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Molecular dynamics of amorphous pharmaceutical fenofibrate studied by broadband dielectric spectroscopy

Journal of Pharmaceutical Analysis 2016年第3期6卷 165-170页

作者： U. sailaja M. shahin Thayyil n.s. krishna kumar G. Govindaraj Department of Physics M.E.S Keveeyam College. Valanchery 676552 Malappuram Kerala India Department of Physics University of Calicut 673635 Kerala. India Department of Physics School of Physical Chemical and Applied Sciences Pondicherry University Puducherry 605014 India

Fenofibrate is mainly used to reduce cholesterol level in patien.s.at risk of cardiovascular disease. Thermal transition.s.udy with the help of differential scanning calorimetry （DsC） shows that the aforesaid active pharmaceutical ingredient （API） is a good glass former. Based on our DsC study, the molecular dynamics of this API has been carried out by broadband dielectric spectroscopy （BDs） covering wide temperature and frequency ranges. Dielectric measuremen.s.of amorphous fenofibrate were per- formed after its vitrification by fast cooling from a few degrees above the melting point （Tm=354.11 K） to deep glassy state. The sample does not show any crystallization tendency during cooling and reaches the glassy state. The temperature dependence of the structural relaxation has been fitted by single Vogel- Fulcher-Tamman （VFT） equation. From VFT fit, glass transition temperature （Tg） was estimated as 250.56 K and fragility （m） was determined as 94.02. This drug is classified as a fragile glass former. Deviations of experimental data from Kohlrausch-Williams-Watts （KWW） fits on high-frequency flank of α-peak indicate the presence of an excess wing in fenofibrate. Based on ngai＇s coupling model, we identified the excess wing as true Johari-Goldstein （JG） process. Below the glass transition temperature one can clearly see a secondary relaxation （γ） with an activation energy of 32.67 kJ/mol.

关键词： Amorphous fenofibrate Bioavailability Broadband dielectric spectroscopy Glass transition Molecular dynamics

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nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： Krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian.s.inal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(Khyeam et al.,2021).

关键词： injured capacity modified

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Combustion.s.nthesis and lumin.s.ence characteristic of rare earth activated LiCaBO_3

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Journal of Rare Earths 2012年第10期30卷 1005-1008页

作者： n.s. Bajaj s.K. Omanwar Department of Physics SGB Amravati University Amravati-444602 (M.S.)

Lithium calcium borate （LiCaBO3） polycrystalline thermolumin.s.ence （TL） phosphor doped with rare earth （Tb3＋ and Dy3＋） elemen.s.was synthesized by novel solution combustion.s.nthesis. The reaction produced very stable crystalline LiCaBO3：D（D=Tb3＋ and Dy3＋） phosphors. These rare earth doped phosphors material showed maximum TL sensitivity with favorable glow curve shape. TL glow curve of X-ray irradiated that LiCaBO3：Tb3＋ and LiCaBO3：Dy3＋ samples showed two major well-separated glow peaks. The TL sensitivity of these phosphors to X-ray radiation was comparable with that of TLD-100（Harshaw）. Photolumin.s.ence spectra of LiCaBO3：Tb3＋ and LiCaBO3：Dy3＋ showed the characteristic Tb3＋ and Dy3＋ peaks respectively. TL response to X-ray radiation dose was linear up to 25 Gy.

关键词： lumin.s.ence LiCaBO3 combustion.s.nthesis rare earths kinetics

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Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali n.Ali Arshad Majid sheffield Institute for Translational neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(Vns)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been.s.gnificant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive Vns paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatmen.s.of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvemen.s.in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

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Investigations on Low speed Axial Compressor with Forward and Backward sweep

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Journal of Thermal science 2007年第2期16卷 121-133页

作者： M.Govardhan O.G.krishna kumar n.s.taram Thermal Turbomachin.s.Laboratory Department of Mechanical EngineeringIndian Institute of Technology MadrasChennai 600036India

