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Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway

World Journal of Diabetes 2024年第9期15卷 1916-1931页

作者： yu Lou yu-Ting Luan Wen-Qing Rong yun Gai Department of Preventive Treatment of Disease Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China Department of Infectious Diseases Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China Department of General Practice(Including Medical Oncology) Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China

BACKGROUnD Diabetic nephropathy(Dn)is the most frequent chronic microvascular consequence of diabetes,and podocyte injury and malfunction are closely related to the development of *** have shown that corilagin(Cor)has hepatoprotective,anti-inflammatory,antibacterial,antioxidant,anti-hypertensive,antidiabetic,and anti-tumor *** To explore the protective effect of Cor against podocyte injury in Dn mice and the underlying *** Streptozotocin and a high-fat diet were combined to generate Dn mice models,which were then divided into either a Cor group or a Dn group(n=8 in each group).Mice in the Cor group were intraperitoneally injected with Cor(30 mg/kg/d)for 12 wk,and mice in the Dn group were treated with *** analysis was used to measure the blood lipid *** and eosin staining was used to detect pathological changes in kidney *** and Western blotting were used to assess the protein expression of nephrin and *** podocyte cells(MPC5)were cultured and treated with glucose(5 mmol/L),Cor(50μM),high glucose(HG)(30 mmol/L),and HG(30 mmol/L)plus Cor(50μM).Real-time quantitative PCR and Western blotting RESULTS Compared with the control group,the Dn mice models had increased fasting blood glucose,glycosylated hemoglobin,triglycerides,and total cholesterol,decreased nephrin and podocin expression,increased apoptosis rate,elevated inflammatory cytokines,and enhanced oxidative *** of the conditions mentioned above were alleviated after intervention with *** addition,Cor therapy improved SIRT1 and AMPK expression(Pnhibited reactive oxygen species and oxidative stress,and elevated autophagy in HG-induced podocytes(PnCLUSIOn Cor alleviates podocyte injury by regulating autophagy via the SIRT1-AMPK pathway,thereby exerting its protective impact on renal function in Dn mice.

关键词： Corilagin Podocyte injury Diabetic nephropathy Autophagy High glucose SIRT1-AMPK pathway

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Artificial enhancement of sturgeon stock in freshwater reservoirs:A case study on sterlet Acipenser ruthenus of the Kama reservoir

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Aquaculture and Fisheries 2024年第2期9卷 287-294页

作者： Pavel B.Mikheev Semyon n.Kazarinov Alla G.Melnikova Stanislav V.Ponosov nikolai G.Petrenko Andrei I.nikiforov Alexey yu Puzik Olga n.Elchenkova Perm State national Research University Perm614990Russia Khabarovsk Branch of the Federal State Budget Scientific Institution“Russian Federal Research Institute of Fisheries and Oceanography”“KhabarovsknIRO” Khabarovsk680038Russia Perm Branch of the Federal State Budget Scientific Institution“Russian Federal Research Institute of Fisheries and Oceanography”“PermnIRO” Perm614991Russia Federal State Budget Scientific Institution“Russian Federal Research Institute of Fisheries and Oceanography”“VnIRO” Moscow117454Russia Moscow State Institute of International Relations(University)of the Ministry for Foreign Affairs of Russia“MGIMO” Moscow117454Russia Department of State Control Supervision and Protection of Aquatic Biological Resources for Perm KraiMiddle-Volga Regional Office of the Federal Fishery AgencyPerm614990Russia

The paper presents the results of the sterlet sturgeon Acipenser ruthenus reintroduction into the Kama Reservoir(Perm Krai,Russia)by sterlet fry from hatcheries into the reservoir since *** effectiveness of hatchery releases was evaluated by monitoring gillnet sampling *** results showed that the species was reported throughout entire Kama Reservoir,which contrasts with 1988-1994 data,when the species was registered only at the upper part of the reservoir near the Kama River *** highest number and biomass values of catch per unit effort(CPUE)of the sterlet were found in submerged river channels-the deepest habitats with flow conditions which are close to the ecological requirements of the *** distribution of the sterlet within the channel biotopes of the reservoir is defined by reduced *** biggest individuals and the widest size range of the sterlet were typical for the upper area of the reservoir and Chusovskoy Bay,which have the greatest *** smallest sizes were typical for fish from catches near the dam of the reservoir,which is consistent with the published data on the distribution of sterlet in reservoir *** presented results may indicate the artificial formation of the sterlet stock in the Kama Reservoir maintained by hatchery *** revealed distribution of the sterlet in the reservoir determines the direction of further research on natural reproduction and thus formation of an artificially formed ***,future studies are required to assess the possibility of hybridization of the sterlet of artificial origin with natural populations of the species,since the low genetic diversity of the sterlet released into the Kama Reservoir which can lead to irreversible loss of genetic individuality of the natural stocks of the species in the catchment of upper course of the Kama River.

