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Therapeutic potentials of peptide-derived nanoformulations in atherosclerosis:present status and future directions

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International Journal of Smart and Nano Materials 2024年第3期15卷 610-651页

作者： Xue Liu Weijiao Wang Qiang Li hongtao niu Weili Zhang Department of Cardiovascular Medicine Yantaishan HospitalYantaiChina Department of Otolaryngology Yantaishan HospitalYantaiChina Department of Geriatric Medicine Yantaishan HospitalYantaiChina

Atherosclerosis is a severe cardiovascular disease followed by the accumulation of atherosclerotic plaques within the lumen of blood vessels resulting in reduced blood flow thus initiating a series of *** therapies for atherosclerosis encounter multiple chal-lenges,especially difficulty in precisely concentrating in certain affected regions and the potential for unwanted side ***,scientists are focused on developing nanoformulations for atherosclerosis diagnosis and ***-based nanomedi-cines improve conventional therapies by offering improved structural and therapeutic stability and enabling target-specific *** inherent biocompatibility and biodegradability additionally render them desirable materials intended for in vivo *** review manu-script aims to provide an in-depth overview of peptide-based nano-medicines for atherosclerosis,focusing on targeted cells like endothelial cells,macrophages,and monocytes and their interaction with different plaque ***,the manuscript also highlights the latest progress in multimodal techniques and provides a comprehensive overview of limitations associated with their practical implementation.

关键词： Atherosclerosis anti-atherosclerotic drugs bioavailability peptide-based nanomedicines drug targeting

THE THRESHOLD DYNAMICS OF A WATERBORNE PATHOGEN MODEL WITH SEASONALITY IN A POLLUTED ENVIRONMENT

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Acta Mathematica Scientia 2024年第6期44卷 2165-2189页

作者： Shun ZHI Youhui SU hongtao niu Lizhong QIANG School of Mathematics and Statistics Xuzhou University of TechnologyXuzhou 221018China School of Science Shenyang University of TechnologyShenyang 110870China College of Mathematics and Statistics Northwest Normal UniversityLanzhou 30070China

This paper concentrates on the dynamics of a waterborne pathogen periodic PDE model with environmental *** this model,we derive the basic reproduction number R0and establish a threshold type result on its global dynamics in terms of R0,which predicts the extinction or persistence of *** precisely,the disease-free steady state is globally attractive if R_(0)***,we carry out some numerical simulations to illustrate the long-term behaviors of solutions and explore the influence of environmental pollution and seasonality on the spread of waterborne diseases.

关键词： waterborne pathogen environmental pollution the basic reproduction number seasonality

Exposure Response Relationship of Acute Effects of Air Pollution on Respiratory Diseases-China,2013−2018

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China CDC weekly 2021年第45期3卷 943-947页

作者： hongtao niu Tao Yu Xuexin Li Hanna Wu Meilin Yan Ruirui Duan Ting Yang Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijingChina National Center for Respiratory Medicine BeijingChina Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijingChina National Clinical Research Center for Respiratory Diseases BeijingChina Peking Union Medical College Chinese Academy of Medical SciencesBeijingChina Peking University China-Japan Friendship School of Clinical Medicine BeijingChina BIC-ESAT and SKL-ESPC College of Environmental Sciences and EngineeringPeking UniversityBeijingChina Center for Environment and Health Peking UniversityBeijingChina Department of Pulmonary and Critical Care Medicine The Second Hospital of Dalian Medical UniversityDalianLiaoningChina

Summary What is already known about this topic?Short-term exposure to air pollutants has been associated with chronic obstructive pulmonary disease(COPD)and asthma,which needs continuous *** is added by this report?This study uses the longest time series data so far from 2013 to 2018 and adds additional data analysis for ozone(O_(3))to existing studies.

关键词： asthma Acute ozone

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陕南地区土岩接触带滑坡地质灾害预测研究

灾害学 2020年第1期35卷 125-130页

作者：牛洪涛安康学院

陕南地区土岩接触带滑坡地质灾害发生频繁且分布广泛,对人们正常生活造成较大影响,因此该文提出基于GIS的陕南地区土岩接触带滑坡地质灾害预测方法。通过划分研究区预测单元,生成土岩接触带斜坡坡度分布图、岩组类型和断层分布图等基础... 详细信息

陕南地区土岩接触带滑坡地质灾害发生频繁且分布广泛,对人们正常生活造成较大影响,因此该文提出基于GIS的陕南地区土岩接触带滑坡地质灾害预测方法。通过划分研究区预测单元,生成土岩接触带斜坡坡度分布图、岩组类型和断层分布图等基础构件,以此建立滑坡地质灾害信息量预测模型,结合信息量模型与GIS技术,对预测出的滑坡地质灾害信息量进行分级,从而得到预测结果,完成陕南地区土岩接触带滑坡地质灾害预测。实例分析结果可知,在研究区坡度在6°~25°之间时,预测发生滑坡灾害比例较高且包括的信息量较多,且滑坡灾害发生前10 d中,第4 d发生降雨,对滑坡灾害影响最大。

