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Superwetting Ag/α-Fe_(2)O_(3) anchored mesh with enhanced photocatalytic and antibacterial activities for efficient water purification

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Green Energy & Environment 2024年第1期9卷 89-103页

作者： Jiakai Li Changpeng Lv Jiajia Song Xiaoling Zhang Xizhen huang Yingzhuo Ma Haijie Cao na Liu Department of Chemistry Tsinghua UniversityBeijing100084China Anhui Provincial Engineering Laboratory of Silicon-based Materials Engineering Technology Research Center of Silicon-based Materials(Anhui)School of Material and Chemical EngineeringBengbu UniversityBengbu233030China Institute of Materials for Energy and Environment College of Materials Science and EngineeringQingdao UniversityQingdao266071China

Superwetting materials have drawn unprecedented attention in the treatment of oily wastewater due to their preferable anti-fouling property and selective oil/water ***,it is still a challenge to fabricate multifunctional and environmentally friendly materials,which can be stably applied to purify the actual complicated ***,a Ag/Ag/α-Fe_(2)O_(3) heterostructure anchored copper mesh was intentionally synthesized using a facile two-step hydrothermal *** resultant mesh with superhydrophilicity and underwater superoleophobicity was capable of separating various oil/water mixtures with superior separation efﬁciency and high permeationﬂux driven by ***ﬁting from the joint effects of the smaller band gap of Ag/α-Fe_(2)O_(3) heterojunction,inherent antibacterial capacity of Ag/α-Fe_(2)O_(3) and Ag nanoparticles,favorable conductive substrate,as well as the hierarchical structure with superwettability,such mesh presented remarkably enhanced degradation capability toward organic dyes under visible light irradiation and antibacterial activity against both Escherichia coli(***)and Staphylococcus aureus(***)compared with the pure Ag/α-Fe_(2)O_(3) coated ***,the mesh exhibited bifunctional water puriﬁcation performance,in which organic dyes were eliminated simultaneously from water during oil/water separation in oneﬁltration *** importantly,this mesh behaved exceptional chemical resistance,mechanical stability and long-term ***,this material with multifunctional integration may hold promising potential for steady water puriﬁcation in practice.

关键词： Superwetting Ag/α-Fe_(2)O_(3)heterostructure Enhanced photocatalytic and antibacterial activities Water purification Long-term reusability

Hydrogel-Assisted Electrokinetics for High-Resolution and Non-invasive Flow Monitoring in Microfluidic Chips

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Chinese Journal of Chemistry 2024年第6期42卷 571-577页

作者： na Zhao Yanni Ma Zehua Yu Jun huang Xiangqian Fu Tao Qiu Kang Liu MOE Key Laboratory of Hydraulic Machinery Transients School of Power and Mechanical EngineeringWuhan UniversityWuhanHubei430072 China Department of Urology Renmin Hospital of Wuhan UniversityWuhanHubei430072 China Department of Organ Transplantation Renmin Hospital of Wuhan UniversityWuhanHubei430072 China

Convenient non-invasive flow monitoring would facilitate the operation and control in microfluidic chips,but is challenging due to the small space of microchannels and complex operation required in traditional optical *** this work,we propose a novel non-invasive strategy to probe microfluidic flows via streaming potential *** sealing one side of the microchannel with a piece of hydrogel film,streaming potential inside the channel can be clearly detected by electrodes at outer surface of the hydrogel due to ion diffusion in the *** is detected without sensors contacting with the internal ***,the electrodes shape like a tiny probe,which can move around mapping the flow distribution in a chip with the spatial resolution of 1 mm and flow rate detection limit of 3μL·min–*** inside the channels can also be detected,due to the fluctuation of streaming voltage when gas-liquid interface flows through the electrode,showing an easy and potential way for multi-functional flow monitoring in microfluidic chips.