关键词： Sterlet Acipenser ruthenus Kama reservoir Hatchery releases CPUE Artificial stock formation

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Plant RnA-binding proteins:Phase separation dynamics and functional mechanisms underlying plant development and stress responses

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Molecular Plant 2024年第4期17卷 531-551页

作者： Sheng Fan yu Zhang Shaobo Zhu Lisha Shen Temasek Life Sciences Laboratory 1 Research LinkNational University of Singapore1 Research LinkSingapore 117604Singapore Department of Biological Sciences National University of Singapore14 Science Drive 4Singapore 117543Singapore

RnA-binding proteins(RBPs)accompany RnA from synthesis to decay,mediating every aspect of RnA metabolism and impacting diverse cellular and developmental processes in *** RBPs undergo phase separation along with their bound RnA to form and function in dynamic membraneless biomolecular condensates for spatiotemporal coordination or regulation of RnA *** evidence suggests that phase-separating RBPs with RnA-binding domains and intrinsically disordered regions play important roles in plant development and stress ***,we summarize the current knowledge about how dynamic partitioning of RBPs into condensates controls plant development and enables sensing of experimental changes to confer growth plasticity under stress conditions,with a focus on the dynamics and functional mechanisms of RBP-rich nuclear condensates and cytoplasmic granules in mediating RnA *** also discuss roles of multiple factors,such as environmental signals,protein modifications,and n6-methyladenosine RnA methylation,in modulating the phase separation behaviors of RBPs,and highlight the prospects and challenges for future research on phase-separating RBPs in crops.

关键词： RnA-binding proteins phase separation biomolecular condensates RnA metabolism development stress resilience

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Recent advances in phenazine-linked porous catalysts toward photo/electrocatalytic applications and mechanism

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Green Energy & Environment 2024年第10期9卷 1518-1549页

作者： Yang Liu yu Zhang Zhao-Di Yang Liqiang Jing Heilongjiang Provincial Key Laboratory of CO2 Resource Utilization and Energy Catalytic Materials School of Material Science and Chemical EngineeringHarbin University of Science and Technology Institute of Process Engineering Chinese Academy of Sciences Key Laboratory of Functional Inorganic Materials Chemistry(Ministry of Education) School of Chemistry and Materials Science International Joint Research Center for Catalytic Technology Heilongjiang University

In recent years, porous organic catalysts have been developed and become research hotspots in photo/electrocatalysis due to their inherent pores, high specific surface area, chemical and thermal stability, and diverse functional building blocks. Phenazine-linked organic catalysts,exhibited excellent conjugation, electrical conductivity, chemical, and thermal stability, could bring in n atoms with specific numbers and positions to regulate electron levels, anchor metals, and absorb near-infrared light, which expands solar energy utilization. These advantages of the phenazine-linked catalysts attracted our group and numerous researchers to conduct experimental and computational work on photo/electrocatalytic applications and mechanisms. This review summarizes the recent significant research progress, synthesis methods, photo/electrocatalytic performance, and applications of relative phenazine-linked catalysts. Furthermore, the photo/electrocatalytic mechanism was systematized and summarized by combining experiments and density functional theory calculations simultaneously.

关键词： Phenazine-linked porous catalysts Photo/electrocatalytic applications Catalytic mechanism

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High corrosion and wear resistant electroless ni–P gradient coatings on aviation aluminum alloy parts

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 155-164页

作者： Bo Wang Jiawei Li Zhihui Xie Gengjie Wang Gang yu College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410012China Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province/College of Chemistry and Chemical Engineering China West Normal UniversityNanchong 637002China Zhongchuan Machinery Ltd.Co. Aero Engine Corporation of ChinaChangsha 410200China

A ni–P alloy gradient coating consisting of multiple electroless ni–P layers with various phosphorus contents was prepared on the aviation aluminum alloy. Several characterization and electrochemical techniques were used to characterize the different ni–P coatings’ morphologies, phase structures, elemental compositions, and corrosion protection. The gradient coating showed good adhesion and high corrosion and wear resistance, enabling the application of aluminum alloy in harsh environments. The results showed that the double zinc immersion was vital in obtaining excellent adhesion (81.2 n). The optimal coating was not peeled and shredded even after bending tests with angles higher than 90°and was not corroded visually after 500 h of neutral salt spray test at 35℃. The high corrosion resistance was attributed to the misaligning of these micro defects in the three different nickel alloy layers and the amorphous structure of the high P content in the outer layer. These findings guide the exploration of functional gradient coatings that meet the high application requirement of aluminum alloy parts in complicated and harsh aviation environments.

