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3D-Stacked Multistage Inertial Microfluidic Chip for High-Throughput Enrichment of Circulating Tumor Cells

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Cyborg and Bionic Systems 2022年第1期2022卷 200-209页

作者： X.Xu X.Huang J.Sun J.Chen G.Wu Y.Yao n.zhou S.Wang L.Sun Ministry of Education Key Laboratory of RF Circuits and Sytems Hangzhou Dianzi UniversityHangzhou310018 ZhejiangChina Institute for Translational Medicine Zhejang UniversityHangzhou310029 ZhejiangChina Key Laboratory of 3D Micro/nano Fabrication and Characterization of Zhejiang Province School of EngineeringWestlake UniversityHangzhou310024 Zhejiang China national Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China Clinical Research Center for Respiratory Disease West Chima HospitalSichuan UniversityChengdu 610065China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Whether for cancer diagnosis or single-cell analysis,it remains a major dhallenge to isolate the target sample cells from a large background cell for high-efficiency downstream detection and analysis in an integrated ***,in this paper,we propose a 3D stacked multistage inertial microfluidic sorting chip for high-throughput enrichment of circulating tumor cells(CTCs)and convenient downstream *** this chip,the first stage is a spiral channel with a trapezoidal cross-section,which has better separation performance than a spiral channel with a rectangular *** second and third stages adopt symmetrical square serpentine channels with different rectangular cross-section widths for further separation and enrichment of sample cells reducing the outlet flow rate for easier downstream detection and *** multistage channel can separate 5 pum and 15 um particles with a separation efficiency of 92.37%and purity of 98.10%at a high inlet flow rate of 1.3 mL/***,it can separate tumor cells(SW480,A549,and Caki-1)from massive red blood cells(RBCs)with *** efficiency of>80%,separation purity of>90%,and a concentration fold of~*** proposed work is aimed at providing a high-throughput sample processing system that can be easily integrated with flowing sample detection methods for rapid CTC analysis.

关键词： fluid diagnosis separation

Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-Xiao Zheng Zi-An.zhou Tiao Feng Hui Li Cheng-Hua Sun nüWang Yang Tian Yong Zhao Shu-Yun.zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Bioinspired Smart Interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology

The Ti-TAn plasmid toolbox for TurboID-based proximity labeling assays in nicotiana benthamiana

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Journal of Integrative Plant Biology 2024年第2期66卷 166-168页

作者： Huang Tan Yu zhou Erik Dinius Rosa Lozano-Durán Department of Plant Biochemistry Center for Plant MolecularBiology(ZMBP)Eberhard Karls UniversityTubingenD‐72076Germany

Protein-protein interactions and the formation of protein complexes play a central role in the regulation of virtually all aspects of *** identification and characterization of interactions between proteins is the bas... 详细信息

关键词： proximity complexes enable

Coke behavior with H_(2)O in a hydrogen-enriched blast furnace:A review

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 959-976页

作者： Feng zhou Daosheng Peng Kejiang Li Alberto n.Conejo Haotian Liao Zixin Xiong Dongtao Li Jianliang Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Chemical Engineering The University of QueenslandSt LuciaQLD 4072Australia Baosteel Central Research Institute(R&D Center of Wuhan Iron&Steel Co. Ltd.)Wuhan 430080China Shougang Research Institute of Technology Shougang Group Corporation Ltd.Beijing 100043China Beijing Key Laboratory of Green Recyclable Process for Iron and Steel Production Technology Beijing 100043China

Hydrogen-enriched blast furnace ironmaking has become an essential route to reduce CO_(2)emissions in the ironmaking ***,hydrogen-enriched reduction produces large amounts of H_(2)O,which places new demands on coke quality in a blast *** a hydrogen-rich blast furnace,the presence of H_(2)O promotes the solution loss *** result improves the reactivity of coke,which is 20%-30%higher in a pure H_(2)O atmosphere than in a pure CO_(2)*** activation energy range is 110-300 kJ/mol between coke and CO_(2)and 80-170 kJ/mol between coke and H_(2)***_(2)and H_(2)O are shown to have different effects on coke degradation *** review provides a comprehensive overview of the effect of H_(2)O on the structure and properties of *** exploring the interactions between H_(2)O and coke,several unresolved issues in the field requiring further research were *** review aims to provide valuable insights into coke behavior in hydrogen-rich environments and promote the further development of hydrogen-rich blast furnace ironmaking processes.

