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Neural Regeneration Research 2014年第24期9卷 2119-2121页

作者： Junyang Jung na young jeong Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University

After peripheral nerve injury, the process of Wallerian degeneration is initiated in the distal stump of injured nerves. Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the myelin sheath in Schwann cells. This provides the necessary conditions for axonal regeneration and remyelination. After nerve injury, macrophages are also recruited to the distal nerve stump and, together with Schwann cells, play a role in the clearance of myelin debris.

关键词： Hydrogen sulfide controls peripheral nerve degeneration and regeneration Figure

Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases

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Neural Regeneration Research 2020年第2期15卷 232-241页

作者： Rubaiya Tabassum na young jeong Junyang Jung Department of Anatomy and Cell Biology College of MedicineDong-A UniversitySeo-guBusanKorea Department of Medicine Graduate SchoolDong-A UniversitySeo-guBusanKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversityDongdaemun-guSeoulKorea

Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus-induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell(β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes in the central nervous system because high blood glucose levels(HbA1 c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus-induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide.

关键词： Alzheimer's disease amyotrophic lateral sclerosis antioxidant diabetic peripheral neuropathy Dna oxidation hydrogen sulfide mitochondrial dysfunction oxidative stress Parkinson's disease reactive oxygen species

Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

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Neural Regeneration Research 2020年第4期15卷 653-662页

作者： Rubaiya Tabassum na young jeong Junyang Jung Department of Anatomy and Cell Biology College of MedicineDong-A UniversityBusanKorea Department of Medicine Graduate SchoolDong-A UniversityBusanKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoulKorea

Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated *** of the major causes of age-related diseases is oxidative *** recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully *** enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of ***,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related *** to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and *** review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome.

关键词： 3-mercaptopyruvate sulfurtransferase aging antioxidant cystathionineβ-synthase cystathionineγ-lyase glutathione hydrogen sulfide neurodegenerative disease oxidative stress reactive oxygen species

A novel therapeutic target for peripheral nerve injury-related diseases: aminoacyl-tRna synthetases

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Neural Regeneration Research 2015年第10期10卷 1656-1662页

作者： Byung Sun Park Seung Geun Yeo Junyang Jung na young jeong Department of Anatomy and Neurobiology School of Medicine Kyung Hee University Department of Otolaryngolgy Head and Neck Surgery School of Medicine Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University

Aminoacyl-t Rna synthetases（Amino ARSs） are essential enzymes that perform the first step of protein synthesis. Beyond their original roles, Amino ARSs possess non-canonical functions, such as cell cycle regulation and signal transduction. Therefore, Amino ARSs represent a powerful pharmaceutical target if their non-canonical functions can be controlled. Using Amino ARSs-specific primers, we screened m Rna expression in the spinal cord dorsal horn of rats with peripheral nerve injury created by sciatic nerve axotomy. Of 20 Amino ARSs, we found that phenylalanyl-t Rna synthetase beta chain（FARSB）, isoleucyl-t Rna synthetase（IARS） and methionyl-t Rna synthetase（MARS） m Rna expression was increased in spinal dorsal horn neurons on the injured side, but not in glial cells. These findings suggest the possibility that FARSB, IARS and MARS, as a neurotransmitter, may transfer abnormal sensory signals after peripheral nerve damage and become a new target for drug treatment.

关键词： nerve regeneration aminoacyl-t Rna synthetases dorsal horn peripheral nerve injury in situ hybridization neural regeneration

Mitophagy links oxidative stress conditions and neurodegenerative diseases

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Neural Regeneration Research 2019年第5期14卷 749-756页

作者： Ulfuara Shefa na young jeong In Ok Song Hyung-Joo Chung Dokyoung Kim Junyang Jung youngbuhm Huh Department of Biomedical Science Graduate School Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University Department of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology Cheil General Hospital Dankook University College of Medicine Department of Anesthesiology and Pain Medicine College of Medicine Kosin University Department of Anatomy and Neurobiology College of Medicine Kyung Hee University

Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases. Proper regulation of mitophagy is crucial for maintaining homeostasis; conversely, inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species, including reactive oxygen species and reactive nitrogen species, resulting in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species. As mitophagy is essential for normal body function, by targeting mitophagic pathways we can improve these disease conditions. The search for effective remedies to treat these disease conditions is an ongoing process, which is why more studies are needed. Additionally, more relevant studies could help establish therapeutic conditions, which are currently in high demand. In this review, we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration. We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases.

