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Polyvinylpyrrolidone-based bioink:influence of bioink properties on printing performance and cell proliferation during inkjet-based bioprinting

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Bio-Design and Manufacturing 2023年第6期6卷 676-690页

作者： Wei Long ng Xi Huang Viktor Shkolnikov Ratima Suntornnond wai yee Yeong HP-NTU Digital Manufacturing Corporate Lab Nanyang Technological University(NTU)Singapore 637460Singapore Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore HP Inc. Palo AltoCA 94304USA

Among the different bioprinting techniques,the drop-on-demand(DOD)jetting-based bioprinting approach facilitates contactless deposition of pico/nanoliter droplets ofmaterials and cells for optimal cell–matrix and cell–cell *** bioinks play a critical role in the bioprinting process,there is a poor understanding of the influence of bioink properties on printing performance(such as filament elongation,formation of satellite droplets,and droplet splashing)and cell health(cell viability and proliferation)during the DOD jetting-based bioprinting *** inert polyvinylpyrrolidone(PVP360,molecular weight=360 kDa)polymerwas used in this study to manipulate the physical properties of the bioinks and investigate the influence of bioink properties on printing performance and cell *** experimental results showed that a higher bioink viscoelasticity helps to stabilize droplet filaments before rupturing from the nozzle *** highly stretched droplet filament resulted in the formation of highly aligned“satellite droplets,”which minimized the displacement of the satellite droplets away from the predefined ***,a significant increase in the bioink viscosity facilitated droplet deposition on the wetted substrate surface in the absence of splashing and significantly improved the accuracy of the deposited main *** analysis showed that cell-laden bioinks with higher viscosity exhibited higher measured average cell viability(%),as the presence of polymer within the printed droplets provides an additional cushioning effect(higher energy dissipation)for the encapsulated cells during droplet impact on the substrate surface,improves the measured average cell viability even at higher droplet impact velocity and retains the proliferation capability of the printed *** the influence of bioink properties(e.g.,bioink viscoelasticity and viscosity)on printing performance and cell proliferation is important for the formulation

关键词： Biofabrication 3D bioprinting Drop-on-demand bioprinting Bioink properties Polyvinylpyrrolidone

A facile method to fabricate cell-laden hydrogel microparticles of tunable sizes using thermal inkjet bioprinting

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Droplet 2024年第4期3卷 29-38页

作者： Ratima Suntornnond Wei Long ng Viktor Shkolnikov wai yee Yeong HP-NTU Digital Manufacturing Corporate Lab Nanyang Technological University(NTU)Singapore Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore HP Inc. Palo AltoCaliforniaUSA

This study investigates the application of a drop-on-demand(DOD)thermal inkjet(TIJ)-based bioprinting system for the fabrication of cell-laden hydrogel microparticles(HMPs)with tunable *** TIJ bioprinting technique involves the formation of vapor bubbles within the print chamber through thermal energy,expelling small droplets of bio-ink onto a *** study employs a heat-treated saponified gelatin-based bio-ink,*** bio-ink is modified through methacrylic anhydride functionalization and undergoes subsequent saponification and heat treatment *** concentrations of SPAN 80 surfactant in mineral oil were evaluated to assess their influence on HMP size and *** results indicate a direct correlation,with higher SPAN 80 concentrations resulting in smaller and more stable *** study further investigates the influence of jetting volume on HMP size distribution,revealing that larger jetting volumes lead to increased HMP sizes,attributed to droplet *** is supported by our further study via a Monte Carlo simulation,which shows that the mean droplet diameter grows approximately linear with the number of dispensed *** addition,the study demonstrates the capability of the TIJ bioprinting system to achieve multimaterial encapsulation within HMPs,exemplified by staining living cells with distinct cytoplasmic membrane *** presented approach provides insights into the controlled fabrication of cell-laden HMPs,highlighting the versatility of the TIJ bioprinting system for potential applications in tissue engineering and drug delivery.

