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Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis

World Journal of Gastroenterology 2011年第36期17卷 4076-4089页

作者： Malgorzata Zwolinska-Wcislo Tomasz Brzozowski Agata Ptak-Belowska Aneta Targosz Katarzyna Urbanczyk Slawomir Kwiecien zbigniew Sliwowski Gastroenterology and Hepatology Clinic Jagiellonian University Medical College31-531 CracowPoland Department of Physiology Jagiellonian University Medical College31-531 CracowPoland Department of Pathomorphology Jagiellonian University Medical College31-531 CracowPoland

AIM:To determine the effect of non-selective cyclooxygenase (COX) inhibitors,selective COX-2 inhibitors and nitric oxide (NO)-releasing aspirin in the healing of ulcerative ***:Rats with 2,4,6 trinitrobenzenesulfonic acid (TNBS)-induced colitis received intragastric (ig) treatment with vehicle,aspirin (ASA) (a nonselective COX inhibitor),celecoxib (a selective COX-2 inhibitor) or NO-releasing ASA for a period of ten *** area of colonic lesions,colonic blood flow (CBF),myeloperoxidase (MPO) activity and expression of proinflammatory markers COX-2,inducible form of nitric oxide synthase (iNOS),IL-1β and tumor necrosis factor (TNF)-α were *** effects of glyceryl trinitrate (GTN),a NO donor,and 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethyl-1H-imidazolyl-1-oxy-3-oxide,onopotassium salt (carboxy-PTIO),a NO scavenger,administered without and with ASA or NO-ASA,and the involvement of capsaicin-sensitive afferent nerves in the mechanism of healing the experimental colitis was also ***:Rats with colitis developed macroscopic and microscopic colonic lesions accompanied by a significant decrease in the CBF,a significant rise in colonic weight,MPO activity and plasma IL-1β and TNF-α *** effects were aggravated by ASA and 5-(4-chlorophenyl)-1-(4-methoxyphenyl)3-(trifluoromethyl)-1H-pyrazole (SC-560),but not celecoxib and counteracted by concurrent treatment with a synthetic prostaglandin E 2 (PGE 2) *** with NO-ASA dose-dependently accelerated colonic healing followed by a rise in plasma NO x content and CBF,suppression of MPO and downregulation of COX-2,iNOS,IL-1β and TNF-α *** with GTN,the NO donor,significantly inhibited the ASA-induced colonic lesions and increased CBF,while carboxy-PTIO or capsaicin-denervation counteracted the NO-ASAinduced improvement of colonic healing and the accompanying increase in the *** effects were restored by co-treatment with calcitonin gene related peptide (CG

关键词：溃疡性结肠炎一氧化氮合酶阿司匹林实验性愈合氮释放降钙素基因相关肽髓过氧化物酶

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Odour reducing microbial-mineral additive for poultry manure treatment

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Frontiers of Environmental Science & Engineering 2017年第3期11卷 87-95页

作者： Kajetan Kalus Sebastian Opalifiski Devin Maurer Somchai Rice Jacek A. Koziel Mariusz Korczynski zbigniew Dobrzafiski Roman Kolacz Beata Gutarowska Department of Environment Hygiene and Animal Welfare Wroclaw University of Environmental and Life Sciences 50-375 Wroclaw Poland Department of Agricultural and Biosystems Engineering Iowa State University Ames IA 50011 USA Institute of Fermentation Technology and Microbiology Lodz University of Technology 90-924 Lodz Poland

Poultry production systems are associated with emissions of odorous volatile organic compounds （VOCs）, ammonia （NH3）, hydrogen sulfide （HES）, greenhouse gases, and particulate matter. Development of mitigation technologies for these emissions is important. Previous laboratory-scale research on microbial-mineral treatment has shown to be effective for mitigation of NH3, H2S and amines emissions from poultry manure. The aim of this research was to assess the effectiveness of surface application of a microbial-mineral treatment for other important odorants, i.e., phenolics and sulfur-containing VOCs. Microbial-mineral litter additive consisting of 20% （w/w） of bacteria powder （six strains ofheterotrophic bacteria） and 80% of mineral carrier （perlite-bentonite） was used at a dose of 500 g·m^-2 （per -31 kg of manure）. Samples of air were collected m two series, 4 and 7 days after application of additives. An odor profile of the poultry manure was determined using simultaneous chemical and sensory analysis. Reduction levels of VOCs determined on Day 4 was between 31% and 83% for mineral adsorbent treatment and in the range of 9% and 96% for microbial-mineral additive, depending on the analyzed compound. Reduction levels on Day 7 were considerably lower than on Day 4, suggesting that the odorous VOCs treatment efficacy is relatively short. There was no significant difference between treatments consisting of microbial-mineral additive and mineral carrier alone.