关键词： aluminum alloy electroless nickel coating corrosion adhesion

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Revealing Al-O/Al-F reaction dynamic effects on the combustion of aluminum nanoparticles in oxygen/fluorine containing environments:A reactive molecular dynamics study meshing together experimental validation

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Defence Technology（防务技术） 2024年第4期34卷 313-327页

作者： Gang Li Chuande Zhao Qian yu Fang Yang Jie Chen Institute of Chemical Materials China Academy of Engineering Physics(CAEP)P.O.Box 919-311Mianyang 621900SichuanChina

Improving the energy conversion efficiency in metallic fuel(e.g.,Al)combustion is always desirable but challenging,which often involves redox reactions of aluminum(Al)with various mixed oxidizing *** instance,Al-O reaction is the most common pathway to release limited energy while Al-F reaction has received much attentions to enhance Al combustion ***,microscopic understanding of the Al-O/Al-F reaction dynamics remains unsolved,which is fundamentally necessary to further improve Al combustion *** this work,for the first time,Al-O/Al-F reaction dynamic effects on the combustion of aluminum nanoparticles(n-Al)in oxygen/fluorine containing environments have been revealed via reactive molecular dynamics(RMD)simulations meshing together combustion *** RMD simulation systems of Al core/O_(2)/HF,n-Al/O_(2)/HF,and n-Al/O_(2)/CF4 with oxygen percentage ranging from 0%to 100%have been *** n-Al combustion in mixed O_(2)/CF_4 environments have been conducted by constant volume combustion *** results show that Al-O reaction exhibits kinetic benefits while Al-F reaction owns thermodynamic benefits for n-Al *** n-Al/O_(2)/HF,Al-O reaction gives faster energy release rate than Al-F reaction(1.1 times).The optimal energy release efficiency can be achieved with suitable oxygen percentage of 10%and 50%for n-Al/O_(2)/HF and n-Al/O_(2)/CF_4,*** combustion experiments,90%of oxygen percentage can optimally enhance the peak pressure,pressurization rate and combustion ***,Al-O reaction prefers to occur on the surface regions while Al-F reaction prefers to proceed in the interior regions of n-Al,confirming the kinetic/thermodynamic benefits of Al-O/Al-F *** synergistic effect of Al-O/Al-F reaction for greatly enhancing n-Al combustion efficiency is demonstrated at atomicscale,which is beneficial for optimizing the combustion performance of metallic fuel.

关键词： Al-O/Al—F reaction Kinetic benefits Thermodynamic benefits Molecular dynamics Combustion

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Cu,n codoped carbon nanosheets encapsulating ultrasmall Cu nanoparticles for enhancing selective 1,2-propanediol oxidation

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Journal of Energy Chemistry 2024年第4期91卷 27-35页

作者： Yonghai Feng Min yu Minjia Meng Lei Liu Dewei Rao Institute for Advanced Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang 212013JiangsuChina School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

In the selective oxidation of biomass-based 1,2-propanediol(PDO)with oxygen as the terminal oxidant,it is challenging to improve the lactic acid(LA)selectivity for nonnoble metal nanoparticles(nPs)due to their limited oxygen reduction rate and easy C-C *** the high economic feasibility of nonnoble metals,i.e.,Cu,in this work,copper and nitrogen codoped porous carbon nanosheets encapsulating ultrafine Cu nanoparticles(Cu@Cu-n-C)were developed to realize highly selective of PDO oxidation to *** carbon-encapsulated ultrasmall Cu^(0)nPs in Cu@Cu-n-C have high PDO dehydrogenation activity while n-coordinated Cu(Cu-n)sites are responsible for the high oxygen reduction ***,the performance of catalytic PDO conversion to LA is optimized by a proposed pathway of PDO→hydroxylacetone→lactaldehyde→***,the enhanced LA selectivity is 88.5%,and the PDO conversion is up to 75.1%in an O_(2)-pressurized reaction system(1.0 MPa O_(2)),superior to other Cu-based catalysts,while in a milder nonpressurized system(O_(2)flow rate of 100 mL min-1),a remarkable LA selectivity(94.2%)is obtained with 39.8%PDO conversion,2.2 times higher than that of supported Au nanoparticles(1%Au/C).Moreover,carbon encapsulation offers Cu@Cu-n-C with strong leaching resistance for better recycling.