关键词： printing thermal sizes

WAVE INDUCED OSCILLATORY AND STEADY FLOWS IN THE ANNULUS OF A CATHETERIZED VISCOELASTIC TUBE

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Journal of Hydrodynamics 2010年第5期22卷 605-617页

作者： ng Chiu-On CHAng Yin-yee Department of Mechanical Engineering The University of Hong Kong

A perturbation analysis based on equations of motion in Lagrangian form is presented for the oscillatory and time-mean viscous flows induced by a propagating wave of small amplitude in an annulus with a viscoelastic outer wall. Owing to the steady streaming effect, the existence of a catheter in a blood vessel brings in an additional steady pressure gradient, a correction to that predicted by the linear theory, and an additional steady shear stress, which may increase the possibility of hemolysis of red blood cells.

关键词： annulus flow steady streaming catheterized artery

A UNIQUENESS THEOREM FOR HOLOMORPHIC MAPPIngS IN THE DISK SHARIng TOTALLY GEODESIC HYPERSURFACES

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Acta Mathematica Scientia 2022年第4期42卷 1631-1644页

作者： Jiaxing HUAng Tuen wai ng College of Mathematics and Statistics Shenzhen UniversityShenzhen518060China Department of Mathematics The University of Hong KongPokfulamHong Kong

In this paper,we prove a Second Main Theorem for holomorphic mappings in a disk whose image intersects some families of nonlinear hypersurfaces(totally geodesic hypersurfaces with respect to a meromorphic connection) in the complex projective space P^(k).This is a generalization of Cartan’s Second Main *** a consequence,we establish a uniqueness theorem for holomorphic mappings which intersect O(k^(3)) many totally geodesic hypersurfaces.

关键词： Second Main Theorem meromorphic connection totally geodesic hypersurfaces uniqueness theorem

Investigation of drinking water bacterial community through high-throughput sequencing

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Journal of Environmental Sciences 2015年第11期27卷 154-156页

作者： Tsz wai ng Guocheng Huang Po Keung Wong School of Life Sciences The Chinese University of Hong Kong

Delivery of safe and pathogen-free drinking water is crucial to public ***,there exist challenges to the maintenance of the sterility of drinking water throughout the drinking water distribution systems（DWDS）.Microbial growth in DWDS,such as growth of opportunistic pathogenic microorganisms,can lead to severe health problems in consumers（Berry et al.,2006;Brettar and Hofle,2006;Lu et al.,2014;Zhang et al.,2015）.

关键词： Drinking water distribution systems Microbial community High-throughput sequencing Water safety

Three-dimensional numerical analysis of plant-soil hydraulic interactions on pore water pressure of vegetated slope under different rainfall patterns

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3696-3706页

作者： Haowen Guo Charles Wang wai ng Qi Zhang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

Understanding the pore water pressure distribution in unsaturated soil is crucial in predicting shallow landslides triggered by rainfall,mainly when dealing with different temporal patterns of rainfall ***,the hydrological response of vegetated slopes,especially three-dimensional(3D)slopes covered with shrubs,under different rainfall patterns remains unclear and requires further *** address this issue,this study adopts a novel 3D numerical model for simulating hydraulic interactions between the root system of the shrub and the surrounding *** series of numerical parametric studies are conducted to investigate the influences of slope inclination,rainfall pattern and rainfall *** rainfall patterns(advanced,bimodal,delayed,and uniform)and two rainfall durations(4-h intense and 168-h mild rainfall)are considered to study the hydrological response of the *** computed results show that 17%higher transpiration-induced suction is found for a steeper slope,which remains even after a short,intense rainfall with a 100-year return *** extreme rainfalls with advanced(PA),bimodal(PB)and uniform(PU)rainfall patterns need to be considered for the short rainfall duration(4 h),while the delayed(PD)and uniform(PU)rainfall patterns are highly recommended for long rainfall durations(168 h).The presence of plants can improve slope stability markedly under extreme rainfall with a short duration(4 h).For the long duration(168 h),the benefit of the plant in preserving pore-water pressure(PWP)and slope stability may not be sufficient.