关键词： Odour mitigation Poultry manure additive GC-MS-Olfactometry Volatile organic compounds

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Cardioactive properties of Solanaceae plant extracts and pure glycoalkaloids on Zophobas atratus

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Insect Science 2015年第2期22卷 251-262页

作者： Emanuela Ventrella Pawel Marciniak zbigniew Adamski Grzegorz Rosirnski Szymon Chowanski Patrizia Falabella Laura Scrano SabinoA. Bufo Department of Science University of Basilicata Potenza Italy Department of Animal Physiology and Development Adam Mickiewicz University Poznan Poland Electron and Confocal Microscope Laboratory Adam Mickiewicz University Poznan Poland Department of European and Mediterranean Cultures University of Basilicata Matera Italy

Glycoalkaloids, the biologically active secondary metabolites produced by Solanaceae plants, are natural defenses against animals, insects and fungi. In this paper, the effects of glycoalkaloids present in extracts of Solanaceae plants （potato, tomato and black nightshade） or pure commercial glycoalkaloids on the coleopteran Zophobas atratus E were evaluated by in vitro and in vivo bioassays using heart experimental models. Each tested extract induced a dose-dependent cardioinhibitory effect. The perfusion of Zophobas atratus semi-isolated heart using the highest potato and tomato extract concentration （1 mmol/L） caused irreversible cardiac arrests, while extract from black nightshade pro- duced fast but reversible arrests. Pure commercial glycoalkaloids caused similar but less evident effects compared with extracts. Our results showed that the bioactivity of tested compounds depended on their structure and suggested the existence of synergistic interac- tions when combinations of the main glycoalkaloids of potato and black nightshade were used for trials. Surprisingly, injection of tomato and potato extracts in 1-day-old pupae of Zophobas atratus induced reversible positive chronotropic effects and decreased the duration of the both phases （anterograde and retrograde） of the heart contractile activity. Furthermore, these extracts affected the amplitude of the heart contractions.

关键词： cardioinhibitory effect glycoalkaloid heart perfusion Solanaceae Zophobas atratus

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The study of the interactions between graphene and Ge（001）/Si（001）

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Nano Research 2017年第11期10卷 3648-3661页

作者： Pawel Dabrowski Maciej Rogala Iwona Pasternak Jacek Baranowski Wlodzimierz Strupinski Marek Kopciuszynski Ryszard Zdyb Mieczyslaw Jalochowski Iaroslav Lutsyk zbigniew Klusek Department of Solid State Physics Faculty of Physics and Applied Informatics University of Lodz Pomorska 149/153 90-236 Lodz Poland Institute of Electronic Materials Technology Wolczynska 133 01-919 Warsaw Poland Institute of Physics Maria Curie-Sklodowska University pl.M.Curie-Sklodowskiej 1 20-031 Lublin Poland Department of Solid State Physics Yuriy Fedkovych Chernivtsi National University Kotsubinsky 2 58012 Chernivtsi Ukraine

The interaction between graphene and germanium surfaces was investigated using a combination of microscopic and macroscopic experimental techniques and complementary theoretical *** functional theory （DFT） calculations for different reconstructions of the Ge（001） surface showed that the interactions between graphene and the Ge（001） surface introduce additional peaks in the density of states,superimposed on the graphene valence and conduction energy *** growth of graphene induces nanofaceting of the Ge（001） surface,which exhibits well-organized hill and valley *** graphene regions covered by hills are of high quality and exhibit an almost linear dispersion relation,which indicates weak graphene-germanium *** the other hand,the graphene component occupying valley regions is significantly perturbed by the interaction with *** was also found that the stronger graphene-germanium interaction observed in the valley regions is connected with a lower local electrical *** of graphene/Ge（001）/Si（001） was performed to obtain a more uniform *** process results in a surface characterized by negligible hill and valley structures;however,the graphene properties unexpectedly deteriorated with increasing uniformity of the Ge（001） *** sum up,it was shown that the mechanism responsible for the formation of local conductivity inhomogeneities in graphene covering the Ge（001） surface is related to the different strength of graphene-germanium *** present results indicate that,in order to obtain high-quality graphene,the experimental efforts should focus on limiting the interactions between germanium and graphene,which can be achieved by adjusting the growth conditions.