关键词： hydrogen ironmaking coke behavior blast furnace gasification microstructure kinetics

TendiffPure:a convolutional tensor-train denoising diffusion model for purification

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 160-169页

作者： Mingyuan BAI Derun.zhou Qibin ZHAO RIKEn AIP Tokyo 1030027Japan School of Environment and Society Tokyo Institute of TechnologyTokyo 1528550Japan

Diffusion models are effective purification methods,where the noises or adversarial attacks are removed using generative approaches before pre-existing classifiers conducting classification ***,the efficiency of diffusion models is still a concern,and existing solutions are based on knowledge distillation which can jeopardize the generation quality because of the small number of generation ***,we propose TendiffPure as a tensorized and compressed diffusion model for *** the knowledge distillation methods,we directly compress U-nets as backbones of diffusion models using tensor-train decomposition,which reduces the number of parameters and captures more spatial information in multi-dimensional data such as *** space complexity is reduced from O(n^(2))to O(nR^(2))with R≤4 as the tensor-train rank and n as the number of *** results show that TendiffPure can more efficiently obtain high-quality purification results and outperforms the baseline purification methods on CIFAR-10,Fashion-MnIST,and MnIST datasets for two noises and one adversarial attack.

关键词： Diffusion models Tensor decomposition Image denoising

Fluidization stability and periodic fluctuations in gas–solid separation fluidized bed using Geldart A dense medium

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Particuology 2024年第7期90卷 522-534页

作者： Weijin Liu Dan Wang Liang Dong Enhui zhou Tatiana Aleksandrova Chenyang zhou Chenlong Duan Key Laboratory of Coal Processing and Efficient Utilization(China University of Mining&Technology) Ministry of EducationXuzhou 221116China School of Chemical Engineering&Technology China University of Mining&TechnologyXuzhou 221116China Department of Chemical and Biochemical Engineering The University of Western OntarioLondonOntario N6A 5B9Canada Mineral Processing Department Saint Petersburg Mining UniversitySt.Petersburg 199106Russia

Gas–solid separation fluidized bed is a typical method for coal separation without water *** A particles is also considered as the ideal dense medium to strengthen separation *** stability reflects the bed pressure fluctuations and the distribution of bubble and emulsion phases,affecting the separation *** the main frequency of pressure fluctuations can directly reflect the degree of pressure ***,the detailed fluidization stability is analyzed combined the method of standard deviation of pressure fluctuations,power spectral density,etc.,for Geldart A *** results showed that maintaining an appropriate gas velocity resulted in an average bed pressure of around 2000 *** main frequency is mainly concentrated around 1–1.5 ***,a prediction model of the main frequency of pressure fluctuations is established,and the error can be controlled within±*** investigation further proved the stable fluidization of Geldart A particles and provides a method for predicting the main frequency of pressure fluctuations in the gas–solid separation fluidized bed.

关键词： Geldart A dense medium Fluidization stability Periodic fluctuations Pressure fluctuations frequency Gas–solid separation fluidized bed

Structural parameter optimization of a furrow opener based on EDEM software

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 115-120页

作者： Longjie Wang Bin.zhou Chang Wan Ling zhou College of Mechanical and Electrical Engineering Tarim UniversityAlar 843300XinjiangChina Modern Agricultural Engineering Key Laboratory at Universities of Education Department of Xinjiang Uygur Autonomous Region Alar 843300XinjiangChina Xinjiang Production and Construction Corps(XPCC)Key Laboratory of Utilization and Equipment of Special Agricultural and Forestry Products in Southern Xinjiang Alar 843300XinjiangChina

To reduce the ditching resistance of a furrow opener during operation,single-factor and multiple-factor combinations were used to explore the influence of the furrow opener’s advance speed,blade opening angle,and width on the ditching resistance based on the discrete element method(DEM).A DEM simulation of the furrow opener was *** changing these influencing factors,the parameters with the least resistance to operation were *** openers were fabricated according to the optimized results,and soil trench tests were carried *** and soil groove tests showed that the minimum ditching resistance was 58.54 n when the current advance speed was 4.47 m/s,the blade opening angle was 32.02°,and the furrow opener width was 51.45 *** error between the simulated value of the ditching resistance and the soil trench test was within 10%,and the trends of resistance change were essentially the same,indicating that it is feasible to optimize the structural parameters of a trench furrow opener using *** research results can provide a reference for the parameter optimization of furrow openers.

