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肾癌螺旋CT三期增强扫描的诊断

中国医学影像技术 2006年第5期22卷 758-760页

作者：南喜文乔英李健丁山西省大同市第三人民医院影像科山西大同037008 山西医科大学第一医院放射科山西太原030001

目的探讨肾癌螺旋CT三期增强扫描征象,提高诊断水平。方法回顾性分析51例经手术病理证实的肾癌多期螺旋CT扫描资料。结果临床典型肾癌多为中等大小(3 cm<<7 cm)肿块,密度不均(实性16/51,囊实性24/51,囊性11/51),皮质期明显强化,实质... 详细信息

目的探讨肾癌螺旋CT三期增强扫描征象,提高诊断水平。方法回顾性分析51例经手术病理证实的肾癌多期螺旋CT扫描资料。结果临床典型肾癌多为中等大小(3 cm<<7 cm)肿块,密度不均(实性16/51,囊实性24/51,囊性11/51),皮质期明显强化,实质期迅速下降。小肾癌(≤3 cm)多突出于肾轮廓外,中等(3 cm<<7 cm)和大肾癌(≥7cm以上)多贯通肾实质,与正常肾实质分界形态多为弧形缺损。肾周间隙改变多提示突破包膜,大肾癌易出现包膜周围血管增粗(5/12)。三期增强易显示肾周淋巴结(14/17),静脉癌栓(15/15)及肾盂受侵(28/32)。结论螺旋CT三期增强扫描可全面显示肾癌病变征象及范围,肾癌仍有值得探讨的有价值征象。

关键词：肾细胞癌体层摄影术,X线计算机三期扫描

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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nano-Micro Letters 2025年第3期17卷 340-354页

作者： Li An Jianyi Li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang nan Zhang Pinxian xi * Zhichuan JXu Chun‑Hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

未行肾替代治疗的慢性肾功能不全患者的尿毒症肺CT分级与血肌酐水平的关系

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中国医学影像技术 2011年第7期27卷 1388-1391页

作者：彭泰松许志高武志峰南喜文大同市第三人民医院放射科山西大同037008 山西医科大学第一医院CT室山西太原030001

目的探讨未行肾替代治疗的慢性肾功能不全患者的尿毒症肺（UL）CT分级与血肌酐（SCr）水平的关系。方法严格按照纳入及排除标准选取58例慢性肾功能不全患者,对所有患者均行MSCT检查,并于CT检查前后3天内测定SCr。按CT征象及肺部病变范... 详细信息

目的探讨未行肾替代治疗的慢性肾功能不全患者的尿毒症肺（UL）CT分级与血肌酐（SCr）水平的关系。方法严格按照纳入及排除标准选取58例慢性肾功能不全患者,对所有患者均行MSCT检查,并于CT检查前后3天内测定SCr。按CT征象及肺部病变范围积分分别进行分级和分组,比较各组间的SCr。结果按CT征象分为0~4级,共5组,各组间SCr差异均有统计学意义（P均〈0.05）;按肺部病变范围积分亦分为0~4级,共5组,各组间SCr差异均有统计学意义（P均〈0.05）。结论 UL的严重程度与肾功能下降程度有关。

关键词：尿毒症肺血肌酐体层摄影术,X线计算机

Lung-targeted polyzwitterionic lipid nanoparticles for effective treatment of lung inflammation

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Science China Chemistry 2025年

作者： wen Zhang Jiaxin Li nan Wang Muzi Li Chen Peng xinyue Zhang Guanghui Ouyang Yan Li Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological Engineering University of Science and Technology Beijing CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences

Lipid nanoparticles (LNPs) are non-viral nucleic acid delivery systems that show great potential in vaccine development and disease treatment. Although LNPs are particularly advantageous for in vivo delivery, the wide application of LNPs is impeded as their systemic delivery of nucleic acid drugs to extrahepatic tissues remains highly challenging. To address this issue, we developed lung-targeted polyzwitterionic LNPs with zwitterionic polymer poly(2-methyacryloyloxyethyl phosphorylcholine)(PMPC) modified 1,2-dimyristoyl-sn-glycerol lipid for the delivery of small interfering RNA (siRNA). Three libraries with 90PMPC-LNPs@siRNA were established. The polyzwitterionic PMPC-LNPs had high siRNA encapsulation efficiency of about90%. The findings revealed that polyzwitterionic PMPC-LNPs@siRNA absorbed protein corona with the main component of Vitronectin, mediating lung-targeted delivery of siRNA. With good cellular uptake and endo/lysosomal escape ability, in vitro and in vivo studies demonstrated that polyzwitterionic PMPC-LNPs with siRNA against tumor necrosis factor-α (TNF-α) could significantly down-regulate the TNF-α in mRNA and protein levels, and improved the pathological features of lung inflammation. Polyzwitterionic PMPC-LNPs@siRNA achieved safe and efficient treatment of lung inflammation. Therefore, this work offered a promising siRNA therapeutic approach for lung diseases.

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四肢恶性纤维组织细胞瘤手术前介入治疗的意义

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当代医学 2009年第23期15卷 440-441页

作者：赵生旺王希南喜文苗来生山西省大同市三医院放射科山西037006 山西大同大学

目的探讨经动脉灌注化疗加栓塞治疗恶性纤维组织细胞瘤后行手术切除的临床效果。方法本组10例患者,男8例、女2例,发病年龄28～76岁,下肢发病8例,上肢2例,经肢体动脉灌注表阿霉素、顺铂后,以明胶海绵栓塞肿瘤及供血动脉后一周左右手术切... 详细信息

目的探讨经动脉灌注化疗加栓塞治疗恶性纤维组织细胞瘤后行手术切除的临床效果。方法本组10例患者,男8例、女2例,发病年龄28～76岁,下肢发病8例,上肢2例,经肢体动脉灌注表阿霉素、顺铂后,以明胶海绵栓塞肿瘤及供血动脉后一周左右手术切除。结果经介入动脉灌注化疗加栓塞一周后,肿瘤明显缩小,手术容易切除,出血少。结论恶性纤维组织细胞瘤行介入治疗后,提高切除率,保存肢体,延长生存期。

关键词：软组织肉瘤恶性纤维组织细胞瘤动脉介入化疗+栓塞

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钢筋混凝土框架结构延性设计的新发展

天水师范学院学报 2001年第2期21卷 25-27页

作者：南喜涛高文妹天水师范学院工科部甘肃天水741001 甘肃省第八建筑工程公司甘肃天水741000

简要回顾了钢筋混凝土框架结构延性设计理论依据及设计方法，特别指出了钢筋混凝土框架结构延性设计的新发展．

关键词：框架结构耗能延性设计钢筋混凝土抗震设计

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

Corporate Credit Ratings Based on Hierarchical Heterogeneous Graph Neural Networks

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Machine Intelligence Research 2024年第2期21卷 257-271页

作者： Bo-Jing Feng xi Cheng Hao-nan Xu wen-Fang Xue Center for Research on Intelligent Perception and Computing National Laboratory of Pattern RecognitionInstitute of AutomationChinese Academy of SciencesBeijing 100190China

order to help investors understand the credit status of target corporations and reduce investment risks,the corporate credit rating model has become an important evaluation tool in the financial *** models are based on statistical learning,machine learning and deep learning especially graph neural networks(GNNs).However,we found that only few models take the hierarchy,heterogeneity or unlabeled data into account in the actual corporate credit rating ***,we propose a novel framework named hierarchical heterogeneous graph neural networks(HHGNN),which can fully model the hierarchy of corporate features and the heterogeneity of relationships between *** addition,we design an adversarial learning block to make full use of the rich unlabeled samples in the financial *** experiments conducted on the public-listed corporate rating dataset prove that HHGNN achieves SOTA compared to the baseline methods.

关键词： Corporate credit rating hierarchical relation heterogeneous graph neural networks adversarial learning