关键词： chemical vapor deposition surface reconstruction scanning tunneling microscopy chemical bonding first-principles calculation

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Van der Waals interlayer potential of graphitic structures:From Lennard–Jones to Kolmogorov–Crespy and Lebedeva models

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Chinese Physics B 2019年第9期28卷 295-302页

作者： zbigniew Koziol Grzegorz Gawlik Jacek Jagielski National Center for Nuclear Research Materials Research Laboratoryul. Andrzeja Soltana 705-400 Otwock-wierkPoland Institute of Electronic Materials Technology ul. Wolczynska 13301-919 WarszawaPoland

The experimental knowledge on interlayer potential of graphitic materials is summarized and compared with the computational results based on phenomenological *** Lennard-Jones approximation, the Mie potential is discussed, as well as the Kolmogorov-Crespy model and equation of Lebedeva et *** agreement is found between a set of reported physical properties of graphite(layer binding energies, compressibility along c-axis in a broad pressure range, Raman frequencies for bulk shear and breathing modes under pressure), when a proper choice of model parameters is *** is argued that anisotropic potentials, Kolmogorov-Crespy and Lebedeva, are preferable for modeling, as they provide a better, self-consistent description.A method of fast numerical modeling, convenient for the accurate estimation of the discussed physical properties, is *** may be useful in studies of other van der Waals homo/heterostructures as well.

关键词： graphene van der Waals structures interlayer potential

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3D Surface velocity retrieval of mountain glacier using an offset tracking technique applied to ascending and descending SAR constellation data:a case study of the Yiga Glacier

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International Journal of Digital Earth 2019年第6期12卷 614-624页

作者： Qun Wang Jinghui Fan Wei Zhou Liqiang Tong Zhaocheng Guo Guang Liu Weilin Yuan Joaquim Joao Sousa zbigniew Perski School of Land Science and Technology China University of GeosciencesBeijingPeople’s Republic of China Division of Remote Sensing for Environment China Aero Geophysical Survey and Remote Sensing Center for Land and ResourcesBeijingPeople’s Republic of China Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingPeople’s Republic of China School of Sciences and Technology University of Trás-os-Montes e Alto DouroVila RealPortugal Centre for Robotics in Industry and Intelligent Systems INESC TECPortoPortugal Polish Geological Institute—National Research Institute CracowPoland

COSMO-SkyMed is a constellation of four X-band high-resolution radar satellites with a minimum revisit period of 12 *** satellites can obtain ascending and descending synthetic aperture radar(SAR)images with very similar periods for use in the three-dimensional(3D)inversion of glacier *** this paper,based on ascending and descending COSMO-SkyMed data acquired at nearly the same time,the surface velocity of the Yiga Glacier,located in the Jiali County,Tibet,China,is estimated in four directions using an offset tracking technique during the periods of 16 January to 3 February 2017 and 1 February to 19 February *** the geometrical relationships between the measurements and the SAR images,the least square method is used to retrieve the 3D components of the glacier surface velocity in the eastward,northward and upward *** results show that applying the offset tracking technique to COSMO-SkyMed images can be used to derive the true 3D velocity of a glacier’s *** the two periods,the Yiga Glacier had a stable velocity,and the maximum surface velocity,2.4 m/d,was observed in the middle portion of the glacier,which corresponds to the location of the steepest slope.

关键词： Mountain glacier inversion of 3D movement offset tracking SAR constellation data

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SYNTHESIS OF NOVEL BLOCK COPOLYMERS OF POLY(3-HYDROXYBUTYRIC ACID)WITH POLY(ETHYLENE GLYCOL)THROUGH ANIONIC POLYMERISATION

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Chinese Journal of Polymer Science 2000年第1期18卷 19-23页

作者： Xin-tao Shuai zbigniew Jedlinski Qiang Luo Nozirow Farhod Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Institute of Polymer Chemistry, Polish Academy of Sciences, 41-800 Zabrze, Poland Institute of Synthetic Fibre, Chinese Academy of Textile Sciences, Beijing 100025, China 中科院化学所北京波兰科学院高分子化学所波兰纺织科学研究院北京 100025

A novel kind of copolymer with ABA-type block structure was synthesized by anionic ring-opening polymerization of beta-butyrolactone (beta-BL) in the presence of a PEG-based dicarboxylates as macroinitiators which were prepared by the esterification of aliphatic cyclic anhydride and poly(ethylene glycol) (PEG) oligomers (M-n = 2000, 4000 and 6000) and conversion of potassium dicarboxylates. The resultant copolymers as well as the intermediates were characterized by IR, H-1-NMR and GPC.

