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Association between Mental Disorders and subsequent Medical Conditions

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四川生理科学杂志 2024年第4期46卷 217-217页

作者： natalie C Momen From the National Center for Register-based Research (N.C.M. O.P.-R. E.A. M.K.C. S.D. J.-C.P.G.D. T.M.L. P.B.M. K.L.M. C.B.P. L.V.P. B.V. N.W. J.J.M.) Center for Integrated Register-based Research (E.A. P.B.M. C.B.P.) the Departments of Biomedicine-Human Genetics (A.D.B.) and Public Health (M.K.C. M.F.-G. K.M.I. M.V. A.P.) the Center for Integrative Sequencing (A.D.B.) and the Big Data Center for Environment and Health (C.B.P.) Aarhus University the Lundbeck Foundation Initiative for Integrative Psychiatric Research (E.A. A.D.B. S.D. O.M. P.B.M. K.L.M. M.N. C.B.P. L.V.P. A.J.S. B.V. T.W.) the Center for Genomics and Personalized Medicine (A.D.B.) the Department of Neurology (J.-C.P.G.D.) and the Research Unit Department of Psychosis (O.M.) Aarhus University Hospital and the Research Unit for General Practice (M.F.-G. A.R.R. M.V. A.P.) Aarhus the Copenhagen Research Center for Mental Health Mental Health Center Copenhagen Copenhagen University Hospital (M.E.B. M.N. H.J.S.) Psychiatric Center Copenhagen (L.V.K.) Faculty of Health and Medical Sciences (L.V.K.) the Department of Clinical Medicine (T.W.) and the Lundbeck Foundation GeoGenetics Center GLOBE Institute (T.W.) University of Copenhagen Copenhagen and the Institute of Biological Psychiatry Mental Health Center Sankt Hans Mental Health Services Capital Region Roskilde (A.J.S. T.W.) - all in Denmark the National Drug and Alcohol Research Centre University of New South Wales Sydney (L.D.) the Department of General Practice Melbourne Medical School University of Melbourne Melbourne VIC (J.M.G.) and the Queensland Brain Institute (C.C.W.L. S.S. J.J.M.) Queensland Centre for Mental Health Research the Park Centre for Mental Health (C.C.W.L. S.S. T.J.S. H.A.W. J.J.M.) and the School of Public Health Faculty of Medicine (H.A.W.) University of Queensland Brisbane - all in Australia the Departments of Psychology (P.J.) and Developmental Psychology (A.M.R.) Heymans Institute and the I

Background:Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical ***:We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016,for a total of 83.9 million person-years.

关键词： conditions milli population

Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： savannah E.Est-Witte sydney R.shannon Dennis H.Gong Kaitlyn G.Calabresi jawaun j.Harris Kaitlyn storm Edwin j.Yoo Ariel Isser Vivek P.jani natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh simone sidoli stephany Y.Tzeng jonathan P.schneck jordan j.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Overcoming EGFR-TKI resistance by targeting the tumor microenvironment

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Chinese Medical journal Pulmonary and Critical Care Medicine 2024年第3期2卷 151-161页

作者： jinsong Zhang natalie Vokes Man Li jiachen Xu Hua Bai jie Wang Zhijie Wang jianjun Zhang state Key Laboratory of Molecular Oncology CAMS Key Laboratory of Translational Research on Lung CancerDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17PanjiayuannanliChaoyang DistrictBeijing 100021China Department of Thoracic/Head and Neck Medical Oncology Department of Genomic MedicineThe Lung Cancer Interception ProgramThe Lung Cancer Genomics ProgramThe University of TexasMD Anderson Cancer CenterHoustonTX 77030USA shanxi Cancer Hospital(shanxi Cancer Institute) Cancer Hospital of Chinese Academy of Medical Sciences Shanxi HospitalShanxi Medical University Affiliated HospitalTaiyuanShanxi 030013China

Targeted therapy has ushered in a new era of precision medicine for non-small cell lung cancer(NsCLC).Currently,epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKIs)stand as the recommended first-line therapy for advanced NsCLC harboring sensitive EGFR ***,most patients inevitably confront the challenge of drug *** phenomenon arises not solely from intrinsic alterations within cancer cells but also from the intricate dynamics of the tumor microenvironment and the complex interactions that occur between cancer cells and their immediate *** review consolidates the current knowledge regarding EGFR-TKI resistance mechanisms,with a specific emphasis on unraveling the role played by the tumor *** addition,the review delineates strategic approaches to surmount TKI resistance,thereby enriching the understanding of the interplay between therapeutic agents and the intricate milieu surrounding cancer cells.