关键词： Microfluidics Hydrogels Electrokinetics Flow monitoring Non-invasive Sensor Charge transport

nanotechnology’s frontier in combatting infectious and inflammatory diseases:prevention and treatment

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Signal Transduction and Targeted Therapy 2024年第3期9卷 998-1047页

作者： Yujing huang Xiaohan Guo Yi Wu Xingyu Chen Lixiang Feng na Xie Guobo Shen Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases,which continuously pose one of the most serious threats to human health,attributed to factors such as the emergence of new pathogens,increasing drug resistance,changes in living environments and lifestyles,and the aging *** rapid advancements in mechanistic research and drug development for these diseases,current treatments often have limited efficacy and notable side effects,necessitating the development of more effective and targeted anti-inflammatory *** recent years,the rapid development of nanotechnology has provided crucial technological support for the prevention,treatment,and detection of inflammation-associated *** types of nanoparticles(NPs)play significant roles,serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and *** can also directly combat pathogens and *** addition,nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory *** review categorizes and characterizes different types of NPs,summarizes their applications in the prevention,treatment,and detection of infectious and inflammatory *** also discusses the challenges associated with clinical translation in this field and explores the latest developments and *** conclusion,nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

关键词： prevention inflammatory treatment

Discovery of GluN2A subtype-selective N-methyl-d-aspartate(NMDA)receptor ligands

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1987-2005页

作者： Liyang Jiang na Liu Fabao Zhao Boshi huang Dongwei Kang Peng Zhan Xinyong Liu Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

The N-methyl-d-aspartate(NMDA)receptors,which belong to the ionotropic Glutamate receptors,constitute a family of ligand-gated ion *** the various subtypes of NMDA receptors,the GluN1/2A subtype plays a significant role in central nervous system(CNS)*** present article aims to provide a comprehensive review of ligands targeting GluN2A-containing NMDA receptors,encompassing negative allosteric modulators(naMs),positive allosteric modulators(PAMs)and competitive ***,the ligands’structure–activity relationships(SARs)and the binding models of representative ligands are also discussed,providing valuable insights for the clinical rational design of effective drugs targeting CNS diseases.

关键词： NMDA receptors GluN2A subtype Subtype-selective ligands SARs Protein ligand interactions

Simple Enzyme-Free Biosensor for Highly Sensitive and Selective Detection of miR-21 Based on Multiple Signal Amplification Strategy

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Journal of Analysis and Testing 2022年第1期6卷 27-34页

作者： Lin-na huang Zi-Jie Zhong Qiu-Jun Lu Feng Chen Ling-Ling Xie Cui-Yan Wu You-Yu Zhang Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China

Due to the fact that most microRnas are small in size,low abundance in biological samples,homologous sequence among family members,and protein enzymes-based strategies display limited practical applications,therefore,we reported a simple enzyme-free Dna sensor for microRna detection utilizing a multiple signal amplification *** sensing system termed as C-CHA-HCR includes six hairpin Dna reactants that are metastable on account of intramolecular *** Dna hairpin reactants are opened and hybridized with the corresponding complementary Dna strand in the presence of miR-21 via toehold-mediated CHA,HCR reaction,and circulation between CHA and HCR,resulting in a hugely amplifying signal *** introducing external protein enzymes,this sensing system showed highly sensitive and selective on the detection of miR-21.A linear response range of miR-21 from 25 pmol/L to 1 nmol/L with a limit of detection(LOD)of 1.8 pmol/L was *** promising biosensor was successfully applied to the detection of microRna in human serum samples with acceptable recovery rates,suggesting the potential applications in disease diagnosis,treatment,and prognosis.