关键词：陕南地区土岩接触带地质灾害预测 GIS 信息量

Influenza and pneumococcal vaccination coverage and associated factors in patients hospitalized with acute exacerbations of COPD in China:Findings from real-world data

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Chinese Medical Journal 2024年第10期137卷 1179-1189页

作者： Ruoxi He Xiaoxia Ren Ke Huang Jieping Lei hongtao niu Wei Li Fen Dong Baicun Li Ye Wang Ting Yang Chen Wang School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Respiratory Medicine National Key Clinical SpecialtyBranch of National Clinical Research Center for Respiratory DiseaseXiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing 100029China National Center for Respiratory Medicine Beijing 100029China National Clinical Research Center for Respiratory Diseases Beijing 100029China Department of Clinical Research and Data Management Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

Background:Influenza and pneumococcal vaccination are a priority in patients with chronic obstructive pulmonary disease(COPD).However,limited information is available on vaccination coverage among patients with acute exacerbations of COPD(AECOPD)in *** study aimed to determine the rates and associated factors of influenza and pneumococcal vaccination in patients hospitalized with ***:Baseline data from a national,multicenter,hospital-based study that included adult inpatients with AECOPD between 2017 and 2021 were *** outcomes of interest were the influenza vaccination in the past year and the pneumococcal vaccination in the past 5 *** ensure national representativeness,rates were weighted according to the distribution of hospital levels and types enrolled in this *** Poisson regression based on mixed-effects models were used to determine the associated *** independent variables included the region and hospital features where the participants were located,sociodemographic characteristics(age,sex,rural/urban residence,education,etc.),and clinical indicators(COPD disease history,lung function parameters,comorbidities,etc.).The treatment profiles of the vaccinated and unvaccinated participants were ***:Of 6949 eligible participants,the weighted rates of influenza/pneumococcal,influenza,and pneumococcal vaccination were 2.72%(95%confidence interval[CI]:2.34%-3.10%),2.09%(95%CI:1.76%-2.43%),and 1.25%(95%CI:0.99%-1.51%),*** multivariable models,age≥60 years(60-69 years,odds ratio[OR]:1.90,95%CI:1.11-3.25;≥80 years,OR:2.00,95%CI:1.06-3.78),geographical regions(Northern China relative to Eastern China,OR:5.09,95%CI:1.96-13.21),urban residence(OR:1.69,95%CI:1.07-2.66),a higher education level(junior high school,OR:1.77,95%CI:1.21-2.58;senior high school or above,OR:2.61,95%CI:1.69-4.03),former smoking(OR:1.79,95%CI:1.15-2.79),and regular inhaled medication treatment(OR:3.28,95%CI:2.29-4.70)were

关键词： Chronic obstructive pulmonary disease Influenza Pneumococcal Vaccine AECOPD

基于LabVIEW的涡旋压缩机曲轴振动测试系统设计

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现代电子技术 2020年第18期43卷 71-74页

作者：牛洪涛李超兰州交通大学化学与生物工程学院甘肃兰州730070 兰州理工大学石油化工学院甘肃兰州730050

涡旋压缩机曲轴振动是反映压缩机工作性能的一个重要参数。为实时显示曲轴振动情况,利用同一平面且相互垂直的2个电涡流传感器,并运用LabVIEW及相关硬件产品,搭建曲轴振动测试系统,实现曲轴振动信号的实时采集、分析和存储,提高了测量... 详细信息

涡旋压缩机曲轴振动是反映压缩机工作性能的一个重要参数。为实时显示曲轴振动情况,利用同一平面且相互垂直的2个电涡流传感器,并运用LabVIEW及相关硬件产品,搭建曲轴振动测试系统,实现曲轴振动信号的实时采集、分析和存储,提高了测量精度。结果表明:该测试系统能及时反馈涡旋压缩机曲轴的振动情况,实时显示曲轴振动位移改变量所形成的轴心轨迹及互相垂直位移信号处理后的波形、功率谱等;并能通过轴心运动轨迹来推断曲轴振动的故障类型,为涡旋压缩机故障预防提供理论参考。