关键词： Non-small cell lung cancer Epidermal growth factor receptor Tumor microenvironment Epidermal growth factor receptor-tyrosine kinase inhibitor Drug resistance

Ubiquitin homeostasis disruption, a common cause of proteostasis collapse in amyotrophic lateral sclerosis?

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Neural Regeneration Research 2022年第10期17卷 2218-2220页

作者： Christen G.Chisholm jeremy s.Lum natalie E.Farrawell justin j.Yerbury Illawarra Health and Medical Research Institute/Molecular Horizons and school of Chemistry and Molecular Bioscience Science Medicine and Health FacultyUniversity of WollongongNorthfields AveWollongongNSWAustralia

Amyotrophic lateral sclerosis(ALs)is associated with proteostasis collapse:ALs is an unrelenting neurodegenerative disease that is characterized by the loss of motor neurons in the brain and spinal cord,resulting in the progressive atrophy,and eventual paralysis,of skeletal *** due to respiratory failure usually occurs within 2-5 years from symptom *** 90%of ALs cases are of unknown etiology and are termed sporadic ALs(sALs).The remaining 10%of ALs cases present with a family history(familial ALs;fALs)and are associated with genetic mutations in a range of over 20 functionally heterogeneous *** of disease origin,the pathological hallmark of ALs is the accumulation of ubiquitylated protein inclusions in motor neurons and surrounding glial *** presence of these inclusions,compromised largely of misfolded and aggregated proteins,implies a collapse in *** refers to the maintenance of the proteome in a state of balance or equilibrium so that a cell can perform its proper function.

关键词： stasis homeostasis collapse

The impact of vitamin D deficiency on neurogenesis in the adult brain

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Neural Regeneration Research 2017年第3期12卷 393-394页

作者： natalie j.Groves Thomas H.j.Burne Queensland Brain Institute The University of QueenslandSt.LuciaAustralia Queensland Centre for Mental Health Research The Park Centrefor Mental HealthWacolAustralia

There is increasing evidence from epidemiological studies indicating that vitamin D deficiency during adulthood is associated with adverse brain outcomes in humans（Ginde et al.,2009）and rodents（Groves et al.,2014）... 详细信息

关键词： The impact of vitamin D deficiency on neurogenesis in the adult brain GAD

Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

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journal of sport and Health science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally natalie Ella Miller Claire Lawrence Rebecca j Beeken Abigail Fisher Department of Behavioural science and Health University College LondonLondon WC1E 6BTUK Department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure score Index(LsI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LsI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LsI *** daily steps)to 0.60(LsI ***).After adjusting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life sleepTagedAPTARAEnd

Galvanically induced potentials to enable minimal tribochemical wear of stainless steel lubricated with sodium chloride and ionic liquid aqueous solution

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Friction 2018年第2期6卷 230-242页

作者： Tobias AMANN Felix GATTI natalie OBERLE Andreas KAILER jürgen RüHE Fraunhofer Institute for Mechanics of Materials IWM Institute for Macromolecular Chemistry University of Freiburg IMTEK-Department of Microsystems Engineering University of Freiburg

The effect of galvanically induced potentials on the friction and wear behavior of a 1 RK91 stainless steel regarding to tribocorrosion was investigated using an oscillating ball-on-disk tribometer equipped with an electrochemical cell. The aim of this investigation is to develop a water-based lubricant. Therefore 1 molar sodium chloride(NaCl) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl] water solutions were used. Tribological performance at two galvanically induced potentials was compared with the non-polarized state: cathodic potential-coupling with pure aluminum- and anodic potential-coupling with pure copper. Frictional and electrochemical response was recorded during the tests. In addition, wear morphology and chemical composition of the steel were analyzed using scanning electron microscopy(sEM) and X-ray photoelectron spectroscopy(XPs), respectively. The galvanically induced cathodic polarization of the stainless steel surface results in electrochemical corrosion protection and the formation of a tribolayer. Cations from the electrolyte(sodium Na^+ and 1-ethyl- 3-methylimidazolium [C_2 mim]^+) interact and adhere on the surface. These chemical interactions lead to considerably reduced wear using 1 NaC l(86%) and 1% 1-ethyl-3-methylimidazolium chloride [C_2 mim][Cl](74%) compared to the nonpolarized system. In addition, mechanical and corrosive part of wear was identified using this electrochemical technique. Therefore this method describes a promising method to develop water-based lubricants for technical applications.