关键词： nerve regeneration mitophagy central nervous system Alzheimer’s disease Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis oxidative species reactive oxygen species reactive nitrogen species

Anatomical distributional defects in mutant genes associated with dominant intermediate Charcot-Marie-Tooth disease type C in an adenovirus-mediated mouse model

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Neural Regeneration Research 2017年第3期12卷 486-492页

作者： Seo Jin Lee Sandesh Panthi Hyun Woo Jo Jaeyoung Cho Min-Sik Kim na young jeong In Ok Song Junyang Jung youngbuhm Huh Department of Biomedical Science Graduate SchoolKyung Hee UniversityDongdaemun-guSeoulKorea Department of Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoulKorea Department of Applied Chemistry College of Applied ScienceKyung Hee UniversityYongin-siGyeonggi-doKorea Department of Anatomy and Cell Biology College of MedicineDong-A UniversitySeo-guBusanKorea Department of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologyCheil General HospitalDankook University College of MedicineJung-guSeoulKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversityDongdaemun-guSeoulKorea

Dominant intermediate Charcot-Marie-Tooth disease type C（DI-CMTC） is a dominantly inherited neuropathy that has been classified primarily based on motor conduction velocity tests but is now known to involve axonal and demyelination ***-CMTC is linked to tyrosyl-t Rna synthetase（YARS）-associated neuropathies,which are caused by E196 K and G41 R missense mutations and a single de novo deletion（153-156 del VKQV）.It is well-established that these YARS mutations induce neuronal dysfunction,morphological symptoms involving axonal degeneration,and impaired motor *** present study is the first to describe a novel mouse model of YARS-mutation-induced neuropathy involving a neuron-specific promoter with a deleted mitochondrial targeting sequence that inhibits the expression of YARS protein in the *** adenovirus vector system and in vivo techniques were utilized to express YARS fusion proteins with a Flag-tag in the spinal cord,peripheral axons,and dorsal root *** transfection of YARS-expressing viruses,the distributions of wild-type（WT） YARS and E196 K mutant proteins were compared in all expressed regions; G41 R was not *** proportion of Flag/green fluorescent protein（GFP） double-positive signaling in the E196 K mutant-type mice did not significantly differ from that of WT mice in dorsal root ganglion *** adenovirus genes,and even the empty vector without the YARS gene,exhibited GFP-positive signaling in the ventral horn of the spinal cord because GFP in an adenovirus vector is driven by a cytomegalovirus *** present study demonstrated that anatomical differences in tissue can lead to dissimilar expressions of YARS ***,use of this novel animal model will provide data regarding distributional defects between mutant and WT genes in neurons,the DICMTC phenotype,and potential treatment approaches for this disease.

关键词： nerve regeneration tyrosyl-tRna synthetase YARS-associated neuropathy YARS mutation Charcot-Marie- Tooth Disease adenoviral vector-mediated mouse models neural regeneration

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay Liu young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

The efficacy of *** adjuvant chemotherapy on biliary tract cancer after R0 resection

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Chinese Journal of Cancer 2017年第5期36卷 222-230页

作者： young Saing Kim Chi-young jeong Haa-na Song Tae Hyo Kim Hong Jun Kim young-Joon Lee Soon Chan Hong Division of Hematology and Oncology Department of Internal MedicineGachon University Gil Medical Center Incheon 405.706 South Korea Department of Surgery Institute of Health Sciences Gyeongsang National University Hospital Gyeongsang National University School of Medicine 79 Gangnam-roJinju 660.702 South Korea Department of Internal Medicine Institute of Health Sciences Gyeongsang National University Hospital Gyeongsang National University School of Medicine Jinju 660.702 South Korea.

