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Cardiac Myeloperoxidase Activity Is Elevated in Hypertensive Pregnant Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2017年第6期37卷 904-909页

作者：朱明林赵金平崔凝 Victor H.Goncalves-Rizzi Jose S.Possomato-Vieira regina A.nascimento Carlos A.Dias-Junior Department of Thoracic and Cardiovascular Surgery Zhongnan HospitalWuhan University Department of Gastroenterology Renmin Hospital of Wuhan University Department of Pharmacology Biosciences Institute of BotucatuSao Paulo State University (UNESP)

Myeloperoxidase（MPO） is released from activated neutrophils. The inflammation in preeclampsia was found to be associated with endothelial dysfunction. We hypothesized that cardiac and circulating MPO levels are elevated in hypertensive pregnancy. Systolic and diastolic blood pressure and heart rate were measured on pregnancy days 14, 16, 18 and 20 in normal pregnant and hypertensive pregnant rats. Left and right ventricle weights, the number of viable fetuses, litter size, fetal and placenta weights were recorded on gestational day 21. Circulating and cardiac MPO activities, soluble fms-like tyrosine kinase-1（sFlt-1） and vascular endothelial growth factor（VEGF） and nitric oxide（NO） were detected. The results showed increases in cardiac（left, but not right ventricle） and circulating MPO activities, and concomitantly lower number of viable fetuses, litter size, and fetal and placenta weights, and decreases in NO in hypertensive pregnant rats. Also, the increases in circulating sFlt-1 and VEGF were found in hypertensive pregnant group. In conclusion, maternal and fetal detrimental changes along with increases in circulating sFlt-1 and VEGF in hypertensive pregnancy may be associated with increases in cardiac and circulating MPO activities, confirming the causative role of inflammatory response in preeclampsia.

关键词： hypertensive pregnancy preeclampsia rats myeloperoxidase

Chemical,Sensorial and Rheological Properties of a New Organic Rice Bran Beverage

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Rice science 2009年第3期16卷 226-234页

作者： Gerson Luis FACCIN Leila do nascimento VIEIRA Letícia Adélia MIOTTo Pedro Luiz Manique BARRETO Edna regina AMANTE Department of Food Science and Technology University Federal of the Santa CatarinaRod Admar Gonzaga1346-Itacorubi FlorianópolisSCCEP 88034001Brazil

Rice bran is a solid residue from rice polishing that is used in animal nutrition and rice oil production. Cultivation conditions with agro-toxics, lipids instability, and tendency for mycotoxin contamination restrict its application in human nutrition. Therefore, organic agriculture is an alternative to use the properties of rice bran. Rice bran beverage is a new cereal product from organic rice. This work presents the preliminary results of the chemical and rheological studies of a bath pasteurized rice bran beverage. Compared with integral defatted milk, soy extracts, and brown rice low-fat milk, the rice bran beverage studied in this work presents itself as an important source of minerals and unsaturated lipids. All essential amino acids were found in this product. Glutamic and aspartic acids were predominant. Bath pasteurization at boiling water temperature for 15 and 30 min was adequate for microbiological safety. Refrigeration storage for 20 days, evaluated by pH and acidity variations, was ideal for assessment of the beverage conservation time. The beverage viscosity was of the Newtonian standard behavior, and its viscosity during storage was not a good parameter to evaluate shelf life. Sensory preference tests showed positive perspectives for this new beverage.

关键词： beverage composition residue rice bran viscosity

FeedEfficiencyService: An architecture for the comparison of data from multiple studies related to dairy cattle feed efficiency indices

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Information Processing in Agriculture 2022年第3期9卷 378-396页

作者： Heitor Magaldi Linhares regina Braga Wagner Antonio Arbex Mariana Magalhaes Campos Fernanda Campos Jose Maria N.David Victor Stroele Programa de Pos-Graduacao em Ciencia da Computacao Universidade Federal de Juiz de ForaCampus UniversitarioRua JoseLourenco Kelmers/n-Sao PedroJuiz de ForaMinas Gerais 36036-900Brasil Brazilian Agricultural Research Corporation-Embrapa Av.Eugenio do Nascimento610-AeroportoJuiz de Fora-MGMinas Gerais 36038-330Brasil

