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采用低频旋转磁场干预高原慢性低氧损伤的初步研究

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空军航空医学 2023年第6期40卷 504-507页

作者：曹征涛聂俊杰郭子川蔚文明田甄雍伟空军军医大学空军特色医学中心研究部北京100142 解放军95419部队空军军医大学空军特色医学中心航空医学工程研究中心北京100142 空军军医大学空军特色医学中心航空救生研究室北京100142

目的探索使用低频旋转磁场对高原慢性低氧损伤的干预效果。方法选取11名志愿者进行连续14 d(60 min/d)低频旋转磁场干预,在干预前后测量血压、血氧饱和度、血常规和血生化等指标。结果经过低频旋转磁场干预后,红细胞计数、血红蛋白浓度... 详细信息

目的探索使用低频旋转磁场对高原慢性低氧损伤的干预效果。方法选取11名志愿者进行连续14 d(60 min/d)低频旋转磁场干预,在干预前后测量血压、血氧饱和度、血常规和血生化等指标。结果经过低频旋转磁场干预后,红细胞计数、血红蛋白浓度、红细胞压积和血尿酸的下降幅度分别为6.16%、5.92%、6.06%和5.61%。与干预前指标相比较,干预后红细胞计数、血红蛋白浓度、红细胞压积下降幅度差异均有统计学意义(t=2.56、2.89、2.41,P=0.014、0.008、0.018),且受试者的收缩压、白细胞计数和血小板计数均有下降(t=2.49、2.91、3.46,P=0.016、0.008、0.004)。结论低频旋转磁场干预改善血液循环的红细胞功能调控,可以有效缓解高原慢性低氧损伤,未来有望形成基于人体自组织能力的系统化的慢性高原病防治方案。

关键词：低频旋转磁场高原红细胞增多症红细胞尿酸

内镜逆行胰胆管造影刷片仅见异型细胞的胆管狭窄患者恶性狭窄的危险因素分析

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中华消化内镜杂志 2016年第8期33卷 539-542页

作者：吴林王飞张秀华李全朋葛贤秀聂俊杰许伯明蒋国斌吴小超季劼缪林南京医科大学第二附属医院消化医学中心南京210011 南京医科大学第一附属医院肝脏外科

目的分析ERCP胆管刷片仅见异型细胞、未明确性质的胆管狭窄进展为恶性狭窄的危险因素。方法纳入2008年1月至2013年12月期间就诊的121名未明确性质的胆管狭窄患者，患者均行ERCP胆管刷片细胞学检查，结果仅见异型细胞。收集的指标包括年... 详细信息

目的分析ERCP胆管刷片仅见异型细胞、未明确性质的胆管狭窄进展为恶性狭窄的危险因素。方法纳入2008年1月至2013年12月期间就诊的121名未明确性质的胆管狭窄患者，患者均行ERCP胆管刷片细胞学检查，结果仅见异型细胞。收集的指标包括年龄、性别、胆管狭窄的部位和长度、随访结果和实验室检查结果，并行Logistic回归分析。结果73名（60．3％）患者最终诊断为胆管恶性狭窄，其中66名患者通过组织病理学检查诊断，7名患者通过疾病进展及影像学检查诊断。Logistic回归分析显示，年龄（OR=1．198，95％CI：1．040～1．381）、胆管狭窄长度（OR=7．065，95％CI：1．558～32．041）、血清CA19—9水平（OR=1．023，95％CI：1．006～1．040）、原发性硬化性胆管炎是胆管刷片仅见异型细胞的患者进展为胆管恶性狭窄的独立危险因素。结论对于ERCP胆管刷片仅见异型细胞、未明确性质的胆管狭窄患者，年龄大于51．5岁，胆管狭窄长度大于1．75cm，血清CA19—9水平大于122．05U／ml，伴有原发性硬化性胆管炎是胆管恶性狭窄的危险因素。

关键词：危险因素未明确性质胆管狭窄胆管刷片异型细胞

3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration

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Bioactive Materials 2022年第10期7卷 218-231页