关键词： furrow opener discrete element optimization ditching resistance

Bivariate attribution of the compound hot and dry summer of 2022 on the Tibetan Plateau

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Science China Earth Sciences 2024年第7期67卷 2122-2136页

作者： Baiquan.zhou Panmao ZHAI Zhen LIAO State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China

The extraordinarily high temperatures experienced during the summer of 2022 on the Tibetan Plateau(TP)demand attention when compared with its typical climatic *** absence of precipitation alongside the elevated temperatures resulted in 2022 being the hottest and driest summer on record on the TP since at least *** the susceptibility of the TP to climate change,this study employed large-ensemble simulations from the HadGEM3-A-n216 attribution system,together with a copula-based joint probability distribution,to investigate the influence of anthropogenic forcing,primarily global greenhouse gas emissions,on this unprecedented compound hot and dry event(CHDE).Findings revealed that the return period for the 2022 CHDE on the TP exceeds 4000 years,as determined from the fitted joint distributions derived using observational data spanning *** CHDE was directly linked to large-scale circulation anomalies,including the control of equivalent-barotropic high-pressure anomalies and the northward displacement of the subtropical westerly jet ***,anthropogenic forcing has,to some extent,promoted the surface warming and increased variability in precipitation on the TP in summer,establishing conditions conducive for the 2022 CHDE from a long-term climate change *** return period for a 2022-like CHDE on the TP was estimated to be approximately 283 years(142-613 years)by the large ensemble forced by both anthropogenic activities and natural ***,ensemble simulations driven solely by natural forcing indicated that the likelihood of occurrence of a 2022-like CHDE was almost *** outcomes underscore that the contribution of anthropogenic forcing to the probability of a 2022-like CHDE was 100%,implying that without anthropogenically induced global warming,a comparable CHDE akin to that observed in 2022 on the TP would not be possible.

关键词： Compound hot and dry event Tibetan Plateau Bivariate event attribution Anthropogenic forcing

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On-chip integrated few-mode erbium–ytterbium co-doped waveguide amplifiers

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Photonics Research 2024年第5期12卷 1067-1077页

作者： XIWEn HE DEYUE MA CHEn.zhou MInGYUE XIAO WEIBIAO CHEn ZHIPInG zhou Aerospace Laser Technology and Systems Department Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Science and Technology of ChinaHefei 230026China School of Microelectronics Shanghai UniversityShanghai 201800China State Key Laboratory of Advanced Optical Communications Systems and networks School of ElectronicsPeking UniversityBeijing 100871China

We propose for the first time,to the best of our knowledge,an on-chip integrated few-mode erbium–ytterbium co-doped waveguide amplifier based on an 800 nm thick Si_(3)n_(4)platform,which demonstrates high amplification gains and low differential modal gains(DMGs)*** eccentric waveguide structure and a co-propagating pumping scheme are adopted to balance the gain of each mode.A hybrid mode/polarization/wavelengthdivision(de)multiplexer with low insertion loss and crosstalk is used for multiplexing and demultiplexing in two operation wavebands centered at 1550 nm and 980 nm,where the light in these two bands serves as the signal light and pump light of the amplifier,*** results demonstrate that with an input signal power of 0.1 mW,TE_(0)mode pump power of 300 mW,and TE_(1)mode pump power of 500 m W,the three signal modes(TE_(0)∕TM_(0)∕TE_(1))all exhibit amplification gains exceeding 30 dB,while maintaining a DMG of less than 0.1 dB.

关键词： waveguide pump amplifier