关键词： Root-soil interactions Rainfall patterns Slope stability Three-dimensional(3D)

Heterogeneous numerical modelling for the auto thermal reforming of crude glycerol in a fixed bed reactor

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Chinese Journal of Chemical Engineering 2022年第2期35卷 261-268页

作者： Jason Williams Hussameldin Ibrahim Nima Karimi Kelvin Tsun wai ng Clean Energy Technologies Research Institute Process Systems EngineeringFaculty of Engineering and Applied ScienceUniversity of ReginaRegina SK S4S 0A2Canada Environmental Systems Engineering Faculty of Engineering and Applied ScienceUniversity of ReginaRegina SK S4S 0A2Canada

A mathematical model for the catalytic autothermal reforming(ATR)reaction of synthetic crude glycerol to hydrogen in a fixed bed tubular reactor(FBTR)and over an in-house developed metal oxide catalyst is presented in this *** heterogeneous model equations account for a two-phase system of solid catalyst and bulk feed ***,the ATR of crude glycerol reaction scheme and intrinsic kinetic rate model over an active,selective,and stable nickel-based catalyst were integrated in the developed ***,the model was validated using experimental data generated in our labs for the ATR of synthetic crude *** modelling results adequately described the detailed gas product composition and distribution,temperature profiles,and conversion propagation in the axial direction of the fixed bed reactor over a wide range of reaction temperature(773–923 K)and mass-time(12.71–158.23 g cat·min·(mol C)^(-1)).The crude glycerol conversion predicted with the model showing a close resemblance to those obtained experimentally with an average absolute deviation(AAD)of less than 8%.The maximum crude glycerol conversion and hydrogen yield were found to be 92%and 3 mol hydrogen/mol crude glycerol,***,the gas product concentration profile in the reactor was adequately described(90%)accuracy with a hydrogen concentration of 39%(volume).

关键词： Hydrogen crude glycerol Autothermal reforming Numerical analysis Fixed-bed reactor

Effects of root morphology and anatomy on cadmium uptake and translocation in rice(Oryza sativa L.)

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Journal of Environmental Sciences 2019年第1期31卷 296-306页

作者： Lu Huang wai Chin Li Nora Fung yee Tam Zhihong Ye School of Life Sciences Sun Yat-sen University Department of Science and Environmental Studies The Education University of Hong Kong State Key Laboratory in Marine Pollution and Department of Chemistry City University of Hong Kong

A clear description of the certain mechanisms of cadmium(Cd) uptake and translocation in rice(Oryza sativa L.) may help to reduce Cd accumulation in rice grain. Hydroponic experiments were carried out to determine the effects of cultivation conditions(aerated and stagnant) on the uptake, translocation and subcellular distribution of Cd in relation to the morphology and anatomy of roots in two rice genotypes with different Cd accumulations in grains. Marked differences in morphology and anatomy were observed between these two genotypes under different cultivation conditions. Genotypes with low Cd accumulation in grains tended to develop fewer root tips per root surface area, larger root porosity and more mature apoplastic barriers. The stagnant cultivation condition decreased the number of root tips per root surface area but increased root porosity and accelerated apoplastic barrier formation in root *** Cd uptake studies revealed that rice plants with fewer number of root tips per root surface area reduced root Cd uptake ability, while mature apoplastic barriers increased root Cd retention in cell walls and the symplast. Thus, the fewer number of root tips per root surface area and the earlier formation of mature apoplastic barriers led to lower Cd uptake and translocation. The results indicated that the morphology and anatomy of roots could play important roles in Cd uptake and translocation in rice, and could be influenced by both genotype and cultivation conditions. The present results would be useful in screening and planting rice plants with low Cd accumulation.

关键词： Apoplastic barriers Cadmium Rice Root morphology

Defined hydrogels for spinal cord organoids:challenges and potential applications

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Neural Regeneration Research 2024年第11期19卷 2329-2330页

作者： wai Hon Chooi Yuewen Wu Shi-Yan ng Institute of Molecular and Cell Biology(IMCB) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Department of Physiology Yong Loo Lin School of MedicineNational University of Singapore(NUS)SingaporeSingapore

Organoids of the central nervous system,primarily derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing *** exposed to the right combinations of signals,they differentiate into a 3D tissue consisting of complex cytoarchitecture and native cell types,including various neuron subtypes and glial *** features closely mimic native tissues,making them invaluable for developmental studies and disease *** recent years,spinal cord organoids(SCOs)have been developed to investigate spinal cord development,injuries,and various neurological *** an integral part of the central nervous system,SCOs play a vital role and serve as a site for studying both neurodevelopment and neurodegenerative diseases.

关键词： properties injuries primarily