作者： Yuanchi Zhang Cairong Li Wei Zhang junjie Deng Yangyi nie Xiangfu Du Ling Qin Yuxiao Lai Centre for Translational Medicine Research&Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina University of Chinese Academy of Sciences ShenzhenChina Key Laboratory of Health Informatics Chinese Academy of SciencesShenzhenChina Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyThe Chinese University of Hong KongHong Kong SARChina CAS-HK Joint Lab of Biomaterials ShenzhenChina

Patients with bone defects suffer from a high rate of disability and *** contact of grafts with defective bones and insufficient osteogenic activities lead to increased loose risks and unsatisfied repair *** self-expanding scaffolds were developed to enhance bone integration,the limitations on the high transition temperature and the unsatisfied bioactivity hindered greatly their clinical ***,we report a near-infrared-responsive and tight-contacting scaffold that comprises of shape memory polyurethane(SMPU)as the thermal-responsive matrix and magnesium(Mg)as the photothermal and bioactive component,which fabricated by the low temperature rapid prototyping(LT-RP)3D printing *** designed,due to synergistic effects of the components and the fabrication approach,the composite scaffold possesses a homogeneously porous structure,significantly improved mechanical properties and stable photothermal *** programmed scaffold can be heated to recover under near infrared irradiation in *** 4 wt%Mg,the scaffold has the balanced shape fixity ratio of 93.6%and shape recovery ratio of 95.4%.The compressed composite scaffold could lift a 100 g weight under NIR light,which was more than 1700 times of its own *** results of the push-out tests and the finite element analysis(FEA)confirmed the tight-contacting ability of the SMPU/4 wt%Mg scaffold,which had a signficant enhancement compared to the scaffold without shape memory ***,The osteopromotive function of the scaffold has been demonstrated through a series of in vitro and in vivo *** envision this scaffold can be a clinically effective strategy for robust bone regeneration.

关键词： Shape memory polyurethane Magnesium 3D printing Robust bone regeneration Tight-contact

Enhanced Electrical Properties of Bi_(2−x)Sb_(x)Te_(3) Nanoflake Thin Films Through Interface Engineering

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Energy & Environmental Materials 2024年第6期7卷 359-366页

作者： Xudong Wu junjie Ding Wenjun Cui Weixiao Lin Zefan Xue Zhi Yang Jiahui Liu Xiaolei nie Wanting Zhu Gustaaf Van Tendeloo Xiahan Sang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China NRC(Nanostructure Research Centre) Wuhan University of TechnologyWuhan 430070China EMAT(Electron Microscopy for Materials Science) University of AntwerpGroenenborgerlaan 171Antwerp 2023Belgium

The structure–property relationship at interfaces is difficult to probe for thermoelectric materials with a complex interfacial *** thermoelectric materials with a simple,structurally-uniform interface provides a facile way to understand how these interfaces influence the transport ***,we synthesized Bi_(2−x)Sb_(x)Te_(3)(x=0,0.1,0.2,0.4)nanoflakes using a hydrothermal method,and prepared Bi_(2−x)Sb_(x)Te_(3) thin films with predominantly(0001)interfaces by stacking the nanoflakes through spin *** influence of the annealing temperature and Sb content on the(0001)interface structure was systematically investigated at atomic scale using aberration-corrected scanning transmission electron *** and Sb doping facilitate atom diffusion and migration between adjacent nanoflakes along the(0001)*** such it enhances interfacial connectivity and improves the electrical transport *** reactions create new interfaces that increase the scattering and the Seebeck *** to the simultaneous optimization of electrical conductivity and Seebeck coefficient,the maximum power factor of the Bi_(1.8)Sb_(0.2)Te_(3) nanoflake films reaches 1.72 mW m^(−1)K^(−2),which is 43%higher than that of a pure Bi_(2)Te_(3) thin film.