Background: The optimal treatment strategy for biliary tract cancer(BTC) after curative?intent resection remains con?troversial. The purpose of this study was to evaluate the efficacy of fluoropyrimidine?based adjuvant chemotherapy for BTC patients undergoing microscopically margin?negative(R0) ***: We retrospectively analyzed the clinical data of BTC patients who underwent curative?intent R0 resection. Patients were eligible if they received either fluoropyrimidine?based adjuvant chemotherapy or observation after R0 ***: A total of 153 patients were included. In the entire patient cohort, no significant differences were observed in 5?year overall survival(OS) rates(48.4% vs. 39.6%, P = 0.439) or 3?year recurrence?free survival(RFS) rates(49.1% vs. 39.5%, P = 0.299) between patients who received fluoropyrimidine?based adjuvant chemotherapy or observation. However, for patients with stages Ⅱ and Ⅲ BTC, chemotherapy significantly improved 5?year OS rate(52.4% vs. 35.6%, P = 0.002) and 3?year RFS rate(55.5% vs. 39.1%, P = 0.021) compared with ***: Fluoropyrimidine?based adjuvant chemotherapy may prolong the survival of patients with stages Ⅱ and Ⅲ BTC after R0 resection.

关键词： Biliary tract cancer Adjuvant chemotherapy Fluoropyrimidine R0 resection Prognosis

Microstructure and properties of alumina-silicon carbide nanocomposites fabricated by pressureless sintering and post hot-isostatic pressing

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 1-6页

作者： young-Keun jeong Koichi NIIHARA national Core Research Center for Hybrid Materials Solution Pusan National University nagaoka University of Technology

A1203/5%SIC nanocomposites were fabricated by pressureless sintering using MgO as a sintering aid and then post hot-isostatic pressed （HIP）, which can subsequently break through the disadvantage of hot-pressing process. The MgO additive was able to promote the densification of the composites, but could not induce the grain growth of A1203 matrix due to the grain growth inhibition by nano-sized SiC particles. After HIP treatment, A12OJSiC nanocomposites achieved full densification and homogeneous distribution of nano-sized SiC particles. Moreover, the fracture morphology of HIP treated specimens was identical with that of the hot-pressed A1203/SiC nanocomposites showing complete transgranular fracture. Consequently, high fracture strength of 1 GPa was achieved for the A1203/5%SIC nanocomposites by pressureless sintering and post HIP process.

关键词： nanocomposite pressureless sintering fracture strength

Effects of foundation damage and water-level change on vibration modal parameters of gravity-type caisson structure

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Science China(Technological Sciences) 2015年第2期58卷 316-329页

作者： LEE So-young KIM jeong-Tae Department of Ocean Engineering Pukyong National University

In this paper,the effects of foundation damage and water-level change on vibration characteristics of gravity-type caisson structure are examined by analyzing modal parameters extracted from output-only *** achieve the objective,the following approaches are ***,vibration response analysis methods are selected to estimate power spectral density and modal parameters such as natural frequency,damping ratio and mode shape of a lab-scale caisson structural ***,vibration tests on the lab-scale caisson system are performed under a series of test scenarios which include three water-level changes and three damage ***,experimental modal parameters corresponding to the damaging cases as well as the water level cases are extracted by frequency domain decomposition method and stochastic subspace identification ***,the effects of the water-level variation and foundation damage on the extracted modal parameters are examined to assess the feasibility of the vibration-based damage detection in gravity-type caisson structures under water-level uncertainty.

关键词： caisson structure gravity-type structure modal parameter effect of water-level foundation damage