(+)的浓度较河流高1~2个数量级,水质超标现象基本集中于湖区,而湖内水质空间差异小.③流域水化学过程主要受蒸发-浓缩和岩石风化下的自然过程控制,各类元素经地表径流进入湖泊后,在蒸发浓缩作用下不断富集最后产生超标.④水质时间差异主要是丰水期更多的元素淋失和更强烈的蒸发作用导致;而空间差异则主要是流动水体和封闭水体的水动力条件差异导致.

关键词：扎日南木措水化学特征时空差异影响因素主成分分析

Inhibiting effect of melittin on pathogens of crops

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2007年第5期52卷 639-644页

作者： PAN LingZi na Jie XING zhuo FANG HongJun WANG GuanLin College of Life Science Liaoning Normal University Dalian 116029 China

The spectrum of antimicrobial effects of melittin were investigated on 19 pathogens by using a cylin-der-plate method with serial dilutions. Bacteriostatic efficiency and possible mechanistic effects were monitored via growth curves. The mechanism of inhibition was further analyzed by SDS-PAGE, flow cytometry and electron microscopy. Melittin had a wide inhibition spectrum and killed pathogens ef-fectively, and bacteriostatic action was influenced by factors such as pH and temperature. We eluci-dated three inhibitory mechanisms: melittin integrated with the cell membrane causing cell bursting and cytoplasm release, inhibited the synthesis of proteins and caused the cytoplasm to condense, and delayed pathogens in phase I (or phase G1) so that they could not complete the cell cycle. These re-sults suggest that melittin could serve as a broad-spectrum biological pesticide with fast-action and high-efficiency.

关键词：蜂毒肽作物病原菌抑制作用抑菌机制抗菌谱

Alterations in Dna damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第8期19卷 1139-1149页

作者： Yujiao Wang Xi Jiao Shuang Li Huan Chen Xin Wei Chang Liu Jifang Gong Xiaotian Zhang Xicheng Wang Zhi Peng Changsong Qi Zhenghang Wang Yanni Wang na zhuo Jianling Zou Henghui Zhang Jian Li Lin Shen Zhihao Lu Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education)Peking University Cancer Hospital&InstituteBeijing 100142China Department of Gastric&Colorectal Surgery The First Hospital of Jilin UniversityChangchun 130021China Genecast Precision Medicine Technology Institute Beijing 100192China Life Sciences Institute Zhejiang UniversityHangzhou 310058China Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective:Immune checkpoint inhibitors(ICIs)have achieved remarkable results in cancer ***,there is no effective predictive biomarker for gastrointestinal(GI)***:We conducted integrative analyses of the genomic and survival data of ICI-treated GI cancer patients from the Memorial Sloan Kettering Cancer Center cohort(MSK-GI,n=227),the Janjigian cohort(n=40),and the Peking University Cancer Hospital&Institute cohort(PUCH,n=80)to determine the possible associations between Dna damage response and repair(DDR)gene mutations and clinical *** from The Cancer Genome Atlas database were analyzed to determine the possible correlations between DDR gene mutations and the tumor ***:In the MSK cohort,the presence of≥2 DDR gene mutations was correlated with prolonged overall survival(OS).The Janjigian and PUCH cohorts further confirmed that subgroups with≥2 DDR gene mutations displayed a prolonged OS and a higher durable clinical ***,the DDR gene mutation load could be considered as an independent prognostic factor,and exhibited a potential predictive value for survival in GI cancer patients treated with ***,we showed that the presence of≥2 DDR gene mutations was correlated with higher levels of tumor mutation burden,neoantigen,and T cell ***:The DDR gene mutation status was correlated with favorable clinical outcomes in GI cancer patients receiving ICIs,which could serve as a potential biomarker to guide patient selection for immunotherapy.