关键词： Dna biosensor MicroRnas Enzyme-free FRET Multiple signal amplification

不同体重指数对妊娠糖尿病合并高血压患者妊娠结局的影响及胰岛功能的变化

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临床和实验医学杂志 2024年第9期23卷 968-972页

作者：杜瑞娟袁乐黄娜孙莉莉王苓王雪梅周静于增荣唐山市妇幼保健院妇产科河北唐山063000

目的探讨孕期不同体重指数(BMI)增长幅度(ΔBMI)变化对妊娠糖尿病(GDM)合并高血压患者妊娠结局的影响,及其胰岛功能的变化。方法回顾性选取2021年1月至2022年12月在唐山市妇幼保健院进行产检及分娩的GDM合并高血压患者200例作为研究对象... 详细信息

目的探讨孕期不同体重指数(BMI)增长幅度(ΔBMI)变化对妊娠糖尿病(GDM)合并高血压患者妊娠结局的影响,及其胰岛功能的变化。方法回顾性选取2021年1月至2022年12月在唐山市妇幼保健院进行产检及分娩的GDM合并高血压患者200例作为研究对象,根据ΔBMI变化量将其分成BMI增长不足组(ΔBMI6 kg/m^(2),n=62),并根据母婴结局不同将患者分为母婴结局不良组(n=60)与母婴结局正常组(n=140)。比较BMI增长不足组、BMI增长正常组、BMI增长过多组的临床资料(年龄、孕前BMI、糖尿病家族病史、文化程度、居住地、分娩方式、新生儿结局、产妇并发症)、孕期胰岛功能[胰岛素抵抗指数(HOMA-IR)及胰岛β细胞功能指数(HOMA-β)]、血压、ΔBMI的差异;分析ΔBMI与母婴不良结局的相关性;比较不同母婴结局产妇临床特征及孕期ΔBMI的差异;采用多因素Logistic回归分析对影响GDM合并高血压发生母婴结局不良的因素进行分析。结果(1)3组分娩方式比较,差异有统计学意义(P5.83、HOMA-IR>4.92、HOMA-β141.15 mmHg、24 h平均舒张压>90.88 mmHg是母婴结局不良的危险因素(P<0.05)。结论孕期ΔBMI增长过多或不足,可导致GDM合并高血压产妇出现胰岛素抵抗增加,β细胞功能降低,血压异常的现象。孕期ΔBMI与GDM合并高血压产妇母婴结局不良呈正相关,ΔBMI增高会增加母婴结局的不良发生率,孕期应监测患者的体重变化。

关键词：妊娠期糖尿病妊娠高血压体重指数母婴结局

Rare leptin in non-alcoholic fatty liver cirrhosis:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10293-10300页

作者： Yao-Bin Nong Hong-na huang Jing-Jing huang Yuan-Qin Du Wen-Xuan Song De-Wen Mao Yue-Xue Zhong Rong-Huo Zhu Xi-Yu Xiao Rui-Xi Zhong The First Clinical Medical College Guangxi University of Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina Department of Internal Medicine of Traditional Chinese Medicine The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina Department of Spleen and Stomach Liver Diseases The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina Department of Hepatology The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanningGuangxi Zhuang Autonomous RegionChina

BACKGROUND Non-alcoholic fatty liver disease(naFLD)-related cirrhosis is mainly caused by naFLD by causing inflammation which leads to *** role of leptin in naFLD-related cirrhosis has been rarely *** SUMMARY This study presents the case of a 65-year-old male patient who was referred to The First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi,Chi-na,for diagnosis and treatment for liver ***,the cause of liver cirrhosis was *** radiology,laboratory examination,pathological results and analysis of the patient’s signs and symptoms,the case was finally diagnosed with final naFLD-related *** this study reports a single case,the findings might expand the understanding of leptin’s role in naFLD-related cirrhosis and might provide a basis for the clinical diagnostic criteria,pathological features and treatment of naFLD-related *** Although the occurrence of marasmus naFLD-related cirrhosis is rare,it needs to be distinguished from other liver diseases,including viral hepatitis,drug-induced liver disease,Wilson’s disease and autoimmune liver *** treatment is needed to prevent the progression of naFLD-related cirrhosis.