The increased demand for food worldwide,the reduced land availability for livestock pro-duction,the increasing cost of animal feed and the need for mitigating livestock-related greenhouse gas emissions have driven the search for animal feeding systems that proves more *** tackle this problem,we propose the use of computational support to help researchers compare data on feed efficiency,therefore improving economic and environ-mental *** a solution,we present an integrative architecture capable of combining heterogeneous data from multiple experiments related to dairy cattle feed efficiency *** proposed architecture,called FeedEfficiencyService,classifies animals according to feed efficiency indices and allows visualizations through ontologies and inference *** results obtained from a case study with researchers from the Brazilian Agri-cultural Research Corporation–Dairy Cattle(EMBRAPA)demonstrate that this architecture is a supporting tool in their daily work *** researchers highlighted the importance of the proposed architecture as it allows analyzing animal data,comparing experiments,having reliable data analyses,and standardizing and organizing data from *** novelty of our approach is the use of ontologies and inference engines to enable the discovery of new knowledge and new relationships between data from feed efficiency-related *** store such data,relationships,and analyses of results in an inte-grated *** solution ensures unified access to the processing history and data from diverse experiments,including those conducted at external research centers.

关键词： Dairy Cattle

Serological evidence of Toxoplasma gondii infection as potential risk for the development of lepromatous leprosy in an endemic area for both neglected tropical diseases in Brazil

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Infectious Diseases of Poverty 2020年第1期9卷 36-45页

作者： Luciana regina Pereira Oliveira Lívia Mattos Martins Rebeka da Conceição Souza Yuri Scheidegger de Castro Letícia Silva nascimento Juliana Azevedo da Silva Edilbert Pellegrini Nahn Junior Wilmar Dias da Silva Alba Lucínia Peixoto-Rangel Laboratory of Recognition Biology Center of Biosciences and BiotechnologyState University of Northern Rio de JaneiroCampos dos GoytacazesRJBrazil Campos Medical School Campos dos GoytacazesRJBrazil Laboratory of Immunochemistry Butantan InstituteSão PauloSPBrazil

Background:Mycobacterium leprae and Toxoplasma gondii infections are both neglected tropical diseases highly prevalent in *** with certain parasite species can significantly alter susceptibility to other important pathogens,and/or influence the development of *** we investigated the possible influence of ***/*** co-parasitism on the manifestation of leprosy and its clinical ***:Participants(n=291)were recruited in Campos dos Goytacazes city,Rio de Janeiro state,southeast Brazil,from August 2015 to December 2019 and clinically diagnosed for *** were selected based on the presence(patients)or absence(healthy controls)of the leprosy *** of patients were also recruited for this *** samples from patients(n=199)with leprosy,contacts(n=40)and healthy controls(n=52)were investigated for levels of IgM and IgG anti-phenolic glycolipid-1(PGL-1)by ***,IgG antibody against soluble Toxoplasma antigen(STAg)was measured in sera samples from leprosy patients,contacts and healthy controls for Toxoplasma gondii serology by ***-PGL-1 IgG and IgM levels were compared using one-way ANOVA Kruskal-Wallis or Mann-Whitney,while Spearman test was used to correlate levels of IgG anti-STAg and IgM/IgG anti-PGL-1 from seropositive and seronegative individuals for *** *** risk of *** infection for leprosy disease was assessed using Fisher’s ***:Levels of IgM anti-PGL-1 antibodies were significantly higher in multibacillary(MB)patients compared to paucibacillary(PB)patients(P=0.0068).Higher IgM and IgG levels anti-PGL-1 were detected in patients with the lepromatous *** serologic prevalence for *** infection was 74.9%.We detected increased anti-STAg antibody levels in leprosy patients(79.4%),reaching 88.8%within those with lepromatous form of this *** leprosy risk increase in *** seropositive individuals was two-fold(odds ratio[OR]=2.055;95% c