关键词： sliding wear tribochemistry potential controlled friction and wear galvanic coupling ionic liquids tribolayer formation

Association between dairy intake,lipids and vascular structure and function in diabetes

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World journal of Diabetes 2017年第5期8卷 202-212页

作者： Kristina s Petersen jennifer B Keogh natalie Lister jacquelyn M Weir Peter j Meikle Peter M Clifton school of Pharmacy and Medical sciences and sansom Institute for Health Research University of South Australia Baker IDI Heart and Diabetes Institute

AIM To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and *** A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes(n = 108). Thispaper comprises post-hoc analyses investigating the relationship between dairy intake, serum lipid species and vascular health. Central and peripheral blood pressure, carotid femoral pulse wave velocity, augmentation index, serum lipid species and dietary intake were measured at baseline and 3-mo. Common carotid artery intima media thickness was measured at baseline and *** serum lipid species [lysophosphatidylcholine(LPC) 14:0, LPC 15:0, LPC 16:1, phosphatidylcholine(PC) 29:0 PC 30:0, PC 31:0 and cholesterol ester(CE) 14:0] were associated with the change in full fat dairy consumption(rho 0.19-0.25; P some lipids was positively associated with the 3-mo change in central systolic [LPC 14:0(rho 0.30; P = 0.007), PC 30:0(rho 0.28; P = 0.010)] and diastolic blood pressure [LPC 14:0(rho 0.32; P = 0.004), LPC 15:0(rho 0.23; P = 0.04), LPC 16:1(rho 0.23; P = 0.035), PC 29:0(rho 0.28; P = 0.01), PC 30:0(rho 0.36; P = 0.001), PC 31:0(rho 0.30; P = 0.007)] and 12-mo change in common carotid artery intimal medial thickness [CE 14:0(rho 0.22; P = 0.02)]. Pulse wave velocity and augmentation index were unrelated to dairy and lipid *** An increase in dairy associated lipids appears to be associated with an increase in blood pressure and common carotid intimal medial thickness.

关键词： Lipids Phospholipids Atherosclerosis Dairy Lysophosphatidylcholine Lipidomics Carotid intima media thickness Pulse wave velocity Diabetes

Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants

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Genes & Diseases 2019年第1期6卷 56-67页

作者： Megan s.Kane Callie j.Diamonstein natalie Hauser john F.Deeken john E.Niederhuber Thierry Vilboux Inova Translational Medicine Institute Inova Health SystemFairfaxVAUnited States Department of Medicine Virginia Commonwealth UniversityRichmondVAUnited States Department of Public Health sciences University of Virginia School of MedicineCharlottesvilleVAUnited States Department of Oncology and surgery Johns Hopkins University School of MedicineBaltimoreMDUnited States

The uncharacterized gene KIAA1109 has recently been associated with a congenital neurological malformation disorder that variably presents with arthrogryposis,craniofacial and/or cardiac *** have identified two additional patients with compound heterozygous KIAA1109 variants presenting with the same neurological *** mechanism whereby KIAA1109 loss of function causes this spectrum of disorders was the primary focus of our *** hypothesized that KIAA1109 function could be conserved relative to the fly gene tweek and examined endocytosis and endosome recycling in patient ***,we examined the structure of the cytoskeleton and cilia based on functional overlap with endocytosis and several known etiologies for neuronal migration *** primary dermal fibroblasts from one patient and a healthy donor,we performed immunofluorescence and endocytosis assays to examine the endosomal,cytoskeletal,and ciliary cellular *** found notable abnormalities in endosomal trafficking and endosome recycling *** also observed changes in the actin cytoskeleton and cilia structural *** conclude that the function of KIAA1109 in humans may indeed overlap with the function of the Drosophila ortholog,resulting in perturbations to endosomal trafficking and the actin *** alterations have ripple effects,altering many pathways that are critical for proper neuronal migration and embryonic development.

关键词： Cilia Endocytosis KIAA1109 Neurological malformation Vesicular trafficking