关键词： Non-alcoholic fatty cirrhosis Leptin type Nonalcoholic fatty liver disease Case report

Characterization and Genetic Analysis of a Novel Rice Spotted-leaf Mutant HM47 with Broad-spectrum Resistance to Xanthomonas oryzae pv. oryzae

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Journal of Integrative Plant Biology 2013年第5期55卷 473-483页

作者： Bao-Hua Feng Yang Yang Yong-Feng Shi Hai-Chao Shen Hui-Mei Wang Qi-na huang Xia Xu Xiang-Guang Lü Jian-Li Wu State Key Laboratory of Rice Biology China National Rice Research Institute College of Life and Environmental Sciences Hangzhou Normal University

A stable inherited rice spotted-leaf mutant HM47 derived from an EMS-induced IR64 mutant bank was identified. The mutant expressed hypersensitive response （HR）-like symptoms throughout its whole life from the first leaf to the flag leaf, without pathogen invasion. Initiation of the lesions was induced by light under natural summer field conditions. Expression of pathogenesis-related genes including PAL, PO-C1, POX22.3 and PBZ1 was enhanced significantly in association with cell death and accumulation of H2O2 at and around the site of lesions in the mutant in contrast to that in the wild-type （WT）. Disease reaction to Xanthomonas oryzae pv. oryzae from the Philippines and China showed that HM47 is a broad-spectrum disease-resistant mutant with enhanced resistance to multiple races of bacterial blight pathogens tested. An F2 progeny test showed that bacterial blight resistance to race HB-17 was cosegregated with the expression of lesions. Genetic analysis indicated that the spotted-leaf trait was controlled by a single recessive gene, tentatively named spl HM47 , flanked by two insertion/deletion markers in a region of approximately 74 kb on the long arm of chromosome 4. Ten open reading frames are predicted, and all of them are expressed proteins. Isolation and validation of the putative genes are currently underway.

关键词： Rice broad-spectrum disease resistance physical map pathogenesis-related genes spotted-leaf.

原子层沉积Al_(2)O_(3)对尖晶石LiNi_(0.5)Mn_(1.5)O_(4)正极材料的影响机理

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矿冶工程 2024年第4期44卷 8-12页

作者：李倩赵妍崔雅茹王硕然黄娜李常林王文培马红周杜金晶何喜红翁雅青西安建筑科技大学冶金工程学院陕西西安710055 江西省科学院应用化学研究所江西南昌330012

为提升尖晶石相LiNi_(0.5)Mn_(1.5)O_(4)正极材料在深度荷电状态下的界面稳定性,采用原子层沉积法在单晶LiNi_(0.5)Mn_(1.5)O_(4)正极材料表面可控沉积了纳米级Al_(2)O_(3)层。改性后的LiNi_(0.5)Mn_(1.5)O_(4)正极材料表现出优异的长... 详细信息

为提升尖晶石相LiNi_(0.5)Mn_(1.5)O_(4)正极材料在深度荷电状态下的界面稳定性,采用原子层沉积法在单晶LiNi_(0.5)Mn_(1.5)O_(4)正极材料表面可控沉积了纳米级Al_(2)O_(3)层。改性后的LiNi_(0.5)Mn_(1.5)O_(4)正极材料表现出优异的长循环耐腐蚀性能(1C电流密度下循环500次的容量保持率高达94.7%)。进一步的表界面解析结果表明:原子层沉积技术构建的纳米级Al_(2)O_(3)包覆层能够明显抑制材料本体与电解液的腐蚀反应,降低过渡金属离子的不可逆溶解与析出;另外,基于HF表面刻蚀产生的AlF_(3)具有增强的耐刻蚀性能,可显著提升LiNi_(0.5)Mn_(1.5)O_(4)正极材料在长循环及高电压下的服役性能。

关键词：锂离子电池 LiNi_(0.5)Mn_(1.5)O_(4) 正极材料原子层沉积 Al_(2)O_(3) 表面改性