关键词： Leprosy Toxoplasmosis Coinfection Co-immunomodulation Immunoglobulins Immune response

Leaf Anatomy of Prosthechea moojenii(Pabst)*** and *** Cath.&***(Orchidaceae)as an Approach to Taxonomy of Species Occurring in Biomes Cerrado and Atlantic Forest of the Bahia

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American Journal of Plant Sciences 2012年第12期3卷 1752-1758页

作者： Filipe de Castro Seixas Silvana Helena nascimento Monteiro Lazaro Benedito da Silva Kelly regina Batista Leite Instituto de Biologia Departamento de BotanicaLaboratório de Anatomia Vegetal e Identificacao de MadeirasCampus Univer-sitário de OndinaUniversidade Federal da BahiaSalvadorBrasil Instituto de Pesquisa Jardim Botanico do Rio de Janeiro Uni-dade de Botanica SistemáticaRio de JaneiroBrasil

Prosthechea is a neotropical genus, belonging to the family Orchidaceae. The Brazil recorded 32 species of the genus of which nine occur in the state of Bahia, including P. silvana and P. moojenii. The first, P. silvana is epiphytic, endemic Atlantic Forest areas of South and Southeast of the Bahia and morphologically similar to P. moojenii, rupicolous species considered endemic to the Chapada Diamantina. There are doubts whether these two species are really distinct, because they differ only as to the way of life and aspects related to the size of the inflorescence and floral structure. Thus the anatomical study of these two species, emerges as a tool that aims to investigate the delimitation of these taxa. For this study, the sheet was cut freehand with a razor blade to obtain cross sections and treated by chemical means to obtain paradermic sections, all the material was stained with safranine/Astra blue (safrablau) and safranin, respectively, and the sections were then mounted between a semipermanent and cover slipped slides. The results allowed to distinguish P. silvana of the P. moojenii through the following characteristics observed in the leaf (thickening of the cell walls of epidermal cells, amount and disposition of sclerenchyma fibers and fiber arrangement of vascular and vascular bundles in the mesophyll) and root (number of arcs of xylem and phloem, thickening of cells median cortex), infers taxonomic characters for the genus. The data indicated anatomical distinction between the two species studied here of the Prosthechea, however, suggest the anatomical analysis of other organs to reproductive and vegetative.

关键词： Laeliinae Flora of Bahia Velamen Endemism

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

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World Journal of Gastroenterology 2021年第11期27卷 1064-1075页

作者： José Carlos Rodrigues nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá Department of Anesthesia and Surgery Liver Transplantation Fortaleza General HospitalFortaleza 60150-160CEBrazil Laboratory of the Biology of Tissue Healing Ontogeny and NutritionDepartment of Morphology and Institute of BiomedicineSchool of MedicineFederal University of CearáFortaleza 60430-270CEBrazil Department of Dental Clinic Federal University of CearáFortaleza 60430-270CEBrazil Department of Surgery Liver Transplant Unit of Federal University of CearáFortaleza 60430-270CEBrazil Transplantation Division Hospital Geral de FortalezaFortaleza 60175-742CEBrazil Institute of Virology CharitéUniversitätsmedizin BerlinBerlin 10117Germany UCL Medical School Royal Free CampusLondon NW32PFUnited Kingdom Department of Specialized Medicine Hepatology Liver Transplantation UnitAzienda Sanitaria Universitaria Integrata of UdineUdine I-33100Italy

BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular *** E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver *** To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)*** injury severity was assessed using different criteria,including METAVIR and models for endstage liver *** polymorphisms were analyzed by quantitative real-time polymerase chain *** The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to *** addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 *** fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

关键词： Apolipoprotein E Polymorphism Liver cirrhosis Hepatitis C virus Hepatocellular carcinoma Liver transplantation

Renal Function after Major Uro-Oncologic Surgery and Dexmedetomidine Infusion

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Open Journal of Anesthesiology 2013年第8期3卷 356-362页