关键词： Bi_(2)Te_(3) nanoflakes interface engineering scanning transmission electron microscopy thermoelectric thin film

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西藏部分地区鼠类调查

中华卫生杀虫药械 2023年第5期29卷 419-421页

作者：张文凯李瑞山林玉莲白冰孙世伟聂俊杰贺真李丽邵中军龙泳陕西中医药大学公共卫生学院陕西咸阳712099 空军军医大学军事预防医学系军队防疫与流行病学教研室特殊作业环境危害评估与防治教育部重点实验室陕西西安710032 甘肃中医药大学公共卫生学院甘肃兰州730000 空军日喀则场站医院西藏日喀则857060 包头医学院公共卫生学院内蒙古包头014040 西藏大学附属阜康医院西藏拉萨850000

目的了解西藏部分地区鼠类分布情况.方法采取夹夜法对林周县、亚东县和桑珠孜区进行鼠类现场调查.结果本次捕获鼠类共124只,分属3科3属3种,即高原鼠兔、小家鼠和白尾松田鼠,林周县38只,亚东县74只,桑珠孜区12只.优势种为高原鼠兔,占比85... 详细信息

目的了解西藏部分地区鼠类分布情况.方法采取夹夜法对林周县、亚东县和桑珠孜区进行鼠类现场调查.结果本次捕获鼠类共124只,分属3科3属3种,即高原鼠兔、小家鼠和白尾松田鼠,林周县38只,亚东县74只,桑珠孜区12只.优势种为高原鼠兔,占比85.4%.结论在鼠类分布较多的地区,应加强监测与防治工作.

关键词：鼠密度种群构成西藏

Effects of different fertilization practices on anammox activity,abundance,and community compositions in a paddy soil

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Soil Ecology Letters 2022年第3期4卷 254-263页

作者： Geng Sun Mei Sun Zunchang Luo Chao Li Xiaoping Xiao Xiaojing Li junjie Zhong Hua Wang San’an nie College of Resources and Environment Hunan Agricultural UniversityChangsha 410125China Hunan Soil and Fertilizer Institute Changsha 410125China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

The return of crop residue and green manure into agricultural soil is known to be important agricultural management strategies,yet how they affect the anammox process remains poorly characterized.A field experiment containing four treatments:chemical fertilizer(F),F plus rice straw(FS),FS plus green manure(FSM),FSM with integrated management(FSMM),was performed to examine the effects of incorporation of rice straw and green manure residues on *** results showed that the anammox activities in FS and FSM treatments(0.65 and 0.80 nmol N g^(–1)soil h^(–1),respectively)were significantly lower than those in F and FSMM treatments(1.60 and 1.28 nmol N g^(–1)soil h^(–1),respectively).Anammox contributed 4.07%-4.95%of total N loss in soil incorporated with residues,lower than soil treated with chemical fertilizer only(9.13%),the remaining being due to ***,the abundance of the hzsB gene(the hydrazine synthaseβ-subunit gene)in FS and FSM treatments(1.13106 and 1.18106 copies g^(–1)soil)were significantly higher than soil using chemical fertilizer only(7.49105 copies g^(–1)soil)while showed no significant difference with FSMM treatment(8.81105 copies g^(–1)soil).Illumina sequencing indicated that Brocadia was the dominant anammox genus,following by Scalindua and *** bacterial diversity was altered after 4-year incorporation of rice straw and green manure,as shown byα-diversity *** concluded that rice straw and green manure incorporated with mineral fertilizer reduce N removal from paddy soil in terms of anammox in spite of stimulating anammox bacterial growth.

