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Determination of estrogens and estrogenic activities in water from three rivers in Tianjin, China

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Journal of Environmental Sciences 2013年第6期25卷 1164-1171页

作者： kaifeng rao Bingli Lei na li mei ma zijian wang Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Institute of Environmental Pollution and Health College of Environmental and Chemical EngineeringShanghai University Key Laboratary for Biomedical Effects of nanomaterials and nanosafety Key Laboratory of Nuclear Analytical TechniquesInstitute of High Energy PhysicsChinese Academy of Sciences

Studies on estrogenic disrupting compounds （EDCs） occurrence and identification of main responsible compounds in river water discharged into the sea are of significance. In the present research, we screened estrogenic activities of 10 river water samples from 3 main rivers discharged into Bohai Sea in Tianjin using a recombinant two-hybrid yeast assay and chemical analysis by gas chromatography-mass spectrometry. All sample extracts induced significant estrogenic activity, with 17^-estradiol equivalents （EEQ） of raw water ranging from 5.72 to 59.06 ng/L. Six most concerned EDCs in the fiver water samples including estrone, 17（5-estradiol, 17ct-ethinylestradiol, estriol, diethylstilbestrol and estradiol valerate were determined, with their concentrations up to 50.70, 31.40, 24.40, 37.20, 2.56, and 8.47 ng/L, respectively. Through causality analysis by comparing the EEQ values of yeast assay and chemical analysis, 17ct-ethinylestradiol and 17[3-estradiol were identified as the main contributors to the estrogenic effects of the river samples, accounting for the whole estrogenic activities （62.99% to 185.66%）, and estrogen antagonistic compounds might presented in the heavy polluted water samples. The proposed approach using both chemical analysis and bioassay could be used for identification and evaluation of the estrogenic activity of EDCs in river water.

关键词： river water endocrine disrupting compounds (EDCs) yeast assay bioassay

In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water of different treatment processes

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Frontiers of Environmental Science & Engineering 2014年第1期8卷 69-78页

作者： kaifeng rao na li mei ma zijian wang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Key Laboratory for Biomedical Effects of nanomaterials and nanosafety Key Laboratory of Nuclear Analytical Techniques Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China

Effluents from wastewater treatment plant （WWTP） have been reported to have a broad spectrum of endocrine disrupting compounds （EDCs）. The majority of studies have focused on the occurrence of estrogenic activity, while ignoring nuclear hormone receptors （NRs） pathways. In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic and agonistic effects on estrogen receptor （ER）, androgen receptor （AR）, progesterone receptor （PR）, estrogen- related receptor （ERR） and aryl hydrocarbon receptor （AHR）, were conducted to evaluate the removal efficien- cies of EDCs by different treatment processes of a WWTP located in Beijing. Estrogenic, anti-estrogenic, anti- androgenic, anti-progesteronic, anti-ERR and the activa- tion of AHR activities were detected in samples from all treatment processes and the receiving water. The concen- tration of estrogenic contaminants with estradiol （E2） equivalent concentrations ranged from 0.82 x 10-9 to 3.54 x 10 9g Ee_EQ.L-1. The concentration of anti-estrogenic contaminants with 4-hydroxytamoxifen （4-OHT） equiva- lent concentrations ranged from 1.24 × 10-6 to 2.36 x 10-6 g 4-OHT-EQ.L-1. The concentration of anti-androgenic contaminants ranged from 2.21 x 10-s to 3.52 × 10-6g flutamide-EQ. L-1. The concentration of anti-progesteronic contaminants ranged from 3.15 x 10^-5 to 2.71 x 10^-4g RU486-EQ. L-1. The concentration of anti-ERR contami- nants ranged from 7.09 x 10-5 to 6.50 x 104 g 4-OHT-EQ × L^-10. The concentration of AHR activators ranged from 1.7 × 10-10 to 3.4 × 10^-10g TCDD-EQ-L-1. These processes including secondary clarifier, coagulation, as well as coal and sand filtration could eliminated 67.2% of estrogenic contaminants, 47.0% of anti-estrogenic contaminants, 98.3% of anti-androgenic contaminants, 88.4% of anti- progesteronic contaminants, 65.4% of anti-ERR contami- nants and 46.9% of AHR activators. WWTP effluents contain multiple receptor disruptors may have very complex adverse ef

