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应用与环境生物学报 2005年第6期11卷 751-755页

作者： SInGH R KUMAR V SHARMA S BEHL RK SInGH BP narula n Department of Microbiology SBS Post Graduate Institute of Biomedical Sciences & Research Balawala Dehradun India Department of Plant Breeding CCS Haryana Agricultural University Hisar India Department of Agronomy CCS Haryana Agricultural University Hisar India Department of Agronomy Microbiology CCS Haryana Agricultural University Hisar India

The persistence and performance (growth promoting potential) of green fluorescent protein (gfp) marked Azotobacter chroococcum strain ABR 4G were studied in sterilized and unsterilized wheat rhizospheric soil. The gfp was integrated via Tn 5 transposition into A. chroococcum chromosome and the resultant gfp marked colonies were identified by green fluorescent emission under UV light. The gfp was stably maintained in A. chroococcum and the gfp insertion had no apparent adverse effect on the growth promoting properties of the marked soil isolate ABR 4G. The growth promoting properties (nitrogen fixation, ammonia excretion, phosphate solubilization and IAA production) of the parent soil isolate and the gfp marked strain were found to be almost the same. All the quantitative wheat plant traits were significantly influenced by inoculation of A. chroococcum ABR 4G strain in sterilized and unsterilized soil. Inoculated bacterial counts increased gradually in wheat rhizosphere, reached maximum on 60 th d and declined on 80 th d. Fertility levels also affected survival of marked strain and the survival was comparable in sterilized and unsterilized soil. The growth promoting properties were also determined from the marked strain reisolated from wheat rhizosphere in both types of soil. Fig 1, Tab 2, Ref

关键词：绿色荧光蛋白固氮菌消毒方法小麦

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来自高冰草的小麦品系对叶斑病和叶锈病田间抗性的遗传学

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麦类作物学报 1984年第5期 20-20页

作者： P.n.narula 郑康乐

交链孢菌(Alternaria triticina)是小麦叶斑病的致病菌。自1961年首次报道在印度比哈尔的马哈拉施特拉和西孟加拉邦的部分地区流行以来,至今已几乎蔓延到印度的所有麦区。由于此病的威胁越来越重,人们一直致力于培育抗性品种来对付这一... 详细信息

交链孢菌(Alternaria triticina)是小麦叶斑病的致病菌。自1961年首次报道在印度比哈尔的马哈拉施特拉和西孟加拉邦的部分地区流行以来,至今已几乎蔓延到印度的所有麦区。由于此病的威胁越来越重,人们一直致力于培育抗性品种来对付这一病害。目前虽已报

关键词：叶锈病高冰草小麦品系叶斑病田间抗性广谱抗性遗传学

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大麦人工杂交时花的敏感性

大麦与谷类科学 1985年第3期 53-53页

作者： P、n、narula O、P、Srivastava 俞世蓉

大麦(Hordeum vulgare L.)由于其闭花授粉,所以是一种严格的自花受精作物。在栽培的情况下,种内和种间杂交可以成功,而无任何困难。但是,由于形态的特殊性,或者异常的气候条件,杂交也会偶然遇到困难(Harlan,Martini 和 Stevens,1943)。... 详细信息

大麦(Hordeum vulgare L.)由于其闭花授粉,所以是一种严格的自花受精作物。在栽培的情况下,种内和种间杂交可以成功,而无任何困难。但是,由于形态的特殊性,或者异常的气候条件,杂交也会偶然遇到困难(Harlan,Martini 和 Stevens,1943)。我们在进行大量品种间杂交时,偶而碰见丁一种罕见情况。即与一个普通亲本

关键词：大麦麦类作物人工杂交敏感性

CURInG KInETICS AnD THERMAL STABILITY OF EPOXY BLEnDS COnTAInInG PHOSPHOROUS-OXIRAnE WITH AROMATIC AMIDE-AMInE AS CURInG AGEnTS

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Chinese Journal of Polymer Science 2012年第5期30卷 694-704页

作者： Geeta Durga A.K.narula School of Basic and Applied Sciences Guru Gobind Singh Indraprastha University