关键词： Gastrointestinal cancer DDR gene mutation immunotherapy biomarker

在线全文

学校读者我要写书评

暂无评论

国内外服务型制造研究热点与发展趋势

科学管理研究 2022年第6期40卷 50-58页

作者：卓娜周明生首都经济贸易大学经济学院北京100070 北京财贸职业学院北京101126

当前世界经济复苏乏力,正处在百年未有之大变局,服务型制造作为我国制造业打破“低端锁定”的有效路径,已成为制造业转型升级的重大趋势。基于文献计量方法,采用CiteSpace对Web of Science和中国知网数据库2000-2021年间服务型制造研究... 详细信息

当前世界经济复苏乏力,正处在百年未有之大变局,服务型制造作为我国制造业打破“低端锁定”的有效路径,已成为制造业转型升级的重大趋势。基于文献计量方法,采用CiteSpace对Web of Science和中国知网数据库2000-2021年间服务型制造研究成果进行可视化对比和分析,梳理了进入21世纪以来国内外学者对服务型制造研究现状,分析了国内外服务型制造研究的热点演化和发展趋势,在此基础上对该领域研究的前沿热点与研究方向进行述评。未来研究重点集中于数字服务化和服务生态系统,云制造、大数据、物联网、智能制造将是未来一个时期服务型制造的热门发展方向。

关键词：服务型制造数字服务化文献计量知识图谱

农村集体产权制度改革的实践探索及启示——来自试点典型地区的案例证据

在线全文

学校读者我要写书评

暂无评论

当代经济管理 2022年第1期44卷 53-60页

作者：卓娜柴智慧内蒙古农业大学经济管理学院内蒙古呼和浩特010010

农村集体产权制度改革是农村集体经济发展壮大的基础前提,是中国特色社会主义进入新时代后我国农村产权制度领域的一项重大变革。文章以6个典型试点地区为案例,发现各地区在组织领导、规范流程、宣传培训、经费保障等方面有序推进,改革... 详细信息

农村集体产权制度改革是农村集体经济发展壮大的基础前提,是中国特色社会主义进入新时代后我国农村产权制度领域的一项重大变革。文章以6个典型试点地区为案例,发现各地区在组织领导、规范流程、宣传培训、经费保障等方面有序推进,改革取得显著成效;然而,从全国范围来看,各地在股权设置与管理、集体收益分配和股权拓展、集体经济有效实现形式的创新等方面仍存在共性且亟待解决的问题。进一步深化改革需要从4个方面加以重视:区分改革重点,差异化改革方式;农民主动参与,透明化管理方式;有效处理改革过程中的重要关系;选准路子、自我“造血”以拓宽集体经济发展路径。

关键词：农村集体产权制度改革实践启示

案例与情景模拟联合教学法在产房助产带教中的应用

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

智慧健康 2022年第33期8卷 191-195,243页

作者：卓娜德阳市人民医院产科四川德阳618000

目的产房助产带教中,分析案例与情景模拟联合教学法的实际应用价值。方法选择2019年1月-2020年12月接受本院产房助产带教的学生100例为研究对象,将2019年1~12月接受本院产房助产带教的学生划为对照组,采用常规方式进行带教,将2020年1~1... 详细信息

目的产房助产带教中,分析案例与情景模拟联合教学法的实际应用价值。方法选择2019年1月-2020年12月接受本院产房助产带教的学生100例为研究对象,将2019年1~12月接受本院产房助产带教的学生划为对照组,采用常规方式进行带教,将2020年1~12月接受本院产房助产带教的学生划为观察组,采用案例与情景模拟联合教学法进行产房助产带教,每组各50名对比两组学生在接受产房助产带教之后理论、操作以及应急能力等方面的考核成绩,同时对比两组学生对于带教的满意度。结果从本次研究结果来看,相比于对照组学生来说,观察组学生在接受产房助产带教之后,其理论考核成绩、操作考核成绩、应急能力考核成绩均相对较高,组间差异显著(P<0.05)。观察组学生对于产房助产带教的满意度也整体高于对照组,组间差异显著(P<0.05)。结论产房助产带教中,通过应用情景模拟与案例联合教学法,能够有效提升学生的考核成绩,同时也非常有利于提升学生自身对于产房助产带教的满意度,教学中的推广价值相对较高。

关键词：案例情景模拟产房助产带教应用