关键词： waste water in vitro recombinant yeast assay,ethoxyresomfin-O-deethylase (EROD) receptor endocrine

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Journal of Environmental Sciences 2011年第2期23卷 301-306页

作者： na li Weiwei Jiang kaifeng rao mei ma zijian wang Satyanarayanan Senthik Kumaran Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Unit of Toxicology Bharathiar University Coimbatore 641046 India

Environmental chemicals in drinking water can impact human health through nuclear receptors. Additionally, estrogen-related receptors （ERRs） are vulnerable to endocrine-disrupting effects. To date, however, ERR disruption of drinking water potency has not been reported. We used ERRy two-hybrid yeast assay to screen ERRy disrupting activities in a drinking water treatment plant （DWTP） located in north China and in source water from a reservoir, focusing on agonistic, antagonistic, and inverse agonistie activity to 4-hydroxytamoxifen （4-OHT）. Water treatment processes in the DWTP consisted of pre-chlorination, coagulation, coal and sand filtration, activated carbon filtration, and secondary chlorination processes. Samples were extracted by solid phase extraction. Results showed that ERRγ antagonistic activities were found in all sample extracts, but agonistic and inverse agonistic activity to 4-OHT was not found. When calibrated with the toxic equivalent of 4-OHT, antagonistic effluent effects ranged from 3.4 to 33.1 μg/L. In the treatment processes, secondary chlorination was effective in removing ERRy antagonists, but the coagulation process led to significantly increased ERRy antagonistic activity. The drinking water treatment processes removed 73.5 % of ERRy antagonists. To our knowledge, the occurrence of ERRy disruption activities on source and drinking water in vitro had not been reported previously. It is vital, therefore, to increase our understanding of ERRγ disrupting activities in drinking water.

关键词： drinking water estrogen receptor estrogen-related receptor two-hybrid yeast solid phase extraction

Spatio-temporal characteristics of genotoxicity in the Yangtze River under the background of COVID-19 pandemic

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Frontiers of Environmental Science & Engineering 2024年第11期18卷 121-132页

作者： Xinge wang na li Yingnan Han Xiao li Weixiao Qi Jian li kaifeng rao zijian wang Yanjie Wei mei ma Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Yangtze Eco-Environment Engineering Research Center China Three Gorges CorporationBeijing 100038China national Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery Beijing 100085China University of Chinese Academy of Sciences Beijing 100049China Center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China Engineering Research Center of Groundwater Pollution Control and Remediation Ministry of EducationCollege of Water SciencesBeijing Normal UniversityBeijing 100875China Key Laboratory of Environmental Protection in Water Transport Engineering Ministry of Communications Tianjin Research Institute of Water Transport EngineeringTianjin 300456China

The global spread of viruses can lead to the release of large amounts of disinfectants or antiviral drugs into the water *** resulting disinfection byproducts(DBPs)and residual antiviral drugs,acting as genotoxic substances or their precursors,may pose risks to aquatic animals and drinking water sources;however,to date,no studies have analyzed the changes in genotoxicity in the Yangtze River before and after the *** the present study,water and sediment samples from the Yangtze River were collected during different seasons,just before and after the outbreak of COVID-19,and were assessed using the SOS/umu test(with and without liver S9).The results indicated that water samples exhibited more pronounced genotoxicity than did sediments,with direct genotoxicity being the primary ***,there were significant regional differences,with notably greater genotoxicity observed in the upper Yangtze River than in the lower reaches before the COVID-19 ***,this trend was reversed six to ten months later,suggesting the accumulation of DBPs or antiviral drugs after the COVID-19 ***,the risk quotient indicated that 65%of the water samples posed a high risk for Paramecium caudatum,whereas 71%of the samples posed a medium risk for Danio rerio,thereby representing a potential threat to the ecological security of the Yangtze *** conclusion,this study,at the basin scale,revealed the impacts of COVID-19 on the Yangtze River,highlighting the need to prevent DBPs and pharmaceutical pollution during similar events in the future.