作者： Marcus Vinicius M. Novaes Paulo Sergio G. Lavinas Grace Haber D. Pires Ana Claudia G. de Carvalho Renata M. B. Lopes regina El Dib Paulo do nascimento Jr. Cancer Institute (INCA) Rio de Janeiro Brazil Department of Anesthesiology Univ Estadual Paulista (UNESP) Botucatu Brazil

Objective: Acute kidney injury in major surgery is associated with increased postoperative mortality. This study aimed to evaluate renal function after major urologic surgery and intraoperative dexmedetomidine infusion. Methods: Thirty oncologic patients with normal renal function scheduled for prostatectomy or nephrectomy, anesthetized with combined epidural and general anesthesia, were randomized to receive either intraoperative blind infusion of dexmedetomidine (Dexmedetomidine Group, n = 15, 0.5 μg/kg load dose plus 0.7 μg/kg/h) or 0.9% saline (Control Group, n = 15) until the end of surgery. Intraoperative and cumulative 24-hour diuresis, serum creatinine (SCr), calculated creatinine clearance (ClCr) and serum cystatin C (SCys) at postoperative days 1, 2 and 3 and 2 weeks after surgery were evaluated. Results: Mean ± standard deviation values for intraoperative diuresis in Dexmedetomidine and Control Groups were 566 ± 396 mL and 298 ± 153 mL, respectively (p = 0.014). Cumulative 24-hour diuresis in Dexmedetomidine and Control Groups was 1947 ± 266 mL and 1748 ± 237 mL, respectively (p = 0.91). Mean values of SCr, ClCr and SCys were not significantly different from their baseline values in both groups and no significant differences were seen between groups at any moment for two weeks (p > 0.05). Conclusion: According to the doses used in this study, despite an intraoperative increase in diuresis, intraoperative infusion of dexmedetomidine did not influence renal performance up to two weeks after major uro-oncologic surgery, as evaluated by SCr, ClCr and SCys.

关键词： Dexmedetomidine Renal Function Nephrectomy Prostatectomy Epidural General Anesthesia

Postcolonialism and the Feminine in Paulina Chiziane＇s O alegre canto da perdiz

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Journal of Literature and Art Studies 2016年第7期6卷 744-750页

作者： Algemira de Macedo Mendes Aurea regina do nascimento Santos State University of Piaui Teresina Brazil Federal Institute ofPiaui Teresina Brazil

Assessment of Educational Videos on the Prevention and Management of Infant Diarrhea:Documental Study

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Health 2015年第9期7卷 1215-1223页

作者： Elizamar regina da Rocha Mendes Jardeliny Correa da Penha Ludmila Alves do nascimento Leidiane Minervina Moraes de Sabino Emanuella Silva Joventino Adria Marcela Vieira Ferreira Olinda Costa Mota Teixeira Maria de Fátima Pereira de Sousa Galvao Lorena Barbosa Ximenes Federal University of Ceará FortalezaBrazil Federal University of Piauí FlorianoBrazil University of International Integration of African-Brazilian Lusophony RedencaoBrazil

Objective: To evaluate the suitability of educational videos produced in Brazil that addressed aspects related to prevention and/or management of infant diarrhea according to content;language;graphic illustrations;stimulation for learning/motivation and cultural fit. Method: Documentary study, which evaluated six educational videos from an adapted and validated tool, the Suitability Assessment of Materials. Three nurses evaluated the videos. Data were processed using the Statistical Package for the Social Sciences, version 17.0, and presented in tables and graphics. Results: It was found that 4 (66.6%) of the educational videos were classified as appropriate, ranging from 60% to 63.3% of full approval, and 2 (33.3%) were assessed as higher, reaching up to 83.3% to 90% approval. Considering the socioeconomic and cultural contexts of the videos to the audience, they assigned notes ranging from 6 to 9 in a rating ranging from 0, the minimum score, to 10, the highest score. Conclusion: The educational videos were considered adequate, with positive results about the content on the prevention and management of infant diarrhea, being appropriate for the target audience. As a result, greater credibility is ratified as the use thereof, since these resources can contribute to health promotion and prevention of diarrhea in children.

关键词： Diarrhea Infantile Educational Technology Child Health