In the recent past, experimental studies have shown.s.me advantages of blade lean and sweep in axial compressors. As most of the experimental results are combined with other features, it is difficult to determine the effect of individual parameters on the performance of the compressor. The present numerical studies are aimed at understanding the performance and three-dimensional flow pattern at the exit of swept and unswept rotors. Three rotors, namely; unswept, 200 forward swept and 200 backward swept rotors are analysed with a specific intention of understanding the pattern of the blade boundary layer flow. The analysis was done using a fully three-dimensional viscous CFD code CFX-5. Results indicated reduction in pressure rise with sweep. Backward sweep is detrimental as far as the performance near endwalls is considered. On the other hand total pressure loss in the wake in mid span region is less with backward sweep, which favours its application here. However, backward sweep adversely affects the stall margin. The ability of the forward sweep to deflect the streamlin.s.towards hub gets dimin.s.ed at low flow rates. Forward sweep changes the streamline pattern in.s.ch a way that the suction.s.rface streamlin.s.are deflected towards the hub and the pressure surface streamlin.s.are deflected towards the easing. An opposite behaviour is observed in backward swept rotors.

关键词： sweep pressure rise streamline shift stall margin blade loading

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support vector regression modeling in recursive just-in-time learning framework for adaptive soft sensing of naphtha boiling point in crude distillation unit

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Petroleum science 2021年第4期18卷 1230-1239页

作者： Venkata Vijayan.s.Hare krishna Mohanta Ajaya kumar Pani Department of Chemical Engineering Birla Institute of Technology and SciencePilaniRajasthan333031India

Prediction of primary quality variables in real time with adaptation capability for varying process conditions is a critical task in process *** article focuses on the development of non-linear adaptive soft sensors for prediction of naphtha initial boiling point(IBP)and end boiling point(EBP)in crude distillation *** this work,adaptive inferential sensors with linear and non-linear local models are reported based on recursive just in time learning(JITL)*** different types of local models designed are locally weighted regression(LWR),multiple linear regression(MLR),partial least squares regression(PLs)and support vector regression.s.R).In addition to model development,the effect of relevant dataset size on model prediction accuracy and model computation time is also *** show that the JITL model based on.s.pport vector regression with iterative single data algorithm optimization(IsDA)local model(JITL-sVR:IsDA)yielded best prediction accuracy in reasonable computation time.

关键词： Adaptive soft sensor Just in time learning Regression support vector regression naphtha boiling point

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Magnetic susceptibility of Al_2RE compoun.s.in crystal and liquid states

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Journal of Rare Earths 2011年第8期29卷 768-771页

作者： n.s. Uporova s.A. Uporov V.E. sidorov Ural state Pedagogical University

Magnetic susceptibility of Al2RE （RE=Y, Ce, sm, Gd, Dy, Ho, Yb） compoun.s.was studied experimentally in wide temperature （T=290–2000 K） and field （B=0.3–1.3 T） intervals. The abnormal increase in.s.sceptibility beginning above the melting point was fixed for all the compositions. The values for the effective magnetic momen.s.per RE atoms in these compoun.s.were found to be smaller than the values typical for free ions RE3＋. The results were discussed in.s.pposition of the directed bon.s.between aluminum and rare-earth atoms.

关键词： Al2RE intermetallic compounds magnetic susceptibility rare earths

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Constructing a biofunctionalized 3D-printed gelatin.s.dium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering

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Bio-Design and Manufacturing 2024年第1期7卷 57-73页

作者： Amit kumar singh krishna Pramanik Amit Biswas Centre of Excellence in Tissue Engineering Department of Biotechnology and Medical EngineeringNational Institute of TechnologyRourkela 769008India

sodium alginate(sA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering *** present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue *** experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and *** resulting tri-polymer complex was used as bioink to fabricate sA/CH/GEmatrices by three-dimensional(3D)*** studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural *** scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue *** tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffn.s. of sA/CH scaffolds upon addition of *** enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the sA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue *** vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red s assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold *** addition.s./CH containing 15%gelatin designated as sA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its pote

关键词： scaffold Biomaterial sodium alginate Chitosan Gelatin 3D printing Tissue engineering

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Olfactory receptors in neural regeneration in the central nervous system

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neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan.s.rrano-Marín Rafael Rivas-santisteban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagn.s.ics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechan.s.s underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compoun.s.and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compoun.s.that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： aden.s.ne receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

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