关键词： Yangtze River COVID-19 Genotoxicity Spatio-temporal characteristics

Fish forewarning of comprehensive toxicity in water environment based on Bayesian sequential method

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Journal of Environmental Sciences 2021年第12期33卷 150-159页

作者： kaifeng rao li Tang Xin Zhang Heyu Xiang liang Tang Yong liu Wei wang Jie Jiang mei ma Yiping Xu zijian wang State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Shenzhen Monitoring Centre of Ecology and Environment Shenzhen 518049China Department of Basic Courses Beijing Union UniversityBeijing 100101China Faculty of mathematics and Statistics Hubei UniversityWuhan 430062China CASA(Wuxi)Environmental Technology Co.Ltd. Wuxi 214024China College of Resources and Environment University of Chinese Academy of SciencesBeijing 101407China

Environmental impact of pollutants can be analyzed effectively by acquiring fish behavioral signals in water with biological behavior sensors. However, a variety of factors, such as the complexity of biological organisms themselves, the device error and the environmental noise, may compromise the accuracy and timeliness of model predictions. The current methods lack prior knowledge about the fish behavioral signals corresponding to characteristic pollutants, and in the event of a pollutant invasion, the fish behavioral signals are poorly discriminated. Therefore, we propose a novel method based on Bayesian sequential,which utilizes multi-channel prior knowledge to calculate the outlier sequence based on wavelet feature followed by calculating the anomaly probability of observed values. Furthermore, the relationship between the anomaly probability and toxicity is analyzed in order to achieve forewarning effectively. At last, our algorithm for fish toxicity detection is verified by integrating the data on laboratory acceptance of characteristic pollutants. The results show that only one false positive occurred in the six experiments, the present algorithm is effective in suppressing false positives and negatives, which increases the reliability of toxicity detections, and thereby has certain applicability and universality in engineering applications.

关键词： Bayesian sequential method Fish electrical signal Outlier detection Anomaly probability Time series forecasting

Retinoid X receptor activities of source waters in China and their removal efficiencies during drinking water treatment processes

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Chinese Science Bulletin 2012年第6期57卷 595-600页

作者： JIANG WeiWei YAN Ye li na ma mei wang DongHong rao kaifeng wang zijian SATYAnaRAYAnaN Senthi Kumaran State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Unit of Toxicology Bharathiar UniversityCoimbatore 641046India

There is increasing evidence of estrogenic activities of source waters and drinking waters in China based on estrogen receptors(ERs) ***,relating such activities to retinoid X receptors(RXRs) in both drinking and source waters are *** rectify this situation,we assessed 23 source water samples from six major river systems in *** also collected samples at various stages of water processing from three drinking water treatment plants(DWTPs) using a two-hybrid RXR yeast assay with and without *** RXR agonistic activity was observed,but significant antagonistic activity was detected in all sample *** RXR antagonistic activities of source water sample extracts ranged from 15.2% to 57.8% without metabolism and 11.5% to 68.3% with metabolism,*** the drinking water treatment processes,RXR antagonistic activities without metabolism and with metabolism of up to 31.4% and 37.5% were removed,***,the remaining RXR antagonists in treated drinking water from these source waters could still be harmful to human *** the best of our knowledge,the occurrence of in vitro RXR disruption activities in source and drinking water has not been previously reported in ***,an attempt was made to conduct detailed studies investigating RXR disrupting activities and their possible risks in source and drinking water.

关键词：雌激素受体水处理过程饮用水维甲酸中国水域去除率新陈代谢

In vitro assay for human thyroid hormone receptor β agonist and antagonist effects of individual polychlorinated naphthalenes and Halowax mixtures

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Chinese Science Bulletin 2011年第6期56卷 508-513页

作者： li na ma mei wang zijian SENTHIL KUmaRAN Satyanarayanan State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Unit of Toxicology Bharathiar University Coimbatore 641046 India