关键词：涡旋压缩机曲轴振动测试系统设计 LabVIEW 信号处理故障预防

陕南地区土岩接触带滑坡地质灾害预测模型构建

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华南地震 2019年第4期39卷 19-24页

作者：牛洪涛安康学院

陕南地区多为黄土泥岩土质,土岩接触带极易发生滑坡地质灾害,亟需构建有效的滑坡预测模型。BP神经网络模型预测滑坡过程中,神经网络的初始权值随机选择性强、缺乏足够科学依据,导致网络结构不稳定、收敛效果差,预测误差大。为此采用全... 详细信息

陕南地区多为黄土泥岩土质,土岩接触带极易发生滑坡地质灾害,亟需构建有效的滑坡预测模型。BP神经网络模型预测滑坡过程中,神经网络的初始权值随机选择性强、缺乏足够科学依据,导致网络结构不稳定、收敛效果差,预测误差大。为此采用全局搜索性能优的遗传算法优化神经网络初始权值,基于BP算法训练神经网络,构建精度高、效率高的BP神经网络滑坡预测模型;模型将体现陕南地区土岩接触带特点的接触带岩性、孔隙比、含水率、液性指数、坡度、坡高因子作为输入信号,输出结果为(0,1)、(1,0),分别表示发生滑坡与不发生滑坡。经过仿真验证,模型预测结果与实际结果一致,可用于陕南地区土岩接触带滑坡地质灾害的实际预测。

关键词：陕南地区土岩接触带滑坡地质灾害 BP神经网络初始权值预测模型

应用LDV测量水洞式游泳机波浪水流速度特性

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实验技术与管理 2018年第9期35卷 55-58页

作者：牛洪涛李治明沈熊清华大学工程力学系北京100084 北京飞骊佳科技服务有限公司北京100084

提出了一种采用导光管和测量体反射镜的激光多普勒测速(LDV)新方法,成功测得了游泳机主流区的流速和速度分布,以及游泳机的速度控制特性,为检验和评价游泳机的技术性能指标提供了依据,对自由水面下的流速测量也有参考价值。

关键词：游泳机波浪水流速度特性激光多普勒测速

Development of a prediction model to identify undiagnosed chronic obstructive pulmonary disease patients in primary care settings in China

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Chinese Medical Journal 2023年第6期136卷 676-682页

作者： Buyu Zhang Dong Sun hongtao niu Fen Dong Jun Lyu Yu Guo Huaidong Du Yalin Chen Junshi Chen Weihua Cao Ting Yang Canqing Yu Zhengming Chen Liming Li on behalf of the China Kadoorie Biobank Collaborative Group Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina–Japan Friendship HospitalBeijing 100029China National Center for Respiratory Medicine and National Clinical Research Center for Respiratory Diseases Beijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesBeijing 100007China Peking University Center for Public Health and Epidemic Preparedness and Response Beijing 100191China Key Laboratory of Molecular Cardiovascular Sciences(Peking University) Ministry of EducationBeijing 100191China National Center for Cardiovascular Diseases Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Medical Research Council Population Health Research Unit at the University of Oxford Oxford OX37LFUK Clinical Trial Service Unit and Epidemiological Studies Unit Nuffield Department of Population HealthUniversity of OxfordOxford OX37LFUK Maiji Center for Disease Control and Prevention TianshuiGansu 741020China China National Center for Food Safety Risk Assessment Beijing 100022China 不详

Background:At present,a large number of chronic obstructive pulmonary disease(COPD)patients are undiagnosed in ***,this study aimed to develop a simple prediction model as a screening tool to identify patients at risk for ***:The study was based on the data of 22,943 subjects aged 30 to 79 years and enrolled in the second resurvey of China Kadoorie Biobank during 2012 and 2013 in *** stepwisely selected the predictors using logistic regression *** we tested the model validity through P-P graph,area under the receiver operating characteristic curve(AUROC),ten-fold cross validation and an external validation in a sample of 3492 individuals from the Enjoying Breathing Program in ***:The final prediction model involved 14 independent variables,including age,sex,location(urban/rural),region,educational background,smoking status,smoking amount(pack-years),years of exposure to air pollution by cooking fuel,family history of COPD,history of tuberculosis,body mass index,shortness of breath,sputum and *** model showed an area under curve(AUC)of 0.72(95%confidence interval[CI]:0.72-0.73)for detecting undiagnosed COPD patients,with the cutoff of predicted probability of COPD=0.22,presenting a sensitivity of 70.13%and a specificity of 62.25%.The AUROC value for screening undiagnosed patients with clinically significant COPD was 0.68(95%CI:0.66-0.69).Moreover,the ten-fold cross validation reported an AUC of 0.72(95%CI:0.71-0.73),and the external validation presented an AUC of 0.69(95%CI:0.68-0.71).Conclusion:This prediction model can serve as a first-stage screening tool for undiagnosed COPD patients in primary care settings.

关键词： Chronic obstructive pulmonary disease Screening Prediction model China Kadoorie Biobank