关键词： Selective oxidation Copper and nitrogen doped carbon 1,2-Propanediol Ultrasmall Cu nanoparticles Lactic acid

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CCM-FL:Covert communication mechanisms for federated learning in crowd sensing IoT

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Digital Communications and networks 2024年第3期10卷 597-608页

作者： Hongruo Zhang Yifei Zou Haofei Yin Dongxiao yu Xiuzhen Cheng Institute of Intelligent Computing School of Computer Science and TechnologyShandong UniversityQingdao266237China

The past decades have witnessed a wide application of federated learning in crowd sensing,to handle the numerous data collected by the sensors and provide the users with precise and customized ***,how to protect the private information of users in federated learning has become an important research *** with the differential privacy(DP)technique and secure multiparty computation(SMC)strategy,the covert communication mechanism in federated learning is more efficient and energy-saving in training the ma-chine learning *** this paper,we study the covert communication problem for federated learning in crowd sensing Internet-of-Things *** from the previous works about covert communication in federated learning,most of which are considered in a centralized framework and experimental-based,we firstly proposes a centralized covert communication mechanism for federated learning among n learning agents,the time complexity of which is O(log n),approximating to the optimal ***,for the federated learning without parameter server,which is a harder case,we show that solving such a problem is nP-hard and prove the existence of a distributed covert communication mechanism with O(log logΔlog n)times,approximating to the optimal solution.Δis the maximum distance between any pair of learning *** analysis and nu-merical simulations are presented to show the performance of our covert communication *** hope that our covert communication work can shed some light on how to protect the privacy of federated learning in crowd sensing from the view of communications.

关键词： Covert communications Federated learning Crowd sensing SInR model

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non-isothermal kinetics and characteristics of calcium carbide nitridation reaction with calcium-based additives

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 49-61页

作者： Zhihan Zhang Mengxiao yu Xiaoyu Zhang Jinli Zhang You Han School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

The nitridation reaction of calcium carbide and n_(2) at high temperatures is the key step in the production of ***,the challenges faced by this process,such as high energy consumption and poor product quality,are mainly attributed to the lack of profound understanding of the *** study aimed to improve this process by investigating the non-isothermal kinetics and reaction characteristics of calcium carbide nitridation reaction at different heating rates(10,15,20,and 30℃·min^(-1))using thermogravimetric *** kinetic equation for the nitridation reaction of additive-free calcium carbide sample was obtained by combining model-free methods and model-fitting *** effect of different calcium-based additives(CaCl_(2) and CaF_(2))on the reaction was also *** results showed that the calcium-based additives significantly reduced reaction temperature and activation energy E_(a) by about 40% with CaF_(2) and by 55%-60% with CaCl_(2).The reaction model f(α)was also changed from contracting volume(R3)to 3-D diffusion models with D3 for CaCl_(2) and D4 for CaF_(2).This study provides valuable information on the mechanism and kinetics of calcium carbide nitridation reaction and new insights into the improvement of the lime-nitrogen process using calcium-based additives.

关键词： lime-nitrogen calcium carbide calciumbased additive thermogravimetric analysis nonisothermal kinetics

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Promoted surface charge density from interlayer Zn–n_(4) configuration in carbon nitride for enhanced CO_(2) photoreduction

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nano Research 2024年第4期17卷 2400-2409页

作者： Xianjin Shi yu Huang Gangqiang Zhu Wei Peng Meijuan Chen State Key Laboratory of Loess and Quaternary Geology(SKLLQG) Key Laboratory of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Center of Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710062China School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China

The solar-driven reduction of CO_(2) into valuable products is a promising method to alleviate global environmental problems and energy ***,the low surface charge density limits the photocatalytic conversion performance of CO_(2).Herein,a polymeric carbon nitride(PCn)photocatalyst with Zn single atoms(Zn1/Cn)was designed and synthesized for CO_(2) *** results of the CO_(2) photoreduction studies show that the CO and CH_(4) yields of Zn1/Cn increased fivefold,reaching 76.9 and 22.9μmol/(g·h),respectively,in contrast to the unmodified ***+plasma-etched X-ray photoelectron spectroscopy and synchrotron radiation-based X-ray absorption fine structure results reveal that Zn single atom is mainly present in the interlayer space of PCn in the Zn–n_(4) *** characterizations indicate that the interlayer Zn–n_(4) configuration can amplify light absorption and establish an interlayer charge transfer ***-assisted Kelvin probe force microscopy confirms that more photogenerated electrons are delivered to the catalyst surface through interlayer Zn–n_(4) configuration,which increases its surface charge ***,in-situ infrared spectroscopy combined with density functional theory calculation reveals that promoted surface charge density accelerates key intermediates(*COOH)conversion,thus achieving efficient CO_(2) *** work elucidates the role of internal single atoms in catalytic surface reactions,which provides important implications for the design of single-atom catalysts.

关键词： single-atom catalysts photocatalytic CO_(2)reduction interlayer modification charge transfer dynamics surface charge density

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