Polychlorinated naphthalenes (PCNs) are dioxin-like environmental contaminants. There is growing concern over the endocrine-disrupting effects of PCNs, but very few studies have investigated the effect of PCNs on the thyroid system. This study used a yeast two-hybrid assay, which included the recombinant human thyroid receptor(TR)-β and reporter genes, to characterize the TRβ-disrupting effects of five individual PCN congeners, five PCN Halowax mixtures, and naphthalene. Their agonist and antagonist effects were studied in the absence and presence of 5×10-7 mol/L 3,3′,5-triiodo-L-thyronine, which induced submaximal β-galactosidase activity. naphthalene, 1,2,3,4,5,6,7,8-octachloronaphthalene and all of the Halowax mixtures (Halowax 1000, 1001, 1013, 1014 and 1099) showed no agonist or antagonist activity on TRβ at the concentrations tested (up to 10-2 g/L). The lighter PCN congeners, namely 1-chloronaphthalene, 2-chloronaphthalene, 1,4-dichloronaphthalene and 1,2,3,4-tetrachloronaphthalene showed no agonist activity but showed significant antagonist activity on TRβ. The 20% relative inhibitory concentrations of these PCNs were less than 9.13 × 10-3 g/L. Thus, bioaccumulation of these lighter PCN congeners may disrupt the thyroid hormone system and inhibit TR-mediated cellular responses. Studies in the future should investigate the possible associations between the presence PCNs and adverse health outcomes.

关键词：甲状腺激素受体多氯萘激动剂混合物拮抗剂测定体外拮抗活性

Baishideng’s Reference Citation Analysis database announces the first Journal Article Influence Index of 101 core journals and a list of high-quality academic journals in gastroenterology and hepatology

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World Journal of Gastroenterology 2022年第37期28卷 5383-5394页

作者： Jin-Lei wang Yu-Jie ma li ma na ma Diao-mei Guo lian-Sheng ma Baishideng Publishing Group Inc PleasantonCA 94566United States

After three rounds of rigorous evaluation of core journals in gastroenterology andhepatology conducted by the Reference Citation Analysis (RCA) editorial team ofBaishideng Publishing Group (Baishideng), the RCA database of Baishidengofficially released the 2022 Journal Article Influence Index (2022 JAII) of 101 corejournals in gastroenterology and hepatology, for the first time. The list of 101 corejournals can be found at: https://***/Search-Journal. Among them, the highest 2022 JAII is 48.014 and the lowest is 3.900. Thisarticle highlights the top 20 journals, describes the calculation method for the 2022JAII, the evaluation process, and the inclusion principles for journals in the *** steps are the underpinning of the RCA’s empirical journal academicevaluation service by which the digital platform addresses the needs of authors toselect reliable journals for submission, readers to select high-quality literature forreading, and editors to track their own journal citation performance. As such, theRCA core journal list will serve as a useful Find-a-Journal tool. Any interestedparty is welcome to use this journal list and recommend it to their peers.

关键词： Reference Citation Analysis Journal Article Influence Index Gastroenterology and hepatology Journal list Find a journal Announcement

Baishideng’s Reference Citation Analysis database announces the first Article Influence Index of multidisciplinary scholars

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World Journal of Clinical Cases 2022年第29期10卷 10391-10398页

作者： Jin-Lei wang Yu-Jie ma li ma na ma Diao-mei Guo lian-Sheng ma Baishideng Publishing Group Inc PleasantonCA 94566United States

After three rounds of rigorous evaluation of registered scholars conducted by the Reference Citation Analysis(RCA)editorial team of Baishideng Publishing Group(Baishideng),the RCA database of Baishideng officially released the 2022 Article Influence Index(2022 AII)of 632 scholars from 74 countries/territories in 98 research categories,for the first *** list of 632 scholars can be found at:https://***/*** them,the highest 2022 AII is 348.211,the highest number of total citations is 42830,and the highest number of total articles is *** category with the largest number of RCA scholars is Gastroenterology&Hepatology,with a total of 100(15.8%),and the second is Surgery,with a total of 46(7.3%).This article summarizes the RCA scholars and describes the mission of RCA,the openness and transparency of RCA evaluation,the calculation method for the 2022 AII,and the evaluation process of RCA *** RCA scholar list will effectively serve as a useful Find-a-Scholar *** interested scholar is welcome to register and join this RCA scholar list.

关键词： Reference Citation Analysis Article Influence Index Scholar list Find a scholar Announcement