关键词： Anammox Rice straw Green manure Scalindua N loss

Kinematical and Structural Patterns of the Yingjing-Mabian-Yanjin Thrust Fault Zone, Southeast of the Qinghai-Xizang (Tibet) Plateau and Its Segmentation from Earthquakes

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Earthquake Research in China 2006年第2期20卷 202-215页

作者： Zhang Shimin nie Gaohong Liu Xudong Ren junjie Su Gang Institute of Crustal Dynamics China Earthquake Administration Beijing 100085 China Institute of Geology China Earthquake Administration Beijing 100029 China

Segmentation of the thrust fault zone is a basic problem for earthquake hazard evaluation. The Yingjing-Mabian-Yanjin thrust fault zone is an important seismic belt NW-trending in the southeast margin of the Qinghal-Xizang （Tibet） plateau. The longitudinal faults in the thrust zone are mainly of the thrust slipping type. The late Quaternary motion modes and displacement rates are quite different from north to south. Investigation on valleys across the fault shows that the transverse faults are mainly of dextral strike-slipping type with a bit dip displacement. Based on their connections with the longitudinal faults, three types of transverse faults are generalized, namely： the separate fault, the transform fault and the tear fault, and their functions in the segmentation of the thrust fault zone are compared. As the result, the Yingjing-Mabian-Yanjin thrust fault zone is divided into three segments, and earthquakes occurring in these three segments are compared. The tri-section of the Yingjing-Mabian-Yanjin thrust fault zone identified by transverse fault types reflects, on the one hand, the differences in slip rate, earthquake magnitude and pace from each segment, and the coherence of earthquake rupturing pace on the other hand. It demonstrates that the transverse faults control the segmentation to a certain degree, and each type of the transverse faults plays a different role.

关键词： Thrust fault zone Transverse fault Longitudinal fault Fault segmentation Terrace phase map

一种低电磁干扰载波斜率随机分布脉宽调制技术

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中国电机工程学报 2017年第14期37卷 4175-4183页

作者：许杰聂子玲朱俊杰舰船综合电力技术国防科技重点实验室(海军工程大学) 湖北省武汉市430033

针对固定载波脉宽调制技术输出电压谐波在载频及其倍频附近集中的问题,提出了一种载波斜率随机分布脉宽调制技术,无需滤波电路即可分散谐波能量,减少谐波突出幅值给电力系统带来的电磁干扰问题。在分析固定载波脉宽调制谐波特性的基础上... 详细信息

针对固定载波脉宽调制技术输出电压谐波在载频及其倍频附近集中的问题,提出了一种载波斜率随机分布脉宽调制技术,无需滤波电路即可分散谐波能量,减少谐波突出幅值给电力系统带来的电磁干扰问题。在分析固定载波脉宽调制谐波特性的基础上,类推出随机载波脉宽调制技术的可行性;从随机信号的数理统计参量出发构建了载波斜率随机分布脉宽调制数学模型,对输出电压功率谱进行推导,阐释了载波斜率随机分布脉宽调制技术分散谐波能量的原理,并对影响谐波能量分布的参数进行了分析;最后,仿真和实验表明载波斜率随机分布脉宽调制输出电压谐波能量更为分散、平缓,对于中大容量电力系统中谐波处理具有重要意义。

关键词：固定载波脉宽调制载波斜率随机分布脉宽调制谐波频域分析功率谱

Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis

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Cancer Communications 2023年第1期43卷 159-163页

作者： Shengzhe Zhang Sung Ho Lee Litong nie Yuanjian Huang Gengyi Zou Youn-Sang Jung Sohee Jun Jie Zhang Esther MLien junjie Chen Jae-Il Park Department of Experimental Radiation Oncology Division of Radiation Oncologythe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Graduate School of Biomedical Sciences the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Program in Genetics and Epigenetics the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Dear Editor,Accumulating evidence suggests that dysregulated lysosomal membrane proteins,including vacuolar ATPase(v-ATPase)and the mammalian target of rapamycin(mTOR),are involved in tumorigenesis[1].Therefore,lysosomal proteins were proposed as potential therapeutic targets in cancer[1].As one of the lysosome-related signaling pathways,mTOR signaling regulates cell proliferation,survival,motility,and metabolism[2].SincemTOR signaling activation promotes tumorigenesis,mTOR inhibitors(mTORi),AZD8055[3],MLN0128[4],and Rapalink-1(the latest third-generation mTORi)[4],have been applied to several ***,the limitations of mTORi include drug resistance and the lack of biomarkers.

关键词： tumorigenesis metabolism mTOR