关键词： block copolymer poly(ethylene glycol) poly(3-hydroxybutyric acid)

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Alternative Polyadenylation of the Sense Transcript Controls Antisense Transcription of DELAY OF GERMINATION 1 in Arabidopsis

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Molecular Plant 2017年第10期10卷 1349-1352页

作者： Justyna Kowalczyk Malgorzata Palusinska Agata Wroblewska-Swiniarska zbigniew Pietras Lukasz Szewc Jakub Dolata Artur Jarmolowski Szymon Swiezewski Department of Protein Biosynthesis Institute of Biochemistry of Biophysics Polish Academy of Sciences Warsaw Poland Department of Gone Expression Institute of Molecular Biology and Biotechnology Adam Mickiewicz University Poznan Poland

Dear Editor,Seed dormancy is adopted by plants to optimize their reproductive strategy. The DOG 1 （DELAY OF GERMINATION 1） gene is the main QTL controlling this trait in Arabidopsis （Bentsink et al., 2006） and therefore is extensively regulated. This includes the alternative polyadenylation （APA） of DOG1 mRNA （Cyrek et al., 2016） and an antisense transcript, asDOGl, which in cis suppresses DOG1 expression during seed maturation （Fedak et al., 2016）. As with many antisense transcripts （Mellor et al., 2016; Rosa et al., 2016）, asDOG1 originates from close to the transcription termination site of the sense gene. This raises the question of how this proximity affects antisense promoter activity.

关键词： the Sense Transcript Controls Transcription

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ECT图像分析法用于贮料仓卸料过程中剪切区域测量(英文)

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Chinese Journal of Chemical Engineering 2012年第2期20卷 337-345页

作者： Krzysztof Grudzien zbigniew Chaniecki Andrzej Romanowski Maciej Niedostatkiewicz Dominik Sankowski Computer Engineering Department Technical University of LodzStefanowskiego 18/22 str90-924 LodzPoland Department of Fundamentals of Building and Material Engineering Gdansk University of TechnologyGdanskPoland

The paper covers the electrical capacitance tomography(ECT) data analysis on shear zones formed during silo discharging *** is due to the ECT aptitude for detection of slight changes of material *** the basis of ECT visualisations,wall-adjacent shear zone profiles are analysed for different wall roughness *** analysis on changes of material concentration,based on ECT images,enables the calculation for the characteristic parameters of shear zones-size and material concentration inside the shear zone in a dynamic process of silo *** order to verify the methodology a series of experiments on gravitational flow of bulk solids under various conditions were conducted with different initial granular material packing densities and silo wall *** investigation shows that the increase in container wall roughness is an effective method for reducing the dynamic effects during the material discharging,since these effects are resulted from the resonance between hopper construction and trembling *** effects will damage industrial equipment in practical applications and need further investigation.

关键词：放电过程剪切带图像分析方法 ECT 筒仓粗糙度参数测量电容层析成像

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Microfluidics:Emerging prospects for anti-cancer drug screening

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World Journal of Clinical Oncology 2010年第1期1卷 18-23页

作者： Donald Wlodkowic zbigniew Darzynkiewicz Auckland Microfabrication Facility Department of ChemistryUniversity of Auckland1142 AucklandNew Zealand Brander Cancer Research Institute Department of PathologyNew York Medical CollegeValhallaNY 10595United States

Cancer constitutes a heterogenic cellular system with a high level of spatio-temporal *** discoveries by systems biologists have provided emerging evidence that cellular responses to anti-cancer modalities are stochastic in *** uncover the intricacies of cell-to-cell variability and its relevance to cancer therapy,new analytical screening technologies are *** last decade has brought forth spectacular innovations in the field of cytometry and single cell cytomics,opening new avenues for systems oncology and high-throughput real-time drug screening *** up-and-coming microfluidic Lab-on-a-Chip(LOC)technology and micrototal analysis systems(μTAS)are arguably the most promising platforms to address the inherent complexity of cellular systems with massive experimental parallelization and 4D analysis on a single cell *** vast miniaturization of LOC systems and multiplexing enables innovative strategies to reduce drug screening expenditures while increasing throughput and content of information from a given *** cell numbers and operational reagent volumes are sufficient for microfluidic analyzers and,as such,they enable next generation high-throughput and high-content screening of anticancer drugs on patient-derived *** we highlight the selected advancements in this emerging field of bioengineering,and provide a snapshot of developments with relevance to anti-cancer drug screening routines.

关键词： Microfluidics Lab-on-a-chip Cytometry Cytomics Cancer Anti-cancer drugs Cancer therapy Drug screening

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