This article describes the synthesis of a series of aromatic amide-amines and their potential use as epoxy hardeners. These amines were synthesized by the reaction of L-phenylalanine （PA） with diamines of different structures i.e. 1,4- phenylene diamine （PD）, 1,5-diamino naphthalene （n）, 4,4＇-（9-fluorenyllidene）-dianiline （F）, 4,4＇-diaminodiphenyl sulphide （DS） and 3,4＇-oxydianiline （O） in a stoichiometric ratio （I ：1）. Structural characterization of synthesized amide-amines was done with the help of elemental analysis and spectroscopic techniques viz. FT-IR, 1H-nMR and 13C-nMR. An epoxy blend was prepared by mixing tris（glycidyloxy） phosphine oxide （TGPO） with conventional epoxy i.e. diglycidyl ether of bisphenol-A （DGEBA） in an equivalent ratio of 2：3 to incorporate phosphorous into the main chain. The curing kinetics of the epoxy blend with synthesized aromatic amide-amines was investigated by non-isothermal DSC technique using multiple heating rate method （5, 10, 15 and 20 K/min.）. The activation energies were determined by fitting the experimental data into Kissinger and Ozawa kinetic models. The activation energies obtained through Ozawa method were slightly higher than those of Kissinger method but were comparable. However, both the energies were found to be dependent on the structure of amines. The thermal stability and weight loss behavior of isothermally cured thermosets were also investigated using thermogravimetric analysis （TGA） in nitrogen atmosphere. All the samples showed improved thermal stability in terms of char yield than using only amines as hardeners.

关键词： Phosphorylated epoxy Amide-Amines Curing kinetics Char yield Thermal stability.

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The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury

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Journal of Geriatric Cardiology 2014年第4期11卷 338-348页

作者： Carol Chen-Scarabelli Pratik R. Agrawal Louis Saravolatz Cadigia Abuniat Gabriele Scarabelli Anastasis Stephanou Leena Loomba Jagat narula Tiziano M. Scarabelli Richard Knight VA Ann Arbor Health Care System University of Michigan 2215 Fuller Rd Ann Arbor M148105 USA Zena and Michael A. Wiener Cardiovascular Institute Mount Sinai Medical Center One Gustave L. Levy Place Box 1030 New York NY 10029-6574 USA St John Hospital and Medical Center Wayne State University School of Medicine 22101 Moross Rd. Detroit M148236 USA Medical and Molecular Biology Unit University College London UCL 30 Guildford St. London WC1N 1EH UK

A physiological sequence called autophagy qualitatively determines cellular viability by removing protein aggregates and damaged cyto-plasmic constituents, and contributes significantly to the degree of myocardial ischemia-reperfusion （I/R） injury. This tightly orchestrated cata-bolic cellular‘housekeeping’ process provides cells with a new source of energy to adapt to stressful conditions. This process was first described as a pro-survival mechanism, but increasing evidence suggests that it can also lead to the demise of the cell. Autophagy has been implicated in the pathogenesis of multiple cardiac conditions including myocardial I/R injury. However, a debate persists as to whether autophagy acts as a protec-tive mechanism or contributes to the injurious effects of I/R injury in the heart. This controversy may stem from several factors including the va-riability in the experimental models and species, and the methodology used to assess autophagy. This review provides updated knowledge on the modulation and role of autophagy in isolated cardiac cells subjected to I/R, and the growing interest towards manipulating autophagy to increase the survival of cardiac myocytes under conditions of stress-most notably being I/R injury. Perturbation of this evolutionarily conserved intracellular cleansing autophagy mechanism, by targeted modulation through, among others, mammalian target of rapamycin （mTOR） inhibitors, adenosine monophosphate-activated protein kinase （AMPK） modulators, calcium lowering agents, resveratrol, longevinex, sirtuin activators, the proapoptotic gene Bnip3, IP3 and lysosome inhibitors, may confer resistance to heart cells against I/R induced cell death. Thus, therapeutic ma-nipulation of autophagy in the challenged myocardium may benefit post-infarction cardiac healing and remodeling.

关键词： Autophagy Heart Ischemia-reperfusion injury Cell survival

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A comparison of duloxetine hydrochloride with fluoxetine hydrochloride in major depressive disorders: a pilot study

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Health 2010年第6期2卷 620-624页

作者： Ravinder Kumar Sah Harmeet Singh Rehan Kannanore Eloremadathil Sadanandan Unni Deepti Chopra Seema Manak Preeta Kaur narula 不详

To compare remission rate, relapse rate and tolerability of duloxetine, a dual reuptake inhibitor of 5-hydroxy serotonin (5-HT) and norepinephrine (nE), versus fluoxetine, a reuptake inhibitor of 5-HT during follow up period of 16 weeks in major depressive disorder (MDD) a open label comparative trial was conducted. Trial was comprising of 60 patients, diagnosed with MDD, were allocated to fluoxetine group (n*-30, 20-60mg od) or duloxetine group (n*-30, 40-60mg od) for 16 weeks. The end points were remission and relapse assessed by Hamilton Rating scale for Depression-24 items (HAMD-24). In results the mean fall in HAMD-24 scores between groups was comparable till 4 weeks. Thereafter, at 8 weeks the mean fall in HAMD-24 score was significantly greater in duloxetine group (p value n fall was highly significant (p value n duloxetine group. Thirty percent patients in duloxetine group achieved remission in comparison to none in fluoxetine group. none of the patient, in any group, reported relapse. Adverse effects were mild to moderate in *** conclusion duloxetine has a better pharmacological profile over fluoxetine in terms of efficacy and safety.

关键词： Major Depressive Disorder Duloxetine Remission Relapse

Cytogenetic Profile in 7209 Indian Patients with de novo Acute Leukemia: A Single Centre Study from India

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Journal of Cancer Therapy 2016年第7期7卷 530-544页

作者： P. S. Kadam Amare H. Jain S. Kabre Y. Deshpande P. Pawar S. Banavali H. Menon M. Sengar B. Arora n. Khattry G. narula D. Sarang S. Kaskar B. Bagal H. Jain Uma Dangi P. G. Subramanian S. Gujral Cancer Cytogenetics Department Tata Memorial Hospital Mumbai India Department of Medical Oncology Tata Memorial Hospital Mumbai India Hematopathology Laboratory Department of Pathology Tata Memorial Hospital Mumbai India

Background: Cytogenetics is one of the most important diagnostic parameters in the classification of acute leukemia. Recurrent chromosomal aberrations in acute leukemia have provided insights into the molecular mechanism of leukemogenesis. The variable frequencies of recurrent cytogenetic markers due to ethical/racial differences have been reported from Western and some Asian countries. Objective: We report cytogenetic data of largest cohort of 7209 adult and pediatric patients with de novo acute leukemia (AL) to determine the prevalence of various cytogenetic sub groups and compare with the Western and Asian population. Material & Methods: The AL patients included 2609 AML (adult: 2042, pediatric: 567), 3708 B-cell-precursor (BCP)-ALL (adult: 1300, pediatric: 2408) and 892 cases of T-ALL (adult: 480, pediatric: 412). Cytogenetic studies included conventional karyotyping and FISH using panel of probes. Results: The incidence of t(8;21) was high, comparable to other Asian countries. In comparison to our series and Western population, t(15;17) was more prevalent in Chinese population. Cytogenetic profiling of BCP-ALL revealed low prevalence of ETV6/RUnX1 in ours as well as other Asian population. The MLL aberrations in BCP-ALL and TLX1 & TLX3 aberrations in T-ALL occurred less frequently in our series as compared with Western population. Conclusion: The present study with a large cohort showed the heterogeneity of AL that involved various factors, such as age, gender and prevalence of distinct cytogenetic subgroups. Our data in comparison with other population based studies revealed differential distribution of some cytogenetic sub-groups indicating geographic heterogeneity due to differential environmental exposure which probably influenced underlying genetic susceptibility.

关键词： Cytogenetics Acute Leukemia Incidence Asian Population Geographic Heterogeneity